Effect of Fufang Xueshuantong Combined with Laser Photocoagulation <i>versus</i> Laser Photocoagulation Along for the Treatment of Diabetic Retinopathy: A Meta-analysis_West China Medical Journal

Authors：

 CHENYong-zhi , MOYuan-wai , LIChun-bei

Pharmaceutical Department, the Central Hospital of Panzhihua City, Panzhihua, Sichuan 617000. P. R. China;

Corresponding author：

Keywords：

Fufang Xueshuantong; Laser photocoagulation; Diabetic Retinopathy; Meta-analysis

DOI：

10.7507/1002-0179.20150475

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Objective To evaluate the effects of Fufang Xueshuantong combined with laser photocoagulation versus laser photocoagulation alone in the treatment of diabetic retinopathy (DR). Method The Web of Science, Medline, Embase, the Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, VIP and Wanfang databases were searched from their establishment until June 2015. We used the method recommended by the Cochrane Collaboration to perform a meta-analysis of randomized controlled trails. RevMan 5.2 software was used for the analysis. Results Eight studies were included. The results of Meta-analysis demonstrated that Fufang Xueshuantong combined with laser photocoagulation was superior to laser photocoagulation alone in the effective rate of visual acuity[RR=1.19, 95%CI (1.12, 1.26), P<0.000 01], fundus[RR=1.34, 95%CI (1.18, 1.52), P<0.000 01], and elimination rate of macular edema[RR=1.29,95%CI(1.09,1.54),P=0.004]. Conclusions Fufang Xueshuantong combined with laser photocoagulation is effective for DR. However, due to the limited quantity and quality of the included studies, the results suggest that larger-scale trials are needed.

Citation： CHENYong-zhi, MOYuan-wai, LIChun-bei. Effect of Fufang Xueshuantong Combined with Laser Photocoagulation versus Laser Photocoagulation Along for the Treatment of Diabetic Retinopathy: A Meta-analysis. West China Medical Journal, 2015, 30(9): 1666-1670. doi: 10.7507/1002-0179.20150475 Copy

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16.	王禹燕, 刘映霞, 麦少云, 等. 复方血栓通对NPDR激光光凝术后的视网膜血流动力学影响[J]. 国际眼科杂志, 2014, 14(7):1327-1328.
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18.	刘林平, 吴伯乐, 叶锌铭, 等. 视网膜激光光凝联合复方血栓通胶囊治疗缺血型视网膜静脉阻塞临床观察[J]. 浙江中西医结合杂志, 2015, 25(1):67-69.

1. 王倩倩, 于珮, 周赛君, 等. 糖尿病视网膜病变发病机制的研究进展[J]. 中华临床医师杂志:电子版, 2012, 6(3):685-687.
2. Neubauer AS, Ulbig MW. Laser treatment in diabetic retinopmhy[J]. Ophthalmologica, 2007, 221(2):95-102.
3. 许国忠, 杨莅, 诸力伟. 复方血栓通胶囊联合激光治疗糖尿病视网膜病变疗效观察[J]. 浙江中西医结合杂志, 2013, 23(10):821-823.
4. Higgins JPT, Altman DG. Cochrane handbook for systematic reviews of interventions Version 5.1.0 (updated March 2011)[EB/OL]. The Cochrane Collaboration, 2011[2013-04-01]. http://www.cochrane-handbook.org.
5. 郑小燕, 潘晓霞. 复方血栓通胶囊联合激光治疗糖尿病视网膜病变的疗效观察[J]. 山西职工医学院学报, 2012, 22(5):14-16.
6. 袁超英, 曾伟清. 局部光凝联合复方血栓通治疗对糖尿病视网膜内微血管异常的影响[J]. 临床医学工程, 2012, 19(6):913-914.
7. 彭志华, 吴岚, 金小琴. 全视网膜光凝术联合复方血栓通胶囊治疗糖尿病视网膜病变的临床观察[J]. 湖北中医药大学学报, 2012, 14(5):54-55.
8. 楼继先, 曹永葆, 徐洁慧, 等. 激光光凝术联合复方血栓通胶囊治疗糖尿病视网膜病变[J]. 浙江中西医结合杂志, 2011, 21(6):419-420.
9. 王顺, 艾明, 贺涛. 多波长激光联合复方血栓通胶囊治疗糖尿病视网膜病变临床疗效观察[J]. 临床眼科杂志, 2009, 17(3):213-215.
10. 林慧, 张邓民, 衡昆山, 等. 光凝联合复方血栓通胶囊治疗糖尿病性视网膜病变临床观察[J]. 山东医药, 2009, 49(40):74-75.
11. 郭翠玲, 赵仲平, 汤爱灿, 等. 激光联合复方血栓通胶囊治疗糖尿病视网膜病变合并黄斑水肿的疗效观察[J]. 广东医学, 2009, 30(2):295-296.
12. Resnikoff S, Pascolini D, Etya'ale D, et al. Global data on visual impairment in the year 2002[J]. Bull World Health Organ, 2004, 82(11):844-851.
13. Park K, Chen Y, Hu Y, et al. Nanoparticle-mediated expression of an angiogenic inhibitor ameliorates ischemia-induced retinal neovascularization and diabetes-induced retinal vascular leakage[J]. Diabetes, 2009, 58(8):1902-1913.
14. 贾俊, 何媛, 刘慧峰, 等. 玻璃体切除联合视网膜光凝治疗增生性糖尿病视网膜病变[J]. 国际眼科杂志, 2014, 14(5):866-867.
15. 符敏, 吴伟, 唐罗生, 等. 糖尿病视网膜病变全视网膜光凝术后玻璃体视网膜界面的变化[J]. 眼科新进展, 2014, 34(11):1038-1042.
16. 王禹燕, 刘映霞, 麦少云, 等. 复方血栓通对NPDR激光光凝术后的视网膜血流动力学影响[J]. 国际眼科杂志, 2014, 14(7):1327-1328.
17. 沈国红. 复方血栓通胶囊治疗糖尿病视网膜病变的系统分析[J]. 中国中医药科技, 2014, 21(5):591-593.
18. 刘林平, 吴伯乐, 叶锌铭, 等. 视网膜激光光凝联合复方血栓通胶囊治疗缺血型视网膜静脉阻塞临床观察[J]. 浙江中西医结合杂志, 2015, 25(1):67-69.

West China Medical Journal

Effect of Fufang Xueshuantong Combined with Laser Photocoagulation versus Laser Photocoagulation Along for the Treatment of Diabetic Retinopathy: A Meta-analysis

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