The Correlation Factors for The Formation of Cholesterol Calculus_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 TANZhi-hui ,  ZHANGXian-lin

Department of General Surgery of Renhe Hospital, Three Gorges University, Yichang 443000, Hubei Province, China;

Corresponding author：

ZHANGXian-lin, Email: 706456093@qq.com

Keywords：

Cholesterol stone; Blood lipid metabolism; Molecular biology; Genetic testing

DOI：

10.7507/1007-9424.20160034

Video：

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Objective To study the latest research progress of the formation mechanism of cholesterol stone disease and forming factors of cholesterol stone disease and to provide new theoretical level and develop a new development direction for guiding clinical application. Methods The related literatures at home and abroad were analyzed, compared and summarized, and the current relevant research dynamic of cholesterol stone disease was sketched. Results The formation of cholesterol gallstone is closely related to the abnormal levels of serum lipids metabolism, bacterial and viral infection, and the expression of genes related to cholesterol gallstone. Conclusions The formation of cholesterol calculus disease is a kind of interaction and intricate disease process involving of environmental factors, genetic factors, and biological factors. Although there has been a lot of blood lipid, protein correlation research with cholesterol stone, there are also many studies such as using gene transplantation and gene knockout, but gene technology of cholesterol stone disease diagnosis and treatment is expected to become the new hot research topic.

Citation： TANZhi-hui, ZHANGXian-lin. The Correlation Factors for The Formation of Cholesterol Calculus. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(1): 123-126. doi: 10.7507/1007-9424.20160034 Copy

