Research updates on the correlation of hypertensive retinopathy and carotid artery lesion_Chinese Journal of Ocular Fundus Diseases

Authors：

ChenXuling ,  YangLiu

Department of Ophthalmology, Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100034, China;

Corresponding author：

YangLiu, Email: lucy02114@163.com

Keywords：

Retinal diseases/etiology; Hypertension/complications; Carotid artery diseases; Review

DOI：

10.3760/cma.j.issn.1005-1015.2016.03.027

Video：

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Abstract Full text Figures/Tables Video References Cited by

Hypertensive retinopathy (HR) often coexist with carotid lesions in hypertensive patients. Carotid lesions are closely associated with cardiovascular and cerebrovascular diseases, as well as end events, offering early important evidence to screening high risk patients. HR has significant value to predict target organ damage (TOD) of hypertension including carotid lesion. In addition, hypertensive retinopathy and carotid lesions-related ischemic ocular diseases will cause serious vision function damage. This article is going to summarize the value and correlation between hypertensive retinopathy and carotid lesions in terms of clinical manifestations, pathological physiological mechanism and target organ damage.

Citation： ChenXuling, YangLiu. Research updates on the correlation of hypertensive retinopathy and carotid artery lesion. Chinese Journal of Ocular Fundus Diseases, 2016, 32(3): 326-330. doi: 10.3760/cma.j.issn.1005-1015.2016.03.027 Copy

