Research Progress of Adjustment Mechanism between MicroRNA and Vascular Endothelial Cell Function_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHANGLei ,  WANGChun

Department of Cardiovascular Surgery, the First Hospital of China Medical University, Shenyang 110001, P. R. China;

Corresponding author：

WANGChun, Email: doctorchun@126.com

Keywords：

Vascular endothelial cells; MicroRNA; Inflammation; Atherosclerosis; Endothelial repair; Summary

DOI：

10.7507/1007-4848.20160069

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Vascular endothelial cell(VEC) is a kind of simple squamous epithelium lined on the inner surface of blood vessels. VEC is an important barrier between the blood and tissue and it also plays a key role in regulating inflammation, thrombosis, endothelial cells mediated vasodilatation and endothelial regeneration. These processes should be controlled by a variety of complex mechanism which requires us to find out. With results of the researches in vascular endothelial cell function, the important roles that microRNA in vascular endothelial cell function draws more and more researchers' attention. MicroRNAs control gene expression in post-transcriptional level and affect the function of endothelial cells. This review focuses on the research progress on regulatory mechanism of microRNA to endothelial cell inflammation, thrombosis, vasodilation and endothelium regeneration.

Citation： ZHANGLei, WANGChun. Research Progress of Adjustment Mechanism between MicroRNA and Vascular Endothelial Cell Function. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(3): 299-303. doi: 10.7507/1007-4848.20160069 Copy

