ANEXPERIMENTAL STUDY OF 131I—LIPIODOL HEPATIC ARTERIAL EMBOLIZATION._CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Wang Zifa ¹ , Pan Chenggen ² , Hu Guoyin ³

Department of Surgery, The Second Hospital Affiliated Hospital of Xian Medical University, Xian 710004;

Corresponding author：

Keywords：

131I-lipiodol; Hepatic arterial embolization; Animal experiment

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１３１Ｉ was labeled on lipiodol molecule by an iodine exchange reaction. The labeling rate was 95%. No dehalogenation was detected within 15 days at room temperature or after slerilization. Animal experiments showed that after hepatic arteial injection, １３１Ｉ-lipiodol was selectively accumulated in the embolizated local area. No increased acti-vity was observed in thyroid, lung or other areas in the body. The blood radioactivity per ml was 0.09±0.04% of the injectd dose. The result suggest that １３１Ｉ-lipiodol is very stable and suitable for clinical application.

Citation： Wang Zifa,Pan Chenggen,Hu Guoyin. ANEXPERIMENTAL STUDY OF 131I—LIPIODOL HEPATIC ARTERIAL EMBOLIZATION.. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1995, 2(1): 8-10. doi: Copy

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1. 王自法，潘承恩.肝血管栓塞治疗肝癌的进展.普外临床，1993；8(3)：176.
2. Madsan MT, Park, CH, Thakur ML. Dosimety of iodinl-131 ethiodol in the treatment of hepatoma. J Nucl Med,1988;29:1038.
3. 潘承恩，李宝生，王自法等.川狗肝解剖研究.中华实验外科杂志，1991；3：182.
4. Miller DL, O’Leary TJ, Girton M. DIstribution of io dined oil within the liver after hepatic arterial injection. Radiology, 1987;162:849.
5. Labayashi H, Inoue H, Shimada J. Intraarterial injection of AMD/MMC lipiodol suspension in liver matastases. Acta Radiogic, 1987;28:275.
6. 小林尚志，中政敬.Radioactive Lipiodol Transcatheter Arterial Embolization .日本医学放射学会杂志，1984；44(1)：96.
7. 王自法，潘承恩，胡国瑛.〔131〕I—碘化油肝动脉栓塞、内照射治疗肝癌.实用肿瘤学杂志，1991；5(3)：80.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

ANEXPERIMENTAL STUDY OF 131I—LIPIODOL HEPATIC ARTERIAL EMBOLIZATION.

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