EFFECT OF INTRACELLULAR GLYCOGEN ON LIVER ISCHEMIA-REPERFUSION AND ITS MECHANISM_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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The PLA Centre of General Surgery, Chengdu General Hospital, Chengdu 610083;

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Keywords：

Liver; Glycogen; Ischemia-reperfusion injury; Animal experiment

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To investigate the effect of intracellular glycogen on liver ischemia-reperfusion and its mechanism, histomorphological and enzymological changes, histic ATP contents, the activity of Ca2+-ATPase on cytoplasmic membrane and intracellular free Ca2+concentration were observed during the ischemia-reperfusion of three groups of rabbit livers with different glycogen content. We found that the more vigorous energy metabolism, the higher activity of Ca2+-ATPase, the lower concentration of intracellular free Ca2+ and the slighter injury of histic structure and function appeared in the liver with the more abundant glycogen. The results suggest that intracellular abundant glycogen may reduce liver ischemiareperfusion injury.

Citation： Tang Lijun,Tian Fuzhou,Wang Yu,et al.. EFFECT OF INTRACELLULAR GLYCOGEN ON LIVER ISCHEMIA-REPERFUSION AND ITS MECHANISM. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(4): 196-198. doi: Copy

1.	Cywes R, Greig PD, Morgan GR, et al. Rapid donor liver nutritional enhancement in a large animal model. Hepatology, 1992; 16(5)∶1271.
2.	Astarcioglu I, Adam R, Gigou M, et al. High levels of glycogen in the donor liver improve survival after liver transplantation in rats. Transplant Proc, 1991; 23(5)∶2465.
3.	Wolf RFE, Hoeven JAB, Kamman RL, et al. Tissue pH in cold stored human donor livers preserved in university of wisconsin solution. Transplantation, 1996; 61(1)∶66.
4.	Cywes R, Paul CB, Juan R, et al. Effect of intrapartal glucose on hepatic glycogen content and degradation, and outcome of liver transplantation. Ann Surg, 1992; 216(3)∶235.
5.	Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem, 1985; 260(9)∶3440.
6.	汤礼军，田伏洲. 肝脏缺血再灌注损伤介质的研究现况. 肝胆外科杂志， 1998； 6(5)∶318.

1. Cywes R, Greig PD, Morgan GR, et al. Rapid donor liver nutritional enhancement in a large animal model. Hepatology, 1992; 16(5)∶1271.
2. Astarcioglu I, Adam R, Gigou M, et al. High levels of glycogen in the donor liver improve survival after liver transplantation in rats. Transplant Proc, 1991; 23(5)∶2465.
3. Wolf RFE, Hoeven JAB, Kamman RL, et al. Tissue pH in cold stored human donor livers preserved in university of wisconsin solution. Transplantation, 1996; 61(1)∶66.
4. Cywes R, Paul CB, Juan R, et al. Effect of intrapartal glucose on hepatic glycogen content and degradation, and outcome of liver transplantation. Ann Surg, 1992; 216(3)∶235.
5. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem, 1985; 260(9)∶3440.
6. 汤礼军，田伏洲. 肝脏缺血再灌注损伤介质的研究现况. 肝胆外科杂志， 1998； 6(5)∶318.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EFFECT OF INTRACELLULAR GLYCOGEN ON LIVER ISCHEMIA-REPERFUSION AND ITS MECHANISM

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