Research status and progress of the application of multicolor imaging in the diagnosis of ocular fundus diseases_Chinese Journal of Ocular Fundus Diseases

Authors：

 Liang Yanhua , Li Yongxiong , Huang Guoshun

Department of Ophthalmology, The People’s Hospital of Jiangmen, Jiangmen 529000, China;

Corresponding author：

Liang Yanhua, Email: 337352464@qq.com

Keywords：

Retinal diseases/diagnosis; Choroid diseases/diagnosis; Microscopy, confocal; Review

DOI：

10.3760/cma.j.cn511434-20180903-00305

Video：

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Multicolor imaging (MCI) based on confocal scanning laser ophthalmoscopy can gather more diagnostic information than traditional fundus photographs through utilizing three wavelengths of laser to scan posterior retina, which gain different layer reflected signal since the depth of penetration into retina is different for each wavelength. Currently, it provides important information and reference value for diagnose of different layer diseases on retina or choroid combining MCI with OCT, FAF, FFA and so on. However, there are still misunderstandings in the diagnosis of retinal diseases with MCI. Careful observation of retinal details in MCI, CFP and other imaging methods is more conducive to the correct diagnosis of fundus ophthalmopathy.

Citation： Liang Yanhua, Li Yongxiong, Huang Guoshun. Research status and progress of the application of multicolor imaging in the diagnosis of ocular fundus diseases. Chinese Journal of Ocular Fundus Diseases, 2020, 36(5): 392-395. doi: 10.3760/cma.j.cn511434-20180903-00305 Copy

