RESEARCH PROGRESS OF CONSTRUCTING INJECTABLE TISSUE ENGINEERED ADIPOSE TISSUE WITH ADIPOSE-DERIVED STEM CELLS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

YANGShuifa ,  YIYangyan

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;

Corresponding author：

YIYangyan, Email: yyy0218@126.com

Keywords：

Tissue engineered adipose; Adipose-derived stem cells; Injectable scaffold; Repair and reconstruction

DOI：

10.7507/1002-1892.20150051

Video：

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Objective To review the research progress of constructing injectable tissue engineered adipose tissue by adipose-derived stem cells (ADSCs). Methods Recent literature about ADSCs composite three-dimensional scaffold to construct injectable tissue engineered adipose tissue is summarized, mainly on the characteristics of ADSCs, innovation of injectable scaffold, and methods to promote blood supply. Results ADSCs have a sufficient amount and powerful ability such as secretion, excellent compatibility with injectable scaffold, plus with methods of promoting blood supply, which can build forms of injectable tissue engineered adipose tissue. Conclusion In despite of many problems to be dealt with, ADSCs constructing injectable tissue engineered adipose tissue may provide a promising source for soft-tissue defect repair and plastic surgery.

Citation： YANGShuifa, YIYangyan. RESEARCH PROGRESS OF CONSTRUCTING INJECTABLE TISSUE ENGINEERED ADIPOSE TISSUE WITH ADIPOSE-DERIVED STEM CELLS. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(2): 245-249. doi: 10.7507/1002-1892.20150051 Copy

