Expert consensus on dual-graft liver transplantation in West China Hospital_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LÜ Tao ^1,2 ^吕 , XU Gang ^1,2 , XU Xi ^1,2 , YANG Jian ^1,2 , SONG Jiulin ^1,2 , WANG Shouping ^1,2 , Yiliyaer Aierken ^1,2 , KONG Lingxiang ^1,2 , YUAN Jingsheng ^1,2 , WEN Tianfu ^2,3 , YAN Lünan ^1,2 ,  WU Hong ^1,2 ,  YANG Jiayin ^1,2

1. Liver Transplant Center, Transplant Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
3. Division of Liver Sugery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

WU Hong, Email: wuhong7801@163.com; YANG Jiayin, Email: doctoryjy@scu.edu.cn

Keywords：

dual-graft liver transplantation; living organ donation; organ donation after citizen death

DOI：

10.7507/1007-9424.202402061

Video：

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Abstract Full text Figures/Tables Video References Cited by

Living donor liver transplantation is one of the main solutions to the organ supply-demand discrepancy at present. However, there was a risk of the recipient developing small-for-size syndrome due to insufficient graft volume, while an excessively large graft volume for donation might lead to postoperative liver failure for the donor. In this context, the dual-graft liver transplantation had emerged, which could minimize the volume of liver resection from the each donor to ensure the donor’s safety and provide the adequate volume of liver for the recipient. Yet, this procedure is less commonly performed in our country. In order to promote the steady implementation of dual-graft liver transplantation in China and serve as an important supplement to the donor pool, the West China Hospital of Sichuan University organized relevant experts and draw on the mature experiences of advanced countries in the field of transplantation jointly formulated the “Expert consensus on dual-graft liver transplantation”. The consensus had been developed around aspects such as donor evaluation and selection, surgical methods, and postoperative complications.

Citation： LÜ Tao, XU Gang, XU Xi, YANG Jian, SONG Jiulin, WANG Shouping, Yiliyaer Aierken, KONG Lingxiang, YUAN Jingsheng, WEN Tianfu, YAN Lünan, WU Hong, YANG Jiayin. Expert consensus on dual-graft liver transplantation in West China Hospital. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2024, 31(4): 385-388. doi: 10.7507/1007-9424.202402061 Copy

