Traditional Chinese Medicine Fumigation versus Western Medicine in the Treatment of Diabetic Peripheral Neuropathy: A Meta-analysis_West China Medical Journal

Authors：

 ZhangLei ¹ , WangGuohao ¹ , WangXinman ¹ ,  MengFanjie ²

1. Graduate College;Tianjin University of Traditional Chinese Medicine, Tianjin 300073, P. R. China;
2. Teacher Development and Evaluation Department;Tianjin University of Traditional Chinese Medicine, Tianjin 300073, P. R. China;

Corresponding author：

MengFanjie, Email: mfj127@tjutcm.edu.cn

Keywords：

Traditional Chinese medicine fumigation; Diabetic peripheral neuropathy; Meta-analysis

DOI：

10.7507/1002-0179.201600128

Video：

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Objective To evaluate the traditional Chinese medicine fumigation curative effect for the treatment of various diabetic peripheral neuropathy. Methods Databases such as China Biology Medicine Database, VIP, China Knowledge Resource Integrated Database, WanFang Data, PubMed, Embase, and the Cochrane Library were searched by computer for controlled clinical trials consistent with the inclusive criteria from the establishment of these databases until February 2016. The literature quality evaluation method of Cochrane system evaluation manual was used to evaluate the methodological quality of the studies, and then relevant data were extracted for Meta-analysis with RevMan 5.1 software. Results A total of 15 randomized controlled trials involving 1579 patients were included. Meta-analysis showed that 15 days after intervention, the total effective rate of the traditional Chinese medicine fumigation group was higher than that of the western medicine group, and the difference between the two groups was statistically significant [RR=1.39, 95%CI (1.25, 1.55), P<0.00001]; one month after intervention, the total effective rate of the traditional Chinese medicine fumigation group was significantly higher than that of the western medicine group [RR=1.26, 95%CI (1.15, 1.38), P<0.00001]; two months after intervention, the total effective rate of the traditional Chinese medicine fumigation group was significantly higher than that of the western medicine group [RR=1.22, 95%CI (1.10, 1.36), P=0.0002]. After 1 month of treatment, motor nerve conduction velocity motion [WMD=4.42 m/s, 95%CI (3.40, 5.43) m/s, P<0.00001] and median nerve sensory nerve conduction velocity [WMD=4.02 m/s, 95%CI (2.96, 5.08) m/s, P<0.00001] increased significantly more in the traditional Chinese medicine fumigation group. Conclusion The Chinese medicine fumigation treatment of diabetic peripheral neuropathy is better than oral or intramuscular vitamin B12, vitamin B1, oral oryzanol and so on.

Citation： ZhangLei, WangGuohao, WangXinman, MengFanjie. Traditional Chinese Medicine Fumigation versus Western Medicine in the Treatment of Diabetic Peripheral Neuropathy: A Meta-analysis. West China Medical Journal, 2016, 31(3): 480-486. doi: 10.7507/1002-0179.201600128 Copy

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1. Dyck PJ, Kratz KM, Karnes JL, et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort:the Rochester Diabetic Neuropathy Study[J]. Neurology, 1993, 43(4):817-824.
2. Prompers L, Schaper N, Apelqvist J, et al. Prediction of outcome in individuals with diabetic foot ulcers:focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study[J]. Diabetologia, 2008, 51(5):747-755.
3. Boulton AJ, Vinik AI, Arezzo JC, et al. Diabetic neuropathies:a statement by the American diabetes association[J]. Diabetes Care, 2005, 28(4):956-962.
4. 李金花. 温经通络熏洗方对糖尿病周围神经病变的疗效观察及机理探讨[D]. 广州:广州中医药大学, 2008.
5. 吕仁和. 2型糖尿病及其并发症中西医诊治学[M]. 北京:人民卫生出版社, 1997:390-394.
6. 郑筱萸. 中药新药临床研究指导原则(试行)[M]. 北京:中国医药科技出版社, 2002:233-237.
7. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0[updated March2011] [M/OL]. The Cochrane Collaboration, 2011. (2011-03-21)[2014-10-20]. http://www.cochrane-handbook.org.
8. 彭宝虹. 自拟糖痛方治疗糖尿病周围神经病变的临床研究[J]. 世界中西医结合杂志, 2012, 7(10):874-876.
9. 刘燕平, 徐玉梅, 黄少娟, 等. 当归活血熏洗方治疗糖尿病周围神经病变的疗效观察[J]. 中国实用护理杂志, 2007, 23(16):18.
10. 闫镛. 糖痛外洗方治疗糖尿病周围神经病变60例[J]. 河南大学学报:医学版, 2005, 24(2):57-58.
11. 李金花, 李惠林, 赵恒侠, 等. 温经通络熏洗方治疗DPN疗效观察及机理探讨[J]. 世界中西医结合杂志, 2010, 5(1):51-53.
12. 管静辉. 温经通络熏洗方治疗糖尿病周围神经病变的临床护理[J]. 中国现代药物应用, 2013, 7(7):94-95.
13. 王晶, 田强. 消渴寒痛乐熏洗治疗糖尿病周围神经病变临床观察[J]. 辽宁中医药大学学报, 2012, 14(7):18-19.
14. 肖玲, 苏波, 周华, 等. 中药熏洗方治疗糖尿病周围神经病变临床观察[J]. 广西中医学院学报, 2004, 7(3):31-32.
15. 孟萍, 孔德明. 中药熏洗治疗2型糖尿病周围神经病变90例疗效观察[J]. 健康必读:下半月, 2011, 2(2):182.
16. 刘萍, 耿田军, 刘振清. 中药熏洗治疗糖尿病周围神经病变31 例[J]. 中国医学创新, 2012, 9(9):109-110.
17. 刘瑾. 中药熏洗治疗糖尿病周围神经病变33例[J]. 浙江中西医结合杂志, 2002, 12(3):162-163.
18. 范广岩, 李娜, 刘圣基. 中药熏洗治疗糖尿病周围神经病变疗效观察[J]. 光明中医, 2012, 27(8):1550-1551.
19. 周潮, 佟杰, 单友琴, 等. 四通散熏洗治疗糖尿病周围神经病变218例临床观察[J]. 河北中医, 1998, 20(4):201-202.
20. 吕孟存. 活血通络汤治疗糖尿病周围神经病变68例[J]. 河南中医, 2007, 27(9):43-44.
21. 王志兴, 钱茜, 梁云武, 等. 黄芪桂枝五物汤熏蒸治疗糖尿病周围神经病变的疗效研究[J]. 现代医院, 2012, 12(11):21-24.
22. 杜亮亮, 颜国富. 中药熏洗治疗糖尿病周围神经病变40例临床研究[J]. 全科医学, 2015(2):55-56.
23. 陆祖谦, 丁维. 糖尿病周围神经病变诊治进展[J]. 药品评价, 2013, 10(17):35-42, 45.
24. 吴艳. 祛瘀通络熏洗方治疗糖尿病周围神经病变患者的临床研究[D]. 武汉:湖北中医药大学, 2011.
25. 高学敏. 中药学[M]. 7版. 北京:中国中医药出版社, 2002:53, 337, 385, 538.

West China Medical Journal

Traditional Chinese Medicine Fumigation versus Western Medicine in the Treatment of Diabetic Peripheral Neuropathy: A Meta-analysis

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