海马硬化与癫痫_Journal of Epilepsy

Authors：

 高杰 ,  邓艳春

第四军医大学西京医院神经内科, 西安, 710032;

Corresponding author：

邓艳春, Email: yanchundeng@yahoo.com

Keywords：

海马硬化; 颞叶癫痫; 研究进展

DOI：

10.7507/2096-0247.20160012

Video：

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难治性癫痫的患者常常伴有海马硬化, 是耐药性癫痫的主要致病因素。海马硬化在长期复杂的癫痫发作过程中逐渐形成, 两者之间的作用关系一直是癫痫领域的研究热点。现结合近年来国内外研究的新进展探讨海马硬化与癫痫之间的关系, 为颞叶癫痫的临床诊疗提供新的思路

Citation： 高杰, 邓艳春. 海马硬化与癫痫. Journal of Epilepsy, 2016, 2(1): 64-66. doi: 10.7507/2096-0247.20160012 Copy

1.	Kasperaviciute D, Catarino CB, Matarin M, et al. Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A. Brain, 2013, 136(Pt10): 3140-3150.
2.	Zhang X, Bertaso F, Yoo JW, et al. Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci, 2010, 13(9): 1056-1058.
3.	Rowley S, Patel M. Mitochondrial involvement and oxidative stress in temporal lobe epilepsy. Free Radic Biol Med, 2013, 62(9) :121-131.
4.	Walker AI, Stevenson DE, Robinson J, et al. The toxicology and pharmacodynamics of dieldrin (HEOD): two-year oral exposures of rats and dogs. Toxicol Appl Pharmacol, 1969, 15(2): 345-373.
5.	朱长庚.神经-免疫-内分泌网络与癫痫发病机理的关系.解剖学报, 2002, 33(3):321-324.
6.	Ong MS, Kohane IS, Cai T, et al. Population-level evidence for an autoimmune etiology of epilepsy. JAMA Neurol, 2014, 71(5): 569-574.
7.	Fang M, Xi ZQ, Wu Y, et al. A new hypothesis of drug refractory epilepsy: neural network hypothesis. Med Hypotheses, 2011, 76(6):871-876.
8.	路蝉伊, 刘立雄, 张云峰, 等.癫痫发病机制的研究进展.解放军医学院学报, 2014, 35(8): 876-880.
9.	Patel LS, Wenzel HJ, Schwartzkroin PA. Physiological and morphological characterization of dentate granule cells in the p35 knock-out mouse hippocampus: evidence for an epileptic circuit. J Neurosci, 2004, 24(41): 9005-9014.
10.	Heck N, Garwood J, Loeffler JP, et al. Differential upregulation of extracellular matrix molecules associated with the appearance of granule cell dispersion and mossy fiber sprouting during epileptogenesis in a murine model of temporal lobe epilepsy. Neuroscience, 2004, 129(2): 309-324.
11.	Dutra JR, Cortés EP, Vonsattel JP. Update on Hippocampal Sclerosis Curr Neurol Neurosci Rep. 2015, 15(10):67.
12.	Merlin LR, Bianchi R, Wong RK. Group I mGluR-dependent epileptogenesis. Epilepsia, 2010, 51(S5):16.
13.	Kandratavicius L, Rosa-Neto P, Monteiro MR, et al. Distinct increased metabotropic glutamate receptor type 5(mGluR5) in temporal lobe epilepsy with and without hippocampal sclerosis. Hippocampus, 2013, 23(12):1212-1230.
