Preliminary study on changes and mechanism of choroidal thickness in silicone oil-filled eyes_Chinese Journal of Ocular Fundus Diseases

Authors：

Yan Ying , Liu Ran , Gao Chengyuan , Ding Qin ,  Chen Xiao

Department of Ophthalmology, Central Theater Command General Hospital, Wuhan 430070, China;

Corresponding author：

Chen Xiao, Email: cxfn817@163.com

Keywords：

Choroid/physiopathology; Refractive errors; Hyperopia; Silicone oils

DOI：

10.3760/cma.j.cn511434-20191231-00419

Video：

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Objective To investigate the potential effect of hyperopia status on subfoveal choroidal thickness (SFCT) in silicone oil (SO)-filled eyes.Methods This self-comparative study was conducted in Department of Ophthalmology, Central Theater Command General Hospital. The 50 patients (100 eyes) were collected with unilateral macula-on rhegmatogenous retinal detachment from January 2019 to July 2019, who successfully underwent pars plana vitrectomy (PPV) and SO tamponade. Retinal reattachment was observed after surgery in all patients. One month after PPV, the affected eye was wore soft, contact lenses for 24 hours to correct refractive error (RE), depending on its optometry value. The SFCT of the affected eyes was measured using OCT before and after lenses wear. The fellow eyes also received OCT examination at the same time. T test was used to compare SFCT between SO-filled eyes and fellow eyes.Results The mean RE of the SO-filled eyes was +6.38±1.12 D. The mean SFCT of SO-filled eyes (247.12±17.63 μm) was significantly thinner than that of the fellow eyes (276.32.55±17.63 μm) (P＜0.001). The SFCT of the SO-filled eyes was significantly thinner than fellow eyes, and the difference was statistically significant (t=－3.95, P＜0.001). After lenses wear, the mean SFCT of the SO-filled eyes increased to 276.32±24.86 μm. Compared with before lenses wear, the difference was statistically significant (t=－4.30, P＜0.001). Compared with the fellow eye, the difference was not statistically significant (t=0.05, P＞0.05).Conclusion SFCT reduction in the SO-filled eyes may be due to the hyperopia status caused by SO, which can be reserved by RE correction.

Citation： Yan Ying, Liu Ran, Gao Chengyuan, Ding Qin, Chen Xiao. Preliminary study on changes and mechanism of choroidal thickness in silicone oil-filled eyes. Chinese Journal of Ocular Fundus Diseases, 2020, 36(8): 625-627. doi: 10.3760/cma.j.cn511434-20191231-00419 Copy

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4.	Winter M, Eberhardt W, Scholz C, et al. Failure of potassium siphoning by Müller cells: a new hypothesis of perfluorocarbon liquid-induced retinopathy[J]. Invest Ophthalmol Vis Sci, 2000, 41(1): 256-261.
5.	Wallman J, Wildsoet C, Xu A, et al. Moving the retina: choroidal modulation of refractive state[J]. Vision Res, 1995, 35(1): 37-50. DOI: 10.1016/0042-6989(94)e0049-q.
6.	Wildsoet C, Wallman J. Choroidal and scleral mechanisms of compensation for spectacle lenses in chicks[J]. Vision Res, 1995, 35(9): 1175-1194. DOI: 10.1016/0042-6989(94)00233-c.
7.	Poukens V, Glasgow BJ, Demer JL. Nonvascular contractile cells in sclera and choroid of humans and monkeys[J]. Invest Ophthalmol Vis Sci, 1998, 39(10): 1765-1774.
8.	Kim M, Eom Y, Song JS, et al. Effect of cataract grade according to wide-field fundus images on measurement of macular thickness in cataract patients[J]. Korean J Ophthalmol, 2018, 32(3): 172-181. DOI: 10.3341/kjo.2017.0067.
9.	Uzun S, Pehlivan E. Vascular density in retina and choriocapillaris as measured by optical coherence tomography angiography[J]. Am J Ophthalmol, 2016, 169: 290. DOI: 10.1016/j.ajo.2016.06.011.
10.	Kikushima W, Imai A, Toriyama Y, et al. Dynamics of macular hole closure in gas-filled eyes within 24 h of surgery observed with swept source optical coherence tomography[J]. Ophthalmic Res, 2015, 53(1): 48-54. DOI: 10.1159/000368437.
11.	Sugawara R, Nagaoka T, Kitaya N, et al. Choroidal blood flow in the foveal region in eyes with rhegmatogenous retinal detachment and scleral buckling procedures[J]. Br J Ophthalmol, 2006, 90(11): 1363-1365. DOI: 10.1136/bjo.2006.097485.
12.	Sayman Muslubas I, Karacorlu M, Hocaoglu M, et al. Subfoveal choroidal thickness changes after pars plana vitrectomy in recent onset rhegmatogenous retinal detachment[J]. Retina, 2016, 36(12): 2371-2376. DOI: 10.1097/IAE.0000000000001096.