1.	Wu kk. Endothelial cells in hemostasis, thrombosis, and inflamma-tion. Hosp Pract (Off Ed), 1992, 27(4): 145-150, 152, 163-166.
2.	Bartel DP. MicroRNAs: genomics, biogenesis, mechanism,function. Cell, 2004, 116(2): 281-297.
3.	Perron MP, Provost P. Protein interactions and complexes in human microRNA biogenesis and function. Front Biosci, 2008, 1(13): 2537-2547.
4.	Small EM, Son EN. Pervasive roles of microRNAs in cardiovascular biology. Nature, 2011, 469(7330): 336-342.
5.	Wang S, Aurora AB, Johnson BA, et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell, 2008, 15(2): 261-271.
6.	Fish JE, Santoro MM, Morton SU, et al. MiR-126 regulates angio-genic signaling and vascular integrity. Dev Cell, 2008, 15(2): 272-284.
7.	Asgeirsdóttir SA, van Solingen C, Kurniati NF, et al. MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. Am J Physiol Renal Physiol, 2012, 302(12): F1630-F1639.
8.	Harris TA, Yamakuchi M, Ferlito M, et al. microRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci USA, 2008, 105(5): 1516-1521.
9.	Wu W, Xiao H, Laguna-Fernandez A, et al. Flowdependent regula-tion of kruppel-like factor 2 is mediated by microRNA-92a. Circulation, 2011, 12(4): 633-641.
10.	Parmar KM, Larman HB, Dai G, et al. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest, 2006, 116(1): 49-58.
11.	SenBanerjee S, Lin Z, Atkins GB, et al. KLF2 is a novel transcrip-tional regulator of endothelial proinflammatory activation. J Exp Med, 2004, 199(10): 1305-1315.
12.	Helbing T, Rothweiler R, Ketterer E, et al. BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothe-lium. Blood, 2011, 118(18): 5040-5049.
13.	Fledderus J, Van Thienen JV, Boon RA, et al. Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2. Blood, 2007, 109(10): 4249-4257.
14.	Boon RA, Leyen TA, Fontijn RD, et al. KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium. Blood, 2010, 115(12): 2533-2542.
15.	Kumarswamy R, Volkmann I, Thum T. Regulation and function of miRNA-21 in health and disease. RNA Biol USA, 2011, 8(5): 706-713.
16.	Zhou J, Wang KC, Wu W, et al. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci USA, 2011, 108(25): 10355-10360.
17.	Wang Y, Lee CG. MicroRNA and cancer--focus on apoptosis. J Cell Mol Med, 2009, 13(1): 12-23.
18.	Fang Y, Shi C, Manduchi E, et al. MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc Natl Acad Sci USA, 2010, 107(30): 13450-13455.
19.	Taganov KD, Boldin MP, Chang KJ, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA, 2006, 103(33): 12481-12486.
20.	Cheng HS, Sivachandran N, Lau A, et al. MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways. EMBO Mol Med, 2013, 5(7): 949-966.
21.	Rau CS, Yang JC, Chen YC, et al. Lipopolysaccharide-induced microRNA-146a targets CARD10 and regulates angiogenesis in human umbilical vein endothelial cells. Toxicol Sci, 2014, 140(2): 315-326.
22.	Pulkkinen KH, Ylä-Herttuala S, Levonen AL. Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells. Free Radic Biol Med, 2011, 51(11): 2124-2131.
23.	Wu XY, Fan WD, Fang R, et al. Regulation of microRNA-155 in endothelial inflammation by targeting nuclear factor (NF)-κB P65. J Cell Biochem, 2014, 15(11): 1928-1936.