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1. Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension:the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)[J]. J Hypertens, 2013, 31(7):1281-1357.DOI:10.1097/01.hjh.0000431740.32696.cc.
2. Liu A, Yu Z, Wang N, et al. Carotid atherosclerosis is associated with hypertension in a hospital-based retrospective cohort[J]. Int J Clin Exp Med, 2015, 8(11):21932-21938.
3. Hu G, Barengo NC, Tuomilehto J, et al. Relationship of physical activity and body mass index to the risk of hypertension:a prospective study in Finland[J]. Hypertension, 2004, 43(1):25-30.DOI:10.1161/01.HYP.0000107400.72456.19.
4. Pang Y, Sang Y, Ballew SH, et al. Carotid intima-media thickness and incident ESRD:The Atherosclerosis Risk in Communities (ARIC) Study[J/OL]. Clin J Am Soc Nephrol, 2016:E11951115[2016-04-12].http://cjasn.asnjournals.org/content/early/2016/04/12/CJN.11951115.abstract.DOI:10.2215/CJN.11951115.[published online ahead of print].
5. Talavera-Garcia E, Delgado-Lista J, Garcia-Rios A, et al. Influence of obesity and metabolic disease on carotid atherosclerosis in patients with coronary artery disease (CordioPrev Study)[J/OL]. PLoS One, 2016, 11(4):153096[2016-04-11]. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827867/.DOI:10.1371/journal.pone.0153096.
6. Tso MO, Jampol LM. Pathophysiology of hypertensive retinopathy[J]. Ophthalmology, 1982, 89(10):1132-1145.DOI:10.1016/S0161-6420(82)34663-1.
7. Coban E, Alkan E, Altuntas S, et al. Serum ferritin levels correlate with hypertensive retinopathy[J]. Med Sci Monit, 2010, 16(2):92-95.
8. Wong TY, Klein R, Couper DJ, et al. Retinal microvascular abnormalities and incident stroke:the atherosclerosis risk in communities study[J]. Lancet, 2001, 358(9288):1134-1140.DOI:10.1016/S0140-6736(01)06253-5.
9. Kim GH, Youn HJ, Kang S, et al. Relation between grade II hypertensive retinopathy and coronary artery disease in treated essential hypertensives[J]. Clin Exp Hypertens, 2010, 32(7):469-473.DOI:10.3109/10641963.2010.496515.
10. Varghese M, Adhyapak SM, Thomas T, et al. The association of severity of retinal vascular changes and cardiac remodelling in systemic hypertension[J/OL]. Ther Adv Cardiovasc Dis, 2016, 1753944716630869[2016-02-14].http://tak.sagepu.com/cgi/pmidlookup?view=long&pmid=26879197.DOI:10.1177/1753944716630869.
11. Nossen J, Vierzigmann T, Weiss W, et al.Calcified plaque of the extracranial carotid arteries in comparison with traditional risk factors as a predictor for relevant coronary artery stenoses[J]. Herz, 2001, 26(7):454-460.
12. Svardsudd K, Wedel H, Aurell E, et al. Hypertensive eye ground changes. Prevalence, relation to blood pressure and prognostic importance. The study of men born in 1913[J]. Acta Med Scand, 1978, 204(3):159-167.
13. De Boever P, Louwies T, Provost E, et al. Fundus photography as a convenient tool to study microvascular responses to cardiovascular disease risk factors in epidemiological studies[J]. J Vis Exp, 2014(92):51904.DOI:10.3791/51904.
14. Grunwald JE, Alexander J, Ying GS, et al. Retinopathy and chronic kidney disease in the Chronic Renal Insufficiency Cohort (CRIC) study[J]. Arch Ophthalmol, 2012, 130(9):1136-1144.DOI:10.1001/archopht.126.9.1266.
15. Arriozola-Rodriguez KJ, Serna-Ojeda JC, Martinez-Hernandez VA, et al. Hypertensive retinopathy as the first manifestation of advanced renal disease in a young patient:report of a case[J]. Case Rep Ophthalmol, 2015, 6(3):415-419.DOI:10.1159/000442660.
16. Goessel H, Rascher W, Bergua A. Hypertensive retinopathy grade iv in an 11-year-old girl with renal arterial hypertension due to recurrent reflux pyelonephritis[J]. Retin Cases Brief Rep, 2010, 4(3):266-267.DOI:10.1097/ICB.0b013e3181ae71a5.
17. 冯彦红, 钱林学, 胡向东, 等.彩色多普勒对颈内动脉狭窄患者视网膜中央动脉的血流检测[J].临床和实验医学杂志, 2011, 10(19):1521-1523.DOI:10.3969/j.issn.1671-4695.2011.19.015.Feng YH, Qian LX, Hu XD, et al. The detection of blood flow in retinal central artery of patients with arteriostenosis of internal carotid artery by color Doppler ultrasonography[J].Journal of Clinical and Experimental Medicine, 2011, 10(19):1521-1523.DOI:10.3969/j.issn.1671-4695.2011.19.015.
