Plasma prealbumin, homocysteine levels and the correlation with high-sensitivity C-reactive protein and body mass index in patients with chronic obstructive pulmonary disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 NIE Xiaohong , ZHANG Yi , HE Hanfu , GU Qin

Department of Respiratory Medicine, The 416 Hospital of Nuclear Industry, The Second Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610051, P. R. China;

Corresponding author：

NIE Xiaohong, Email: xhnie1226@sina.com

Keywords：

Chronic obstructive pulmonary disease; Prealbumin; Homocysteine; High-sensitivity C-reactive protein; Body mass index; Correlation analysis

DOI：

10.7507/1671-6205.201712026

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ObjectiveTo explore the changes of plasma prealbumin (PA), homocysteine (Hcy) and high-sensitivity C-reactive protein (hs-CRP) levels before and after treatment in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and analyze the correlation of PA and Hcy with hs-CRP and body mass index (BMI).MethodsA total of 132 hospitalized AECOPD patients with GOLD lung function as grade III-IV were recruited as an experimental group and 45 healthy subjects as a control group. The levels of plasma PA, Hcy and hs-CRP were measured by automatic biochemical analyzer, and the main indexes of pulmonary function were determined in all subjects.ResultsCompared with the control group, the level of plasma PA before and after treatment in the experimental group decreased significantly [(146.49±36.53) mg/L and (219.60±41.29) mg/L vs. (269.48±42.63) mg/L], the level of plasma Hcy before and after treatment increased significantly [(16.44±5.21) μmol/L and (12.61±4.56) μmol /L vs. (10.13±3.25) μmol/L], and the levels of plasma hs-CRP before and after treatment increased significantly [(45.24±29.94) mg/L and (7.71±3.41) mg/L vs. (5.01±1.52) mg/L] (all P<0.05). The levels of plasma PA, Hcy and hs-CRP after treatment were significantly better than before treatment in the experimental group (allP<0.01). The plasma PA values before and after treatment were negatively correlated with the level of hs-CRP before and after treatment, and positively correlated with BMI (bothP<0.05).ConclusionsThe levels of plasma PA, Hcy and hs-CRP are significantly different before and after the treatment in AECOPD patients and the healthy controls. PA is negatively correlated with hs-CRP and positively correlated with BMI. The detection of plasma PA and Hcy can help to determine the condition and efficacy of patients with COPD, and PA can reflect the level of inflammation and nutritional status to a certain extent.

Citation： NIE Xiaohong, ZHANG Yi, HE Hanfu, GU Qin. Plasma prealbumin, homocysteine levels and the correlation with high-sensitivity C-reactive protein and body mass index in patients with chronic obstructive pulmonary disease. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(4): 331-335. doi: 10.7507/1671-6205.201712026 Copy

