Analysis of inner and outer retinal thickness after photodynamic therapy in chronic central serous chorioretinopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

ZhangTongmei ,  HanMei , XieShiyong

Clinical College of Ophthalmology Tianjin Medical University, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin 300020, China;

Corresponding author：

HanMei, Email: hanmay69@sina.com

Keywords：

Central serous chorioretinopathy/therapy; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2015.03.006

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the characteristic variation of the patients' inner and outer retina who had chronic central serous chorioretinopathy (CSC) after being treated of photodynamic therapy (PDT). Methods Nineteen patients with chronic CSC were recruited, including 15 eye of men and 4 eye of women, logMAR BCVA was 0.1-1.0, 0.39±0.30. Meanwhile, 24 healthy people were located in the control group. All the patients received PDT for the first time. All subjects including 24 healthy people underwent fourier domain optical coherence tomography (FD-OCT). Retinal thickness were investigated before PDT and 1, 4, 12, 20 weeks after PDT respectively. Data were recorded including inner layer and outer layer. Retinal thickness were compared in fovea (1 mm), parafovea (3 mm)and perifovea(5 mm). Paired-samples t test was used to compare retinal thickness before and after PDT. The statistical differences of patients and control group were evaluated by independent-samples t test. The correlations between the best logMAR corrected visual acuity (BCVA) was analyzed by Pearson statistical analyses. Results The inner(F=13.814, 10.095, 4.689) and outer(F=9.354, 5.878, 3.978)layer fovea thickness of CSC subjects in 1, 4, 12 week was thinner, the difference was statistically significant (P < 0.05). The outer layer fovea thickness at P12(t=-3.725), parafovea of inner and outer retinal(t=-3.198, -2.722)was reduced when compared with control group, and differences have statistical sense, respectively (P < 0.05). There was correlation between logMAR BCVA and outer retinal thickness in fovea and parafovea (r=0.465, -0.728, -0.687; P < 0.05). Conclusion In our study, the inner and outer layer retinal thickness decreased generally after the first time PDT in CSC patients.

Citation： ZhangTongmei, HanMei, XieShiyong. Analysis of inner and outer retinal thickness after photodynamic therapy in chronic central serous chorioretinopathy. Chinese Journal of Ocular Fundus Diseases, 2015, 31(3): 235-239. doi: 10.3760/cma.j.issn.1005-1015.2015.03.006 Copy

1.	Landa G, Bukelman A, Katz H, et al. Early OCT changes of neuroretinal foveal thickness after first versus repeated PDT in AMD[J]. Int Ophthalmol, 2009, 29(1):1-5.
2.	Shin YU, Cho HY, Lee BR.Outer photoreceptor layer thickness mapping in normal eyes and eyes with various macular diseases using spectral domain optical coherence tomography:apilot study[J]. Graefe's Arch Clin Exp Ophthalmol, 2013, 251(11):2529-2537.
3.	Kim HC, Cho WB, Chung H. Morphologic changes in acute central serous chorioretinopathy using spectral domain optical coherence tomography[J]. Korean J Ophthalmol, 2012, 26(5):347-354.
4.	Pryds A, Larsen M. Choroidal thickness following extrafoveal photodynamic treatment with verteporfin in patients with central serous chorioretinopathy[J]. Acta Ophthalmol, 2012, 90(8):738-743.
5.	Nicoló M, Eandi CM, Alovisi C, et al. Half-fluence versus half-dose photodynamic therapy in chronic central serous chorioretinopathy[J].Am J Ophthalmol, 2014, 157(5):1033-1037.
6.	Liu CF, Chen LJ, Tsai SH, et al. Half-dose verteporfin combined with half-fluence photodynamic therapy for chronic central serous chorioretinopathy[J]. J Ocul Pharmacol Ther, 2014, 30(5):400-405.
7.	Vasconcelos H, Marques I, Santos AR, et al. Long-term chorioretinal changes after photodynamic therapy for chronic central serous chorioretinopathy[J]. Graefe's Arch Clin Exp Ophthalmol, 2013, 251(7):1697-1705.
8.	Kim SK, Kim SW, Oh J, et al. Near-infrared and short-wavelength autofluorescence in resolved central serous chorioretinopathy:association with outer retinal layer abnormalities[J]. Am J Ophthalmol, 2013, 156(1):157-164.
9.	Chan WM, Lai TY, Lai RY, et al. Safety enhanced photodynamic therapy for chronic central serous chorioretinopathy:one-year results of a prospective study[J]. Retina, 2008, 28(1):85-93.
10.	Reinke MH, Canakis C, Husain D, et al. Verteporfin photodynamic therapy retreatment of normal retina and choroid in the cynomolgus monkey[J]. Ophthalmology, 1999, 106:1915-1923.
11.	Ohnishi Y, Yoshitomi T, Murata T, et al. Electron microscopic study of monkey retina after photodynamic treatment[J].Med Electron Microsc, 2002, 35(1):46-52.
12.	Ishikawa H, Stein DM, Wollstein G, et al.Macular segmentation with optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2005, 46(6):2012-2017.
13.	Yamamoto M, Nishijima K, Nakamura M, et al. Inner retinal changes in acute-phase Vogt-Koyanagi-Harada disease measured by enhanced spectral domain optical coherence tomography[J]. Jpn J Ophthalmol, 2011, 55(1):1-6.
14.	Pryds A, Larsen M.Foveal function and thickness after verteporfin photodynamic therapy in central serous chorioretinopathy with hyperautofluorescent subretinal deposits[J].Retina, 2013, 33(1):128-135.
15.	Wachtlin J, Behme T, Heimann H, et al. Concentric retinal pigment epithelium atrophy after a single photodynamic therapy[J]. Graefe's Arch Clin Exp Ophthalmol, 2003, 241(6):518-521.
16.	Schmidt-Erfurth U, Michels S, Barbazetto I, et al Photodynamic effects on choroidal neovascularization and physiological choroid[J].Invest Ophthalmol Vis Sci, 2002, 43(3):830-841.
17.	Schlotzer-Schrehardt U, Viestenz A, Nanmann GO, et al. Dose-related structural effects of photodynamic therapy on choroidaland retinal structures of human eyes[J].Graefe's Arch Clin Exp Ophthalmol, 2002, 240(19):748-757.
18.	禹海, 夏国英, 高明宏, 等.频域相干光断层扫描观察急性浆液性脉络膜视网膜病变的形态学变化特征[J].中华眼科杂志, 2011, 47(6):508-515.

