Clinical characteristics of ocular toxocariasis patients on the first attendance_Chinese Journal of Ocular Fundus Diseases

Authors：

LiXiaochun ,  ChangQing , JiangRui , HuangXin , ZhangYanqiong , ChenQian , YanSaimei

Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China;

Corresponding author：

ChangQing, Email: qngchang@aliyun.com

Keywords：

Toxocariasis/diagnosis; Toxocariasis/complications; Retinal diseases/diagnosis; Retinal diseases/etiology

DOI：

10.3760/cma.j.issn.1005-1015.2016.01.010

Video：

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Objective To investigate the clinical characteristics of 40 patients with ocular toxocariasis (OT) on the first attendance. Methods A total of 40 consecutive patients who were clinically and serologically diagnosed with OT were retrospectively reviewed. Results The mean age of patients was (12.12±10.42) years. There were 29 males and 11 females. 29 cases presented with decreased vision, 4 children with leukocoria, 2 cases with strabismus and 5 cases was found abnormal during regular eye examination. Initially 8 eyes (20%) were misdiagnosed as retinoblastoma (1 eye), Coat's disease(1 eye), cataract (2 eyes), iridocyclitis (2 eyes) and retinal detachment (2 eyes). 23 eyes had retinal detachment, 19 eyes had cataract. OT was the initial diagnosis for 15 patients (37.5%). The best corrected visual acuity (BCVA) were NLP to 0.7. Ultrasound biomicroscopy (UBM) were performed in 29 eyes, and identified peripheral granulomas in 23 eyes and adjacent tractional retinal detachment in 12 eyes. We also identified 17 cases (68.0%) with elevated IgE level among 25 patients with positive serological antibody test. Conclusions Tractional retinal detachment, vitreous opacities and cataract are the common clinical findings at the first attendance of OT patients. The adjunctive test of serum total IgE level may be helpful for the diagnosis. The application of UBM and specific IgG detection in serum and intraocular fluid, can also improve the diagnosis.

Citation： LiXiaochun, ChangQing, JiangRui, HuangXin, ZhangYanqiong, ChenQian, YanSaimei. Clinical characteristics of ocular toxocariasis patients on the first attendance. Chinese Journal of Ocular Fundus Diseases, 2016, 32(1): 40-43. doi: 10.3760/cma.j.issn.1005-1015.2016.01.010 Copy

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1. 王朱健, 周旻, 吉建, 等.OT患者眼内液与血清犬弓蛔虫特异IgG抗体检测[J].中华眼底病杂志, 2015, 31(1):41-44.DOI:10.3760/cma.j.issn.1005-1015.2015.01.011.Wang ZJ, Zhou M, Ji J, et al.Application of specific IgG detection in intraocular fluid for the laboratory diagnosis of ocular toxocariasis[J].Chin J Ocul Fundus Dis, 2015, 31(1):41-44.DOI:10.3760/cma.j.issn.1005-1015.2015.01.011.
2. Molk R.Ocular toxocariasis: a review of the literature[J].Ann Ophthalmol, 1983, 15(3):216-219, 222-227, 230-231.
3. Zhou M, Chang Q, Gonzales JA, et a1.Clinical characteristics of ocular toxocariasis in Eastern china[J].Graefe's Arch Clin Exp Ophthalmol, 2012, 250(9):1373-1378. DOI:10.1007/s00417-012-1971-2.
4. Shields CL, Schoenberg E, Kocher K, et al.Lesions simulating retinoblastoma (pseudoretinoblastoma) in 604 cases: results based on age at presentation[J]. Ophthalmology, 2013, 120(2):311-316. DOI: 10.1016/j.ophtha.2012.07.067.
5. 刘亚鲁, 张琦, 赵培泉.眼弓蛔虫病[J].中华眼底病杂志, 2014, 30(1):112-114.DOI: 10.3760/cma.j.issn.1005-1015.2014.01.033.Liu YL, Zhang Q, Zhao PQ.Ocular toxocariasis[J].Chin J Ocul Fundus Dis, 2014, 30(1): 112-114.DOI:10.3760/cma.j.issn.1005-1015.2014.01.033.
6. Kwon SI, Lee JP, Park SP, et a1.0cular toxocariasis in korea[J].Jpn J 0phthalmol, 2011, 55(2):143-147.DOI: 10.1007/s10384-010-0909-7.
7. Rubinsky-Elefant G, Hirata CE, Yamamoto JH, et al. Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms[J]. Ann Trop Med Parasitol, 2010, 104(1):3-23.DOI: 10.1179/136485910X12607012373957.
8. Smith H, Holland C, Taylor M, et al. How common is human toxocariasis? Towards standardizing our knowledge[J]. Trends Parasitol, 2009, 25(4):182-188.DOI: 10.1016/j.pt.2009.01.006.
9. Macpherson CN. The epidemiology and public health importance of toxocariasis: a zoonosis of global importance[J]. Int J Parasitol, 2013, 43: 999-1008. DOI: 10.1016/j.jpara.2013.07.004.
10. De Visser L, Rothova A, De Boer JH, et al.Diagnosis of ocular toxocariasis by establishing intraocular antibody production [J].Am J Ophthalmol, 2008, 145:369-374. DOI:10.1016/j.aj.2007.09.020.
11. Ahn SJ, Woo SJ, JinY, et al. Clinical features and course of ocular toxocariasis in adults. PLoS Negl Trop Dis, 2014, 8:2938. http://journals.Plos.org/plosntds/article?id=10.1371/journal.pntd.0002938. DOI:10.1371/journal.pntd.0002938.
12. Jee D, Kim KS, Lee WK, et al.Clinical features of ocular toxocariasis in adult Korean patients[J].Ocul Immunol Inflamm, 2015, 24:1-10.DOI: 10.3109/09273948.2014.994783.

Chinese Journal of Ocular Fundus Diseases

Clinical characteristics of ocular toxocariasis patients on the first attendance

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