1.	Kilic Muftuoglu I, Bartsch DU, Barteselli G, et al. Visualization of macular pucker by multicolor scanning laser imaging[J]. Retina, 2018, 38(2): 352-358. DOI: 10.1097/IAE.0000000000001525.
2.	Feng HL, Sharma S, Asrani S, et al. Multicolor imaging of inner retinal alterations after internal limiting membrane peeling[J]. Retin Cases Brief Rep, 2017, 11(3): 198-202. DOI: 10.1097/ICB.0000000000000330.
3.	Ahmad MSZ, Carrim ZI. Multicolor scanning laser imaging in diabetic retinopathy[J]. Optom Vis Sci, 2017, 94(11): 1058-1061. DOI: 10.1097/OPX.0000000000001128.
4.	李淑婷, 王相宁, 杜新华, 等. 共焦激光扫描炫彩眼底成像与彩色眼底照相对糖尿病视网膜病变的检出比较[J]. 中华眼底病杂志, 2018, 34(4): 388-342. DOI: 10.3760/cma.j.issn.1005-1015.2018.04.006.Li ST, Wang XN, Du XH, et al. Comparison of confocal laser scanning colorful fundus imaging and color fundus photography for detection of diabetic retinopathy[J]. Chin J Ocul Fundus Dis, 2018, 34(4): 388-342. DOI: 10.3760/cma.j.issn.1005-1015.2018.04.006.
5.	Rivera-De LPD, Perez-Peralta L, Toldi J, et al. Multicolor scanning laser imaging in lipemia retinalis[J]. Retin Cases Brief Rep, 2017, 11(Suppl 1): S132-135. DOI: 10.1097/ICB.0000000000000469.
6.	De Salvo G, Vaz-Pereira S, Arora R, et al. Multicolor imaging in the diagnosis and follow up of type 2 acute macular neuroretinopathy[J]. Eye (Lond), 2017, 31(1): 127-131. DOI: 10.1038/eye.2016.193.
7.	Capuano V, Souied EH, Semoun O, et al. Multicolor imaging in a case of acute macular neuroretinopathy[J]. J Fr Ophtalmol, 2015, 38(2): 19-21. DOI: 10.1016/j.jfo.2014.04.018.
8.	Dhrami-Gavazi E, Lee W, Balaratnasingam C, et al. Multimodal imaging documentation of rapid evolution of retinal changes in handheld laser-induced maculopathy[J]. Int J Retina Vitreous, 2015, 1: 14. DOI: 10.1186/s40942-015-0014-7.
9.	Kawali AA, Bavaharan B, Mahendradas P. A lava lake on multicolor imaging of bilateral diffuse uveal melanocytic proliferation[J/OL]. JAMA Ophthalmol, 2019, 137(5): 185065[2019-05-01]. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=31070686.ui. DOI: 10.1001/jamaophthalmol.2018.5065.
10.	Graham KW, Chakravarthy U, Hogg RE, et al. Identifying features of early and late age-related macular degeneration: a comparison of multicolor versus traditional color fundus photography[J]. Retina, 2018, 38(9): 1751-1758. DOI: 10.1097/IAE.0000000000001777.
11.	De Bats F, Mathis T, Mauget-Faysse M, et al. Prevalence of reticular pseudodrusen in age-related macular degeneration using multimodal imaging[J]. Retina, 2016, 36(1): 46-52. DOI: 10.1097/IAE.0000000000000648.
12.	Badal J, Biarnes M, Mones J. Performance characteristics of multicolor versus blue light and infrared imaging in the identification of reticular pseudodrusen[J]. Int Ophthalmol, 2018, 38(1): 199-206. DOI: 10.1007/s10792-017-0448-z.
13.	Tan A, Yanagi Y, Cheung G. Comparison of multicolor imaging and color fundus photography in the detection of pathological findings in eyes with polypoidal choroidal vasculopathy[J/OL]. Retina, 2019, 2019: E1[2019-08-27]. http://dx.doi.org/10.1097/IAE.0000000000002638. DOI: 10.1097/IAE.0000000000002638. [published onlineahead of print].
14.	Govindahari V, Singh SR, Rajesh B, et al. Multicolor imaging in central serous chorioretinopathy - a quantitative and qualitative comparison with fundus autofluorescence[J/OL]. Sci Rep, 2019, 9(1): 11728[2019-08-13]. http://europepmc.org/article/MED/31409843. DOI: 10.1038/s41598-019-48040-4.
15.	He L, Chen C, Yi Z, et al. Clinical application of multicolor imaging in central serous chorioretinopathy[J]. Retina, 2020, 40(4): 743-749. DOI: 10.1097/IAE.0000000000002441.
16.	Liu G, Du Q, Keyal K, et al. Morphologic characteristics and clinical significance of the macular-sparing area in patients with retinitis pigmentosa as revealed by multicolor imaging[J]. Exp Ther Med, 2017, 14(6): 5387-5394. DOI: 10.3892/etm.2017.5227.