1.	Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Respirology, 2017, 22(3): 575-601.
2.	邱川, 李明才, 武燕, 等. 慢性阻塞性肺疾病气道炎症的研究进展. 中国呼吸与危重监护杂志, 2011, 10(2): 196-199.
3.	孙洪岩, 程雪松, 周平, 等. 老年慢性阻塞性肺疾病急性加重期患者血清 hs-CRP Cys-C PA 变化及临床意义. 安徽医学, 2016, 6(37): 739-740.
4.	Mohan A, Arora S, Uniyal A, et al. Evaluation of plasma leptin, tumor necrosis factor-α, and prealbumin as prognostic biomarkers during clinical recovery from acute exacerbations of chronic obstructive pulmonary disease. Lung India, 2017, 34(1): 3-8.
5.	高恒兴, 温中梅, 袁海波, 等. 慢性阻塞性肺病发病机制研究的最新进展. 中国老年学杂志, 2015, 35(19): 5668-5670.
6.	董燕燕, 陈光亮. 高同型半胱氨酸血症危害及致病机制研究进展. 中国药理学通报, 2014, 30(9): 1205-1208.
7.	Karkhah A, Ataee R, Ataie A. Morphine pre- and post-conditioning exacerbates apoptosis in rat hippocampus cells in a model of homocysteine-induced oxidative stress. Biomed Rep, 2017, 7(4): 309-313.
8.	慢性阻塞性肺疾病急性发作(AECOPD)诊治专家组. 慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(2017 年更新版). 国际呼吸杂志, 2017, 37(14): 1041-1057.
9.	Wedzicha JA, Calverley PMA, Albert RK, et al. Prevention of COPD exacerbations: European Respiratory Society/ American Thoracic Society guideline. Eur Respir J, 2017, 50(3):1-12.
10.	麻雅婷, 李新军, 杨明, 等. C 反应蛋白的研究进展及临床应用. 临床检验杂志(电子版), 2015, 4(4): 997-1002.
11.	Jing Z, Chun C, Ning S, et al. Systemic inflammatory marker CRP was better predictor of readmission for AECOPD than sputum inflammatory markers. Arch Bronconeumol, 2016, 52(3): 138-144.
12.	Gao D, Chen X, Wu H, et al. The levels of serum pro-calcitonin and high-sensitivity C-reactive protein in the early diagnosis ofchronic obstructive pulmonary disease during acute exacerbation. Exp Ther Med, 2017, 14(1): 193-198.
13.	Gaudiani JL, Sabel AL, Mehler PS. Low prealbumin is a significant predictor of medical complications in severe anorexianervosa. Int J Eat Disord, 2014, 47(2): 148-156.
14.	孙佳, 张艳华, 刘树军, 等. 老年慢性疾病与血清前白蛋白关系的研究进展. 吉林大学学报(医学版), 2016, 42(1): 186-190.
15.	陶新曹, 林江涛, 刘国梁, 等. 血清前白蛋白水平评价呼吸危重症患者预后的价值. 中日友好医院学报, 2015, 18(3): 158-160.
16.	诸兴桂, 叶兆萍, 曾垂利, 等. 前白蛋白对慢性阻塞性肺疾病的诊断与病原菌感染的影响研究. 中华医院感染学杂志, 2016, 26(15): 3387-3388, 3397.
17.	赵彦楠, 杨博逸, 孙贵范. 同型半胱氨酸与主要慢性病关系研究进展. 中国公共卫生, 2015, 31(2): 241-245.
18.	Khan NA, Saini H, Mawari G, et al. The effect of folic acid supplementation on hyperhomocysteinemia and pulmonary function parameters in chronic obstructive pulmonary disease: a pilot study. J Clin Diagn Res, 2016, 10(11): OC17-OC21.
19.	Beletić A, Mirković D, Dudvarski-Ilić A, et al. Questionable reliability of homocysteine as the metabolic marker for folate and vitamin B12 deficiency in patients with chronic obstructive pulmonary disease. J Med Biochem, 2015, 34(4): 467-472.
20.	杨雪娇, 赵国厚, 袁开芬. 血清同型半胱氨酸与慢阻肺相关性的研究进展. 中国老年保健医学, 2015, 13(4): 76-77.
21.	Seemungal TA, Lun JC, Davis G, et al. Plasma homocysteine is elevated in COPD patients and is related to COPD severity. Int J Chron Obstruct Pulmon Dis, 2007, 2(3): 313-321.
22.	杨海涛, 刘海峰, 王海彦. Hcy、NO 及 IL-8 在慢性阻塞性肺疾病中的变化与意义. 中国医药导刊, 2015, 17(30): 246-247.
23.	胡萍, 王娟, 张运剑. 慢性阻塞性肺疾病患者同型半胱氨酸及血脂水平分析. 中华全科医学, 2017, 15 (10): 1711-1713, 1751.

1. Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Respirology, 2017, 22(3): 575-601.
2. 邱川, 李明才, 武燕, 等. 慢性阻塞性肺疾病气道炎症的研究进展. 中国呼吸与危重监护杂志, 2011, 10(2): 196-199.
3. 孙洪岩, 程雪松, 周平, 等. 老年慢性阻塞性肺疾病急性加重期患者血清 hs-CRP Cys-C PA 变化及临床意义. 安徽医学, 2016, 6(37): 739-740.
4. Mohan A, Arora S, Uniyal A, et al. Evaluation of plasma leptin, tumor necrosis factor-α, and prealbumin as prognostic biomarkers during clinical recovery from acute exacerbations of chronic obstructive pulmonary disease. Lung India, 2017, 34(1): 3-8.
5. 高恒兴, 温中梅, 袁海波, 等. 慢性阻塞性肺病发病机制研究的最新进展. 中国老年学杂志, 2015, 35(19): 5668-5670.
6. 董燕燕, 陈光亮. 高同型半胱氨酸血症危害及致病机制研究进展. 中国药理学通报, 2014, 30(9): 1205-1208.
7. Karkhah A, Ataee R, Ataie A. Morphine pre- and post-conditioning exacerbates apoptosis in rat hippocampus cells in a model of homocysteine-induced oxidative stress. Biomed Rep, 2017, 7(4): 309-313.
8. 慢性阻塞性肺疾病急性发作(AECOPD)诊治专家组. 慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(2017 年更新版). 国际呼吸杂志, 2017, 37(14): 1041-1057.
9. Wedzicha JA, Calverley PMA, Albert RK, et al. Prevention of COPD exacerbations: European Respiratory Society/ American Thoracic Society guideline. Eur Respir J, 2017, 50(3):1-12.
10. 麻雅婷, 李新军, 杨明, 等. C 反应蛋白的研究进展及临床应用. 临床检验杂志(电子版), 2015, 4(4): 997-1002.
11. Jing Z, Chun C, Ning S, et al. Systemic inflammatory marker CRP was better predictor of readmission for AECOPD than sputum inflammatory markers. Arch Bronconeumol, 2016, 52(3): 138-144.
12. Gao D, Chen X, Wu H, et al. The levels of serum pro-calcitonin and high-sensitivity C-reactive protein in the early diagnosis ofchronic obstructive pulmonary disease during acute exacerbation. Exp Ther Med, 2017, 14(1): 193-198.
13. Gaudiani JL, Sabel AL, Mehler PS. Low prealbumin is a significant predictor of medical complications in severe anorexianervosa. Int J Eat Disord, 2014, 47(2): 148-156.
14. 孙佳, 张艳华, 刘树军, 等. 老年慢性疾病与血清前白蛋白关系的研究进展. 吉林大学学报(医学版), 2016, 42(1): 186-190.
15. 陶新曹, 林江涛, 刘国梁, 等. 血清前白蛋白水平评价呼吸危重症患者预后的价值. 中日友好医院学报, 2015, 18(3): 158-160.
16. 诸兴桂, 叶兆萍, 曾垂利, 等. 前白蛋白对慢性阻塞性肺疾病的诊断与病原菌感染的影响研究. 中华医院感染学杂志, 2016, 26(15): 3387-3388, 3397.
17. 赵彦楠, 杨博逸, 孙贵范. 同型半胱氨酸与主要慢性病关系研究进展. 中国公共卫生, 2015, 31(2): 241-245.
18. Khan NA, Saini H, Mawari G, et al. The effect of folic acid supplementation on hyperhomocysteinemia and pulmonary function parameters in chronic obstructive pulmonary disease: a pilot study. J Clin Diagn Res, 2016, 10(11): OC17-OC21.
19. Beletić A, Mirković D, Dudvarski-Ilić A, et al. Questionable reliability of homocysteine as the metabolic marker for folate and vitamin B12 deficiency in patients with chronic obstructive pulmonary disease. J Med Biochem, 2015, 34(4): 467-472.
20. 杨雪娇, 赵国厚, 袁开芬. 血清同型半胱氨酸与慢阻肺相关性的研究进展. 中国老年保健医学, 2015, 13(4): 76-77.
21. Seemungal TA, Lun JC, Davis G, et al. Plasma homocysteine is elevated in COPD patients and is related to COPD severity. Int J Chron Obstruct Pulmon Dis, 2007, 2(3): 313-321.
22. 杨海涛, 刘海峰, 王海彦. Hcy、NO 及 IL-8 在慢性阻塞性肺疾病中的变化与意义. 中国医药导刊, 2015, 17(30): 246-247.
23. 胡萍, 王娟, 张运剑. 慢性阻塞性肺疾病患者同型半胱氨酸及血脂水平分析. 中华全科医学, 2017, 15 (10): 1711-1713, 1751.

Chinese Journal of Respiratory and Critical Care Medicine

Plasma prealbumin, homocysteine levels and the correlation with high-sensitivity C-reactive protein and body mass index in patients with chronic obstructive pulmonary disease

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