RESEARCH ON THE KINETIC EFFECT OF INFLAMMATORY CYTOKINES PRODUCTION IN THE MONOCYTES OF MULTIPLE SYSTEM ORGAN FAILURE PATIENTS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Zhao Qi , Cui Naiqiang , Li Jikun , et al.

Department of Biochemistry and Molecular Biology, Tianjin Institute of Acute Abdominal Diseases, Tianjin 300100;

Corresponding author：

Keywords：

Multiple system organ failure; Tumor necrosis factor; Interleukine 1; Interleukine 6; System inflammatory response syndrome; Pathogenesis

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The synthesis and secretion of inflammatory cytokines in the monocytes of 68 cases of multiple system organ failure (MSOF) patients was investigated by the method of MTT stained in cytokines dependent defferential cell strain. The data showed that the serum levels of tumor necrosis factor, interleukine 1 and interleukine 6 were increased (Ｐ＜0.01) in the monocytes of MSOF patients. The synthesis and secretion of these inflammatory cytokines gradually increased in the monocytes after onset of MSOF. After 5 days of treatment with antibiotics and electrolytes intravenous infusion, the secretion of TNF, IL-1 and IL-6 were decreased respectively. These results suggested that the TNF, IL-1 and IL-6 are integrated into system inflammatory responese and caused the injury to the tissues and organs. The production levels of these cytokines can be regarded as the index of MSOF and its severity.

Citation： Zhao Qi,Cui Naiqiang,Li Jikun,et al.. RESEARCH ON THE KINETIC EFFECT OF INFLAMMATORY CYTOKINES PRODUCTION IN THE MONOCYTES OF MULTIPLE SYSTEM ORGAN FAILURE PATIENTS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(6): 347-349. doi: Copy

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1. 王今达.90年代多脏衰综合征：SIRS与MODS.中国危重病急救医学，1995； 7(6)∶324.
2. 王今达，王宝恩.多脏器功能失常综合征(MODS)病情分期诊断及严重程度评分标准.中国危重病急救医学，1995； 7(6)∶346.
3. 崔乃强，赵琪，葛智慧等.通里攻下法对急腹症所致MODS的疗效观察.中国中西医结合外科杂志，1996； 2(5)∶315.
4. 赵琪，崔乃强，李继坤等.MODS患者外周血单核细胞炎性细胞因子分泌及及影响.河北中西医结合杂志，1998； 7(5)∶657.
5. Beal AL, Gerr FB. Multiple organ failure syndrome in the 1990s, system inflammatory response and organ dysfunction. JAMA, 1994; 271(3)∶226.
6. 赵琪，崔乃强，吴咸中等.内毒素对人外周血单核细胞内游离钙离子浓度的影响.中国中西医结合外科杂志， 1996； 2(2)∶115.
7. Schutze S, Nottrott S, Pfizenmaier K, et al. Tumor necrosis factor signal transduction. J Immunol, 1990; 144(7)∶2604.
8. SanchoTello M, PerezRoger I, Imakawa K, et al. Expression of tumor necrosis factorα in the rat ovary. Endocrinology, 1992; 130(3)∶1359.
9. Gorospe M, Kumar S, Baglioni C. Tumor necrosis factor increases stability of interleukin1 mRNA by activating protein kinase C. J Biol Chem, 1993; 268(9)∶6214.
10. Crowe PD, VanArsdale TL, Goodwin RG, et al. Specific induction of 80 kDa tumor necrosis factor recepter shedding in T lymphocytes involves the cytoplasmic domain and phosphorylation. J Immunol, 1993; 151(12)∶6882.
11. Miura M, Friedlander RM, Yuan J. Tumor necrosis factorinduced apoptosis is mediated by a CrmAsensitive cell death pathway. Proc Natl Acad Sci USA, 1995; 92∶8318.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

RESEARCH ON THE KINETIC EFFECT OF INFLAMMATORY CYTOKINES PRODUCTION IN THE MONOCYTES OF MULTIPLE SYSTEM ORGAN FAILURE PATIENTS

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