Experimental Study on Preventing Postoperative Intestinal Adhesions by Methylene Blue and Aprotinin_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Surgical Department，Medical College of Hangzhou Teachers College, Hangzhou 310012;

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Intestinal adhesionPreventionMethylene blueAprotininAnimal experimental

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ObjectiveTo investigate the synergetic effects of the combination methylene blue or/and aprotinin on preventing postoperative intestinal adhesions (POIA).MethodsFourtyeight rabbits were divided into control group (group A), methylene blue group (group B), aprotinin group (group C), methylene blue+aprotinin group (group D). Each group contained 12 rabbits and established models of intestinal adhesions through laporotomy. Fourteen days after operation, the rabbits were reoperated to see whether there were adhesions and the degree of adhesions. ResultsThe adhesions of group A was the most serious, then in sequence were group B, C, group D showed very light adhesion. Group A was much more severe than B, C, D group (P lt;0.01); group D was very different from B, C group (P＜0.05). ConclusionMethylene blue and aprotinin have significant effects on preventing POIA and the combination of the two drugs can have a synergetic effects on POIA.

Citation： DING Min,WANG Yuao,JIANG Sujun,et al.. Experimental Study on Preventing Postoperative Intestinal Adhesions by Methylene Blue and Aprotinin. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(3): 175-176. doi: Copy

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1. ScottCoomber D,Whawell SA,Vipond MN,et al. Human intraperitoneal fibrinlytic response to surgery [J].Br J Surg,1995； 82(3)∶414.
2. Ellis H.The clinical significance of adhesions: focus on intestinal obstruction [J].Eur J Surg，1997； 577（Suppl）∶5.
3. 胡建敏，黄绍贤，候忠民,等.人体脂肪、γ糜蛋白酶联合腹腔灌注预防粘连的实验及临床研究 [J].中华实验外科杂志，1989； 6（3）∶101.
4. Phillips PKS.The effect of tetracycline lavage and trauma on visceral and parietal peritoneal ultrastructure and adhesion formation [J].Br J Surg, 1984； 71（7）∶537.
5. Galili Y,BenAbraham R,Rabau M,et al.Reduction of surgeryinduced peritoneal adhesions by methylene blue [J].Am J Surg,1998；175(1)∶30.
6. Ozogul Y,Baykal A,Onat D,et al.An experimental study of the effect of aprotinin on intestinal adhesion formation [J].Am J Surg,1998; 175(2)∶137.
7. 毛志福.抑肽酶止血作用的研究进展 [J].国外医学外科分册，1994; (6)∶323.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Experimental Study on Preventing Postoperative Intestinal Adhesions by Methylene Blue and Aprotinin

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