14.	Kang JQ, Barnes G. A common susceptibility factor of both autism and epilepsy :functional deficiency of GABA A receptors. Autism Dev Disord, 2013, 43(1):68-79.
15.	Frugier G, Coussen F, Giraud MF, et al. A gamma 2(R43Q) mutation, linked to epilepsy in humans, alters GABA A receptor assembly and modifies subunit composition on the cell surface. J Biol Chem, 2007, 282(6):3819-3828.
16.	Yi JH, Hazell AS. Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem Int, 2006, 48(5): 394-403.
17.	Yernool D, Boudker O, Jin Y, et al. Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature, 2004, 431(7010): 811-818.
18.	O'Shea RD, Lau CL, Farso MC, et al. Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1. Neurochem Int, 2006, 48(6-7): 604-610.
19.	Baer-Dubowska W, Majchrzak-Celi?ska A, Cichocki M. Pharmacoepigenetics: a new approach to predicting individual drug responses and targeting new drugs. Pharmacol Rep, 2011, 63(2): 293-304.
20.	James EJ, Gu J, Ramirez-Vizcarrondo CM, et al. Valproate-induced neurodevelopmental deficits in Xenopus laevis tadpoles. J Neurosci. 2015, 35(7): 3218-3229.
21.	Feng J, Cen J, Li J, et al. Histone deacetylase inhibitor valproic acid (VPA) promotes the epithelial mesenchymal transition of colorectal cancer cells via up regulation of Snail. Cell Adh Migr. 2015 Dec 2:0, Epub ahead of print.
22.	Mendoza-Sanchez R, Cotnoir-White D, Kulpa J, et al. Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids. Bioorg Med Chem, 2015, 11: S0968-0896(15)30130-9, Epub ahead of print.
23.	Sendrowski K, Sobaniec W. Hippocampus, hippocampal sclerosis and epilepsy. Pharmacol Rep, 2013, 65(3): 555-565.
24.	Chatzikonstantinou A. Epilepsy and the hippocampus. Front Neurol Neurosci, 2014, 34(16): 121-142.
25.	张立颖.卡马西平联合丙戊酸钠治疗颞叶癫痫.中国医药指南, 2014, 12(21): 127-128.
26.	张杰, 高晋健, 吴建兵, 等.术后早期停药对颞叶癫痫患者远期预后的影响.实用医学杂志, 2014, 13: 2115-2117.
27.	Ladino LD, Hernández-Ronquillo L. Management of antiepileptic drugs following epilepsy surgery: a meta-analysis. Epilepsy Res, 2014, 108(4): 765-774.
28.	LM Selwa, SL Schmidt, BA Malow, et al. Long-term outcome of nonsurgical candidates with medically refractory localization-related epilepsy. Epilepsia, 2003, 44 (12): 1568-1572.
29.	AE Elsharkawy, R Thorbecke, A Ebner, et al. Determinants of quality of life in patients with refractory focal epilepsy who were not eligible for surgery or who rejected surgery. Epilepsy & Behavior, 2012, 24 (2): 249-255.