24.	Sun HX, Zeng DY. Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitricoxide synthase.Hypertension, 2012, 60(6): 1407-1414.
25.	Yamamoto K, Protack CD, Kuwahara G, et al. Disturbed shear stress reduces Klf2 expression in arterial-venous fistulae in vivo. Physiol Rep, 2015, 3(3): e12348.
26.	Doddaballapur A, Michalik KM, Manavski Y, et al. Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3. Arterioscler Thromb Vasc Biol, 2015, 35(1): 137-145.
27.	Fang Y, Davies PF. Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium. Arterioscler Thromb Vasc Biol, 2012, 32(4): 979-987.
28.	Sen A, Most P, Peppel K. Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction. FEBS Lett, 2014, 588(6): 906-914.
29.	Weber M, Baker MB, Moore JP, et al. MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity. Biochem Biophys Res Commun, 2010, 393(7): 643-648.
30.	Church JE, Qian J, Kumar S, et al. Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN. Vascul Pharmacol. Vascul Pharmacol, 2010, 52(5-6): 191-198.
31.	Malek AM, Jackman R, Rosenberg RD, et al. Endothelial Expression of Thrombomodulin Is Reversibly Regulated by Fluid Shear Stress. Circ Res, 1994, 74(5): 852-860.
32.	Daniel JM, Penzkofer D, Teske R, et al. Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury. Cardiovasc Res, 2014, 103(4): 564-572.
33.	Lin Z, Kumar A, SenBanerjee S, et al. Kruppel-Like Factor 2(KLF2) Regulates Endothelial Thrombotic Function. Circ Res, 2005, 96(5): e48-e57.
34.	Loyer X, Potteaux S, Vion AC, et al. Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice. Circ Res, 2014, 114(3): 434-443.
35.	Li S, Chen H, Ren J, et al. MicroRNA-223 inhibits tissue factor expression in vascular endothe lial cells. Atherosc, 2014, 237(2): 514-520.
36.	Van Schie MC, De Maat MP, Isaacs A, et al. Variation in the von Willebrand factor gene is associated with von Willebrand factor levels and with the risk for cardiovascular disease. Blood, 2011, 117(4): 1393-1399.
37.	Xiang Y, Cheng J, Wang D, et al. Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of Von Willebrand Factor. Blood, 2015, 125(22): 3377-3387.
38.	Esposito B, Gambara G, Lewis AM, et al. NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endo-thelial cells. Blood, 2011, 117(18): 4968-4977.
39.	Zou J, Li WQ, Li Q. Two functional microRNA-126s repress a novel target gene p21-Activated kinase 1 to regulate vascular integrit in zebrafish. Circ Res, 2011, 108(2): 201-209.
40.	Sabatel C, Malvaux L, Bovy N, et al. MicroRNA-21 exhibits antian-giogenic function by targeting RhoB expression in endothelial cells. PloS ONE, 2011, 6(2): e16979.
41.	Liu LZ, Li C, Chen Q, et al. MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1 alpha expression. PLoS One, 2011, 6(4): e19139.
42.	Zhang X, Mao H, Chen JY, et al. Increased expression of microRNA-221 inhibits PAK1 in endothelial progenitor cells and impairs its function via c-Raf/MEK/ERK pathway. Biochem Biophys Res Commun, 2013, 431(3): 404-408.
43.	Wang S, Aurora AB, Johnson BA, et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell, 2008, 15(2): 261-271.
44.	Li X, Han Y, Pang W, et al. AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arterioscler Thromb, 2008, 28(10): 1789-1795.

