光相干断层扫描技术在神经眼科应用的现状_Chinese Journal of Ocular Fundus Diseases

Authors：

彭春霞 ,  魏世辉

100853 北京, 解放军总医院神经眼科;

Corresponding author：

魏世辉, Email: weishihui706@hotmail.com

Keywords：

视神经疾病/诊断; 体层摄影术, 光学相干; 综述

DOI：

10.3760/cam.j.issn.1005-1015.2014.06.030

Video：

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光相干断层扫描(OCT)技术在神经眼科的应用日益广泛。研究发现, 视神经炎(ON)、非动脉炎性前部缺血性视神经病变及外伤性视神经病变视盘周围神经纤维层(RNFL)厚度均变薄。遗传性视神经病变视盘RNFL厚度变薄部位局限在颞侧; 黄斑部视网膜厚度变薄部位发生在鼻侧, 与盘斑束位置一致。随着高清OCT的普及, 黄斑部神经节细胞复合体(GCC)的变化在神经眼科疾病的意义也日益受到重视, 已有研究发现, GCC与ON视功能预后密切相关。神经眼科疾病的这些OCT特征将为其诊断及鉴别诊断带来更多帮助。

Citation： 彭春霞, 魏世辉. 光相干断层扫描技术在神经眼科应用的现状. Chinese Journal of Ocular Fundus Diseases, 2014, 30(6): 633-636. doi: 10.3760/cam.j.issn.1005-1015.2014.06.030 Copy