1.	Acalovschi M. Callstones in patients with liver cirrhosis:Incidence, etiology, clinical and therapeutical aspects. World J Gastroenterol, 2014, 20(23):7277-7285.
2.	Chuang SC, Hsi E, Lee KT. Genetics of gallstone disease. Adv Clin Chem, 2013, 60:143-185.
3.	Stringer MD, Fraser S, Gordon KC, et al. Gallstones in New Zealand:composition, risk factors and ethnic differences. ANZ J Surg, 2013, 83(7-8):575-580.
4.	蒋兆彦, 韩天权, 张圣道.胆固醇结石病的发生机制.世界华人消化杂志, 2010, 18(12):1191-1195.
5.	Katsika A, Krivokapić J, Mooshammer C, et al. The coordination of boundary tones and its interaction with prominence. J Phon, 2014, 44:62-82.
6.	Katsika A, Shattuck-Hufnagel, Mooshammer C, et al. Effects of compatible versus competing rhythmic grouping on errors and timing variability in speech. Lang Speech, 2014, 57(Pt 4):544-562.
7.	邓代彬.药物与手术治疗老年胆结石的疗效比较.当代医学, 2013, 19(33):68-69.
8.	刘姗, 许国强.胆囊胆固醇结石症易感基因的研究进展.国际消化病杂志, 2014, 34(3):182-183, 187.
9.	Klass DM, Bührmann K, Sauter G, et al. Biliary lipids, cholesterol and bile synthesis:different adaptive mechanisms to dietary cholesterol in lean and obese subjects. Aliment Pharmacol Ther, 2006, 23(7):895-905.
10.	Mathew LK, Ko C. Dietary fat and protein intake are not associated with incident biliary sludge and stones during pregnancy. JPEN J Parenter Enteral Nutr, 2015, 39(1):124-128.
11.	梅莘苓, 赵萍, 高朋, 等.老年高血压患者血尿酸、血胆红素及血脂与心脑血管并发症的关系.中华医学会心血管病学分会第八次全国心血管病学术会议汇编, 福建厦门:2006.
12.	刘培彬, 叶子璐, 蔡潭溪, 等.脂蛋白质组学研究进展.生物化学与生物物理进展, 2014, 12:1197-1206.
13.	Cavigiolio G, Shao B, Geier EG, et al. The interplay between size, morphology, stability, and functionality of high-density lipoprotein subclasses. Biochemistry, 2008, 47(16):4770-4779.
14.	陆浩.高糖、高胰岛素对树突状细胞成熟及清道夫受体表达的影响及其机制.复旦大学, 2012.
15.	Krieger M, Kozarsky K. Influence of the HDL receptor SR-BI on atherosclerosis. Curr Opin Lipidol, 1999, 10(6):491-497.
16.	Rothblat GH, da la Llera-Moya M, Atger V, et al. Cell cholesterol efflux:integration of old and new observations provide new insights. J Lipid Res, 1999, 40(5):781-796.
17.	苘瑜琳, 李永红, 马贺远.高胆固醇血症患者血小板B族Ⅰ型清道夫受体表达的变化.中国动脉硬化杂志, 2009, 17(9):739-742.
18.	王娟, 司书毅, 洪斌.与动脉粥样硬化密切相关的清道夫受体.中国分子心脏病学杂志, 2004, 4(6):58-63.
19.	Dorffel Y, Swidsinski A, Loening-Baucke V, et al. Common biostructure of the colonic microbiota in neuroendocrine tumors and Crohn's disease and the effect of therapy. Inflamm Bowel Dis, 2012, 18(9):1663-1671.
20.	Femia AP, Swidsinski A, Dolara P, et al. Mucin depleted foci, colonic preneoplastic lesions lacking Muc2, show up-regulation of Tlr2 but not bacterial infiltration. PLoS One, 2012, 7(1):e29918.
