Immunogammopathy maculopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

Zhou Nan ,  Wei Wenbin

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Science Key Laboratory of Beijing, Beijing 100730, China;

Corresponding author：

Wei Wenbin, Email: weiwenbintr@163.com

Keywords：

Immunoglobulins; Macular degenerat; Waldenstrom macroglobulinemia; Review

DOI：

10.3760/cma.j.issn.1005-1015.2019.04.025

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Immunogammopathy maculopathy is a newly discovered retinopathy associated with macroglobulinemia in recent years. The main manifestations were retinal vein convulsion and dilation caused by high blood viscosity, retinal interlaminar effusion and macular serous detachment. With the prolongation of the course of disease, the photoreceptor layer and RPE layer in the detachment area showed atrophic changes. The pathogenesis of ophthalmopathy is still unknown. Understanding the clinical features, diagnosis, differential diagnosis and treatment of ophthalmopathy is of great significance for understanding this kind of disease and improving the level of diagnosis and treatment of ophthalmopathy.

Citation： Zhou Nan, Wei Wenbin. Immunogammopathy maculopathy. Chinese Journal of Ocular Fundus Diseases, 2019, 35(4): 417-419. doi: 10.3760/cma.j.issn.1005-1015.2019.04.025 Copy

1.	Gertz MA. Waldenström macroglobulinemia[J]. Hematology, 2012, 17(Suppl 1): S112-116. DOI: 10.1179/102453312X13336169156212.
2.	Gass JDM. Stereoscopic atlas of macular disease: diagnosis and treatment[M]. 4th ed. St. Louis: Mosby, 1997: 198.
3.	Menke MN, Feke GT, McMeel JW, et al. Hyperviscosity-related retinopathy in Waldenström macroglobulinemia[J]. Arch Ophthalmol, 2006, 124(11): 1601-1606. DOI: 10.1001/archopht.124.11.1601.
4.	Baker PS, Garg SJ, Fineman MS, et al. Serous macular detachment in Waldenström macroglobulinemia: a report of four cases[J]. Am J Ophthalmol, 2013, 155(3): 448-455. DOI: 10.1016/j.ajo.2012.09.018.
5.	Fenicia V, Balestrieri M, Perdicchi A, et al. Intravitreal injection of dexamethasone implant in serous macular detachment associated with Waldenström's disease[J]. Case Rep Ophthalmol, 2013, 4(2): 64-69. DOI: 10.1159/000354066.
6.	Ho AC, Benson WE, Wong J. Unusual immunogammopathy maculopathy[J]. Ophthalmology, 2000, 107(6): 1099-1103. DOI: 10.1016/S0161-6420(00)00118-4.
7.	Pilon AF, Rhee PS, Messner LV. Bilateral, persistent serous macular detachments with Waldenström's macroglobulinemia[J]. Optom Vis Sci, 2005, 82(7): 573-578. DOI: 10.1097/01.opx.0000171333.64652.a4.
8.	Xu LT, Courtney RJ, Ehlers JP. Bevacizumab therapy and multimodal ultrawide-field imaging in immunogammopathy maculopathysecondary to Waldenström's macroglobulinemia[J]. Ophthalmic Surg Lasers Imaging Retina, 2015, 46(2): 262-265. DOI: 10.3928/23258160-20150213-06.
