Serum transthyretin in patients with different stages of diabetic retinopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

Zhuang Miao , Tan Chengye , Xie Tianhua , Shao Jun , Sun Chao , Bao Xin , Li Yunping , Tang Xiaojie ,  Yao Yong , Zhu Jing

Department of ophthalmology, Wuxi People’ Hospital, Wuxi 214023, China;

Corresponding author：

Yao Yong, Email: pard1@126.com

Keywords：

Diabetic retinopathy/etiology; Prealbumin

DOI：

10.3760/cma.j.issn.1005-1015.2017.03.005

Video：

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Objective To measure the concentration of serum transthyretin (TTR) of patients with different stages of diabetic retinopathy (DR). Methods A total of 176 patients with diabetes mellitus were included in this study. There were 104 males and 72 females. The patients aged from 21 to 74 years, with the mean age of (56±11) years. The diabetes duration raged from 1 to 30 years, with the mean diabetes duration of (10±7) years. The HbA1C was 5.2%−14.1%, with the mean HbA1C of (8.6±2.0)%. According to the fundus examination, 58 patients had DR (33.0%), but the other 118 patients not (67.0%). For these DR patients, 10 patients were in stage Ⅰ (5.7%), 26 patients in stage Ⅱ (14.8%), 8 patients in stage Ⅲ (4.5%), and 14 patients in stage Ⅳ (8.0%). The concentration of serum TTR was measured by enzyme-linked immunosorbentassay kit. The differences in the concentration of serum TTR between different DR stages were compared.Bivariate analysis was used to analyze the influencing factors of TTR. Results The concentrations of serum TTR of the patients without DR or with DR of stage Ⅰ to Ⅳ were (224.96±65.47), (383.68±102.99), (247.44±63.21), (228.2±45.89), (189.34±70.12) mg/L, respectively. The difference between different DR stages was statistically significant (F=14.690,P＜0.001).Bivariate analysis showed that the concentration of TTR was correlation to DR (r=0.179,P=0.017). There was no correlation between the concentration of TTR and diabetes duration (r=−0.027,P=0.727), hypertension (r=0.018,P=0.810), hyperlipoidemia (r=0.101,P=0.182), and the use of insulin (r=−0.032,P=0.675). Conclusion The concentration of serum TTR was increased in early DR patients, and gradually decreased with the progression of DR. The concentration of TTR is correlated to DR.

Citation： Zhuang Miao, Tan Chengye, Xie Tianhua, Shao Jun, Sun Chao, Bao Xin, Li Yunping, Tang Xiaojie, Yao Yong, Zhu Jing. Serum transthyretin in patients with different stages of diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2017, 33(3): 240-243. doi: 10.3760/cma.j.issn.1005-1015.2017.03.005 Copy

