Clinical Analysis of 7 Cases with Chronic Hepatitis B Relapse and Exacerbations Caused by Corticosteroids and Immunosuppressant Reactivation_West China Medical Journal

Authors：

RAN Jing , FENG Ping

Center of Infectious Disease，West China Hospital，Sichuan University，Chengdu 610041，China;

Corresponding author：

Keywords：

慢性乙肝病毒感染; 激素和免疫抑制剂; 再激活

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目的:探讨激素及免疫抑制剂导致乙肝病毒再激活所致的肝损害的危害性及治疗效果，指导临床治疗。方法：总结本院近2年收治的7例慢性乙肝病毒感染者在使用激素及免疫抑制剂致肝炎再激活并加重患者的临床资料进行分析。结果：慢性乙肝病毒感染者因各种原因使用激素及免疫抑制剂所导致的慢性乙肝的复发加重，病情发展迅速，病死率高。结论：抗乙肝病毒治疗是预防肝病复发并恶化的关键，在激素或免疫抑制剂治疗前和治疗中都应使乙肝病毒降至尽可能低的水平。

Citation： RAN Jing,FENG Ping. Clinical Analysis of 7 Cases with Chronic Hepatitis B Relapse and Exacerbations Caused by Corticosteroids and Immunosuppressant Reactivation. West China Medical Journal, 2009, 24(2): 419-421. doi: Copy

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1.
2. Rossi G，Pelizzari A，Motta M，et al.Primary prophylaxis with lamivudine of hepatitis B virus reactivation in chronic HbsAg carriers with lymphoid malignancies treated with chemotherapy[J].Br J Haematol，2001，115(1)：58-62..
3. Brid AM，Bennett MK，Bassenine MF，et al.Nucleoside analogue therapy in fibrosing cholestatic hepatitis：a case report in an HBsAg postive renal transplant recipient[J].Liver，1998，18(2)：134-139..
4. Benner KG，Loe RG，Keeffe EB，et al.Fibrosing cytolytic liver failure secondary to recurrent hepatitis B after livertransplantation[J].Gastroenterology，1992，103(4)：1307-1312..
5. Lee WC，Wu MJ，Cheng CH，et al.Lamivudine is effective for the treatment of reactivation of hepatitis B virus and fulminant hepatic failure in renal transplant recipients[J].Am J Kidney Dis，2001，38(5)：1074-81..
6. 中华医学会感染病学分会、肝病学分会.慢性乙型肝炎防治指南[S].肝脏，2005，10(4)：348-357..

West China Medical Journal

Clinical Analysis of 7 Cases with Chronic Hepatitis B Relapse and Exacerbations Caused by Corticosteroids and Immunosuppressant Reactivation

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