Comparison Analysis of Risk Factors between Multiple Cerebral Infarction and Single Cerebral Infarction_Chinese Journal of Evidence-Based Medicine

Authors：

ZHAO Songyao ,  LIU Ming , LIU Zhiqin

Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

LIU Ming, Email: zhaosongyao715@163.com

Keywords：

Multiple cerebral infarction; Single cerebral infarction; Risk factors

DOI：

10.7507/1672-2531.20080019

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective　 To compare the risk factors between multiple cerebral infarction (MCI) and single cerebral infarction (SCI). This would be beneficial for carrying out corresponding prevention and treatment.
Methods　 We prospectively registered consecutive cases of ischemic stroke in the neurological wards and divided them into two groups: MCI group and SCI group according to their clinical and imaging data. Firstly, the single variable analyses of 24 factors that could be related to the onset of MCI were conducted, and then the multivariate non-condition stepwise logistic regression was performed.
Results　 Significant differences were noted between MCI group and SCI group in terms of age, gender, hpertension, diabetes, heart valvular disease, smoking, cerebral infarction history and first systolic blood pressure after admission. The logistic regression analyses showed that factors of age (OR=1.014, 95%CI 1.003 to 1.026), hypertension (OR=1.566, 95%CI 1.185 to 2.068), smoking (OR=1.473, 95%CI 1.052 to 2.061), cerebral infarction history (OR=1.948, 95%CI 1.326 to 2.864) were independent risk factors for MCI.
Conclusion　 Compared to SCI, age, hypertension, smoking and cerebral infarction history were independent risk factors for MCI patients.

Citation： ZHAO Songyao,LIU Ming,LIU Zhiqin. Comparison Analysis of Risk Factors between Multiple Cerebral Infarction and Single Cerebral Infarction. Chinese Journal of Evidence-Based Medicine, 2008, 08(2): 75-78. doi: 10.7507/1672-2531.20080019 Copy

1.	Roh JK, Kang DW, Lee SH, et al. Significance of acute multiple brain infarction on diffusion-weighted imaging. Stroke, 2000, 31(3): 688-694.
2.	Bernasconi A, Bogousslavsky J, Bassetti C, et al. Multiple acute infarcts in the posterior circulation. J Neurol Neurosurg Psychiatry. 1996, 60(3): 289-296.
3.	Bogousslavsky J, Bernasconi A, Kumral E. Acute multiple infarction involving the anterior circulation. Arch Neurol, 1996, 53(1): 50-57.
4.	Meng J, Meng C, Yang P, et al. Cognitive impairment in multiple cerebral infarction. Chinese Medical Journal, 1995, 108(4): 315.
5.	[No authors listed]. Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989, 20(10): 1407-1431.
6.	周农, 高宗良. 多发性脑梗塞和单发性脑梗塞的对比分析. 安徽医科大学学报, 1990, 25(4): 275-277.
7.	郭宗君, 袁桂芬, 刘学生, 等. 不同病程单发及多发脑梗塞对病人认知障碍的影响. 中国实用内科杂志, 2000, 20(9): 561-562.
8.	汪凯, 卞兴华, 孟玉, 等. 多发梗塞性痴呆与多发性脑梗塞脑容积线性指标的对照研究. 安徽医科大学学报, 2002, 37(6): 451-453.
9.	Jackson C, Sudlow C. Are lacunar strokes really different? A systematic review of differences in risk factor profiles between lacunar and nonlacunar infarcts. Stroke, 2005, 36(4): 891-901.
10.	Arauz A, Murillo L, Cantú C, et al. Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging: risk factors, recurrence, and outcome in 175 consecutive cases. Stroke, 2003, 34(10): 2453-2458.
11.	李轶男. 高血压病患者并发缺血性脑卒中危险因素分析. 国外医学神经病学神经外科学分册, 1999, 2: 64.
12.	Vermeer SE, Den Heijer T, Koudstaal PJ, et al. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke, 2003, 34(2):392-396.
13.	Eguchi K, Kabino K, Hoshide S, et al. Smoking is associated with silent cerebrovascular disease in a high-risk Japanese community-dwelling population. Hypertens Res, 2004, 27(10): 747-754.
14.	Yamagishi K, Iso H, Kitamura A, et al. Smoking raises the risk of total and ischemic strokes in hypertensive men. Hypertens Res, 2003, 26(3): 209–217.
15.	Halperin RO, Michael Gaziano J, Sesso HD, et al. Smoking and the Risk of Incident Hypertension in Middle-aged and Older Men. American Journal of Hypertension, 2008, Epub ahead of print.

1. Roh JK, Kang DW, Lee SH, et al. Significance of acute multiple brain infarction on diffusion-weighted imaging. Stroke, 2000, 31(3): 688-694.
2. Bernasconi A, Bogousslavsky J, Bassetti C, et al. Multiple acute infarcts in the posterior circulation. J Neurol Neurosurg Psychiatry. 1996, 60(3): 289-296.
3. Bogousslavsky J, Bernasconi A, Kumral E. Acute multiple infarction involving the anterior circulation. Arch Neurol, 1996, 53(1): 50-57.
4. Meng J, Meng C, Yang P, et al. Cognitive impairment in multiple cerebral infarction. Chinese Medical Journal, 1995, 108(4): 315.
5. [No authors listed]. Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989, 20(10): 1407-1431.
6. 周农, 高宗良. 多发性脑梗塞和单发性脑梗塞的对比分析. 安徽医科大学学报, 1990, 25(4): 275-277.
7. 郭宗君, 袁桂芬, 刘学生, 等. 不同病程单发及多发脑梗塞对病人认知障碍的影响. 中国实用内科杂志, 2000, 20(9): 561-562.
8. 汪凯, 卞兴华, 孟玉, 等. 多发梗塞性痴呆与多发性脑梗塞脑容积线性指标的对照研究. 安徽医科大学学报, 2002, 37(6): 451-453.
9. Jackson C, Sudlow C. Are lacunar strokes really different? A systematic review of differences in risk factor profiles between lacunar and nonlacunar infarcts. Stroke, 2005, 36(4): 891-901.
10. Arauz A, Murillo L, Cantú C, et al. Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging: risk factors, recurrence, and outcome in 175 consecutive cases. Stroke, 2003, 34(10): 2453-2458.
11. 李轶男. 高血压病患者并发缺血性脑卒中危险因素分析. 国外医学神经病学神经外科学分册, 1999, 2: 64.
12. Vermeer SE, Den Heijer T, Koudstaal PJ, et al. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke, 2003, 34(2):392-396.
13. Eguchi K, Kabino K, Hoshide S, et al. Smoking is associated with silent cerebrovascular disease in a high-risk Japanese community-dwelling population. Hypertens Res, 2004, 27(10): 747-754.
14. Yamagishi K, Iso H, Kitamura A, et al. Smoking raises the risk of total and ischemic strokes in hypertensive men. Hypertens Res, 2003, 26(3): 209–217.
15. Halperin RO, Michael Gaziano J, Sesso HD, et al. Smoking and the Risk of Incident Hypertension in Middle-aged and Older Men. American Journal of Hypertension, 2008, Epub ahead of print.

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