17.	Krill AE, Deutman AF. Acute retinal pigment epitheliitus[J]. Am J Ophthalmol, 1972, 74(2): 193-205. DOI: 10.1016/0002-9394(72)90535-1.
18.	Iu L, Lee R, Fan M, et al. Serial spectral-domain optical coherence tomography findings in acute retinal pigment epitheliitis and the correlation to visual acuity[J]. Ophthalmology, 2017, 124(6): 903-909. DOI: 10.1016/j.ophtha.2017.01.043.
19.	Roy R, Saurabh K, Thomas NR. Multicolor imaging in a case of acute retinal pigment epitheliitis[J/OL]. Retin Cases Brief Rep, 2018, 2018: E1[2018-02-22]. http://dx.doi.org/10.1097/ICB.0000000000000726. DOI: 10.1097/ICB.0000000000000726.[published online ahead of print].
20.	Cho HJ, Han SY, Cho SW, et al. Acute retinal pigment epitheliitis: spectral-domain optical coherence tomography findings in 18 cases[J]. Invest Ophthalmol Vis Sci, 2014, 55(5): 3314-3319. DOI: 10.1167/iovs.14-14324.
21.	何璐, 易佐慧子, 王晓玲, 等. 孤立性视网膜星状细胞错构瘤多波长炫彩和光相干断层扫描血管成像观察一例[J]. 中华眼底病杂志, 2019, 35(1): 79-81. DOI: 10.3760/cma.j.issn.1005-1015.2019.01.017.He L, Yi ZHZ, Wang XL, et al. A case of isolated retinal astrocytic hamartoma by multicolor imaging and OCT angiography[J]. Chin J Ocul Fundus Dis, 2019, 35(1): 79-81. DOI: 10.3760/cma.j.issn.1005-1015.2019.01.017.
22.	李海东, 徐永根, 毛剑波, 等. 视网膜和视网膜色素上皮联合错构瘤多模式影像检查一例[J]. 中华眼底病杂志, 2019, 35(4): 391-393. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.017.Li HD, Xu YG, Mao JB, et al. A case of combined hamartoma of retina and retinal pigment epithelium by mutimodal imaging[J]. Chin J Ocul Fundus Dis, 2019, 35(4): 391-393. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.017.
23.	Thomas NR, Ghosh PS, Chowdhury M, et al. Multicolor imaging in optic disc swelling[J]. Indian J Ophthalmol, 2017, 65(11): 1251-1255. DOI: 10.4103/ijo.IJO_473_17.
24.	Malem A, De Salvo G, West S. Use of multicolor imaging in the assessment of suspected papilledema in 20 consecutive children[J]. J AAPOS, 2016, 20(6): 532-536. DOI: 10.1016/j.jaapos.2016.08.012.
25.	Bhattacharya S, Goel S, Saurabh K, et al. Multicolor Imaging of myelinated nerve fibers contiguous to the optic disc[J]. J Neuroophthalmol, 2020, 40(1): 104-105. DOI: 10.1097/WNO.0000000000000810.
26.	金陈进. 常见眼底病炫彩OCT影像解读[J]. 中国激光医学杂志, 2016, 25(5): 309.Jin CJ. OCT imaging interpretation of common fundus diseases[J]. Chin J Laser Med Surg, 2016, 25(5): 309.
27.	Pang CE, Freund KB. Ghost maculopathy: an artifact on near-infrared reflectance and multicolor imaging masquerading as chorioretinal pathology[J]. Am J Ophthalmol, 2014, 158(1): 171-178. DOI: 10.1016/j.ajo.2014.03.003.
28.	Gorrand JM, Alfieri R, Boire JY. Diffusion of the retinal layers of the living human eye[J]. Vision Res, 1984, 24(9): 1097-1106. DOI: 10.1016/0042-6989(84)90088-9.
29.	Gorrand JM, Delori FC. Reflectance and curvature of the inner limiting membrane at the foveola[J]. J Opt Soc Am A Opt Image Sci Vis, 1999, 16(6): 1229-1237. DOI: 10.1364/josaa.16.001229.
30.	Ben MN, Georges A, Capuano V, et al. Multicolor imaging in the evaluation of geographic atrophy due to age-related macular degeneration[J]. Br J Ophthalmol, 2015, 99(6): 842-847. DOI: 10.1136/bjophthalmol-2014-305643.
31.	Kalevar A, Johnson RN, Lujan BJ. Pebble beach artifact: an apparent multicolor imaging maculopathy due to corneal desiccation[J]. Indian J Ophthalmol, 2018, 66(2): 291-292. DOI: 10.4103/ijo.IJO_757_16.
32.	Muftuoglu IK, Gaber R, Bartsch DU, et al. Comparison of conventional color fundus photography and multicolor imaging in choroidal or retinal lesions[J]. Graefe’s Arch Clin Exp Ophthalmol, 2018, 256(4): 643-649. DOI: 10.1007/s00417-017-3884-6.
33.	Tan AC, Fleckenstein M, Schmitz-Valckenberg S, et al. Clinical application of multicolor imaging technology[J]. Ophthalmologica, 2016, 236(1): 8-18. DOI: 10.1159/000446857.