1.	Myron Johnson A, Merlini G, Sheldon J, et al. Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition [J]. Clin Chem Lab Med, 2007, 45(3): 419-426.
2.	庄淼, 邵珺, 谭澄烨, 等. 转甲状腺素蛋白对RPE细胞及视网膜微血管内皮细胞生物学行为的影响[J]. 中华眼科杂志, 2016, 52(11): 856-860. DOI: 10.3760/cma.j.issn.0412-4081.2016.11.010.Zhuang M, Shao J, Tan CY, et al. Effects of transthyretin on biological behavior of retinal pigment epithelial cells and retinal microvascular epithelial cells[J].Chin J Ophthalmol, 2016, 52(11): 856-860. DOI: 10.3760/cma.j.issn.0412-4081.2016.11.010.
3.	庄淼, 邵珺, 谭澄烨, 等. 转甲状腺素蛋白对视网膜微血管内皮细胞生物学行为的影响[J].中华眼底病杂志, 2015, 31(4): 368-370. DOI: 10.3760/cma.j.issn.1005-1015.2015.04.014.Zhuang M, Shao J, Tan CY, et al. Effects of transthyretin on biological behavior of retinal microvascular epithelial cell[J].Chin J Ocul Fundus Dis, 2015, 31(4): 368-370. DOI: 10.3760/cma.j.issn.1005-1015.2015.04.014.
4.	邵珺, 姚勇. 高糖缺氧环境下转甲状腺素蛋白对视网膜血管内皮细胞的影响[J].中华眼底病杂志, 2016, 32(2): 159-162. DOI: 10.3760/cma.j.issn.1005-1015.2016.02.011.Shao J, Yao Y. Transthyretinin repress retinal microvascular endothelial cells under high glucose and hypoxia environment[J].Chin J Ocul Fundus Dis, 2016, 32(2): 159-162. DOI: 10.3760/cma.j.issn.1005-1015.2016.02.011.
5.	蒋伏松, 成兴波, 张慧. 血清视黄醇结合蛋白4在2型糖尿病视网膜病中的价值[J]. 中华糖尿病杂志, 2010, 2(5): 339-343. DOI: 10.3760/cma.j.issn.1674-5809.2010.05.005.Jiang FH, Cheng XB, Zhang H. Serum retinal binding protein 4 in type 2 diabetic retinopathy[J]. Chin J Diabetes Mellitus, 2010, 2(5): 339-343. DOI: 10.3760/cma.j.issn.1674-5809.2010.05.005.
6.	中国高血压防治指南修订委员会. 中国高血压防治指南2010[J].中华心血管病杂志, 2011, 39(7): 579-616. DOI: 10.3760/cma.j.issn.0253-3758.2011.07.002.Hypertension Writing Group of Chinese. 2010 Chinese Guidelines for the Management of Hypertension[J]. Chin J Cardiol, 2011, 39(7): 579-616. DOI: 10.3760/cma.j.issn.0253-3758.2011.07.002.
7.	中国成人血脂异常防治指南制订联合委员会. 中国成人血脂异常防治指南[J].中华心血管病杂志, 2007, 35(5): 390-419. DOI: 10.3760/j.issn:0253-3758.2007.05.003.Adults Joint Committee for Developing. Chinese Guidelines On Prevention and Treatment of Dyslipidemia in Adults [J]. Chin J Cardiol, 2007, 35(5): 390-419. DOI: 10.3760/j.issn:0253-3758.2007.05.003.
8.	中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2013年版)[J]. 中华糖尿病杂志, 2014, 6(7): 447-498. DOI: 10.3760/cma.j.issn.1674-5809.2014.07.004.Chinese Diabetes Society, Chinese Medical Association. Standards of care for type 2 diabetes in China[J].Chin J Diabetes Mellitus, 2014, 6(7): 447-498. DOI: 10.3760/cma.j.issn.1674-5809.2014.07.004.
9.	中华医学会眼科学会眼底病学组. 我国糖尿病视网膜病变临床诊疗指南(2014年)[J]. 中华眼科杂志, 2014, 50(11): 851-865. DOI: 10.3760/cma.j.issn.0412-4081.2014.11.014.Chinese Ocular Fundus Diseases Society, Chinese Ophthalmological Society, Chinese Medical Association. Guidelines for clinical diagnosis and treatment of diabetic retinopathy in China[J].Chin J Ophthalmol, 2014, 50(11): 851-865. DOI: 10.3760/cma.j.issn.0412-4081.2014.11.014.