1.	Chang Q, Lu F. A novel strategy for creating a large amount of engineered fat tissue with an axial vascular pedicle and a prefabricated scaffold. Med Hypotheses, 2012, 79(2):267-270.
2.	Tanzi MC, Farè S. Adipose tissue engineering:state of the art, recent advances and innovative approaches. Expert Rev Med Devices, 2009, 6(5):533-551.
3.	Eto H, Kato H, Suga H, et al. The fate of adipocytes after nonvascularized fat grafting:evidence of early death and replacement of adipocytes. Plast Reconstr Surg, 2012, 129(5):1081-1092.
4.	Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue:implications for cell-based therapies. Tissue Eng, 2001, 7(2):211-228.
5.	Tang W, Zeve D, Suh JM, et al. White fat progenitor cells reside in the adipose vasculature. Science, 2008, 322(5901):583-586.
6.	Strem BM, Zhu M, Alfonso Z, et al. Expression of cardiomyocytic markers on adipose tissue-derived cells in a murine model of acute myocardial injury. Cytotherapy, 2005, 7(3):282-291.
7.	Bianchi F, Maioli M, Leonardi E, et al. A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates. Cell Transplant, 2013, 22(11):2063-2077.
8.	Li Q, Qi LJ, Guo ZK, et al. CD73⁺ adipose-derived mesenchymal stem cells possess higher potential to differentiate into cardiomyocytes in vitro. J Mol Histol, 2013, 44(4):411-422.
9.	Seo MJ, Suh SY, Bae YC, et al. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun, 2005, 328(1):258-264.
10.	Yamamoto Y, Banas A, Murata S, et al. A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells. FEBS J, 2008, 275(6):1260-1273.
11.	Kajiyama H, Hamazaki TS, Tokuhara M, et al. Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice. Int J Dev Biol, 2010, 54(4):699-705.
12.	Zhu M, Zhou Z, Chen Y, et al. Supplementation of fat grafts with adipose-derived regenerative cells improves long-term graft retention. Ann Plast Surg, 2010, 64(2):222-228.
13.	Hsiao ST, Lokmic Z, Peshavariya H, et al. Hypoxic conditioning enhances the angiogenic paracrine activity of human adipose-derived stem cells. Stem Cells Dev, 2013, 22(10):1614-1623.
14.	付冰川, 高建华, 鲁峰, 等. 新鲜分离的脂肪SVF细胞促进脂肪移植存活的实验研究. 中华整形外科杂志, 2010, 26(4):289-294.
15.	Rigotti G, Marchi A, Galie M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant:a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg, 2007, 119(5):1409-1424.
16.	Mazzola RF, Cantarella G, Torretta S, et al. Autologous fat injection to face and neck:from soft tissue augmentation to regenerative medicine. Acta Otorhinolaryngol Ital, 2011, 31(2):59-69.
17.	Neuss S, Stainforth R, Salber J, et al. Long-term survival and bipotent terminal differentiation of human mesenchymal stem cells (hMSC) in combination with a commercially available three-dimensional collagen scaffold. Cell Transplant, 2008, 17(8):977-986.
18.	张云松, 高建华, 鲁峰, 等. 人脂肪来源干细胞复合I型胶原支架构建工程化脂肪组织的实验研究. 中华整形外科杂志, 2008, 24(5):385-389.
19.	Shaterian A, Borboa A, Sawada R, et al. Real-time analysis of the kinetics of angiogenesis and vascular permeability in an animal model of wound healing. Burns, 2009, 35(6):811-817.
20.	Vashi AV, Abberton KM, Thomas GP, et al. Adipose tissue engineering based on the controlled release of fibroblast growth factor-2 in a collagen matrix. Tissue Eng, 2006, 12(11):3035-3043.
21.	Verseijden F, Posthumus-van SS, van Neck JW, et al. Comparing scaffold-free and fibrin-based adipose-derived stromal cell constructs for adipose tissue engineering:an in vitro and in vivo study. Cell Transplant, 2012, 21(10):2283-2297.
22.	张云松, 高建华, 鲁峰, 等. 人脂肪来源干细胞复合纤维蛋白胶构建可注射型工程化脂肪组织的实验研究. 中华医学杂志, 2008, 88(38):2705-2709.
23.	许兆峰, 高建华, 李劼, 等. 纤维蛋白胶与脂肪来源干细胞影响脂肪注射移植的实验研究. 南方医科大学学报, 2009, 29(5):1073-1075.
24.	Tan H, Ramirez CM, Miljkovic N, et al. Thermosensitive injectable hyaluronic acid hydrogel for adipose tissue engineering. Biomaterials, 2009, 30(36):6844-6853.
25.	Zheng L, Fan HS, Sun J, et al. Chondrogenic differentiation of mesenchymal stem cells induced by collagen-based hydrogel:an in vivo study. J Biomed Mater Res A, 2010, 93(2):783-792.
26.	于文渊, 崔磊, 赵宇, 等. 人脂肪干细胞与聚L-谷氨酸/海藻酸钠可注射水凝胶的生物相容性研究. 安徽医科大学学报, 2012, 47(6):727-731.
27.	Wu I, Nahas Z, Kimmerling KA, et al. An injectable adipose matrix for soft-tissue reconstruction. Plast Reconstr Surg, 2012, 129(6):1247-1257.
28.	察鹏飞, 高建华, 陈阳, 等. 人细胞外基质支架联合脂肪干细胞构建脂肪组织. 中华实验外科杂志, 2012, 29(6):1085-1088.
29.	Matsumoto D, Sato K, Gonda K, et al. Cell-assisted lipotransfer:supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection. Tissue Eng, 2006, 12 (12):3375-3382.
30.	Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for facial lipoatrophy:efficacy of clinical use of adipose-derived stem cells. Dermatol Surg, 2008, 34(9):1178-1185.
31.	Wei X, Li G, Yang X, et al. Effects of bone morphogenetic protein-4 (BMP-4) on adipocyte differentiation from mouse adipose-derived stem cells. Cell Prolif, 2013, 46(4):416-424.
32.	Wang B, Han J, Gao Y, et al. The differentiation of rat adipose-derived stem cells into OEC-like cells on collagen scaffolds by co-culturing with OECs. Neurosci Lett, 2007, 421(3):191-196.
33.	许海委, 徐宝山, 杨强,等. 细胞共培养法诱导兔脂肪来源干细胞向软骨细胞分化的实验研究. 中国修复重建外科杂志, 2013, 27(2):193-198.
34.	Stosich MS, Moioli EK, Wu JK, et al. Bioengineering strategies to generate vascularized soft tissue grafts with sustained shape. Methods, 2009, 47(2):116-121.
35.	黎洪棉, 高建华, 吴涛, 等. 脂肪干细胞与外源性血管内皮生长因子及纤维蛋白胶复合物体内构建血管化组织工程脂肪. 中国组织工程研究与临床康复, 2011, 15(40):7480-7484.
36.	杨波, 沈宏亮, 徐志飞, 等. 血管内皮细胞生长因子165基因转染干细胞促进组织工程化脂肪的存活. 中国组织工程研究, 2012, 16(14):2534-2539.
37.	Taniyama Y, Morishita R, Aoki M, et al. Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models:preclinical study for treatment of peripheral arterial disease. Gene Ther, 2001, 8(3):181-189.
38.	王有虎, 刘毅, 哈小琴, 等. 转染肝细胞生长因子基因对移植颗粒脂肪新生血管形成的影响. 中华实验外科杂志, 2008, 25(8):1079.
39.	黎洪棉, 柳大烈, 赵培冉, 等. 脂肪干细胞与自体富血小板血浆载体复合物体内构建血管化组织工程脂肪. 中国组织工程研究, 2012, 16(45):8424-8429.
40.	Mazzola RF, Cantarella G, Torretta S, et al. Autologous fat injection to face and neck:from soft tissue augmentation to regenerative medicine. Acta Otorhinolaryngol Ital, 2011, 31(2):59-69.
41.	Adams WJ Jr. Discussion:Breast augmentation using preexpansion and autologous fat transplantation:a clinical radiographic study. Plast Reconstr Surg, 2011, 127(6):2453-2454.

