The alterations of macular vascular density and the area of foveal avascular zone in branch retinal vein occlusion eyes_Chinese Journal of Ocular Fundus Diseases

Authors：

Li Kejia ,  Yu Xiaobing , Chen Qin

Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China(Li Kejia, now working at the Department of Ophthalmology, Beijing Changping Hospital of Integrated Chinese and Western Medicine; Chen Qin, now working at the Department of Ophthalmology, West China Hospital, Sichuan University);

Corresponding author：

Yu Xiaobing, Email: yuxiaobing@sina.com

Keywords：

Retinal vein occlusion/diagnosis; Regional blood flow; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2018.01.005

Video：

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Objective To observe the alterations of macular vascular density and the area of foveal avascular zone (FAZ) in branch retinal vein occlusion (BRVO) eyes. Methods A retrospective case-control study. Forty-five patients with unilateral BRVO and macular edema were enrolled in this study. Optical coherence tomography angiography (OCTA) was performed on the BRVO and fellow eyes. The scanning region in the macular area was 3 mm×3 mm. Macular vascular density and FAZ area in the superficial and deep retinal capillary plexi were measured in all eyes. The values of macular vascular density and FAZ area between BRVO eyes and fellow eyes, affected sector and unaffected sector were compared. Results The mean overall vascular density measured in the entire scan was lower in BRVO eyes compared with fellow eyes in both the superficial and deep capillary plexus (t=14.186, 9.468; P＜0.05). The reduce degree of vascular density in the deep capillary plexus (7.65%) was higher than that in the superficial plexus (7.27%). In the superficial plexus, the vascular density was lower in the affected sector and the unaffected sector of the BRVO eyes compared with the corresponding sector in the fellow eyes (t=15.386, 9.435; P＜0.05). The FAZ area enlarged in the BRVO eyes compared with the fellow eyes in the superficial capillary plexus and in the deep capillary plexus (t=3.216, 5.119; P＜0.05). The degree of enlargement of FAZ area in the deep capillary plexus (0.19 mm²) was higher than that in the superficial plexus (0.11 mm²). Conclusions In eyes with BRVO, quantitative OCTA measurements confirm that vascular density decreased and FAZ area enlarged in the superficial and deep capillary plexi. The reduce degree of vascular density and enlargement degree of FAZ area in the deep capillary plexus are higher than those in the superficial plexus.

Citation： Li Kejia, Yu Xiaobing, Chen Qin. The alterations of macular vascular density and the area of foveal avascular zone in branch retinal vein occlusion eyes. Chinese Journal of Ocular Fundus Diseases, 2018, 34(1): 17-20. doi: 10.3760/cma.j.issn.1005-1015.2018.01.005 Copy

1.	Kwiterovich KA, Maguire MG, Murphy RP, et al. Frequency of adverse systemic reactions after fluorescein angiography: results of a prospective study[J]. Ophthalmology, 1991, 98(7): 1139-1142.
2.	Huang D, Jia Y, Gao SS, et al. Optical coherence tomography angiography using the optovue device[J]. Dev Ophthalmol, 2016, 56: 6-12. DOI: 10.1159/000442770.
3.	Lupidi M, Coscas F, Cagini C, et al. Automated quantitative analysis of retinal microvasculature in normal eyes on optical coherence tomography angiography[J]. Am J Ophthalmol, 2016, 169: 9-23. DOI: 10.1016/j.ajo.2016.06.008.
4.	Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography[J]. Opt Express, 2012, 20(4): 4710-4725. DOI: 10.1364/OE.20.004710.
5.	Carpineto P, Mastropasqua R, Marchini G, et al. Reproducibility and repeatability of foveal avascular zone measurements in healthy subjects by optical coherence tomography angiography[J]. Br J Ophthalmol, 2016, 100(5): 671-676. DOI: 10.1136/bjophthalmol-2015-307330.
6.	Chalam KV, Sambhav K. Optical coherence tomography angiography in retinal diseases[J]. J Ophthalmic Vis Res, 2016, 11(1): 84-92. DOI: 10.4103/2008-322X.180709.
7.	卢宁, 张承芬. 视网膜分支静脉阻塞[M]//张承芬. 眼底病学. 2版. 北京: 人民卫生出版社, 2010: 237-243.Lu N, Zhang CF. Branch retinal vein occlusion[M]//Zhang CF. Diseases of ocular fundus. 2nd ed. Beijing: People’s Medical Publishing House, 2010: 237-243.
8.	Campochiaro PA, Bhisitkul RB, Shapiro H, et al. Vascular endothelial growth factor promotes progressive retinal nonperfusion in patients with retinal vein occlusion[J]. Ophthalmology, 2013, 120(4): 795-802. DOI: 10.1016/j.ophtha.2012.09.032.
9.	Hockley DJ, Tripathi RC, Ashton N. Experimental retinal branch vein occlusion in rhesus monkeysⅢ: histopathological and electron microscopical studies[J]. Br J Ophthalmol, 1979, 63(6): 393-411.
10.	Paques M, Tadayoni R, Sercombe R, et al. Structural and hemodynamic analysis of the mouse retinal microcirculation[J]. Invest Ophthalmol Vis Sci, 2003, 44(11): 4960-4967.
11.	Coscas F, Glacet-Bernard A, Miere A, et al. Optical coherence tomography angiography in retinal vein occlusion: evaluation of superficial and deep capillary plexa[J]. Am J Ophthalmol, 2016, 161(1): 160-171. DOI: 10.1016/j.ajo.2015.10.008.
12.	Rahimy E, Sarraf D. Paraeentral acute middle maculopathy spectral--domain optical coherence tomography feature of deep capillary ischemia[J]. Curr Opin Ophthalmol, 2014, 25(3): 207-212. DOI: 10.1097/ICU.0000000000000045.
13.	Parodi MB, Visintin F, Della Rupe P, et al. Foveal avascular zone in macular branch retinal vein occlusion[J]. Int Ophthalmol, 1995, 19(1): 25-28.
14.	Bandello F, Corbelli E, Carnevali A, et al. Optical coherence tomography angiography of diabetic retinopathy[J]. Dev Ophthalmol, 2016, 56: 107-112. DOI: 10.1159/000442801.
15.	Arend O, Wolf S, Harris A, et al. The relationship of macular microcirculation to visual acuity in diabetic patients[J]. Arch Ophthalmol, 1995, 113(5): 610-614.
16.	Sim DA, Keane PA, Zarranz-Ventura J, et al. Predictive factors for the progression of diabetic macular ischemia[J]. Am J Ophthalmol, 2013, 156(4): 684-692. DOI: 10.1016/j.ajo.2013.05.033.