1. Wu kk. Endothelial cells in hemostasis, thrombosis, and inflamma-tion. Hosp Pract (Off Ed), 1992, 27(4): 145-150, 152, 163-166.
2. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism,function. Cell, 2004, 116(2): 281-297.
3. Perron MP, Provost P. Protein interactions and complexes in human microRNA biogenesis and function. Front Biosci, 2008, 1(13): 2537-2547.
4. Small EM, Son EN. Pervasive roles of microRNAs in cardiovascular biology. Nature, 2011, 469(7330): 336-342.
5. Wang S, Aurora AB, Johnson BA, et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell, 2008, 15(2): 261-271.
6. Fish JE, Santoro MM, Morton SU, et al. MiR-126 regulates angio-genic signaling and vascular integrity. Dev Cell, 2008, 15(2): 272-284.
7. Asgeirsdóttir SA, van Solingen C, Kurniati NF, et al. MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. Am J Physiol Renal Physiol, 2012, 302(12): F1630-F1639.
8. Harris TA, Yamakuchi M, Ferlito M, et al. microRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci USA, 2008, 105(5): 1516-1521.
9. Wu W, Xiao H, Laguna-Fernandez A, et al. Flowdependent regula-tion of kruppel-like factor 2 is mediated by microRNA-92a. Circulation, 2011, 12(4): 633-641.
10. Parmar KM, Larman HB, Dai G, et al. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest, 2006, 116(1): 49-58.
11. SenBanerjee S, Lin Z, Atkins GB, et al. KLF2 is a novel transcrip-tional regulator of endothelial proinflammatory activation. J Exp Med, 2004, 199(10): 1305-1315.
12. Helbing T, Rothweiler R, Ketterer E, et al. BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothe-lium. Blood, 2011, 118(18): 5040-5049.
13. Fledderus J, Van Thienen JV, Boon RA, et al. Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2. Blood, 2007, 109(10): 4249-4257.
14. Boon RA, Leyen TA, Fontijn RD, et al. KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium. Blood, 2010, 115(12): 2533-2542.
15. Kumarswamy R, Volkmann I, Thum T. Regulation and function of miRNA-21 in health and disease. RNA Biol USA, 2011, 8(5): 706-713.
16. Zhou J, Wang KC, Wu W, et al. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci USA, 2011, 108(25): 10355-10360.
17. Wang Y, Lee CG. MicroRNA and cancer--focus on apoptosis. J Cell Mol Med, 2009, 13(1): 12-23.
18. Fang Y, Shi C, Manduchi E, et al. MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc Natl Acad Sci USA, 2010, 107(30): 13450-13455.
19. Taganov KD, Boldin MP, Chang KJ, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA, 2006, 103(33): 12481-12486.
20. Cheng HS, Sivachandran N, Lau A, et al. MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways. EMBO Mol Med, 2013, 5(7): 949-966.
21. Rau CS, Yang JC, Chen YC, et al. Lipopolysaccharide-induced microRNA-146a targets CARD10 and regulates angiogenesis in human umbilical vein endothelial cells. Toxicol Sci, 2014, 140(2): 315-326.
22. Pulkkinen KH, Ylä-Herttuala S, Levonen AL. Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells. Free Radic Biol Med, 2011, 51(11): 2124-2131.
23. Wu XY, Fan WD, Fang R, et al. Regulation of microRNA-155 in endothelial inflammation by targeting nuclear factor (NF)-κB P65. J Cell Biochem, 2014, 15(11): 1928-1936.
24. Sun HX, Zeng DY. Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitricoxide synthase.Hypertension, 2012, 60(6): 1407-1414.
25. Yamamoto K, Protack CD, Kuwahara G, et al. Disturbed shear stress reduces Klf2 expression in arterial-venous fistulae in vivo. Physiol Rep, 2015, 3(3): e12348.
26. Doddaballapur A, Michalik KM, Manavski Y, et al. Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3. Arterioscler Thromb Vasc Biol, 2015, 35(1): 137-145.
27. Fang Y, Davies PF. Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium. Arterioscler Thromb Vasc Biol, 2012, 32(4): 979-987.
28. Sen A, Most P, Peppel K. Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction. FEBS Lett, 2014, 588(6): 906-914.
29. Weber M, Baker MB, Moore JP, et al. MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity. Biochem Biophys Res Commun, 2010, 393(7): 643-648.
30. Church JE, Qian J, Kumar S, et al. Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN. Vascul Pharmacol. Vascul Pharmacol, 2010, 52(5-6): 191-198.
31. Malek AM, Jackman R, Rosenberg RD, et al. Endothelial Expression of Thrombomodulin Is Reversibly Regulated by Fluid Shear Stress. Circ Res, 1994, 74(5): 852-860.
32. Daniel JM, Penzkofer D, Teske R, et al. Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury. Cardiovasc Res, 2014, 103(4): 564-572.
33. Lin Z, Kumar A, SenBanerjee S, et al. Kruppel-Like Factor 2(KLF2) Regulates Endothelial Thrombotic Function. Circ Res, 2005, 96(5): e48-e57.
34. Loyer X, Potteaux S, Vion AC, et al. Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice. Circ Res, 2014, 114(3): 434-443.
35. Li S, Chen H, Ren J, et al. MicroRNA-223 inhibits tissue factor expression in vascular endothe lial cells. Atherosc, 2014, 237(2): 514-520.
36. Van Schie MC, De Maat MP, Isaacs A, et al. Variation in the von Willebrand factor gene is associated with von Willebrand factor levels and with the risk for cardiovascular disease. Blood, 2011, 117(4): 1393-1399.
37. Xiang Y, Cheng J, Wang D, et al. Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of Von Willebrand Factor. Blood, 2015, 125(22): 3377-3387.
38. Esposito B, Gambara G, Lewis AM, et al. NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endo-thelial cells. Blood, 2011, 117(18): 4968-4977.
39. Zou J, Li WQ, Li Q. Two functional microRNA-126s repress a novel target gene p21-Activated kinase 1 to regulate vascular integrit in zebrafish. Circ Res, 2011, 108(2): 201-209.
40. Sabatel C, Malvaux L, Bovy N, et al. MicroRNA-21 exhibits antian-giogenic function by targeting RhoB expression in endothelial cells. PloS ONE, 2011, 6(2): e16979.
41. Liu LZ, Li C, Chen Q, et al. MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1 alpha expression. PLoS One, 2011, 6(4): e19139.
42. Zhang X, Mao H, Chen JY, et al. Increased expression of microRNA-221 inhibits PAK1 in endothelial progenitor cells and impairs its function via c-Raf/MEK/ERK pathway. Biochem Biophys Res Commun, 2013, 431(3): 404-408.
43. Wang S, Aurora AB, Johnson BA, et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell, 2008, 15(2): 261-271.
44. Li X, Han Y, Pang W, et al. AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arterioscler Thromb, 2008, 28(10): 1789-1795.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Research Progress of Adjustment Mechanism between MicroRNA and Vascular Endothelial Cell Function

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content