1. Chang Q, Lu F. A novel strategy for creating a large amount of engineered fat tissue with an axial vascular pedicle and a prefabricated scaffold. Med Hypotheses, 2012, 79(2):267-270.
2. Tanzi MC, Farè S. Adipose tissue engineering:state of the art, recent advances and innovative approaches. Expert Rev Med Devices, 2009, 6(5):533-551.
3. Eto H, Kato H, Suga H, et al. The fate of adipocytes after nonvascularized fat grafting:evidence of early death and replacement of adipocytes. Plast Reconstr Surg, 2012, 129(5):1081-1092.
4. Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue:implications for cell-based therapies. Tissue Eng, 2001, 7(2):211-228.
5. Tang W, Zeve D, Suh JM, et al. White fat progenitor cells reside in the adipose vasculature. Science, 2008, 322(5901):583-586.
6. Strem BM, Zhu M, Alfonso Z, et al. Expression of cardiomyocytic markers on adipose tissue-derived cells in a murine model of acute myocardial injury. Cytotherapy, 2005, 7(3):282-291.
7. Bianchi F, Maioli M, Leonardi E, et al. A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates. Cell Transplant, 2013, 22(11):2063-2077.
8. Li Q, Qi LJ, Guo ZK, et al. CD73⁺ adipose-derived mesenchymal stem cells possess higher potential to differentiate into cardiomyocytes in vitro. J Mol Histol, 2013, 44(4):411-422.
9. Seo MJ, Suh SY, Bae YC, et al. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun, 2005, 328(1):258-264.
10. Yamamoto Y, Banas A, Murata S, et al. A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells. FEBS J, 2008, 275(6):1260-1273.
11. Kajiyama H, Hamazaki TS, Tokuhara M, et al. Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice. Int J Dev Biol, 2010, 54(4):699-705.
12. Zhu M, Zhou Z, Chen Y, et al. Supplementation of fat grafts with adipose-derived regenerative cells improves long-term graft retention. Ann Plast Surg, 2010, 64(2):222-228.
13. Hsiao ST, Lokmic Z, Peshavariya H, et al. Hypoxic conditioning enhances the angiogenic paracrine activity of human adipose-derived stem cells. Stem Cells Dev, 2013, 22(10):1614-1623.
14. 付冰川, 高建华, 鲁峰, 等. 新鲜分离的脂肪SVF细胞促进脂肪移植存活的实验研究. 中华整形外科杂志, 2010, 26(4):289-294.
15. Rigotti G, Marchi A, Galie M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant:a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg, 2007, 119(5):1409-1424.
16. Mazzola RF, Cantarella G, Torretta S, et al. Autologous fat injection to face and neck:from soft tissue augmentation to regenerative medicine. Acta Otorhinolaryngol Ital, 2011, 31(2):59-69.
17. Neuss S, Stainforth R, Salber J, et al. Long-term survival and bipotent terminal differentiation of human mesenchymal stem cells (hMSC) in combination with a commercially available three-dimensional collagen scaffold. Cell Transplant, 2008, 17(8):977-986.
18. 张云松, 高建华, 鲁峰, 等. 人脂肪来源干细胞复合I型胶原支架构建工程化脂肪组织的实验研究. 中华整形外科杂志, 2008, 24(5):385-389.
19. Shaterian A, Borboa A, Sawada R, et al. Real-time analysis of the kinetics of angiogenesis and vascular permeability in an animal model of wound healing. Burns, 2009, 35(6):811-817.
20. Vashi AV, Abberton KM, Thomas GP, et al. Adipose tissue engineering based on the controlled release of fibroblast growth factor-2 in a collagen matrix. Tissue Eng, 2006, 12(11):3035-3043.