21.	Okimoto N, Kawai Y, Katoh T, et al. Clinical effect of biapenem on nursing and healthcare-associated pneumonia (NHCAP). J Infect Chemother, 2015, 21(8):592-595.
22.	Swidsinski A, Dorffel Y, Loening-Baucke V, et al. Dissimilarity in the occurrence of Bifidobacteriaceae in vaginal and perianal microbiota in women with bacterial vaginosis. Anaerobe, 2010, 16(5):478-482.
23.	Figura MG, Coppola A, Bottitta M, et al. Seizures and EEG pattern in the 22q13.3 deletion syndrome:clinical report of six Italian cases. Seizure, 2014, 23(9):774-779.
24.	Kawai M, Iwahashi M, Uchiyama K, et al. Gram-positive cocci are associated with the formation of completely pure cholesterol stones. Am J Gastroenterol, 2002, 97(1):83-88.
25.	Sabinski F, Wosiewitz U. The sugar spectrum of human cholesterol gallstones, mixed and pigment gallstones:combined quantitative analysis of neutral sugars, N-acetylhexosamines, hexuronic and N-acetylneuraminic acids by capillary gas-liquid chromatography. J Clin Chem Clin Biochem, 1984, 22(7):453-459.
26.	Figura N, Cetta F, Angelico M, et al. Most Helicobacter pylori-infected patients have specific antibodies, and some also have H. pylori antigens and genomic material in bile:is it a risk factor for gallstone formation? Dig Dis Sci, 1998, 43(4):854-862.
27.	Khanuja B, Cheah YC, Hunt M, et al. Lithl, a major gene affecting cholesterol gallstone formation among inbred strains of mice. Proc Natl Acad Sci U S A, 1995, 92(17):7729-7733.
28.	Figueroa C, Droppelmann K, Quiñones V, et al. Nicotinic acid increases cellular transport of high density lipoprotein cholesterol in patients with hypoalphalipoproteinemia. Rev Med Chil, 2015, 143(9):1097-1104.
29.	Buch S, Stickel F, Trépo E, et al. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat Genet, 2015, 47(12):1443-1448.
30.	Katsika D, Magnusson P, Krawczyk M, et al. Gallstone disease in Swedish twins:risk is associated with ABCG8 D19H genotype. J Intern Med, 2010, 268(3):279-285.
31.	Wang Y, Jiang ZY, Fei J, et al. ATP binding cassette G8 T400K polymorphism may affect the risk of gallstone disease among Chinese males. Clin Chim Acta, 2007, 384(1-2):80-85.
32.	刘姗, 许国强.胆囊胆固醇结石症易感基因的研究进展.国际消化病杂志, 2014, 34(3):182-183, 187.
33.	Zelcer N, Hong C, Boyadjian R, et al. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science, 2009, 325(5936):100-104.
34.	Ge Y, Siegel AP, Jordan R, et al. Ligand binding alters dimerization and sequestering of urokinase receptors in raft-mimicking lipid mixtures. Biophys J, 2014, 107(9):2101-2111.
35.	Davis HR, Altmann SW. Niemann-Pick C1 Like 1 (NPC1L1) an intestinal sterol tansporter. Biochim Biophys Acta, 2009, 1791(7):679-683.
36.	郭嵩, 曹红勇, 杨士勇.胆囊结石致石基因的研究进展.外科理论与实践, 2013, 18(1):94-98.