10.	Vieira M, Saraiva MJ. Transthyretin: a multifaceted protein[J]. Biomol Concepts, 2014, 5(1): 45-54. DOI: 10.1515/bmc-2013-0038.
11.	宋康平, 张玲玲, 朱艳, 等. 血清前白蛋白与脑出血预后的相关性研究[J]. 中风与神经疾病杂志, 2016, 33(10): 920-922.Song KP, Zhang LL, Zhu Y, et al. Correlation of serum prealbumin with functional outcome of cerebral hemorrhage[J].J Apoplexy Nerv Dis, 2016, 33(10): 920-922.
12.	赵蕾, 张志华, 白春强, 等. 转甲状腺素蛋白在早期类风湿关节炎患者中的临床意义[J].实用医学杂志, 2016, 32(14): 2337-2339. DOI: 10.3969/j.issn.1006-5725.2016.14.025.Zhao L, Zhang ZH, Bai CQ, et al. Clinical value of transthyretin from patients with early rheumatoid arthritis[J]. J Pract Med, 2016, 32(14): 2337-2339. DOI: 10.3969/j.issn.1006-5725.2016.14.025.
13.	蔡川奇, 林志鸿, 蔺佩鸿, 等. 血清白蛋白和前白蛋白对老年肺炎病情的预测价值[J].中国老年学杂志, 2014, 34(1): 103-105. DOI: 10.3969/j.issn.1005-9202.2014.01.048.Cai CQ, Lin ZH, Lin PH, et al. The predictive value of serum albumin and prealbumin for senile pneumonia[J].Chin J Gerontol, 2014, 34(1): 103-105. DOI: 10.3969/j.issn.1005-9202.2014.01.048.
14.	殷晓明, 胡晓荃, 张金惠, 等. 老年慢性阻塞性肺病稳定期血浆前白蛋白、脑钠肽及C反应蛋白水平与肺动脉高压的相关性[J]. 中国老年学杂志, 2013, 33(20): 5152-5153. DOI: 10.3969/j.issn.1005-9202.2013.20.108.Yin XM, Hu XQ, Zhang JH, et al. Relation between the level of plasma prealbumin, brain natriuretic peptide, C-reactive protein in stable phase of elderly with chronic obstructive pulmonary disease and pulmonary hypertension[J].Chin J Gerontol, 2013, 33(20): 5152-5153. DOI: 10.3969/j.issn.1005-9202.2013.20.108.
15.	Yang HT, Yim H, Cho YS, et al. Serum transthyretin level is associated with clinical severity rather than nutrition status in massively burned patients[J]. JPEN J Parenter Enteral Nutr, 2014, 38(8): 966-972. DOI: 10.1177/0148607113499588.
16.	Shao J, Xin Y, Li R, et al. Vitreous and serum levels of transthyretin (TTR) in high myopia patients are correlated with ocular pathologies[J]. Clin Biochem, 2011, 44(8-9): 681-685. DOI: 10.1016/j.clinbiochem.2011.03.032.
17.	Pullakhandam R, Palika R, Ghosh S, et al. Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: the significance of transthyretin[J]. IUBMB Life, 2012, 64(12): 975-982. DOI: 10.1002/iub.1096.
18.	邵珺, 辛瑜, 姚勇, 等. 转甲状腺素蛋白在病理性近视患者玻璃体中的表达及其结构分析[J]. 中华眼视光学与视觉科学杂志, 2012, 14(7): 429-433. DOI: 10.3760/cma.j.issn.1674-845X.2012.07.013.Shao J, Xin Y, Yao Y, et al. Analysis of the Abnormal Expression and Structure of Transthyretin in the Vitreous of Patients with Pathological Myopia[J]. Chin J Optom Ophthalmol Vis Sci, 2012, 14(7): 429-433. DOI: 10.3760/cma.j.issn.1674-845X.2012.07.013.