1. Landa G, Bukelman A, Katz H, et al. Early OCT changes of neuroretinal foveal thickness after first versus repeated PDT in AMD[J]. Int Ophthalmol, 2009, 29(1):1-5.
2. Shin YU, Cho HY, Lee BR.Outer photoreceptor layer thickness mapping in normal eyes and eyes with various macular diseases using spectral domain optical coherence tomography:apilot study[J]. Graefe's Arch Clin Exp Ophthalmol, 2013, 251(11):2529-2537.
3. Kim HC, Cho WB, Chung H. Morphologic changes in acute central serous chorioretinopathy using spectral domain optical coherence tomography[J]. Korean J Ophthalmol, 2012, 26(5):347-354.
4. Pryds A, Larsen M. Choroidal thickness following extrafoveal photodynamic treatment with verteporfin in patients with central serous chorioretinopathy[J]. Acta Ophthalmol, 2012, 90(8):738-743.
5. Nicoló M, Eandi CM, Alovisi C, et al. Half-fluence versus half-dose photodynamic therapy in chronic central serous chorioretinopathy[J].Am J Ophthalmol, 2014, 157(5):1033-1037.
6. Liu CF, Chen LJ, Tsai SH, et al. Half-dose verteporfin combined with half-fluence photodynamic therapy for chronic central serous chorioretinopathy[J]. J Ocul Pharmacol Ther, 2014, 30(5):400-405.
7. Vasconcelos H, Marques I, Santos AR, et al. Long-term chorioretinal changes after photodynamic therapy for chronic central serous chorioretinopathy[J]. Graefe's Arch Clin Exp Ophthalmol, 2013, 251(7):1697-1705.
8. Kim SK, Kim SW, Oh J, et al. Near-infrared and short-wavelength autofluorescence in resolved central serous chorioretinopathy:association with outer retinal layer abnormalities[J]. Am J Ophthalmol, 2013, 156(1):157-164.
9. Chan WM, Lai TY, Lai RY, et al. Safety enhanced photodynamic therapy for chronic central serous chorioretinopathy:one-year results of a prospective study[J]. Retina, 2008, 28(1):85-93.
10. Reinke MH, Canakis C, Husain D, et al. Verteporfin photodynamic therapy retreatment of normal retina and choroid in the cynomolgus monkey[J]. Ophthalmology, 1999, 106:1915-1923.
11. Ohnishi Y, Yoshitomi T, Murata T, et al. Electron microscopic study of monkey retina after photodynamic treatment[J].Med Electron Microsc, 2002, 35(1):46-52.
12. Ishikawa H, Stein DM, Wollstein G, et al.Macular segmentation with optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2005, 46(6):2012-2017.
13. Yamamoto M, Nishijima K, Nakamura M, et al. Inner retinal changes in acute-phase Vogt-Koyanagi-Harada disease measured by enhanced spectral domain optical coherence tomography[J]. Jpn J Ophthalmol, 2011, 55(1):1-6.
14. Pryds A, Larsen M.Foveal function and thickness after verteporfin photodynamic therapy in central serous chorioretinopathy with hyperautofluorescent subretinal deposits[J].Retina, 2013, 33(1):128-135.
15. Wachtlin J, Behme T, Heimann H, et al. Concentric retinal pigment epithelium atrophy after a single photodynamic therapy[J]. Graefe's Arch Clin Exp Ophthalmol, 2003, 241(6):518-521.
16. Schmidt-Erfurth U, Michels S, Barbazetto I, et al Photodynamic effects on choroidal neovascularization and physiological choroid[J].Invest Ophthalmol Vis Sci, 2002, 43(3):830-841.
17. Schlotzer-Schrehardt U, Viestenz A, Nanmann GO, et al. Dose-related structural effects of photodynamic therapy on choroidaland retinal structures of human eyes[J].Graefe's Arch Clin Exp Ophthalmol, 2002, 240(19):748-757.
18. 禹海, 夏国英, 高明宏, 等.频域相干光断层扫描观察急性浆液性脉络膜视网膜病变的形态学变化特征[J].中华眼科杂志, 2011, 47(6):508-515.

Chinese Journal of Ocular Fundus Diseases

Analysis of inner and outer retinal thickness after photodynamic therapy in chronic central serous chorioretinopathy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content