1. Acalovschi M. Callstones in patients with liver cirrhosis:Incidence, etiology, clinical and therapeutical aspects. World J Gastroenterol, 2014, 20(23):7277-7285.
2. Chuang SC, Hsi E, Lee KT. Genetics of gallstone disease. Adv Clin Chem, 2013, 60:143-185.
3. Stringer MD, Fraser S, Gordon KC, et al. Gallstones in New Zealand:composition, risk factors and ethnic differences. ANZ J Surg, 2013, 83(7-8):575-580.
4. 蒋兆彦, 韩天权, 张圣道.胆固醇结石病的发生机制.世界华人消化杂志, 2010, 18(12):1191-1195.
5. Katsika A, Krivokapić J, Mooshammer C, et al. The coordination of boundary tones and its interaction with prominence. J Phon, 2014, 44:62-82.
6. Katsika A, Shattuck-Hufnagel, Mooshammer C, et al. Effects of compatible versus competing rhythmic grouping on errors and timing variability in speech. Lang Speech, 2014, 57(Pt 4):544-562.
7. 邓代彬.药物与手术治疗老年胆结石的疗效比较.当代医学, 2013, 19(33):68-69.
8. 刘姗, 许国强.胆囊胆固醇结石症易感基因的研究进展.国际消化病杂志, 2014, 34(3):182-183, 187.
9. Klass DM, Bührmann K, Sauter G, et al. Biliary lipids, cholesterol and bile synthesis:different adaptive mechanisms to dietary cholesterol in lean and obese subjects. Aliment Pharmacol Ther, 2006, 23(7):895-905.
10. Mathew LK, Ko C. Dietary fat and protein intake are not associated with incident biliary sludge and stones during pregnancy. JPEN J Parenter Enteral Nutr, 2015, 39(1):124-128.
11. 梅莘苓, 赵萍, 高朋, 等.老年高血压患者血尿酸、血胆红素及血脂与心脑血管并发症的关系.中华医学会心血管病学分会第八次全国心血管病学术会议汇编, 福建厦门:2006.
12. 刘培彬, 叶子璐, 蔡潭溪, 等.脂蛋白质组学研究进展.生物化学与生物物理进展, 2014, 12:1197-1206.
13. Cavigiolio G, Shao B, Geier EG, et al. The interplay between size, morphology, stability, and functionality of high-density lipoprotein subclasses. Biochemistry, 2008, 47(16):4770-4779.
14. 陆浩.高糖、高胰岛素对树突状细胞成熟及清道夫受体表达的影响及其机制.复旦大学, 2012.
15. Krieger M, Kozarsky K. Influence of the HDL receptor SR-BI on atherosclerosis. Curr Opin Lipidol, 1999, 10(6):491-497.
16. Rothblat GH, da la Llera-Moya M, Atger V, et al. Cell cholesterol efflux:integration of old and new observations provide new insights. J Lipid Res, 1999, 40(5):781-796.
17. 苘瑜琳, 李永红, 马贺远.高胆固醇血症患者血小板B族Ⅰ型清道夫受体表达的变化.中国动脉硬化杂志, 2009, 17(9):739-742.
18. 王娟, 司书毅, 洪斌.与动脉粥样硬化密切相关的清道夫受体.中国分子心脏病学杂志, 2004, 4(6):58-63.
19. Dorffel Y, Swidsinski A, Loening-Baucke V, et al. Common biostructure of the colonic microbiota in neuroendocrine tumors and Crohn's disease and the effect of therapy. Inflamm Bowel Dis, 2012, 18(9):1663-1671.
20. Femia AP, Swidsinski A, Dolara P, et al. Mucin depleted foci, colonic preneoplastic lesions lacking Muc2, show up-regulation of Tlr2 but not bacterial infiltration. PLoS One, 2012, 7(1):e29918.
21. Okimoto N, Kawai Y, Katoh T, et al. Clinical effect of biapenem on nursing and healthcare-associated pneumonia (NHCAP). J Infect Chemother, 2015, 21(8):592-595.
22. Swidsinski A, Dorffel Y, Loening-Baucke V, et al. Dissimilarity in the occurrence of Bifidobacteriaceae in vaginal and perianal microbiota in women with bacterial vaginosis. Anaerobe, 2010, 16(5):478-482.
23. Figura MG, Coppola A, Bottitta M, et al. Seizures and EEG pattern in the 22q13.3 deletion syndrome:clinical report of six Italian cases. Seizure, 2014, 23(9):774-779.
24. Kawai M, Iwahashi M, Uchiyama K, et al. Gram-positive cocci are associated with the formation of completely pure cholesterol stones. Am J Gastroenterol, 2002, 97(1):83-88.
25. Sabinski F, Wosiewitz U. The sugar spectrum of human cholesterol gallstones, mixed and pigment gallstones:combined quantitative analysis of neutral sugars, N-acetylhexosamines, hexuronic and N-acetylneuraminic acids by capillary gas-liquid chromatography. J Clin Chem Clin Biochem, 1984, 22(7):453-459.
26. Figura N, Cetta F, Angelico M, et al. Most Helicobacter pylori-infected patients have specific antibodies, and some also have H. pylori antigens and genomic material in bile:is it a risk factor for gallstone formation? Dig Dis Sci, 1998, 43(4):854-862.
27. Khanuja B, Cheah YC, Hunt M, et al. Lithl, a major gene affecting cholesterol gallstone formation among inbred strains of mice. Proc Natl Acad Sci U S A, 1995, 92(17):7729-7733.
28. Figueroa C, Droppelmann K, Quiñones V, et al. Nicotinic acid increases cellular transport of high density lipoprotein cholesterol in patients with hypoalphalipoproteinemia. Rev Med Chil, 2015, 143(9):1097-1104.
29. Buch S, Stickel F, Trépo E, et al. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat Genet, 2015, 47(12):1443-1448.
30. Katsika D, Magnusson P, Krawczyk M, et al. Gallstone disease in Swedish twins:risk is associated with ABCG8 D19H genotype. J Intern Med, 2010, 268(3):279-285.
31. Wang Y, Jiang ZY, Fei J, et al. ATP binding cassette G8 T400K polymorphism may affect the risk of gallstone disease among Chinese males. Clin Chim Acta, 2007, 384(1-2):80-85.
32. 刘姗, 许国强.胆囊胆固醇结石症易感基因的研究进展.国际消化病杂志, 2014, 34(3):182-183, 187.
33. Zelcer N, Hong C, Boyadjian R, et al. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science, 2009, 325(5936):100-104.
34. Ge Y, Siegel AP, Jordan R, et al. Ligand binding alters dimerization and sequestering of urokinase receptors in raft-mimicking lipid mixtures. Biophys J, 2014, 107(9):2101-2111.
35. Davis HR, Altmann SW. Niemann-Pick C1 Like 1 (NPC1L1) an intestinal sterol tansporter. Biochim Biophys Acta, 2009, 1791(7):679-683.
36. 郭嵩, 曹红勇, 杨士勇.胆囊结石致石基因的研究进展.外科理论与实践, 2013, 18(1):94-98.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Correlation Factors for The Formation of Cholesterol Calculus

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