1. Myron Johnson A, Merlini G, Sheldon J, et al. Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition [J]. Clin Chem Lab Med, 2007, 45(3): 419-426.
2. 庄淼, 邵珺, 谭澄烨, 等. 转甲状腺素蛋白对RPE细胞及视网膜微血管内皮细胞生物学行为的影响[J]. 中华眼科杂志, 2016, 52(11): 856-860. DOI: 10.3760/cma.j.issn.0412-4081.2016.11.010.Zhuang M, Shao J, Tan CY, et al. Effects of transthyretin on biological behavior of retinal pigment epithelial cells and retinal microvascular epithelial cells[J].Chin J Ophthalmol, 2016, 52(11): 856-860. DOI: 10.3760/cma.j.issn.0412-4081.2016.11.010.
3. 庄淼, 邵珺, 谭澄烨, 等. 转甲状腺素蛋白对视网膜微血管内皮细胞生物学行为的影响[J].中华眼底病杂志, 2015, 31(4): 368-370. DOI: 10.3760/cma.j.issn.1005-1015.2015.04.014.Zhuang M, Shao J, Tan CY, et al. Effects of transthyretin on biological behavior of retinal microvascular epithelial cell[J].Chin J Ocul Fundus Dis, 2015, 31(4): 368-370. DOI: 10.3760/cma.j.issn.1005-1015.2015.04.014.
4. 邵珺, 姚勇. 高糖缺氧环境下转甲状腺素蛋白对视网膜血管内皮细胞的影响[J].中华眼底病杂志, 2016, 32(2): 159-162. DOI: 10.3760/cma.j.issn.1005-1015.2016.02.011.Shao J, Yao Y. Transthyretinin repress retinal microvascular endothelial cells under high glucose and hypoxia environment[J].Chin J Ocul Fundus Dis, 2016, 32(2): 159-162. DOI: 10.3760/cma.j.issn.1005-1015.2016.02.011.
5. 蒋伏松, 成兴波, 张慧. 血清视黄醇结合蛋白4在2型糖尿病视网膜病中的价值[J]. 中华糖尿病杂志, 2010, 2(5): 339-343. DOI: 10.3760/cma.j.issn.1674-5809.2010.05.005.Jiang FH, Cheng XB, Zhang H. Serum retinal binding protein 4 in type 2 diabetic retinopathy[J]. Chin J Diabetes Mellitus, 2010, 2(5): 339-343. DOI: 10.3760/cma.j.issn.1674-5809.2010.05.005.
6. 中国高血压防治指南修订委员会. 中国高血压防治指南2010[J].中华心血管病杂志, 2011, 39(7): 579-616. DOI: 10.3760/cma.j.issn.0253-3758.2011.07.002.Hypertension Writing Group of Chinese. 2010 Chinese Guidelines for the Management of Hypertension[J]. Chin J Cardiol, 2011, 39(7): 579-616. DOI: 10.3760/cma.j.issn.0253-3758.2011.07.002.
7. 中国成人血脂异常防治指南制订联合委员会. 中国成人血脂异常防治指南[J].中华心血管病杂志, 2007, 35(5): 390-419. DOI: 10.3760/j.issn:0253-3758.2007.05.003.Adults Joint Committee for Developing. Chinese Guidelines On Prevention and Treatment of Dyslipidemia in Adults [J]. Chin J Cardiol, 2007, 35(5): 390-419. DOI: 10.3760/j.issn:0253-3758.2007.05.003.
8. 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2013年版)[J]. 中华糖尿病杂志, 2014, 6(7): 447-498. DOI: 10.3760/cma.j.issn.1674-5809.2014.07.004.Chinese Diabetes Society, Chinese Medical Association. Standards of care for type 2 diabetes in China[J].Chin J Diabetes Mellitus, 2014, 6(7): 447-498. DOI: 10.3760/cma.j.issn.1674-5809.2014.07.004.
9. 中华医学会眼科学会眼底病学组. 我国糖尿病视网膜病变临床诊疗指南(2014年)[J]. 中华眼科杂志, 2014, 50(11): 851-865. DOI: 10.3760/cma.j.issn.0412-4081.2014.11.014.Chinese Ocular Fundus Diseases Society, Chinese Ophthalmological Society, Chinese Medical Association. Guidelines for clinical diagnosis and treatment of diabetic retinopathy in China[J].Chin J Ophthalmol, 2014, 50(11): 851-865. DOI: 10.3760/cma.j.issn.0412-4081.2014.11.014.