9.	Ratra D, Ratra V, Kishnani M. Localized retinal degeneration secondary to Waldenström's macroglobulinemia[J]. Oman J Ophthalmol, 2017, 10(3): 244-246. DOI: 10.4103/ojo.OJO_126_2016.
10.	Chung YY, Wang CC, Lai KJ, et al. Waldenström's macroglobulinemia-associated renal amyloidosis presenting as a solitary lung mass[J]. Ren Fail, 2012, 34(9): 1173-1176. DOI: 10.3109/0886022X.2012.717488.
11.	Camp BJ, Magro CM. Cutaneous macroglobulinosis: a case series[J]. J Cutan Pathol, 2012, 39(10): 962-970. DOI: 10.1111/j.1600-0560.2012.01983.x.
12.	Besirli CG, Johnson MW. Immunogammopathy maculopathy associated with Waldenström macroglobulinemia is refractory to conventional interventions for macular edema[J]. Retin Cases Brief Rep, 2013, 7(4): 319-324. DOI: 10.1097/ICB.0b013e31828ef0dc.
13.	Rusu IM, Mrejen S, Engelbert M, et al. Immunogammopathies and acquired vitelliform detachments: a report of four cases[J]. Am J Ophthalmol, 2014, 157(3): 648-657. DOI: 10.1016/j.ajo.2013.11.020.
14.	Freidman AH, Marchevsky A, Odel JG, et al. Immunofluorescent studies of the eye in Waldenström's macroglobulinemia[J]. Arch Ophthalmol, 1980, 98(4): 743-746. DOI: 10.1001/archopht.1980.01020030737020.
15.	Berta A, Beck P, Mikita J. IgM paraprotein in the subretinal fluid of a patient with recurrent retinal detachment and Waldenström's macroglobulinaemia[J]. Acta Medi Hung, 1985, 42(3-4): 179-186.
16.	Do JL, Olmos de Koo LC, Ameri H. Atypical chronic central serous chorioretinopathy with cystoid macular edema: therapeutic response to medical and laser therapy[J]. J Curr Ophthalmol, 2017, 29(2): 133-135. DOI: 10.1016/j.joco.2017.01.004.
17.	Verbakel SK, van de Ven JP, Le Blanc LM, et al. Carbonic anhydrase inhibitors for the treatment of cystic macular lesions in children with x-linked juvenile retinoschisis[J]. Invest Ophthalmol Vis Sci, 2016, 57(13): 5143-5147. DOI: 10.1167/iovs.16-20078.
18.	Grewal DS, Fishman GA, Jampol LM. Autoimmune retinopathy and antiretinal antibodies: a review[J]. Retina, 2014, 34(5): 827-845. DOI: 10.1097/IAE.0000000000000119.
19.	Mittal R, Cherepanoff S, Thornton S, et al. Bilateral diffuse uveal melanocytic proliferation: molecular genetic analysis of a case and review of the literature[J]. Ocul Oncol Pathol, 2015, 2(2): 94-99. DOI: 10.1159/000440766.
20.	Dalal MD, Morgans CW, Duvoisin RM, et al. Diagnosis of occult melanoma using transient receptor potential melastatin 1 (TRPM1) autoantibody testing: a novel approach[J]. Ophthalmology, 2013, 120(12): 2560-2564. DOI: 10.1016/j.ophtha.2013.07.037.
21.	Kapoor KG, Wagner MS. Bevacizumab in macular serous detachments associated with Waldenström's macroglobulinemia[J]. Ophthalmic Surg Lasers Imaging Retina, 2015, 46(1): 95-97. DOI: 10.3928/23258160-20150101-18.