21. Verseijden F, Posthumus-van SS, van Neck JW, et al. Comparing scaffold-free and fibrin-based adipose-derived stromal cell constructs for adipose tissue engineering:an in vitro and in vivo study. Cell Transplant, 2012, 21(10):2283-2297.
22. 张云松, 高建华, 鲁峰, 等. 人脂肪来源干细胞复合纤维蛋白胶构建可注射型工程化脂肪组织的实验研究. 中华医学杂志, 2008, 88(38):2705-2709.
23. 许兆峰, 高建华, 李劼, 等. 纤维蛋白胶与脂肪来源干细胞影响脂肪注射移植的实验研究. 南方医科大学学报, 2009, 29(5):1073-1075.
24. Tan H, Ramirez CM, Miljkovic N, et al. Thermosensitive injectable hyaluronic acid hydrogel for adipose tissue engineering. Biomaterials, 2009, 30(36):6844-6853.
25. Zheng L, Fan HS, Sun J, et al. Chondrogenic differentiation of mesenchymal stem cells induced by collagen-based hydrogel:an in vivo study. J Biomed Mater Res A, 2010, 93(2):783-792.
26. 于文渊, 崔磊, 赵宇, 等. 人脂肪干细胞与聚L-谷氨酸/海藻酸钠可注射水凝胶的生物相容性研究. 安徽医科大学学报, 2012, 47(6):727-731.
27. Wu I, Nahas Z, Kimmerling KA, et al. An injectable adipose matrix for soft-tissue reconstruction. Plast Reconstr Surg, 2012, 129(6):1247-1257.
28. 察鹏飞, 高建华, 陈阳, 等. 人细胞外基质支架联合脂肪干细胞构建脂肪组织. 中华实验外科杂志, 2012, 29(6):1085-1088.
29. Matsumoto D, Sato K, Gonda K, et al. Cell-assisted lipotransfer:supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection. Tissue Eng, 2006, 12 (12):3375-3382.
30. Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for facial lipoatrophy:efficacy of clinical use of adipose-derived stem cells. Dermatol Surg, 2008, 34(9):1178-1185.
31. Wei X, Li G, Yang X, et al. Effects of bone morphogenetic protein-4 (BMP-4) on adipocyte differentiation from mouse adipose-derived stem cells. Cell Prolif, 2013, 46(4):416-424.
32. Wang B, Han J, Gao Y, et al. The differentiation of rat adipose-derived stem cells into OEC-like cells on collagen scaffolds by co-culturing with OECs. Neurosci Lett, 2007, 421(3):191-196.
33. 许海委, 徐宝山, 杨强,等. 细胞共培养法诱导兔脂肪来源干细胞向软骨细胞分化的实验研究. 中国修复重建外科杂志, 2013, 27(2):193-198.
34. Stosich MS, Moioli EK, Wu JK, et al. Bioengineering strategies to generate vascularized soft tissue grafts with sustained shape. Methods, 2009, 47(2):116-121.
35. 黎洪棉, 高建华, 吴涛, 等. 脂肪干细胞与外源性血管内皮生长因子及纤维蛋白胶复合物体内构建血管化组织工程脂肪. 中国组织工程研究与临床康复, 2011, 15(40):7480-7484.
36. 杨波, 沈宏亮, 徐志飞, 等. 血管内皮细胞生长因子165基因转染干细胞促进组织工程化脂肪的存活. 中国组织工程研究, 2012, 16(14):2534-2539.
37. Taniyama Y, Morishita R, Aoki M, et al. Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models:preclinical study for treatment of peripheral arterial disease. Gene Ther, 2001, 8(3):181-189.
38. 王有虎, 刘毅, 哈小琴, 等. 转染肝细胞生长因子基因对移植颗粒脂肪新生血管形成的影响. 中华实验外科杂志, 2008, 25(8):1079.
39. 黎洪棉, 柳大烈, 赵培冉, 等. 脂肪干细胞与自体富血小板血浆载体复合物体内构建血管化组织工程脂肪. 中国组织工程研究, 2012, 16(45):8424-8429.
40. Mazzola RF, Cantarella G, Torretta S, et al. Autologous fat injection to face and neck:from soft tissue augmentation to regenerative medicine. Acta Otorhinolaryngol Ital, 2011, 31(2):59-69.
41. Adams WJ Jr. Discussion:Breast augmentation using preexpansion and autologous fat transplantation:a clinical radiographic study. Plast Reconstr Surg, 2011, 127(6):2453-2454.

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RESEARCH PROGRESS OF CONSTRUCTING INJECTABLE TISSUE ENGINEERED ADIPOSE TISSUE WITH ADIPOSE-DERIVED STEM CELLS

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