10. Vieira M, Saraiva MJ. Transthyretin: a multifaceted protein[J]. Biomol Concepts, 2014, 5(1): 45-54. DOI: 10.1515/bmc-2013-0038.
11. 宋康平, 张玲玲, 朱艳, 等. 血清前白蛋白与脑出血预后的相关性研究[J]. 中风与神经疾病杂志, 2016, 33(10): 920-922.Song KP, Zhang LL, Zhu Y, et al. Correlation of serum prealbumin with functional outcome of cerebral hemorrhage[J].J Apoplexy Nerv Dis, 2016, 33(10): 920-922.
12. 赵蕾, 张志华, 白春强, 等. 转甲状腺素蛋白在早期类风湿关节炎患者中的临床意义[J].实用医学杂志, 2016, 32(14): 2337-2339. DOI: 10.3969/j.issn.1006-5725.2016.14.025.Zhao L, Zhang ZH, Bai CQ, et al. Clinical value of transthyretin from patients with early rheumatoid arthritis[J]. J Pract Med, 2016, 32(14): 2337-2339. DOI: 10.3969/j.issn.1006-5725.2016.14.025.
13. 蔡川奇, 林志鸿, 蔺佩鸿, 等. 血清白蛋白和前白蛋白对老年肺炎病情的预测价值[J].中国老年学杂志, 2014, 34(1): 103-105. DOI: 10.3969/j.issn.1005-9202.2014.01.048.Cai CQ, Lin ZH, Lin PH, et al. The predictive value of serum albumin and prealbumin for senile pneumonia[J].Chin J Gerontol, 2014, 34(1): 103-105. DOI: 10.3969/j.issn.1005-9202.2014.01.048.
14. 殷晓明, 胡晓荃, 张金惠, 等. 老年慢性阻塞性肺病稳定期血浆前白蛋白、脑钠肽及C反应蛋白水平与肺动脉高压的相关性[J]. 中国老年学杂志, 2013, 33(20): 5152-5153. DOI: 10.3969/j.issn.1005-9202.2013.20.108.Yin XM, Hu XQ, Zhang JH, et al. Relation between the level of plasma prealbumin, brain natriuretic peptide, C-reactive protein in stable phase of elderly with chronic obstructive pulmonary disease and pulmonary hypertension[J].Chin J Gerontol, 2013, 33(20): 5152-5153. DOI: 10.3969/j.issn.1005-9202.2013.20.108.
15. Yang HT, Yim H, Cho YS, et al. Serum transthyretin level is associated with clinical severity rather than nutrition status in massively burned patients[J]. JPEN J Parenter Enteral Nutr, 2014, 38(8): 966-972. DOI: 10.1177/0148607113499588.
16. Shao J, Xin Y, Li R, et al. Vitreous and serum levels of transthyretin (TTR) in high myopia patients are correlated with ocular pathologies[J]. Clin Biochem, 2011, 44(8-9): 681-685. DOI: 10.1016/j.clinbiochem.2011.03.032.
17. Pullakhandam R, Palika R, Ghosh S, et al. Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: the significance of transthyretin[J]. IUBMB Life, 2012, 64(12): 975-982. DOI: 10.1002/iub.1096.
18. 邵珺, 辛瑜, 姚勇, 等. 转甲状腺素蛋白在病理性近视患者玻璃体中的表达及其结构分析[J]. 中华眼视光学与视觉科学杂志, 2012, 14(7): 429-433. DOI: 10.3760/cma.j.issn.1674-845X.2012.07.013.Shao J, Xin Y, Yao Y, et al. Analysis of the Abnormal Expression and Structure of Transthyretin in the Vitreous of Patients with Pathological Myopia[J]. Chin J Optom Ophthalmol Vis Sci, 2012, 14(7): 429-433. DOI: 10.3760/cma.j.issn.1674-845X.2012.07.013.

Chinese Journal of Ocular Fundus Diseases

Serum transthyretin in patients with different stages of diabetic retinopathy

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