Experimental Study of the Therapeutic Effect and Mechanism of Photodynamic therapy to Pancreatic Cancer by Intratumoral Injecting Photosensitizer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Bo ¹ , ZHAO Yupei ² , LIU Weiping ³ , DENG Yiling. ³

Department of General Surgery, West China Hospital，Sichuan University, Chengdu 610041， China;

Corresponding author：

Keywords：

Pancreatic cance; rPhotosensitizer; Photodynamic therapy

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bjectiveTo study the therapeutic effect and mechanism of photodynamic therapy (PDT) to the nude mice model of pancreatic cancer by intratumoral injecting photosensitizers hematoporphyrin derivatives (HpD), hypocrellin A (HA) and 2butylamino2demethoxyhypocrellin A (2BA2DMHA).MethodsThe animal model of human pancreatic cancer was developed by injecting human pancreatic cancer cells SW1990 into the back of the nude mice. After photosensitizers HpD, HA and 2BA2DMHA was given by the intratumoral injection, the 632.8 nm HeNe laser was used to irradiate the tumor. The curative effect was recorded and factorⅧ was used in the immunohistochemical staining to study the vessel change. ResultsPDT can destroy the pancreatic neoplasm, the tumor growth rate was significantly reduced after PDT. The immunohistochemical staining showed PDT could make injury to vessel endothelial cell.ConclusionPDT can induce injuries of pancreatic cancer; vascular injury is an important way to exert function.

Citation： ZHANG Bo,ZHAO Yupei,LIU Weiping,DENG Yiling.. Experimental Study of the Therapeutic Effect and Mechanism of Photodynamic therapy to Pancreatic Cancer by Intratumoral Injecting Photosensitizer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(1): 30-32. doi: Copy

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1. 赵玉沛, 张波, 张太平，等. 光动力治疗裸小鼠胰腺移植癌的实验研究 [Ｊ]. 中华肝胆外科杂志, 2000； 6（2）∶102.
2. Hawes RH,Xiong Q,Waxman I, et al. A multispeciality approach to the diagnosis and management of pancreatic cancer [Ｊ]. Am J Gastroenterol, 2000； 95(1)∶17.
3. 李波. 胰腺癌综合治疗现状 [Ｊ]. 中国普外基础与临床杂志, 2000； 7(6)∶390.
4. Hajri A,Coffy S,Vallat F,et al. Human pancreatic carcinoma cells are sensitive to photodynamic therapy in vitro and in vivo [Ｊ]. Br J Surg, 1999； 86(7)∶899.
5. Ortner MA, Liebetruth J, Schreiber S, et al. Photodynamic therapy of nonresectable cholangiocarcinoma [Ｊ]. Gastroenterology, 1998； 114(3)∶536.
6. Liu CD,Kwan D,Saxton RE,et al. Hypericin and Photodynamic therapy decreases human pancreatic cancer in vitro and in vivo [Ｊ]. J Surg Res, 2000； 93(1)∶137.
7. Zhang WG, Weng M, Pang SZ, et al. A novel photosensitizer, 2butylamino2demethoxyhypocrellin A(2BA2DMHA) 1.Synthesis of 2BA2DMHA and its phototoxicity to MGC803 cells [Ｊ]. J Photochem Photobiol B, 1998； 44(1)∶21.
8. Engbrecht BW, Menon C, Kachur AV, et al. Photofrinmediated photodynamic therapy induces vascular occlusion and apoptosis in a human sarcoma xenograft model [Ｊ]. Cancer Res， 1999； 59（17）∶4334.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Experimental Study of the Therapeutic Effect and Mechanism of Photodynamic therapy to Pancreatic Cancer by Intratumoral Injecting Photosensitizer

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