• Department of Ophthalmology, Peking University People's Hospital; Eye diseases and optometry institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China;
Hou Jing, Email: drhoujing@163.com
Export PDF Favorites Scan Get Citation

Vaccine-associated uveitis (VAU) usually refers to a rare adverse reaction that occurs after vaccination. The clinical manifestations of VAU are most often anterior with mild symptoms and responded promptly to topical corticosteroids. However, more severe forms of posterior and panuveitis may also occur, such as multiple evanescent white dot syndrome, Vogt-Koyanagi-Harada syndrome, and acute posterior multifocal placoid pigment epitheliopathy. The pathogenesis of VAU is still unclear. Currently, it mainly includes vaccine Shoenfeld syndrome, type Ⅲ hypersensitivity reaction caused by immune complex deposition, direct infection with live attenuated vaccine, and molecular mimicry theory. VAU is self-limiting, and most patients heal without treatment. In the future, it is recommended to ask all patients with uveitis about their recent vaccination history in the clinic. For patients with inactivated vaccine or recombinant/subunit vaccination history, the possibility of developing Shoenfeld syndrome should be considered, and the history, signs and symptoms related to autoimmune diseases should be carefully looked for.

Citation: Wu Shuo, Zhang Chuan, Zhao Mingwei, Hou Jing. A review of pathogenesis and diagnosis and treatment of vaccine-associated uveitis. Chinese Journal of Ocular Fundus Diseases, 2023, 39(9): 773-778. doi: 10.3760/cma.j.cn511434-20220126-00046 Copy

  • Previous Article

    双眼视网膜色素变性伴色素性玻璃体囊肿
  • Next Article

    Research progress of serum anti-retinal autoantibodies in retinal diseases