Research progress of exosomes in the treatment of retinal ischemia-reperfusion injury_Chinese Journal of Ocular Fundus Diseases

Authors：

Yang Weiqiang ,  Tao Yong

Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;

Corresponding author：

Tao Yong, Email: taoyong@bjcyh.com

Keywords：

Exosomes; Reperfusion injury; Review

DOI：

10.3760/cma.j.cn511434-20210308-00123

Video：

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Abstract Full text Figures/Tables Video References Cited by

Exosomes are nanovesicles actively secreted by cells, which selectively encapsulate biologically active molecules such as proteins, RNA, and cytokines. They play an important role in intercellular communication, immune regulation, and maintenance of homeostasis, which can also be used as carriers for targeted drug delivery. Retinal ischemia-reperfusion injury (RIRI) is a retinopathy that seriously threatens human vision. At present, the clinical treatment of these diseases are symptomatic treatments, and some patients have poor efficacy or even blindness. As extracellular vesicles rich in functional proteins and RNAs, exosomes can not only be used as drugs for the treatment of RIRI, but also be used as carriers for drug delivery to play synergistic therapeutic effects. In the future, with the deepening of the research on the molecular structure, contents and biological functions of exosomes, as well as the continuous development of ophthalmic biology and genetic engineering technology, exosomes are expected to exert their great potential as therapeutic drugs and carriers, and become an important means of treating RIRI.

Citation： Yang Weiqiang, Tao Yong. Research progress of exosomes in the treatment of retinal ischemia-reperfusion injury. Chinese Journal of Ocular Fundus Diseases, 2022, 38(5): 423-427. doi: 10.3760/cma.j.cn511434-20210308-00123 Copy

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27. Chen B, Caballero S, Seo S, et al. Delivery of antioxidant enzyme genes to protect against ischemia/reperfusion-induced injury to retinal microvasculature[J]. Invest Ophthalmol Vis Sci, 2009, 50(12): 5587-5595. DOI: 10.1167/iovs.09-3633.
28. Ma Q. Role of nrf2 in oxidative stress and toxicity[J]. Annu Rev Pharmacol Toxicol, 2013, 53: 401-426. DOI: 10.1146/annurev-pharmtox-011112-140320.
29. Wan P, Su W, Zhang Y, et al. LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury[J]. Cell Death Differ, 2020, 27(1): 176-191. DOI: 10.1038/s41418-019-0351-4.
30. Zhang Y, Zhang Z, Yan H. Simvastatin inhibits ischemia/reperfusion injury-induced apoptosis of retinal cells via downregulation of the tumor necrosis factor-α/nuclear factor-κB pathway[J]. Int J Mol Med, 2015, 36(2): 399-405. DOI: 10.3892/ijmm.2015.2244.
31. Aydemir O, Celebi S, Yilmaz T, et al. Protective effects of vitamin E forms (alpha-tocopherol, gamma-tocopherol and d-alpha-tocopherol polyethylene glycol 1000 succinate) on retinal edema during ischemia-reperfusion injury in the guinea pig retina[J]. Int Ophthalmol, 2004, 25(5-6): 283-289. DOI: 10.1007/s10792-005-2034-z.
32. Yazici A, Aksit H, Sari ES, et al. Comparison of pre-treatment and post-treatment use of selenium in retinal ischemia reperfusion injury[J]. Int J Ophthalmol, 2015, 8(2): 263-268. DOI: 10.3980/j.issn.2222-3959.2015.02.09.
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