XU Jianzhong.
  • Tissue Engineering Research and Development Institute of the Third Military Medical University, Department of Orthopedics, Military Orthopedic Center of PLA, Southwest Hospital, Third Military Medical University, Chongqing, 400038, P.R.China.;
Bone tissue engineering; Bone defect Induced pluripotent stem cells; Bioreactors
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Objective To review new progress of related research of bone tissue engineering in recent years. Methods Domestic and international l iterature concerning bone tissue engineering was reviewed and analyzed. Results In the recent years, great progression had been made in the research and development of bone tissue engineering, it had been used in more and more hospitals, and relevant national regulations and protocols had been set up. As to seed cells of bone tissue engineering, autologous and allogeneic stem cells had been widely used, while recently embryonic stem cells and induced pluri potent stem cells had attracted most attentions. In the field of scaffolds materials, significant improvements
had been made, from natural extractions to artificial polymers; from single construction to multiple compounds with surface modifications. As to the methods of construction, the static seeding approach had been widely accepted, and the appl ications of bioreactor had provided a stable and various micro-enviroment for the vitro-culture of different stem cells, which had beenregarded as an alternative way of vitro-culture and construction for bone tissue engineering. Conclusion With the tremendous help of the techniques and approaches above, we shall expect a promising future of a new generation bone tissue engineering based medical products in the years to come.

Citation： XU Jianzhong.. NEW PROGRESS OF RELATED RESEARCH OF BONE TISSUE ENGINEERING. Chinese Journal of Reparative and Reconstructive Surgery, 2010, 24(7): 769-773. doi: Copy