1. Odrobina D, Golebiewska J, Maroszynska I, et al. Choroidal thickness changes after vitrectomy with silicone oiltamponade for proliferative vitreoretinopathy retinal detachment[J]. Retina, 2017, 37(11): 2124-2129. DOI: 10.1097/IAE.0000000000001437.
2. Karimia S, Entezaria M, Nikkhah H, et al. Effects of intravitreal silicone oil on subfoveal choroidal thickness[J]. Ophthalmologica, 2018, 239(2-3): 159-166. DOI: 10.1159/000485851.
3. Kim M, Kim SS, Kwon HJ, et al. Association between choroidal thickness and ocular perfusion pressure in young, healthy subjects: enhanced depth imaging optical coherence tomography study[J]. Invest Ophthalmol Vis Sci, 2012, 53(12): 7710-7717. DOI: 10.1167/iovs.12-10464.
4. Winter M, Eberhardt W, Scholz C, et al. Failure of potassium siphoning by Müller cells: a new hypothesis of perfluorocarbon liquid-induced retinopathy[J]. Invest Ophthalmol Vis Sci, 2000, 41(1): 256-261.
5. Wallman J, Wildsoet C, Xu A, et al. Moving the retina: choroidal modulation of refractive state[J]. Vision Res, 1995, 35(1): 37-50. DOI: 10.1016/0042-6989(94)e0049-q.
6. Wildsoet C, Wallman J. Choroidal and scleral mechanisms of compensation for spectacle lenses in chicks[J]. Vision Res, 1995, 35(9): 1175-1194. DOI: 10.1016/0042-6989(94)00233-c.
7. Poukens V, Glasgow BJ, Demer JL. Nonvascular contractile cells in sclera and choroid of humans and monkeys[J]. Invest Ophthalmol Vis Sci, 1998, 39(10): 1765-1774.
8. Kim M, Eom Y, Song JS, et al. Effect of cataract grade according to wide-field fundus images on measurement of macular thickness in cataract patients[J]. Korean J Ophthalmol, 2018, 32(3): 172-181. DOI: 10.3341/kjo.2017.0067.
9. Uzun S, Pehlivan E. Vascular density in retina and choriocapillaris as measured by optical coherence tomography angiography[J]. Am J Ophthalmol, 2016, 169: 290. DOI: 10.1016/j.ajo.2016.06.011.
10. Kikushima W, Imai A, Toriyama Y, et al. Dynamics of macular hole closure in gas-filled eyes within 24 h of surgery observed with swept source optical coherence tomography[J]. Ophthalmic Res, 2015, 53(1): 48-54. DOI: 10.1159/000368437.
11. Sugawara R, Nagaoka T, Kitaya N, et al. Choroidal blood flow in the foveal region in eyes with rhegmatogenous retinal detachment and scleral buckling procedures[J]. Br J Ophthalmol, 2006, 90(11): 1363-1365. DOI: 10.1136/bjo.2006.097485.
12. Sayman Muslubas I, Karacorlu M, Hocaoglu M, et al. Subfoveal choroidal thickness changes after pars plana vitrectomy in recent onset rhegmatogenous retinal detachment[J]. Retina, 2016, 36(12): 2371-2376. DOI: 10.1097/IAE.0000000000001096.

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Preliminary study on changes and mechanism of choroidal thickness in silicone oil-filled eyes

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