1. Gertz MA. Waldenström macroglobulinemia[J]. Hematology, 2012, 17(Suppl 1): S112-116. DOI: 10.1179/102453312X13336169156212.
2. Gass JDM. Stereoscopic atlas of macular disease: diagnosis and treatment[M]. 4th ed. St. Louis: Mosby, 1997: 198.
3. Menke MN, Feke GT, McMeel JW, et al. Hyperviscosity-related retinopathy in Waldenström macroglobulinemia[J]. Arch Ophthalmol, 2006, 124(11): 1601-1606. DOI: 10.1001/archopht.124.11.1601.
4. Baker PS, Garg SJ, Fineman MS, et al. Serous macular detachment in Waldenström macroglobulinemia: a report of four cases[J]. Am J Ophthalmol, 2013, 155(3): 448-455. DOI: 10.1016/j.ajo.2012.09.018.
5. Fenicia V, Balestrieri M, Perdicchi A, et al. Intravitreal injection of dexamethasone implant in serous macular detachment associated with Waldenström's disease[J]. Case Rep Ophthalmol, 2013, 4(2): 64-69. DOI: 10.1159/000354066.
6. Ho AC, Benson WE, Wong J. Unusual immunogammopathy maculopathy[J]. Ophthalmology, 2000, 107(6): 1099-1103. DOI: 10.1016/S0161-6420(00)00118-4.
7. Pilon AF, Rhee PS, Messner LV. Bilateral, persistent serous macular detachments with Waldenström's macroglobulinemia[J]. Optom Vis Sci, 2005, 82(7): 573-578. DOI: 10.1097/01.opx.0000171333.64652.a4.
8. Xu LT, Courtney RJ, Ehlers JP. Bevacizumab therapy and multimodal ultrawide-field imaging in immunogammopathy maculopathysecondary to Waldenström's macroglobulinemia[J]. Ophthalmic Surg Lasers Imaging Retina, 2015, 46(2): 262-265. DOI: 10.3928/23258160-20150213-06.
9. Ratra D, Ratra V, Kishnani M. Localized retinal degeneration secondary to Waldenström's macroglobulinemia[J]. Oman J Ophthalmol, 2017, 10(3): 244-246. DOI: 10.4103/ojo.OJO_126_2016.
10. Chung YY, Wang CC, Lai KJ, et al. Waldenström's macroglobulinemia-associated renal amyloidosis presenting as a solitary lung mass[J]. Ren Fail, 2012, 34(9): 1173-1176. DOI: 10.3109/0886022X.2012.717488.
11. Camp BJ, Magro CM. Cutaneous macroglobulinosis: a case series[J]. J Cutan Pathol, 2012, 39(10): 962-970. DOI: 10.1111/j.1600-0560.2012.01983.x.
12. Besirli CG, Johnson MW. Immunogammopathy maculopathy associated with Waldenström macroglobulinemia is refractory to conventional interventions for macular edema[J]. Retin Cases Brief Rep, 2013, 7(4): 319-324. DOI: 10.1097/ICB.0b013e31828ef0dc.
13. Rusu IM, Mrejen S, Engelbert M, et al. Immunogammopathies and acquired vitelliform detachments: a report of four cases[J]. Am J Ophthalmol, 2014, 157(3): 648-657. DOI: 10.1016/j.ajo.2013.11.020.
14. Freidman AH, Marchevsky A, Odel JG, et al. Immunofluorescent studies of the eye in Waldenström's macroglobulinemia[J]. Arch Ophthalmol, 1980, 98(4): 743-746. DOI: 10.1001/archopht.1980.01020030737020.
15. Berta A, Beck P, Mikita J. IgM paraprotein in the subretinal fluid of a patient with recurrent retinal detachment and Waldenström's macroglobulinaemia[J]. Acta Medi Hung, 1985, 42(3-4): 179-186.
16. Do JL, Olmos de Koo LC, Ameri H. Atypical chronic central serous chorioretinopathy with cystoid macular edema: therapeutic response to medical and laser therapy[J]. J Curr Ophthalmol, 2017, 29(2): 133-135. DOI: 10.1016/j.joco.2017.01.004.
17. Verbakel SK, van de Ven JP, Le Blanc LM, et al. Carbonic anhydrase inhibitors for the treatment of cystic macular lesions in children with x-linked juvenile retinoschisis[J]. Invest Ophthalmol Vis Sci, 2016, 57(13): 5143-5147. DOI: 10.1167/iovs.16-20078.
18. Grewal DS, Fishman GA, Jampol LM. Autoimmune retinopathy and antiretinal antibodies: a review[J]. Retina, 2014, 34(5): 827-845. DOI: 10.1097/IAE.0000000000000119.
19. Mittal R, Cherepanoff S, Thornton S, et al. Bilateral diffuse uveal melanocytic proliferation: molecular genetic analysis of a case and review of the literature[J]. Ocul Oncol Pathol, 2015, 2(2): 94-99. DOI: 10.1159/000440766.
20. Dalal MD, Morgans CW, Duvoisin RM, et al. Diagnosis of occult melanoma using transient receptor potential melastatin 1 (TRPM1) autoantibody testing: a novel approach[J]. Ophthalmology, 2013, 120(12): 2560-2564. DOI: 10.1016/j.ophtha.2013.07.037.
21. Kapoor KG, Wagner MS. Bevacizumab in macular serous detachments associated with Waldenström's macroglobulinemia[J]. Ophthalmic Surg Lasers Imaging Retina, 2015, 46(1): 95-97. DOI: 10.3928/23258160-20150101-18.

Previous Article
An update on evidence for mineralocorticoid receptor antagonist in the treatment of chronic central serous retinopathy

Chinese Journal of Ocular Fundus Diseases

Immunogammopathy maculopathy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Format

Content