Applying optical coherence tomography and optical coherence tomography angiography to improve the diagnosis and treatment of neuro-ophthalmic diseases_Chinese Journal of Ocular Fundus Diseases

Authors：

 Lu Fang , She Kaiqin , Liang Licong

Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, China;

Corresponding author：

Lu Fang, Email: lufang@wchscu.cn

Keywords：

Tomography, optical coherence; Nervous system diseases; Editorial; Neuro-ophthalmology

DOI：

10.3760/cma.j.cn511434-20210316-00139

Video：

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Abstract Full text Figures/Tables Video References Cited by

With the development of ophthalmic optical coherence tomography (OCT) and OCT angiography (OCTA), including the improving of light source, resolution, scanning depth and upgrade of analysis softwares, they can more accurately display the structure of retinal layers and give accurate quantitative measurement. In neuro-ophthalmic diseases, the OCT indicators (the thickness of retinal nerve fiber layer around optic disc and plexus layer in macular gangle cells) and OCTA indicators (the blood flow density of capillaries around optic disc, superficial and deep capillaries in macular area, and the area of foveal avascualr zone) had special changes. It has important value in the differential diagnosis of central nervous system diseases and retinal diseases with visual dysfunction as the first symptom, the diagnosis and differential diagnosis of neuro-ophthalmic disease, the evaluation of progression of neurodegenerative diseases. Neuro-ophthamologists should pay more attention to the exploration and application of OCT and OCTA in the field of neuro-ophthalmology.

Citation： Lu Fang, She Kaiqin, Liang Licong. Applying optical coherence tomography and optical coherence tomography angiography to improve the diagnosis and treatment of neuro-ophthalmic diseases. Chinese Journal of Ocular Fundus Diseases, 2021, 37(3): 169-172. doi: 10.3760/cma.j.cn511434-20210316-00139 Copy

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8.	Fard MA, Sahraiyan A, Jalili J, et al. Optical coherence tomography angiography in papilledema compared with pseudopapilledema[J]. Invest Ophthalmol Vis Sci, 2019, 60(1): 168-175. DOI: 10.1167/iovs.18-25453.
9.	Berisha F, Feke GT, Trempe CL, et al. Retinal abnormalities in early Alzheimer’s disease[J]. Invest Ophthalmol Vis Sci, 2007, 48(5): 2285-2289. DOI: 10.1167/iovs.06-1029.
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11.	Bodis-Wollner I, Kozlowski PB, Glazman S, et al. Alpha-synuclein in the inner retina in Parkinson disease[J]. Ann Neurol, 2014, 75(6): 964-966. DOI: 10.1002/ana.24182.
12.	Zou J, Liu K, Li F, et al. Combination of optical coherence tomography (OCT) and OCT angiography increases diagnostic efficacy of Parkinson’s disease[J]. Quant Imaging Med Sure, 2020, 10(10): 1930-1939. DOI: 10.21037/qims-20-460.
13.	Swanson JW, Aleman TS, Xu W, et al. Evaluation of optical coherence tomography to detect elevated intracranial pressure in children[J]. JAMA Ophthalmol, 2017, 135(4): 320-328. DOI: 10.1001/jamaophthalmol.2017.0025.
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1. Hee MR, Izatt JA, Swanson EA, et al. Optical coherence tomography of the human retina[J]. Arch Ophthalmol, 1995, 113(3): 325-332. DOI: 10.1001/archopht.1995.01100030081025.
2. Wojtkowski M, Fercher AF, Leitgeb R. Phase sensitive interferometry in optical coherence tomography[J]. Proc SPIE, 2001, 4515: 250-255. DOI: 10.1117/12.432985.
3. Podoleanu AG, Rosen RB. Combinations of techniques in imaging the retina with high resolution[J]. Prog Retin Eye Res, 2008, 27(4): 464-499. DOI: 10.1016/j.preteyeres.2008.03.002.
4. Kim DY, Fingler J, Zawadzki RJ, et al. Optical Imaging of the chorioretinal vasculature in the living human eye[J]. Proc Natl Acad Sci, 2013, 110(35): 14354-14359. DOI: 10.1073/pnas.1307315110.
5. Lanzillo R, Cennamo G, Criscuolo C, et al. Optical coherence tomography angiography retinal vascular network assessment in multiple sclerosis[J]. Mult Scler, 2017, 24(13): 1706-1714. DOI: 10.1177/1352458517729463.
6. Fard MA, Ghahvehchian H, Subramanian PS. Optical coherence tomography in ischemic optic neuropathy[J/OL]. Ann Eye Sci, 2020, 5: 6[2020-03-15]. http://dx.doi.org/10.21037/aes.2019.12.05. DOI: 10.21037/aes.2019.12.05.
7. Kuspersmith MJ, Sibony P, Mandel G et al. Optical coherence tomography of the swollen optic nerve head: deformation of the peripapillary retinal pigment epithelium layer in papilledema[J]. Invest Ophthalmol Vis Sci, 2011, 52(9): 6558-6564. DOI: 10.1167/iovs.10-6782.
8. Fard MA, Sahraiyan A, Jalili J, et al. Optical coherence tomography angiography in papilledema compared with pseudopapilledema[J]. Invest Ophthalmol Vis Sci, 2019, 60(1): 168-175. DOI: 10.1167/iovs.18-25453.
9. Berisha F, Feke GT, Trempe CL, et al. Retinal abnormalities in early Alzheimer’s disease[J]. Invest Ophthalmol Vis Sci, 2007, 48(5): 2285-2289. DOI: 10.1167/iovs.06-1029.
10. Jiang H, Wei Y, Shi Y, et al. Altered macular microvasculature in mild cognitive impairment and Alzheimer disease[J]. J Neuroophthalmol, 2018, 38(3): 292-298. DOI: 10.1097/WNO.0000000000000580.
11. Bodis-Wollner I, Kozlowski PB, Glazman S, et al. Alpha-synuclein in the inner retina in Parkinson disease[J]. Ann Neurol, 2014, 75(6): 964-966. DOI: 10.1002/ana.24182.
12. Zou J, Liu K, Li F, et al. Combination of optical coherence tomography (OCT) and OCT angiography increases diagnostic efficacy of Parkinson’s disease[J]. Quant Imaging Med Sure, 2020, 10(10): 1930-1939. DOI: 10.21037/qims-20-460.
13. Swanson JW, Aleman TS, Xu W, et al. Evaluation of optical coherence tomography to detect elevated intracranial pressure in children[J]. JAMA Ophthalmol, 2017, 135(4): 320-328. DOI: 10.1001/jamaophthalmol.2017.0025.
14. Vijay V, Mollan SP, Mitchell JL, et al. Using optical coherence tomography as a surrogate of measurements of intracranial pressure in idiopathic intracranial hypertension[J]. JAMA Ophthalmol, 2020, 138(10): 1264-1271. DOI: 10.1001/jamaophthalmol.2020.4242.

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Chinese Journal of Ocular Fundus Diseases

Applying optical coherence tomography and optical coherence tomography angiography to improve the diagnosis and treatment of neuro-ophthalmic diseases

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