1.	Schneider E, Zimmermann H, Oberwahrenbrock T, et al.Optical coherence tomography reveals distinct patterns of retinal damage in neuromyelitis optica and multiple sclerosis[J/OL].PLoS One, 2013, 8:66151[2013-06-21].http://www.Plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0066151.
2.	Monteiro ML, Fernandes DB, Apóstolos-Pereira SL, et al.Quantification of retinal neural loss in patients with neuromyelitis optica and multiple sclerosis with or without optic neuritis using Fourier-domain optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2012, 53:3959-3966.
3.	Youngquist RC, Carr S, Davies DE. Optical coherence-domain reflectometry:a new optical evaluation technique[J].Opt Lett, 1987, 12:158-160.
4.	Lamirel C, Newman NJ, Biousse V. The use of optical coherence tomography in neurology[J].Rev Neurol Dis, 2009, 6:105-120.
5.	Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography[J].Science, 1991, 254:1178-1181.
6.	Wojtkowski M, Bajraszewski T, Gorczynska I, et al.Ophthalmic imaging by spectral optical coherence tomography[J]. Am J Ophthalmol, 2004, 138:412-419.
7.	Wojtkowski M, Srinivasan V, Fujimoto JG, et al. Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography[J]. Ophthalmology, 2005, 112:1734-1746.
8.	Liu L, Gardecki JA, Nadkarni SK, et al.Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomogramphy[J]. Nat Med, 2011, 17:1010-1014.
9.	Kardon RH.Role of the macular optical coherence tomography scan in neuro-ophthalmology[J].J Neuroophthalmol, 2011, 31:353-361.
10.	Sigal IA, Wang B, Strouthidis NG, et al Recent advances in OCT imaging of the lamina cribrosa[J].Br J Ophthalmol, 2014, 98 Suppl 2:S34-39.
11.	Yamanari M, Lim Y, Makita S, et al.Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1-microm probe[J]. Opt Express, 2009, 17:12385-12396.
12.	黎晓新, 陈玮志, 李立新.眼科光学相干断层成像应用新解[M].北京:人民卫生出版社, 2011:24-25.
13.	Behbehani R. Clinical approach to optic neuropathies[J].Clin Ophthalmol, 2007, 1:233-246.
14.	Papchenko T, Grainger BT, Savino PJ, et al. Macular thickness predictive of visual field in ischemic optic neuropathy[J]. Acta Ophthalmol, 2012, 90:463-469.
15.	Savino PJ, Danesh-Meyer HV. Neuro-ophthalmology[M]. 2nd ed. Philadelphia:Lippincott Williams & Wilkins, 2012:162.
16.	Toosy AT, Mason DF, Miller DH.Optic neuritis[J].Lancet Neurol, 2014, 13:83-99.
17.	Beck R, Cleary P, Anderson M, et al. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis[J].N Engl J Med, 1992, 326: 581-588.
18.	Levin LA, Louhab A. Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy[J].Arch Ophthalmol, 1996, 114:488-491.
19.	Carelli V, Ross-Cisneros FN, Sadun AA. Mitochondrial dysfunction as a cause of optic neuropathies[J].Prog Retin Eye Res, 2004, 23:53-89.
20.	Maresca A, la Morgia C, Caporali L, et al.The optic nerve: a "mito-window" on mitochondrial neurodegeneration[J]. Mol Cell Neurosci, 2013, 55:62-76.
21.	Petzold A, Plant GT.Diagnosis and classification of autoimmune optic neuropathy[J]. Autoimmun Rev, 2014, 13:539-545.
22.	Speculcre J, Murie FM, Salinas AA, et al. Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS[J]. Neurology, 2007, 68: 1488-1494.
23.	Garcia-Martin E, Polo V, Larrosa JM, et al. Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography[J].Ophthalmology, 2014, 121:573-579.
24.	Fernandes DB, Raza AS, Nogueira RG, et al.Evaluation of inner retinal layers in patients multiple sclerosis or neuromyelitis optica using optical coherence tomography[J].Ophthalmology, 2013, 120:387-394.
25.	Sotirchos ES, Saidha S, Byraiah G, et al.In vivo identification of morphologic retinal abnormalities in neuromyelitis optica[J].Neurology, 2013, 80: 1406-1414.
26.	Ratchford JN, Quigg ME, Conger A, et al. Optical coherence tomography helps diff erentiate neuromyelitis optica and MS optic neuropathies[J]. Neurology, 2009, 73:302-308.
27.	Saidha S, Sotirchos ES, Ibrahim MA, et al.Microcystic macular oedema, thickness of the inner nuclear layer of the retina, and disease characteristics in multiple sclerosis: a retrospective study[J]. Lancet Neurol, 2012, 11:963-972.
28.	Gelfand JM, Nolan R, Schwartz DM, et al. Microcystic macular oedema in multiple sclerosis is associated with disease severity[J]. Brain, 2012, 135:1786-1793.
29.	Wolff B, Azar G, Vasseur V, et al.Microcystic changes in the retinal internal nuclear layer associated with optic atrophy: a pros-pective study[J/OL].J Ophthalmol, 2014, 2014: 395189[2014-02-23]. http://www.hindawi.com/journals/joph/2014/395189/.
30.	Abegg M, Dysli M, Wolf S, et al. Microcystic macular edema :retrograde maculopathy caused by optic neuropathy[J].Ophthalmology, 2014, 121:142-149.
