Changes in ocular surface following minimal vitreoretinal surgery in postmenopausal women patients with proliferative diabetic retinopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

Gao Shaohui , Li Zhanrong , Pei Han , Li Shiqing ,  Zhao Zhaoxia

Henan Eye Institute&Henan Eye Hospital, Henan Provincial People's Hospital, Zhengzhou 450003, China;

Corresponding author：

Zhao Zhaoxia, Email: zhaozhaoxia61@126.com

Keywords：

Vitrectomy/adverse effects; Menopause; Ocular surface

DOI：

10.3760/cma.j.issn.1005-1015.2017.03.008

Video：

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Objective To evaluate ocular surface changes following minimal vitreoretinal surgery in postmenopausal women patients with proliferative diabetic retinopathy (PDR). Methods Sixty-one women PDR patients (61 eyes) underwent vitreous microsurgery were recruited in this prospective study, including 31 postmenopausal women (PMW group) and 30 non-postmenopausal women (non-PMW group). The contralateral eyes were considered as the control group. Corneal fluorescein (FL) staining, tear break-up time (TBUT), Schirmer I test (SIT), central corneal sensitivity and ocular surface disease index (OSDI) were estimated. All tests were carried out 1 day preoperatively and 1 day, 10 days, 1 month and 3 months postoperatively. The student’st test or Mann-WhitneyU and ANOVA for repeat measurements test were used. Results Preoperatively, TBUT of surgery and non-surgery eyes in PMW were shorter than non-PMW (t=−2.115, −2.035;P＜0.05), but higher OSDI scores were found in PMW (t=2.482, 2.208;P＜0.05). TBUT reduction rate (Z=−2.771, −1.993;P＜0.05) and OSDI rising rate (Z=2.539, 2.157;P＜0.05) of surgery eyes in PMW were higher than non-PMW 1 day and 10 days postoperatively. The lower SIT of surgery eyes in PMW were observed at 1 day and 10 days (t=−2.403, −2.029;P＜0.05) after surgery. At 10 days after surgery, FL and OSDI scores of surgery eyes in non-PMW returned to preoperative level (Z=−0.447, −0.513;P＞0.05), but in PMW, the recovery process experienced 1 month (Z=−1.500, −0.853;P＞0.05). TBUT and SIT of surgery eyes in two groups both reached preoperative level at 1 month following surgery (Z=−0.715, −1.266, −1.531, −0.522;P＞0.05). Conclusions PMW with PDR had ocular surface dysfunction, which resulted in aggravated dry eye after minimal vitreoretinal surgery.

Citation： Gao Shaohui, Li Zhanrong, Pei Han, Li Shiqing, Zhao Zhaoxia. Changes in ocular surface following minimal vitreoretinal surgery in postmenopausal women patients with proliferative diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2017, 33(3): 252-256. doi: 10.3760/cma.j.issn.1005-1015.2017.03.008 Copy

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13.	陈春丽, 宋宗明, 孙敏, 等.高血压患者微创玻璃体视网膜手术后泪膜变化观察[J]. 中华眼底病杂志, 2012, 28(2): 145-148. DOI: 10.3760/cma.j.issn.1005-1015.2012.02.010.Chen CL, Song ZM, Sun M, et al. Changes in tear film after minimal vitreoretinal surgery in patients with hypertension[J]. Chin J Ocul Fundus Dis, 2012, 28(2): 145-148. DOI: 10.3760/cma.j.issn.1005-1015.2012.02.010.

