LIU Shanshan 1,2 , HE Yujing 1 , LI Chuyi 1 , ZHENG Ying 1 , LU Lixia 1 , LI Bin 1 , YU Xiaohui 1
  • 1. Department of Gastroenterology, 940 Hospital of the Joint Logistics Support Force of the People’s Liberation Army of China, Lanzhou 730050, P. R. China;
  • 2. The First Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, P. R. China;
YU Xiaohui, Email: yuxiaohui528@126.com
Drinking; Liver cancer; Disease burden; China
10.7507/1672-2531.202309068
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Objective  To analyze the trend of changes in the burden of liver cancer diseases attributed to alcohol consumption in China from 1990 to 2019. Methods  Data on liver cancer burden attributed to drinking in China from 1990 to 2019 were obtained from the global burden of disease 2019. Joinpoint regression model was used to analyze the temporal trend of disease burden, and age-period-cohort model was used to evaluate age, period, and cohort effects. Results  From 1990 to 2019, the standardized incidence rate of liver cancer attributable to drinking among the total population, men and women showed a downward trend. The AAPC was −2.52% (95%CI −2.83% to −2.21%), 3.26% (95%CI −3.62% to −2.89%) and −2.24% (95%CI −2.61% to −1.86%), respectively; The standardized mortality rates showed a decreasing trend, with AAPC values of −2.86% (95%CI −3.46% to −2.26%), −3.48% (95%CI −4.20% to −2.76%), and −2.67% (95%CI −2.99% to −2.34%), respectively; The standardized DALY rates showed a downward trend, with AAPC values of −3.09% (95%CI −3.65% to −2.53%), −2.92% (95%CI −3.25% to −2.58%), and −3.77 (95%CI −4.21% to −3.31%), respectively. The trend changes were statistically significant (P<0.05). From 1990 to 2019, the overall risk of liver cancer incidence and death attributed to drinking in China, both males and females, showed a trend of first increasing and then decreasing with age; As the period increases, both the overall population and the male population showed a downward trend, followed by an upward trend, while the female population remains relatively stable; The lower the risk of liver cancer incidence and death attributed to drinking as the queue progresses. Conclusion  The standardized incidence rate, mortality and DALY rate of liver cancer attributable to drinking in China are generally declining, we should strengthen health education and early diagnosis and treatment for both male and elderly populations to reduce the burden of liver cancer.