31.	Kernstock C, Beisse F, Wiethoff S, et al. Assessment of functional and morphometric endpoints in patients with non-arteritic anterior ischemic optic neuropathy (NAION)[J]. Graefe′s Arch Clin Exp Ophthalmol, 2014, 252:515-521.
32.	Dotan G, Goldstein M, Kesler A, et al.Long-term retinal nerve fiber layer changes following nonarteritic anterior ischemic optic neuropathy[J]. Clin Ophthalmol, 2013, 7:735-740.
33.	Talman LS, Bisker ER, Sackel DJ, et al. Longitudinal study of and retinal nerve fiber layer thickness in multiple sclerosis[J].Ann Neurol, 2010, 67:749-760.
34.	Aggarwal D, Tan O, Huang D, et al. Patterns of ganglion cell complex and nerve fiber loss in non arteritic ischemic optic neuropathy by Fourier-domain optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2012, 53:4539-4545.
35.	Gonul S, Koktekir BE, Bakbak B, et al.Comparison of the ganglion cell complex and retinal nerve fibre layer measurements using Fourier domain optical coherence tomography to detect ganglion cell loss in non-arteritic anterior ischaemic optic neuropathy[J].Br J Ophthalmol, 2013, 97:1045-1050.
36.	Dotan G, Goldenberg D, Kesler A, et al.The use of spectral-domain optical coherence tomography for differentiating long-standing central retinal artery occlusion and nonarteritic anterior ischemic optic neuropathy[J].Ophthalmic Surg Lasers Imaging Retina, 2014, 45:38-44.
37.	Barboni P, Carbonelli M, Savini G, et al. Natural history of Leber′s hereditary optic neuropathy: longitudinal analysis of the retinal nerve by optical coherence tomography[J].Ophthalmology, 2010, 117:623-627.
38.	Pan BX, Ross-Cisneros FN, Carelli V, et al.Mathematically modeling the involvement of axons in Leber′s hereditary optic neuropathy[J]. Invest Ophthalmol Vis Sci, 2012, 53:7608-7617.
39.	Zhang Y, Huang H, Wei S, et al. Characterization of retinal nerve fiber layer thickness changes associated with Leber′s hereditary opticneuropathy by optical coherence tomography[J]. Exp Ther Med, 2014, 7:483-487.
40.	Zhang Y, Huang H, Wei S, et al. Characterization of macular thickness change in Leber′s hereditary optic neuropathy by optical coherencetomography[J].BMC Ophthalmol, 2014, 14:105-111.
41.	Yu-Wai-Man P, Bailie M, Atawan A, et al.Pattern of retinal ganglion cell loss in dominant optic atrophy due to OPA1 mutations[J].Eye (Lond), 2011, 25:596-602.
42.	Savini G, Barboni P, Valentino ML, et al. Retina nerve fiber layer evaluation by optical coherence tomography in unaffected carriers with Leber′s hereditary optic neuropathy mutations[J]. Ophthalmology, 2005, 112:127-131.
43.	Barboni P, Savini G, Parisi V, et al.Retinal nerve fiber layer thickness in dominant optic atrophy measurements by optical coherence tomography and correlation with age[J]. Ophthalmology, 2011, 118:2076-2080.
44.	Zhao Z, Lan Y, Bai S, et al.Late-onset radiation-induced optic neuropathy after radiotherapy for nasopharyngeal carcinoma[J].J Clin Neurosci, 2013, 20:702-706.
45.	Xia Y, Chen J, Xiong L, et al.Retinal whole genome microarray analysis and early changes in the optic nerves of monkeys after an intraorbital nerve irradiated injury[J].Mol Vis, 2011, 17:2920-2933.
46.	Levy RL, Miller NR.Hyperbaric oxygen therapy for radiation-induced optic neuropathy[J]. Ann Acad Med Singapore, 2006, 35:151-157.
47.	McClenaghan FC, Ezra DG, Holmes SB. Mechanisms and management of vision loss following orbital and facial trauma[J].Curr Opin Ophthalmol, 2011, 22:426-431.
48.	Shi W, Wang HZ, Song WX, et al. Axonal loss and blood flow disturbances in the natural course of indirect traumatic optic neuropathy[J]. Chin Med J (Engl), 2013, 126:1292-1297.
49.	Ustymowicz A, Mariak Z, Obuchowska I, et al. Blood flow disturbances in the central retinal artery in patients with traumatic optic neuropathy[J]. Med Sci Monit, 2009, 15:366-371.
50.	Cunha LP, Costa-Cunha LV, Malta RF, et al. Comparison between retinal nerve fiber layer and macular thickness measured with OCT detecting progressive axonal loss following traumatic optic n-europathy[J]. Arq Bras Oftalmol, 2009, 72: 622-625.
51.	Gabriele ML, Ishikawa H, Schuman JS, et al. Optic nerve crush mice followed nerve crush mice followed longitudinally with spectral domain optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2011, 52:2250-2254.
52.	Chauhan BC, Stevens KT, Levesque JM, et al.Longitudinal in vivo imaging of retinal ganglion cells and retinal thickness changes following nerve injury in mice[J/OL].PLoSOne, 2012, 7:40352[2012-06-29].http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0040352.
53.	Duan XR, Liang YB, Friedman DS, et al. Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese person: the Handan Eye Study[J].Ophthalmology, 2010, 117:1585-1594.