1. Kilic Muftuoglu I, Bartsch DU, Barteselli G, et al. Visualization of macular pucker by multicolor scanning laser imaging[J]. Retina, 2018, 38(2): 352-358. DOI: 10.1097/IAE.0000000000001525.
2. Feng HL, Sharma S, Asrani S, et al. Multicolor imaging of inner retinal alterations after internal limiting membrane peeling[J]. Retin Cases Brief Rep, 2017, 11(3): 198-202. DOI: 10.1097/ICB.0000000000000330.
3. Ahmad MSZ, Carrim ZI. Multicolor scanning laser imaging in diabetic retinopathy[J]. Optom Vis Sci, 2017, 94(11): 1058-1061. DOI: 10.1097/OPX.0000000000001128.
4. 李淑婷, 王相宁, 杜新华, 等. 共焦激光扫描炫彩眼底成像与彩色眼底照相对糖尿病视网膜病变的检出比较[J]. 中华眼底病杂志, 2018, 34(4): 388-342. DOI: 10.3760/cma.j.issn.1005-1015.2018.04.006.Li ST, Wang XN, Du XH, et al. Comparison of confocal laser scanning colorful fundus imaging and color fundus photography for detection of diabetic retinopathy[J]. Chin J Ocul Fundus Dis, 2018, 34(4): 388-342. DOI: 10.3760/cma.j.issn.1005-1015.2018.04.006.
5. Rivera-De LPD, Perez-Peralta L, Toldi J, et al. Multicolor scanning laser imaging in lipemia retinalis[J]. Retin Cases Brief Rep, 2017, 11(Suppl 1): S132-135. DOI: 10.1097/ICB.0000000000000469.
6. De Salvo G, Vaz-Pereira S, Arora R, et al. Multicolor imaging in the diagnosis and follow up of type 2 acute macular neuroretinopathy[J]. Eye (Lond), 2017, 31(1): 127-131. DOI: 10.1038/eye.2016.193.
7. Capuano V, Souied EH, Semoun O, et al. Multicolor imaging in a case of acute macular neuroretinopathy[J]. J Fr Ophtalmol, 2015, 38(2): 19-21. DOI: 10.1016/j.jfo.2014.04.018.
8. Dhrami-Gavazi E, Lee W, Balaratnasingam C, et al. Multimodal imaging documentation of rapid evolution of retinal changes in handheld laser-induced maculopathy[J]. Int J Retina Vitreous, 2015, 1: 14. DOI: 10.1186/s40942-015-0014-7.
9. Kawali AA, Bavaharan B, Mahendradas P. A lava lake on multicolor imaging of bilateral diffuse uveal melanocytic proliferation[J/OL]. JAMA Ophthalmol, 2019, 137(5): 185065[2019-05-01]. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=31070686.ui. DOI: 10.1001/jamaophthalmol.2018.5065.
10. Graham KW, Chakravarthy U, Hogg RE, et al. Identifying features of early and late age-related macular degeneration: a comparison of multicolor versus traditional color fundus photography[J]. Retina, 2018, 38(9): 1751-1758. DOI: 10.1097/IAE.0000000000001777.
11. De Bats F, Mathis T, Mauget-Faysse M, et al. Prevalence of reticular pseudodrusen in age-related macular degeneration using multimodal imaging[J]. Retina, 2016, 36(1): 46-52. DOI: 10.1097/IAE.0000000000000648.
12. Badal J, Biarnes M, Mones J. Performance characteristics of multicolor versus blue light and infrared imaging in the identification of reticular pseudodrusen[J]. Int Ophthalmol, 2018, 38(1): 199-206. DOI: 10.1007/s10792-017-0448-z.
13. Tan A, Yanagi Y, Cheung G. Comparison of multicolor imaging and color fundus photography in the detection of pathological findings in eyes with polypoidal choroidal vasculopathy[J/OL]. Retina, 2019, 2019: E1[2019-08-27]. http://dx.doi.org/10.1097/IAE.0000000000002638. DOI: 10.1097/IAE.0000000000002638. [published onlineahead of print].
14. Govindahari V, Singh SR, Rajesh B, et al. Multicolor imaging in central serous chorioretinopathy - a quantitative and qualitative comparison with fundus autofluorescence[J/OL]. Sci Rep, 2019, 9(1): 11728[2019-08-13]. http://europepmc.org/article/MED/31409843. DOI: 10.1038/s41598-019-48040-4.
15. He L, Chen C, Yi Z, et al. Clinical application of multicolor imaging in central serous chorioretinopathy[J]. Retina, 2020, 40(4): 743-749. DOI: 10.1097/IAE.0000000000002441.
16. Liu G, Du Q, Keyal K, et al. Morphologic characteristics and clinical significance of the macular-sparing area in patients with retinitis pigmentosa as revealed by multicolor imaging[J]. Exp Ther Med, 2017, 14(6): 5387-5394. DOI: 10.3892/etm.2017.5227.