1. Kwiterovich KA, Maguire MG, Murphy RP, et al. Frequency of adverse systemic reactions after fluorescein angiography: results of a prospective study[J]. Ophthalmology, 1991, 98(7): 1139-1142.
2. Huang D, Jia Y, Gao SS, et al. Optical coherence tomography angiography using the optovue device[J]. Dev Ophthalmol, 2016, 56: 6-12. DOI: 10.1159/000442770.
3. Lupidi M, Coscas F, Cagini C, et al. Automated quantitative analysis of retinal microvasculature in normal eyes on optical coherence tomography angiography[J]. Am J Ophthalmol, 2016, 169: 9-23. DOI: 10.1016/j.ajo.2016.06.008.
4. Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography[J]. Opt Express, 2012, 20(4): 4710-4725. DOI: 10.1364/OE.20.004710.
5. Carpineto P, Mastropasqua R, Marchini G, et al. Reproducibility and repeatability of foveal avascular zone measurements in healthy subjects by optical coherence tomography angiography[J]. Br J Ophthalmol, 2016, 100(5): 671-676. DOI: 10.1136/bjophthalmol-2015-307330.
6. Chalam KV, Sambhav K. Optical coherence tomography angiography in retinal diseases[J]. J Ophthalmic Vis Res, 2016, 11(1): 84-92. DOI: 10.4103/2008-322X.180709.
7. 卢宁, 张承芬. 视网膜分支静脉阻塞[M]//张承芬. 眼底病学. 2版. 北京: 人民卫生出版社, 2010: 237-243.Lu N, Zhang CF. Branch retinal vein occlusion[M]//Zhang CF. Diseases of ocular fundus. 2nd ed. Beijing: People’s Medical Publishing House, 2010: 237-243.
8. Campochiaro PA, Bhisitkul RB, Shapiro H, et al. Vascular endothelial growth factor promotes progressive retinal nonperfusion in patients with retinal vein occlusion[J]. Ophthalmology, 2013, 120(4): 795-802. DOI: 10.1016/j.ophtha.2012.09.032.
9. Hockley DJ, Tripathi RC, Ashton N. Experimental retinal branch vein occlusion in rhesus monkeysⅢ: histopathological and electron microscopical studies[J]. Br J Ophthalmol, 1979, 63(6): 393-411.
10. Paques M, Tadayoni R, Sercombe R, et al. Structural and hemodynamic analysis of the mouse retinal microcirculation[J]. Invest Ophthalmol Vis Sci, 2003, 44(11): 4960-4967.
11. Coscas F, Glacet-Bernard A, Miere A, et al. Optical coherence tomography angiography in retinal vein occlusion: evaluation of superficial and deep capillary plexa[J]. Am J Ophthalmol, 2016, 161(1): 160-171. DOI: 10.1016/j.ajo.2015.10.008.
12. Rahimy E, Sarraf D. Paraeentral acute middle maculopathy spectral--domain optical coherence tomography feature of deep capillary ischemia[J]. Curr Opin Ophthalmol, 2014, 25(3): 207-212. DOI: 10.1097/ICU.0000000000000045.
13. Parodi MB, Visintin F, Della Rupe P, et al. Foveal avascular zone in macular branch retinal vein occlusion[J]. Int Ophthalmol, 1995, 19(1): 25-28.
14. Bandello F, Corbelli E, Carnevali A, et al. Optical coherence tomography angiography of diabetic retinopathy[J]. Dev Ophthalmol, 2016, 56: 107-112. DOI: 10.1159/000442801.
15. Arend O, Wolf S, Harris A, et al. The relationship of macular microcirculation to visual acuity in diabetic patients[J]. Arch Ophthalmol, 1995, 113(5): 610-614.
16. Sim DA, Keane PA, Zarranz-Ventura J, et al. Predictive factors for the progression of diabetic macular ischemia[J]. Am J Ophthalmol, 2013, 156(4): 684-692. DOI: 10.1016/j.ajo.2013.05.033.

Chinese Journal of Ocular Fundus Diseases

The alterations of macular vascular density and the area of foveal avascular zone in branch retinal vein occlusion eyes

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