1. Schneider E, Zimmermann H, Oberwahrenbrock T, et al.Optical coherence tomography reveals distinct patterns of retinal damage in neuromyelitis optica and multiple sclerosis[J/OL].PLoS One, 2013, 8:66151[2013-06-21].http://www.Plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0066151.
2. Monteiro ML, Fernandes DB, Apóstolos-Pereira SL, et al.Quantification of retinal neural loss in patients with neuromyelitis optica and multiple sclerosis with or without optic neuritis using Fourier-domain optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2012, 53:3959-3966.
3. Youngquist RC, Carr S, Davies DE. Optical coherence-domain reflectometry:a new optical evaluation technique[J].Opt Lett, 1987, 12:158-160.
4. Lamirel C, Newman NJ, Biousse V. The use of optical coherence tomography in neurology[J].Rev Neurol Dis, 2009, 6:105-120.
5. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography[J].Science, 1991, 254:1178-1181.
6. Wojtkowski M, Bajraszewski T, Gorczynska I, et al.Ophthalmic imaging by spectral optical coherence tomography[J]. Am J Ophthalmol, 2004, 138:412-419.
7. Wojtkowski M, Srinivasan V, Fujimoto JG, et al. Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography[J]. Ophthalmology, 2005, 112:1734-1746.
8. Liu L, Gardecki JA, Nadkarni SK, et al.Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomogramphy[J]. Nat Med, 2011, 17:1010-1014.
9. Kardon RH.Role of the macular optical coherence tomography scan in neuro-ophthalmology[J].J Neuroophthalmol, 2011, 31:353-361.
10. Sigal IA, Wang B, Strouthidis NG, et al Recent advances in OCT imaging of the lamina cribrosa[J].Br J Ophthalmol, 2014, 98 Suppl 2:S34-39.
11. Yamanari M, Lim Y, Makita S, et al.Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1-microm probe[J]. Opt Express, 2009, 17:12385-12396.
12. 黎晓新, 陈玮志, 李立新.眼科光学相干断层成像应用新解[M].北京:人民卫生出版社, 2011:24-25.
13. Behbehani R. Clinical approach to optic neuropathies[J].Clin Ophthalmol, 2007, 1:233-246.
14. Papchenko T, Grainger BT, Savino PJ, et al. Macular thickness predictive of visual field in ischemic optic neuropathy[J]. Acta Ophthalmol, 2012, 90:463-469.
15. Savino PJ, Danesh-Meyer HV. Neuro-ophthalmology[M]. 2nd ed. Philadelphia:Lippincott Williams & Wilkins, 2012:162.
16. Toosy AT, Mason DF, Miller DH.Optic neuritis[J].Lancet Neurol, 2014, 13:83-99.
17. Beck R, Cleary P, Anderson M, et al. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis[J].N Engl J Med, 1992, 326: 581-588.
18. Levin LA, Louhab A. Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy[J].Arch Ophthalmol, 1996, 114:488-491.
19. Carelli V, Ross-Cisneros FN, Sadun AA. Mitochondrial dysfunction as a cause of optic neuropathies[J].Prog Retin Eye Res, 2004, 23:53-89.
20. Maresca A, la Morgia C, Caporali L, et al.The optic nerve: a "mito-window" on mitochondrial neurodegeneration[J]. Mol Cell Neurosci, 2013, 55:62-76.
21. Petzold A, Plant GT.Diagnosis and classification of autoimmune optic neuropathy[J]. Autoimmun Rev, 2014, 13:539-545.
22. Speculcre J, Murie FM, Salinas AA, et al. Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS[J]. Neurology, 2007, 68: 1488-1494.
23. Garcia-Martin E, Polo V, Larrosa JM, et al. Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography[J].Ophthalmology, 2014, 121:573-579.
24. Fernandes DB, Raza AS, Nogueira RG, et al.Evaluation of inner retinal layers in patients multiple sclerosis or neuromyelitis optica using optical coherence tomography[J].Ophthalmology, 2013, 120:387-394.
25. Sotirchos ES, Saidha S, Byraiah G, et al.In vivo identification of morphologic retinal abnormalities in neuromyelitis optica[J].Neurology, 2013, 80: 1406-1414.
26. Ratchford JN, Quigg ME, Conger A, et al. Optical coherence tomography helps diff erentiate neuromyelitis optica and MS optic neuropathies[J]. Neurology, 2009, 73:302-308.
27. Saidha S, Sotirchos ES, Ibrahim MA, et al.Microcystic macular oedema, thickness of the inner nuclear layer of the retina, and disease characteristics in multiple sclerosis: a retrospective study[J]. Lancet Neurol, 2012, 11:963-972.
28. Gelfand JM, Nolan R, Schwartz DM, et al. Microcystic macular oedema in multiple sclerosis is associated with disease severity[J]. Brain, 2012, 135:1786-1793.
29. Wolff B, Azar G, Vasseur V, et al.Microcystic changes in the retinal internal nuclear layer associated with optic atrophy: a pros-pective study[J/OL].J Ophthalmol, 2014, 2014: 395189[2014-02-23]. http://www.hindawi.com/journals/joph/2014/395189/.
30. Abegg M, Dysli M, Wolf S, et al. Microcystic macular edema :retrograde maculopathy caused by optic neuropathy[J].Ophthalmology, 2014, 121:142-149.