17. Krill AE, Deutman AF. Acute retinal pigment epitheliitus[J]. Am J Ophthalmol, 1972, 74(2): 193-205. DOI: 10.1016/0002-9394(72)90535-1.
18. Iu L, Lee R, Fan M, et al. Serial spectral-domain optical coherence tomography findings in acute retinal pigment epitheliitis and the correlation to visual acuity[J]. Ophthalmology, 2017, 124(6): 903-909. DOI: 10.1016/j.ophtha.2017.01.043.
19. Roy R, Saurabh K, Thomas NR. Multicolor imaging in a case of acute retinal pigment epitheliitis[J/OL]. Retin Cases Brief Rep, 2018, 2018: E1[2018-02-22]. http://dx.doi.org/10.1097/ICB.0000000000000726. DOI: 10.1097/ICB.0000000000000726.[published online ahead of print].
20. Cho HJ, Han SY, Cho SW, et al. Acute retinal pigment epitheliitis: spectral-domain optical coherence tomography findings in 18 cases[J]. Invest Ophthalmol Vis Sci, 2014, 55(5): 3314-3319. DOI: 10.1167/iovs.14-14324.
21. 何璐, 易佐慧子, 王晓玲, 等. 孤立性视网膜星状细胞错构瘤多波长炫彩和光相干断层扫描血管成像观察一例[J]. 中华眼底病杂志, 2019, 35(1): 79-81. DOI: 10.3760/cma.j.issn.1005-1015.2019.01.017.He L, Yi ZHZ, Wang XL, et al. A case of isolated retinal astrocytic hamartoma by multicolor imaging and OCT angiography[J]. Chin J Ocul Fundus Dis, 2019, 35(1): 79-81. DOI: 10.3760/cma.j.issn.1005-1015.2019.01.017.
22. 李海东, 徐永根, 毛剑波, 等. 视网膜和视网膜色素上皮联合错构瘤多模式影像检查一例[J]. 中华眼底病杂志, 2019, 35(4): 391-393. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.017.Li HD, Xu YG, Mao JB, et al. A case of combined hamartoma of retina and retinal pigment epithelium by mutimodal imaging[J]. Chin J Ocul Fundus Dis, 2019, 35(4): 391-393. DOI: 10.3760/cma.j.issn.1005-1015.2019.04.017.
23. Thomas NR, Ghosh PS, Chowdhury M, et al. Multicolor imaging in optic disc swelling[J]. Indian J Ophthalmol, 2017, 65(11): 1251-1255. DOI: 10.4103/ijo.IJO_473_17.
24. Malem A, De Salvo G, West S. Use of multicolor imaging in the assessment of suspected papilledema in 20 consecutive children[J]. J AAPOS, 2016, 20(6): 532-536. DOI: 10.1016/j.jaapos.2016.08.012.
25. Bhattacharya S, Goel S, Saurabh K, et al. Multicolor Imaging of myelinated nerve fibers contiguous to the optic disc[J]. J Neuroophthalmol, 2020, 40(1): 104-105. DOI: 10.1097/WNO.0000000000000810.
26. 金陈进. 常见眼底病炫彩OCT影像解读[J]. 中国激光医学杂志, 2016, 25(5): 309.Jin CJ. OCT imaging interpretation of common fundus diseases[J]. Chin J Laser Med Surg, 2016, 25(5): 309.
27. Pang CE, Freund KB. Ghost maculopathy: an artifact on near-infrared reflectance and multicolor imaging masquerading as chorioretinal pathology[J]. Am J Ophthalmol, 2014, 158(1): 171-178. DOI: 10.1016/j.ajo.2014.03.003.
28. Gorrand JM, Alfieri R, Boire JY. Diffusion of the retinal layers of the living human eye[J]. Vision Res, 1984, 24(9): 1097-1106. DOI: 10.1016/0042-6989(84)90088-9.
29. Gorrand JM, Delori FC. Reflectance and curvature of the inner limiting membrane at the foveola[J]. J Opt Soc Am A Opt Image Sci Vis, 1999, 16(6): 1229-1237. DOI: 10.1364/josaa.16.001229.
30. Ben MN, Georges A, Capuano V, et al. Multicolor imaging in the evaluation of geographic atrophy due to age-related macular degeneration[J]. Br J Ophthalmol, 2015, 99(6): 842-847. DOI: 10.1136/bjophthalmol-2014-305643.
31. Kalevar A, Johnson RN, Lujan BJ. Pebble beach artifact: an apparent multicolor imaging maculopathy due to corneal desiccation[J]. Indian J Ophthalmol, 2018, 66(2): 291-292. DOI: 10.4103/ijo.IJO_757_16.
32. Muftuoglu IK, Gaber R, Bartsch DU, et al. Comparison of conventional color fundus photography and multicolor imaging in choroidal or retinal lesions[J]. Graefe’s Arch Clin Exp Ophthalmol, 2018, 256(4): 643-649. DOI: 10.1007/s00417-017-3884-6.
33. Tan AC, Fleckenstein M, Schmitz-Valckenberg S, et al. Clinical application of multicolor imaging technology[J]. Ophthalmologica, 2016, 236(1): 8-18. DOI: 10.1159/000446857.

Chinese Journal of Ocular Fundus Diseases

Research status and progress of the application of multicolor imaging in the diagnosis of ocular fundus diseases

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