HE Shunpo 1,2 , LAI Xiaodong 3 , LIN Jianzhong 1 , CHEN Xingyu 1 , YANG Qingwei 1 , CHEN Zhongjie 1 , CHEN Liangyi 1 , YANG Huili 1 , PENG Zhongwei 1
  • 1. Department of Neurology, Zhongshan Hospital Xiamen University, Xiamen, Fujian 361004, P. R. China;
  • 2. College of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian 350108, P. R. China;
  • 3. Fuzhou Medical College, Nanchang University, Fuzhou, Jiangxi 344100, P. R. China;
YANG Qingwei, Email: yiheng66@126.com
Transient global amnesia; Risk factors; Imaging features; Prognosis
10.7507/1002-0179.202005003
Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables References Cited by

Objective To explore the related factors, responsible lesions, and prognosis of transient global amnesia (TGA).Methods We retrospectively collected TGA patients admitted to Zhongshan Hospital Xiamen University between October 1st 2011 and October 31st 2018 and age- and sex-matched health examinees in the Department of Physical Examination in the same period as a control group. We recorded the relevant clinical information of the two groups, such as sex, age, hypertension, diabetes, hyperlipidemia, atrial fibrillation, stroke, migraine, TGA and epilepsy, and the imaging data of the TGA patients. The occurrences of cerebral infarction, cerebral hemorrhage, recurrence of TGA, and myocardial infarction of the two groups were followed up.Results A total of 73 TGA patients and 73 age- and sex-matched controls were included. The difference in the history of migraine was statistically significant (χ2=4.000, P=0.038), while there was no significant difference in the history of hypertension, diabetes or other medical history between the two groups (P>0.05). It was found that the responsible focus of TGA was in the hippocampal CA1 region, while the fornix column and the hippocampal CA1 region existed in the same functional loop. The mean follow-up time was (36.0±22.6) months. Sixty-nine TGA patients and 67 healthy controls were followed up. During the follow-up, there was no significant difference in the incidence of cerebral infarction, cerebral hemorrhage, myocardial infarction, or TGA attacks between the two groups (P>0.05). There was no statistically significant difference (P>0.05) in the clinical or follow-up data between the TGA patients with lesion on DWI (n=9) and the ones without lesion on DWI (n=58).Conclusions Migraine may be a risk factor for TGA. The responsible brain area of TGA may involve a memory loop, including hippocampal CA1 region, fornix column and so on. After the attack of TGA, the long-term prognosis is well.

Citation： HE Shunpo, LAI Xiaodong, LIN Jianzhong, CHEN Xingyu, YANG Qingwei, CHEN Zhongjie, CHEN Liangyi, YANG Huili, PENG Zhongwei. Transient global amnesia: related factors, imaging features, and prognosis. West China Medical Journal, 2020, 35(12): 1478-1483. doi: 10.7507/1002-0179.202005003 Copy