31. Kernstock C, Beisse F, Wiethoff S, et al. Assessment of functional and morphometric endpoints in patients with non-arteritic anterior ischemic optic neuropathy (NAION)[J]. Graefe′s Arch Clin Exp Ophthalmol, 2014, 252:515-521.
32. Dotan G, Goldstein M, Kesler A, et al.Long-term retinal nerve fiber layer changes following nonarteritic anterior ischemic optic neuropathy[J]. Clin Ophthalmol, 2013, 7:735-740.
33. Talman LS, Bisker ER, Sackel DJ, et al. Longitudinal study of and retinal nerve fiber layer thickness in multiple sclerosis[J].Ann Neurol, 2010, 67:749-760.
34. Aggarwal D, Tan O, Huang D, et al. Patterns of ganglion cell complex and nerve fiber loss in non arteritic ischemic optic neuropathy by Fourier-domain optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2012, 53:4539-4545.
35. Gonul S, Koktekir BE, Bakbak B, et al.Comparison of the ganglion cell complex and retinal nerve fibre layer measurements using Fourier domain optical coherence tomography to detect ganglion cell loss in non-arteritic anterior ischaemic optic neuropathy[J].Br J Ophthalmol, 2013, 97:1045-1050.
36. Dotan G, Goldenberg D, Kesler A, et al.The use of spectral-domain optical coherence tomography for differentiating long-standing central retinal artery occlusion and nonarteritic anterior ischemic optic neuropathy[J].Ophthalmic Surg Lasers Imaging Retina, 2014, 45:38-44.
37. Barboni P, Carbonelli M, Savini G, et al. Natural history of Leber′s hereditary optic neuropathy: longitudinal analysis of the retinal nerve by optical coherence tomography[J].Ophthalmology, 2010, 117:623-627.
38. Pan BX, Ross-Cisneros FN, Carelli V, et al.Mathematically modeling the involvement of axons in Leber′s hereditary optic neuropathy[J]. Invest Ophthalmol Vis Sci, 2012, 53:7608-7617.
39. Zhang Y, Huang H, Wei S, et al. Characterization of retinal nerve fiber layer thickness changes associated with Leber′s hereditary opticneuropathy by optical coherence tomography[J]. Exp Ther Med, 2014, 7:483-487.
40. Zhang Y, Huang H, Wei S, et al. Characterization of macular thickness change in Leber′s hereditary optic neuropathy by optical coherencetomography[J].BMC Ophthalmol, 2014, 14:105-111.
41. Yu-Wai-Man P, Bailie M, Atawan A, et al.Pattern of retinal ganglion cell loss in dominant optic atrophy due to OPA1 mutations[J].Eye (Lond), 2011, 25:596-602.
42. Savini G, Barboni P, Valentino ML, et al. Retina nerve fiber layer evaluation by optical coherence tomography in unaffected carriers with Leber′s hereditary optic neuropathy mutations[J]. Ophthalmology, 2005, 112:127-131.
43. Barboni P, Savini G, Parisi V, et al.Retinal nerve fiber layer thickness in dominant optic atrophy measurements by optical coherence tomography and correlation with age[J]. Ophthalmology, 2011, 118:2076-2080.
44. Zhao Z, Lan Y, Bai S, et al.Late-onset radiation-induced optic neuropathy after radiotherapy for nasopharyngeal carcinoma[J].J Clin Neurosci, 2013, 20:702-706.
45. Xia Y, Chen J, Xiong L, et al.Retinal whole genome microarray analysis and early changes in the optic nerves of monkeys after an intraorbital nerve irradiated injury[J].Mol Vis, 2011, 17:2920-2933.
46. Levy RL, Miller NR.Hyperbaric oxygen therapy for radiation-induced optic neuropathy[J]. Ann Acad Med Singapore, 2006, 35:151-157.
47. McClenaghan FC, Ezra DG, Holmes SB. Mechanisms and management of vision loss following orbital and facial trauma[J].Curr Opin Ophthalmol, 2011, 22:426-431.
48. Shi W, Wang HZ, Song WX, et al. Axonal loss and blood flow disturbances in the natural course of indirect traumatic optic neuropathy[J]. Chin Med J (Engl), 2013, 126:1292-1297.
49. Ustymowicz A, Mariak Z, Obuchowska I, et al. Blood flow disturbances in the central retinal artery in patients with traumatic optic neuropathy[J]. Med Sci Monit, 2009, 15:366-371.
50. Cunha LP, Costa-Cunha LV, Malta RF, et al. Comparison between retinal nerve fiber layer and macular thickness measured with OCT detecting progressive axonal loss following traumatic optic n-europathy[J]. Arq Bras Oftalmol, 2009, 72: 622-625.
51. Gabriele ML, Ishikawa H, Schuman JS, et al. Optic nerve crush mice followed nerve crush mice followed longitudinally with spectral domain optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2011, 52:2250-2254.
52. Chauhan BC, Stevens KT, Levesque JM, et al.Longitudinal in vivo imaging of retinal ganglion cells and retinal thickness changes following nerve injury in mice[J/OL].PLoSOne, 2012, 7:40352[2012-06-29].http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0040352.
53. Duan XR, Liang YB, Friedman DS, et al. Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese person: the Handan Eye Study[J].Ophthalmology, 2010, 117:1585-1594.

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光相干断层扫描技术在神经眼科应用的现状

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