The oxygen saturation and retinal blood vessel diameter in patients with convalescence Vogt-Koyanagi-Harada syndrome_Chinese Journal of Ocular Fundus Diseases

Authors：

YueYi , ZhangXiaomin , WangMeiyan , 陈曦腾 , 杨锦 ,  李筱荣

Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, School of Optometry and Ophthalmology, Tianjin Medical University, Tianjin 300384, China;

Corresponding author：

Keywords：

Uveomeningoencephalitic syndrome/complications; Oximetry; Retinal vessels/ physiopathology

DOI：

10.3760/cma.j.issn.1005-1015.2015.06.008

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Objective To measure and analyze the oxygen saturation and retinal blood vessel diameter in the eyes of patients with convalescence Vogt-Koyanagi-Harada (VKH) syndrome. Methods In this cross-sectional study, 28 eyes of 14 patients with convalescence VKH syndrome (VKH group) and 20 eyes of 10 healthy subjects (control group) were enrolled. The oxygen saturation and retinal blood vessel diameter were detected by spectrophotometric oximetry unit. Retinal images were collected using filters with wavelengths of 570 nm and 600 nm in the darkroom by the same technologist and then the fused image was obtained. The oxygen saturation of retinal vessels was marked in different colors. The measurement was repeated 2-3 times for each patient, then take an average. A top-quality image in each eye was selected to detect the oxygen saturation and diameter of retinal vessel which located in 1.5-3.0 disc diameter from the optic disc. Image analysis and data acquisition were completed by another technologist. Results Retinal venous oxygen saturation was (54.34±8.05)% in the VKH group and (60.07±7.91)% in the control group. The former was lower than the latter, the difference was significant (t=2.443, P=0.017). The mean diameter of retinal arteries was (102.8±18.1) μm in the VKH group and (112.9±19.8) μm in the control group. The former was smaller than the latter, the difference was significant (t=2.406, P=0.018). There was no significant difference of the mean diameter of retinal veins, oxygen saturation of retinal arteries and the arterial-venous difference between two groups (t=-0.330, 0.804, -0.631; P=0.743, 0.403, 0.536). Conclusions Retinal venous oxygen saturation and the mean diameter of retinal arteries are significantly decreased in patients with VKH syndrome. There is no significant difference of diameter of retinal veins, oxygen saturation of retinal arteries and the arterial-venous difference between VKH syndrome patients and healthy subjects.

Citation： YueYi, ZhangXiaomin, WangMeiyan. The oxygen saturation and retinal blood vessel diameter in patients with convalescence Vogt-Koyanagi-Harada syndrome. Chinese Journal of Ocular Fundus Diseases, 2015, 31(6): 545-548. doi: 10.3760/cma.j.issn.1005-1015.2015.06.008 Copy

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7.	Hardarson SH. Retinal oximetry[J]. Acta Ophthalmologica, 2013, 91(5):489-490.
8.	Goharian I, Iverson SM, Ruiz RC, et al. Reproducibility of retinal oxygen saturation in normal and treated glaucomatous eyes[J]. Br J Ophthalmol, 2015, 99(3):318-322.
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11.	Hirooka K, Saito W, Namba K, et al. Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt-Koyanagi-Harada disease[J]. Graefe's Arch Clin Exp Ophthalmol, 2015, 253(4):609-617.
12.	Arellanes-García L, Hernández-Barrios M, Fromow-Guerra J, et al. Fluorescein fundus angiographic findings in Vogt-Koyanagi-Harada syndrome[J]. Int Ophthalmol, 2007, 27(2-3):155-161.

1. Hirose S, Saito W, Yoshida K, et al. Elevated choroidal blood flow velocity during systemic corticosteroid therapy in Vogt-Koyanagi-Harada disease[J]. Acta Ophthalmologica, 2008, 86(8):902-907.
2. Sonoda S, Nakao K, Ohba N. Extensive chorioretinal atrophy in Vogt-Koyanagi-Harada disease[J]. Jpn J Ophthalmol, 1999, 43(2):113-119.
3. Geirsdottir A, Hardarson SH, Olafsdottir OB, et al. Retinal oxygen metabolism in exudative age-related macular degeneration[J]. Acta Ophthalmologica, 2014, 92(1):27-33.
4. Read RW, Holland GN, Rao NA, et al. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature[J]. Am J Ophthalmol, 2001, 131(5): 647-652.
5. Moorthy RS, Inomata H, Rao NA. Vogt-Koyanagi-Harada syndrome[J]. Surv Ophthalmol, 1995, 39(4):265-292.
6. Paul JP, O'Connell RA, Hosking SL, et al. Retinal oxygen saturation: novel analysis method for the oxymap[J]. Optom Vis Sci, 2013, 90(10):1104-1110.
7. Hardarson SH. Retinal oximetry[J]. Acta Ophthalmologica, 2013, 91(5):489-490.
8. Goharian I, Iverson SM, Ruiz RC, et al. Reproducibility of retinal oxygen saturation in normal and treated glaucomatous eyes[J]. Br J Ophthalmol, 2015, 99(3):318-322.
9. Linsenmeier RA, Padnick-Silver L. Metabolic dependence of photoreceptors on the choroid in the normal and detached retina[J]. Invest Ophthalmol Vis Sci, 2000, 41(10):3117-3123.
10. Eysteinsson T, Hardarson SH, Bragason D, et al. Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa[J]. Acta Ophthalmologica, 2014, 92(5):449-453.
11. Hirooka K, Saito W, Namba K, et al. Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt-Koyanagi-Harada disease[J]. Graefe's Arch Clin Exp Ophthalmol, 2015, 253(4):609-617.
12. Arellanes-García L, Hernández-Barrios M, Fromow-Guerra J, et al. Fluorescein fundus angiographic findings in Vogt-Koyanagi-Harada syndrome[J]. Int Ophthalmol, 2007, 27(2-3):155-161.

Chinese Journal of Ocular Fundus Diseases

The oxygen saturation and retinal blood vessel diameter in patients with convalescence Vogt-Koyanagi-Harada syndrome

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