Pay attention to the study of spontaneous regression of retinopathy of prematurity_Chinese Journal of Ocular Fundus Diseases

Authors：

 Wang Yusheng ¹ , Wang Liang ²

1. Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;
2. Department of Ophthalmology, The Northern Theater Air Force Hospital, Shenyang 110041, China;

Corresponding author：

Wang Yusheng, Email: wangys003@126.com

Keywords：

Retinopathy of prematurity; Regression; Editorial

DOI：

10.3760/cma.j.cn511434-20220418-00220

Video：

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Retinopathy of prematurity (ROP) has become the leading blinding eye disease in children worldwide. In recent years, the recognition and treatment of acute stage lesions have achieved remarkable results. Fundus lesions could spontaneously regress in most of children with ROP, while the understanding of the law of spontaneous regression is still very limited. Although the fundus morphology is significantly improved after spontaneous regression, the long-term prognosis of visual function is not optimistic. The introduction of new technologies such as fundus fluorescence angiography and optical coherence tomography and angiography will help further understanding the nature of the spontaneous regression. To increase the study about spontaneous regression of ROP, which has significance for rationally arranging an economical and efficient screening time, formulating a scientific and individual treatment and follow-up plan, and improving the prognosis of visual function.

Citation： Wang Yusheng, Wang Liang. Pay attention to the study of spontaneous regression of retinopathy of prematurity. Chinese Journal of Ocular Fundus Diseases, 2022, 38(7): 531-534. doi: 10.3760/cma.j.cn511434-20220418-00220 Copy