1. Beckman KA. Characterization of dry eye disease in diabetic patients versus nondiabetic patients[J]. Cornea, 2014, 33(8): 851-854. DOI: 10.1097/ICO.0000000000000163.
2. Manaviat MR, Rashidi M, Afkhami-Ardekani M, et al. Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients[J]. BMC Ophthalmol, 2008, 2(8): 10. DOI: 10.1186/1471-2415-8-10.
3. Versura P, Giannaccare G, Campos EC. Sex-steroid imbalance in females and dry eye[J]. Curr Eye Res, 2015, 40(2): 162-175. DOI: 10.3109/02713683.2014.966847.
4. 中华医学会眼科学会眼底病学组.我国糖尿病视网膜病变临床诊疗指南(2014年) [J]. 中华眼科杂志, 2014, 50(11): 851-865. DOI: 10.3760/cma.j.issn.0412-4081.2014.11.014.Chinese Ocular Fundus Diseases Society, Chinese Ophthalmological Society, Chinese Medical Association. Guidelines for clinical diagnosis and treatment of diabetic retinopathy in China(2014) [J]. Chin J Ophthalmol, 2014, 50(11): 851-865. DOI: 10.3760/cma.j.issn.0412-4081.2014.11.014.
5. Gao S, Wu J, Li L, et al. Effects of silicone hydrogel contact lenses on ocular surface after Sub-Bowman's Keratomileusis[J]. Curr Eye Res. 2013, 38(11): 1118-1123. DOI: 10.3109/02713683.2013.809768.
6. Ozcura F, Aydin S, Helvaci MR. Ocular surface disease index for the diagnosis of dry eye syndrome[J]. Ocul Immunol Inflamm, 2007, 15(5): 389-393. DOI: 10.1080/09273940701486803.
7. Fuerst N, Langelier N, Massaro-Giordano M, et al. Tear osmolarity and dry eye symptoms in diabetics[J]. Clin Ophthalmol, 2014, 8: 507-515. DOI: 10.2147/OPTH.S51514.
8. 曹葭, 姚勇, 傅东红, 等. 无锡市滨湖区50岁及以上糖尿病人群中干眼流行病学调查[J]. 中华实验眼科杂志, 2014, 32(11): 1036-1040. DOI: 10.3760/cma.j.issn.2095-0160.2014.11.015.Cao J, Yao Y, Fu DH, et al. .Epidemiology study on incidence of dry eye in over 50-year residents with type 2 diabetes mellitus in Binhu district, Wuxi [J]. Chin J Exp Ophthalmol, 2014, 32(11): 1036-1040. DOI: 10.3760/cma.j.issn.2095-0160.2014.11.015.
9. Yang WJ, Yang YN, Cao J, et al. Risk factors for dry eye syndrome: a retrospective case-control study[J]. Optom Vis Sci, 2015, 92(9): 199-205. DOI: 10.1097/OPX.0000000000000541.
10. Cox SM, Nichols JJ. The neurobiology of the meibomian glands[J]. Ocul Surf, 2014, 12(3): 167-177. DOI: 10.1016/j.jtos.2014.01.005.
11. Gagliano C, Caruso S, Napolitano G, et al. Low levels of 17-β-oestradiol, oestrone and testosterone correlate with severe evaporative dysfunctional tear syndrome in postmenopausal women: a case-control study[J]. Br J Ophthalmol, 2014, 98(3): 371-376. DOI: 10.1136/bjophthalmol-2012-302705.
12. Ablamowicz AF, Nichols JJ, Nichols KK. Association between serum levels of testosterone and estradiol with meibomian gland assessments in postmenopausal women[J]. Invest Ophthalmol Vis Sci, 2016, 57(2): 295-300. DOI: 10.1167/iovs.15-18158.
13. 陈春丽, 宋宗明, 孙敏, 等.高血压患者微创玻璃体视网膜手术后泪膜变化观察[J]. 中华眼底病杂志, 2012, 28(2): 145-148. DOI: 10.3760/cma.j.issn.1005-1015.2012.02.010.Chen CL, Song ZM, Sun M, et al. Changes in tear film after minimal vitreoretinal surgery in patients with hypertension[J]. Chin J Ocul Fundus Dis, 2012, 28(2): 145-148. DOI: 10.3760/cma.j.issn.1005-1015.2012.02.010.

Chinese Journal of Ocular Fundus Diseases

Changes in ocular surface following minimal vitreoretinal surgery in postmenopausal women patients with proliferative diabetic retinopathy

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