1. Kasperaviciute D, Catarino CB, Matarin M, et al. Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A. Brain, 2013, 136(Pt10): 3140-3150.
2. Zhang X, Bertaso F, Yoo JW, et al. Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci, 2010, 13(9): 1056-1058.
3. Rowley S, Patel M. Mitochondrial involvement and oxidative stress in temporal lobe epilepsy. Free Radic Biol Med, 2013, 62(9) :121-131.
4. Walker AI, Stevenson DE, Robinson J, et al. The toxicology and pharmacodynamics of dieldrin (HEOD): two-year oral exposures of rats and dogs. Toxicol Appl Pharmacol, 1969, 15(2): 345-373.
5. 朱长庚.神经-免疫-内分泌网络与癫痫发病机理的关系.解剖学报, 2002, 33(3):321-324.
6. Ong MS, Kohane IS, Cai T, et al. Population-level evidence for an autoimmune etiology of epilepsy. JAMA Neurol, 2014, 71(5): 569-574.
7. Fang M, Xi ZQ, Wu Y, et al. A new hypothesis of drug refractory epilepsy: neural network hypothesis. Med Hypotheses, 2011, 76(6):871-876.
8. 路蝉伊, 刘立雄, 张云峰, 等.癫痫发病机制的研究进展.解放军医学院学报, 2014, 35(8): 876-880.
9. Patel LS, Wenzel HJ, Schwartzkroin PA. Physiological and morphological characterization of dentate granule cells in the p35 knock-out mouse hippocampus: evidence for an epileptic circuit. J Neurosci, 2004, 24(41): 9005-9014.
10. Heck N, Garwood J, Loeffler JP, et al. Differential upregulation of extracellular matrix molecules associated with the appearance of granule cell dispersion and mossy fiber sprouting during epileptogenesis in a murine model of temporal lobe epilepsy. Neuroscience, 2004, 129(2): 309-324.
11. Dutra JR, Cortés EP, Vonsattel JP. Update on Hippocampal Sclerosis Curr Neurol Neurosci Rep. 2015, 15(10):67.
12. Merlin LR, Bianchi R, Wong RK. Group I mGluR-dependent epileptogenesis. Epilepsia, 2010, 51(S5):16.
13. Kandratavicius L, Rosa-Neto P, Monteiro MR, et al. Distinct increased metabotropic glutamate receptor type 5(mGluR5) in temporal lobe epilepsy with and without hippocampal sclerosis. Hippocampus, 2013, 23(12):1212-1230.
14. Kang JQ, Barnes G. A common susceptibility factor of both autism and epilepsy :functional deficiency of GABA A receptors. Autism Dev Disord, 2013, 43(1):68-79.
15. Frugier G, Coussen F, Giraud MF, et al. A gamma 2(R43Q) mutation, linked to epilepsy in humans, alters GABA A receptor assembly and modifies subunit composition on the cell surface. J Biol Chem, 2007, 282(6):3819-3828.
16. Yi JH, Hazell AS. Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem Int, 2006, 48(5): 394-403.
17. Yernool D, Boudker O, Jin Y, et al. Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature, 2004, 431(7010): 811-818.
18. O'Shea RD, Lau CL, Farso MC, et al. Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1. Neurochem Int, 2006, 48(6-7): 604-610.
19. Baer-Dubowska W, Majchrzak-Celi?ska A, Cichocki M. Pharmacoepigenetics: a new approach to predicting individual drug responses and targeting new drugs. Pharmacol Rep, 2011, 63(2): 293-304.
20. James EJ, Gu J, Ramirez-Vizcarrondo CM, et al. Valproate-induced neurodevelopmental deficits in Xenopus laevis tadpoles. J Neurosci. 2015, 35(7): 3218-3229.
21. Feng J, Cen J, Li J, et al. Histone deacetylase inhibitor valproic acid (VPA) promotes the epithelial mesenchymal transition of colorectal cancer cells via up regulation of Snail. Cell Adh Migr. 2015 Dec 2:0, Epub ahead of print.
22. Mendoza-Sanchez R, Cotnoir-White D, Kulpa J, et al. Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids. Bioorg Med Chem, 2015, 11: S0968-0896(15)30130-9, Epub ahead of print.
23. Sendrowski K, Sobaniec W. Hippocampus, hippocampal sclerosis and epilepsy. Pharmacol Rep, 2013, 65(3): 555-565.
24. Chatzikonstantinou A. Epilepsy and the hippocampus. Front Neurol Neurosci, 2014, 34(16): 121-142.
25. 张立颖.卡马西平联合丙戊酸钠治疗颞叶癫痫.中国医药指南, 2014, 12(21): 127-128.
26. 张杰, 高晋健, 吴建兵, 等.术后早期停药对颞叶癫痫患者远期预后的影响.实用医学杂志, 2014, 13: 2115-2117.
27. Ladino LD, Hernández-Ronquillo L. Management of antiepileptic drugs following epilepsy surgery: a meta-analysis. Epilepsy Res, 2014, 108(4): 765-774.
28. LM Selwa, SL Schmidt, BA Malow, et al. Long-term outcome of nonsurgical candidates with medically refractory localization-related epilepsy. Epilepsia, 2003, 44 (12): 1568-1572.
29. AE Elsharkawy, R Thorbecke, A Ebner, et al. Determinants of quality of life in patients with refractory focal epilepsy who were not eligible for surgery or who rejected surgery. Epilepsy & Behavior, 2012, 24 (2): 249-255.

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Journal of Epilepsy

海马硬化与癫痫

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