1.	Lee S, Hwang S, Park K, et al. An adult-to-adult living donor liver transplant using dual left lobe grafts. Surgery, 2001, 129(5): 647-650.
2.	Khan A, Arkam F, Dar FS, et al. Dual graft living donor liver transplantation for high acuity patients: a single-center experience. J Clin Exp Hepatol, 2023, 13(3): 447-453.
3.	Kwon JH, Song GW, Hwang S, et al. Dual-graft adult living donor liver transplantation with ABO-incompatible graft: short-term and long-term outcomes. Am J Transplant, 2018, 18(2): 424-433.
4.	Song GW, Lee SG, Moon DB, et al. Dual-graft adult living donor liver transplantation: an innovative surgical procedure for live liver donor pool expansion. Ann Surg, 2017, 266(1): 10-18.
5.	严律南, 曾勇, 王文涛, 等. 成人间双供体活体肝脏移植成功2例报告. 中国普外基础与临床杂志, 2005, 12(4): 399-402.
6.	Brown RS. Live donors in liver transplantation. Gastroenterology, 2008, 134(6): 1802-1813.
7.	Chen YS, Cheng YF, De Villa VH, et al. Evaluation of living liver donors. Transplantation, 2003, 75(3 Suppl): S16-S19. doi: 10.1097/01.TP.0000046535.49186.EB.
8.	Fan ST, Lo CM, Liu CL, et al. Safety of donors in live donor liver transplantation using right lobe grafts. Arch Surg, 2000, 135(3): 336-340.
9.	Lee SG, Moon DB, Hwang S, et al. Liver transplantation in Korea: past, present, and future. Transplant Proc, 2015, 47(3): 705-708.
10.	Park GC, Song GW, Moon DB, et al. A review of current status of living donor liver transplantation. Hepatobiliary Surg Nutr, 2016, 5(2): 107-117.
11.	Trotter JF, Wachs M, Everson GT, et al. Adult-to-adult transplantation of the right hepatic lobe from a living donor. N Engl J Med, 2002, 346(14): 1074-1082.
12.	Barr ML, Belghiti J, Villamil FG, et al. A report of the Vancouver Forum on the care of the live organ donor: lung, liver, pancreas, and intestine data and medical guidelines. Transplantation, 2006, 81(10): 1373-1385.
13.	中华医学会外科学分会外科手术学学组, 中华医学会外科学分会移植学组. 劈离式肝移植专家共识. 中华肝脏外科手术学电子杂志, 2020, 9(5): 429-434.
14.	Vinayak N, Ravi M, Ankush G, et al. Dual graft living donor liver transplantation—a case report. BMC Surg, 2019, 19(1): 149. doi: 10.1186/s12893-019-0606-5.
15.	Zidan A, Sturdevant M, Alkhail FA, et al. The first two cases of living donor liver transplantation using dual grafts in Saudi Arabia. Ann Saudi Med, 2019, 39(2): 118-123.
16.	Xiao Y, Huang X, Shi Y, et al. Emergent hybrid-dual-graft liver transplantation: a life-saving strategy for a patient with inadequate living donor graft during the COVID-19 pandemic. Hepatobiliary Surg Nutr, 2022, 11(5): 785-788.
17.	Kim JD, Choi DL, Han YS. Salvage dual graft living donor liver transplantation after major hepatectomy. Ann Surg Treat Res, 2014, 87(2): 108-111.
18.	Lee SG, Hwang S, Park KM, et al. Seventeen adult-to-adult living donor liver transplantations using dual grafts. Transplant Proc, 2001, 33(7-8): 3461-3463.
19.	Chen Z, Yan L, Li B, et al. Prevent small-for-size syndrome using dual grafts in living donor liver transplantation. J Surg Res, 2009, 155(2): 261-267.
20.	Chen Z, Zeng Y, Wen TF, et al. Dual grafts live donor liver transplantation for acute-on-chronic hepatitis B liver failure. Transplant Proc, 2010, 42(10): 4552-4554.
21.	Xu Y, Chen H, Yeh H, et al. Living donor liver transplantation using dual grafts: Experience and lessons learned from cases worldwide. Liver Transpl, 2015, 21(11): 1438-1448.
22.	夏强. 双供一受肝移植的选择与实施. 肝胆外科杂志, 2015, 23(4): 241-242.
23.	王文涛, 严律南, 李波, 等. 二例成人间双活体供肝移植的手术重建技巧. 中华器官移植杂志, 2006, 27(5): 277-279.
24.	张博瀚, 宋九林, 蒋利, 等. 成人活体供者肝右叶联合脑死亡捐献者肝左外叶的双供肝活体肝移植治疗肝细胞癌的应用价值. 中华消化外科杂志, 2020, 19(2): 196-203.
25.	Wan Z, Wang X, Zhang X, et al. Atrophy of the left graft secondary to arterial inflow failure in dual liver transplantation. Exp Clin Transplant, 2021, 19(6): 617-619.

