Objective To introduce the evidence-based evaluation on off-label uses at home and abroad, so as to investigate a systematic method of evidence-based evaluation on off-label uses.
Methods In combination with the domestic and international research literature, a systematic method of evidence-based evaluation on off-label uses was discussed from the following three aspects: sources of evidence, levels of evidence, and recommendation strength.
Results Sources of evidence included Clinical Pharmacology, DRUGDEX? System, NCCN Drugs amp; Biologics Compendium and handsearched literature. Levels of evidence and recommendation strength could refer to the 2009 grade system of Oxford Centre for Evidence-Based Medicine, and the strength of recommendations and scientific support of DRUGDEX? System.
Conclusion A systematic method of evidence-based evaluation on off-label uses is initially established.
Citation： YI Zhanmiao,LIU Fang,ZHAI Suodi. Method of Evidence-Based Evaluation on Off-label Uses. Chinese Journal of Evidence-Based Medicine, 2011, 11(12): 1464-1467. doi: 10.7507/1672-2531.20110247 Copy