18. Schmidt D. Unusual course of disease due to extensive stenosis of the internal carotid artery with ocular ischemia by occlusion of the ophthalmic artery[J]. Ophthalmologe, 2015, 112(12):1022.DOI:10.1007/s00347-015-0161-0.
19. 宫华芳, 张屹辉, 王晓旭, 等.彩色多普勒超声观测脑缺血时眼动脉的血流动力学改变[J].实用医技杂志, 2008(17):2184-2186.DOI:10.3969/j.issn.1671-5098.2008.17.004.Gong HF, Zhang YH, Wang XX, et al. To observe the hemodynamical changes of ophthalmical arterial in cerebral ischemia using color Doppler flow imaging[J]. JPMT, 2008, 15(17):2184-2186.DOI:10.3969/j.issn.1671-5098.2008.17.004.
20. Stevens WD, Fortin T, Pappas BA. Retinal and optic nerve degeneration after chronic carotid ligation:time course and role of light exposure[J]. Stroke, 2002, 33(4):1107-1112.DOI:10.1161/01.STR.0000014204.05597.0C.
21. Yamaguchi S, Fukuyama H, Yonekura Y, et al. Effect of brovincamine on cerebral circulation and metabolism in internal carotid artery occlusion examined by positron emission tomography[J]. Eur Neurol, 1992, 32(6):314-317.
22. Yamauchi H, Fukuyama H, Kimura J, et al. Hemodynamics in internal carotid artery occlusion examined by positron emission tomography[J]. Stroke, 1990, 21(10):1400-1406.DOI:10.1161/01.STR.21.10.1400.
23. Barkana Y, Harris A, Hefez L, et al. Unrecordable pulsatile ocular blood flow may signify severe stenosis of the ipsilateral internal carotid artery[J]. Br J Ophthalmol, 2003, 87(12):1478-1480.DOI:10.1136/bjo.87.12.1478.
24. 黄辉, 吴意赟, 周正国, 等.原发性高血压病患者眼球后动脉血流变化的多普勒超声观察[J].临床超声医学杂志, 2010, 12(1):21-23.DOI:10.3969/j.issn.1008-6978.2010.01.007.Huang H, Wu YY, Zhou ZG, et al. Observation of postocular artery hemodynamic changes in hypertension patients by ultrasonography[J].JUltrasound Clin Med, 2010, 12(1):21-23.DOI:10.3969/j.issn.1008-6978.2010.01.007.
25. 李军, 李志勇, 杨光, 等.常见眼底病及不同中医证型的患者颈内动脉和眼动脉血流状态分析[J].中国中医眼科杂志, 1995, 5(2):98-100.Li J, Li ZY, Yang G, et al.Internal carotid artery and ophthalmic artery blood flow state analysis in common ocular fundus disease and patients with different symptom complex of traditional Chinese medicine[J].Journal of Traditional Chinese Ophthalmology, 1995, 5(2):98-100.
26. Geisel MH, Coassin S, Hessler N, et al. Update of the effect estimates for common variants associated with carotid intima media thickness within four independent samples:The Bonn IMT Family Study, the Heinz Nixdorf Recall Study, the SAPHIR Study and the Bruneck Study[J]. Atherosclerosis, 2016, 249:83-87. DOI:10.1016/j.atherosclerosis.2016.03.042.
27. Sucato V, Evola S, Novo G, et al. The association between coronary microvascular dysfunction and carotid intima media thickness in patients with cardiac syndrome X[J]. Int J Cardiol, 2016, 214:383-386.DOI:10.1016/j.ijcard.2016.04.028.
28. Qu B, Qu T, Liu Y, et al. Risk factors associated with increased carotid intima-media thickness in a male population with chronic alcohol consumption:a prospective observational study[J]. Medicine (Baltimore), 2016, 95(15):3322.DOI:10.1097/MD.0000000000003322.
29. Takiuchi S, Kamide K, Miwa Y, et al. Diagnostic value of carotid intima-media thickness and plaque score for predicting target organ damage in patients with essential hypertension[J].J Hum Hypertens, 2004, 18(1):17-23. DOI:10.1038/sj.jhh.1001628.
30. Touboul PJ, Labreuche J, Vicaut E, et al. Carotid intima-media thickness, plaques, and Framingham risk score as independent determinants of stroke risk[J]. Stroke, 2005, 36(8):1741-1745.DOI:10.1161/01.STR.0000174490.23495.57.
31. Owolabi MO, Akpa OM, Agunloye AM. Carotid IMT is more associated with stroke than risk calculators[J].Acta Neurol Scand, 2016, 133(6):442-450.DOI:10.1111/ane.12482.
32. Homma S, Hirose N, Ishida H, et al. Carotid plaque and intima-media thickness assessed by b-mode ultrasonography in subjects ranging from young adults to centenarians[J]. Stroke, 2001, 32(4):830-835.DOI:10.1161/01.STR.32.4.830.
33. Grant EG, Benson CB, Moneta GL, et al. Carotid artery stenosis:grayscale and Doppler ultrasound diagnosis——Society of Radiologists in Ultrasound consensus conference[J]. Ultrasound Q, 2003, 19(4):190-198.
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