1. Lee S, Hwang S, Park K, et al. An adult-to-adult living donor liver transplant using dual left lobe grafts. Surgery, 2001, 129(5): 647-650.
2. Khan A, Arkam F, Dar FS, et al. Dual graft living donor liver transplantation for high acuity patients: a single-center experience. J Clin Exp Hepatol, 2023, 13(3): 447-453.
3. Kwon JH, Song GW, Hwang S, et al. Dual-graft adult living donor liver transplantation with ABO-incompatible graft: short-term and long-term outcomes. Am J Transplant, 2018, 18(2): 424-433.
4. Song GW, Lee SG, Moon DB, et al. Dual-graft adult living donor liver transplantation: an innovative surgical procedure for live liver donor pool expansion. Ann Surg, 2017, 266(1): 10-18.
5. 严律南, 曾勇, 王文涛, 等. 成人间双供体活体肝脏移植成功2例报告. 中国普外基础与临床杂志, 2005, 12(4): 399-402.
6. Brown RS. Live donors in liver transplantation. Gastroenterology, 2008, 134(6): 1802-1813.
7. Chen YS, Cheng YF, De Villa VH, et al. Evaluation of living liver donors. Transplantation, 2003, 75(3 Suppl): S16-S19. doi: 10.1097/01.TP.0000046535.49186.EB.
8. Fan ST, Lo CM, Liu CL, et al. Safety of donors in live donor liver transplantation using right lobe grafts. Arch Surg, 2000, 135(3): 336-340.
9. Lee SG, Moon DB, Hwang S, et al. Liver transplantation in Korea: past, present, and future. Transplant Proc, 2015, 47(3): 705-708.
10. Park GC, Song GW, Moon DB, et al. A review of current status of living donor liver transplantation. Hepatobiliary Surg Nutr, 2016, 5(2): 107-117.
11. Trotter JF, Wachs M, Everson GT, et al. Adult-to-adult transplantation of the right hepatic lobe from a living donor. N Engl J Med, 2002, 346(14): 1074-1082.
12. Barr ML, Belghiti J, Villamil FG, et al. A report of the Vancouver Forum on the care of the live organ donor: lung, liver, pancreas, and intestine data and medical guidelines. Transplantation, 2006, 81(10): 1373-1385.
13. 中华医学会外科学分会外科手术学学组, 中华医学会外科学分会移植学组. 劈离式肝移植专家共识. 中华肝脏外科手术学电子杂志, 2020, 9(5): 429-434.
14. Vinayak N, Ravi M, Ankush G, et al. Dual graft living donor liver transplantation—a case report. BMC Surg, 2019, 19(1): 149. doi: 10.1186/s12893-019-0606-5.
15. Zidan A, Sturdevant M, Alkhail FA, et al. The first two cases of living donor liver transplantation using dual grafts in Saudi Arabia. Ann Saudi Med, 2019, 39(2): 118-123.
16. Xiao Y, Huang X, Shi Y, et al. Emergent hybrid-dual-graft liver transplantation: a life-saving strategy for a patient with inadequate living donor graft during the COVID-19 pandemic. Hepatobiliary Surg Nutr, 2022, 11(5): 785-788.
17. Kim JD, Choi DL, Han YS. Salvage dual graft living donor liver transplantation after major hepatectomy. Ann Surg Treat Res, 2014, 87(2): 108-111.
18. Lee SG, Hwang S, Park KM, et al. Seventeen adult-to-adult living donor liver transplantations using dual grafts. Transplant Proc, 2001, 33(7-8): 3461-3463.
19. Chen Z, Yan L, Li B, et al. Prevent small-for-size syndrome using dual grafts in living donor liver transplantation. J Surg Res, 2009, 155(2): 261-267.
20. Chen Z, Zeng Y, Wen TF, et al. Dual grafts live donor liver transplantation for acute-on-chronic hepatitis B liver failure. Transplant Proc, 2010, 42(10): 4552-4554.
21. Xu Y, Chen H, Yeh H, et al. Living donor liver transplantation using dual grafts: Experience and lessons learned from cases worldwide. Liver Transpl, 2015, 21(11): 1438-1448.
22. 夏强. 双供一受肝移植的选择与实施. 肝胆外科杂志, 2015, 23(4): 241-242.
23. 王文涛, 严律南, 李波, 等. 二例成人间双活体供肝移植的手术重建技巧. 中华器官移植杂志, 2006, 27(5): 277-279.
24. 张博瀚, 宋九林, 蒋利, 等. 成人活体供者肝右叶联合脑死亡捐献者肝左外叶的双供肝活体肝移植治疗肝细胞癌的应用价值. 中华消化外科杂志, 2020, 19(2): 196-203.
25. Wan Z, Wang X, Zhang X, et al. Atrophy of the left graft secondary to arterial inflow failure in dual liver transplantation. Exp Clin Transplant, 2021, 19(6): 617-619.

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