1.	Hartnett ME, Penn JS. Mechanisms and management of retinopathy of prematurity[J]. N Engl J Med, 2012, 367(26): 2515-2526. DOI: 10.1056/NEJMra1208129.
2.	Sen P, Wu WC, Chandra P, et al. Retinopathy of prematurity treatment: Asian perspectives[J]. Eye (Lond), 2020, 34(4): 632-642. DOI: 10.1038/s41433-019-0643-4.
3.	Yan HX, Li MH, Wang L, et al. Twelve-year profile of screening results of retinopathy of prematurity at a tertiary care institute in Northwest China[J]. Int J Ophthalmol, 2022, 15(2): 312-319. DOI: 10.18240/ijo.2022.02.18.
4.	Bashinsky AL. Retinopathy of prematurity[J]. N C Med J, 2017, 78(2): 124-128. DOI: 10.18043/ncm.78.2.124.
5.	Koucheki R, Isaac M, N Tehrani N, et al. Natural history and outcomes of stage 3 retinopathy of prematurity persisting beyond 40 weeks of post-menstrual age: dilemma for treatment and follow up[J]. Clin Exp Ophthalmol, 2020, 48(7): 956-963. DOI: 10.1111/ceo.13827.
6.	王亮, 张自峰, 李曼红, 等. 早产儿视网膜病变的自然退行[J]. 中华眼科杂志, 2021, 2(57): 150-155. DOI: 10.3760/cma.j.cn112142-20200331-00231.Wang L, Zhang ZF, Li MH, et al. Spontaneous regression of the retinopathy of prematurity[J]. Chin J Ophthalmol, 2021, 2(57): 150-155. DOI: 10.3760/cma.j.cn112142-20200331-00231.
7.	Wang L, Li M, Zhu J, et al. Clinical features of spontaneous regression of retinopathy of prematurity in China: a 5-year retrospective case series[J/OL]. Front Med (Lausanne), 2021, 8: 731421[2021-08-31]. https://pubmed.ncbi.nlm.nih.gov/34532335/. DOI: 10.3389/fmed.2021.731421.
8.	Chiang MF, Quinn GE, Fielder AR, et al. International classification of retinopathy of prematurity, third edition[J/OL]. Ophthalmology, 2021, 128(10): e51-e68[2021-07-08]. https://pubmed.ncbi.nlm.nih.gov/34247850/. DOI: 10.1016/j.ophtha.2021.05.031.
9.	Repka MX, Palmer EA, Tung B. Involution of retinopathy of prematurity. Cryotherapy for Retinopathy of Prematurity Cooperative Group[J]. Arch Ophthalmol, 2000, 118(5): 645-649. DOI: 10.1001/archopht.118.5.645.
10.	Wu WC, Lin RI, Shih CP, et al. Visual acuity, optical components, and macular abnormalities in patients with a history of retinopathy of prematurity[J]. Ophthalmology, 2012, 119(9): 1907-1916. DOI: 10.1016/j.ophtha.2012.02.040.
11.	Mansukhani SA, Hutchinson AK, Neustein R, et al. Fluorescein angiography in retinopathy of prematurity: comparison of infants treated with bevacizumab to those with spontaneous regression[J]. Ophthalmol Retina, 2019, 3(5): 436-443. DOI: 10.1016/j.oret.2019.01.016.
12.	尹虹, 黎晓新. 与早产儿视网膜病变自然退行有关因素的分析[J]. 眼科研究, 2006, 24(6): 643-646. DOI: 10.3760/cma.j.issn.2095-0160.2006.06.021.Yin H, Li XX. Analysis of factors of spontaneous regression of prematurity retinopathy[J]. Chin Ophthalmol Res, 2006, 24(6): 643-646. DOI: 10.3760/cma.j.issn.2095-0160.2006.06.021.
13.	Ni YQ, Huang X, Xue K, et al. Natural involution of acute retinopathy of prematurity not requiring treatment: factors associated with the time course of involution[J]. Invest Ophthalmol Vis Sci, 2014, 55(5): 3165-3170. DOI: 10.1167/iovs.13-13744.
14.	Ju RH, Zhang JQ, Ke XY, et al. Spontaneous regression of retinopathy of prematurity: incidence and predictive factors[J]. Int J Ophthalmol, 2013, 6(4): 475-480. DOI: 10.3980/j.issn.2222-3959.2013.04.13.
15.	李慧林, 张国明, 张福燕, 等. 退行期早产儿视网膜病变广角荧光素眼底血管造影特征[J]. 中华眼底病杂志, 2016, 32(4): 430-431. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.020.Li HL, Zhang GM, Zhang FY, et al. Features of wide-angle fundus fluorescein angiography in the regression of retinopathy of prematurity[J]. Chin J Ocul Fundus Dis, 2016, 32(4): 430-431. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.020.
16.	吴桢泉, 赵金凤, 张福燕, 等. 早产儿视网膜病变自然消退患儿黄斑光学相干断层扫描血管成像(OCTA)变化[J]. 眼科新进展, 2019, 39(5): 449-452. DOI: 10.13389/j.cnki.rao.2019.0103.Wu ZQ, Zhao JF, Zhang FY, et al. Observation of macular changes in spontaneously regressed retinopathy of prematurity by optical coherence tomography angiography[J]. Rec Adv Ophthalmol, 2019, 39(5): 449-452. DOI: 10.13389/j.cnki.rao.2019.0103.
17.	袁海琴, 陈妙虹, 赵金凤, 等. 早产儿视网膜病变自然消退儿童的屈光研究[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 115-118. DOI: 10.6040/j.issn.1673-3770.0.2019.010.Yuan HQ, Chen MH, Zhao JF, et al. Refractive study of children with spontaneous regression of retinopathy of prematurity[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 115-118. DOI: 10.6040/j.issn.1673-3770.0.2019.010.
18.	Fielder AR. The natural ocular outcome of premature birth and retinopathy: status at 1 year[J]. Arch Ophthalmol, 1995, 113(7): 850-851. DOI: 10.1001/archopht.1995.01100070020008.
19.	Klufas MA, Patel SN, Ryan MC, et al. Influence of fluorescein angiography on the diagnosis and management of retinopathy of prematurity[J]. Ophthalmology, 2015, 122(8): 1601-1608. DOI: 10.1016/j.ophtha.2015.04.023.
20.	张国明, 曾键. 深入研究儿童适宜眼底影像检查技术, 努力提高小儿视网膜疾病诊断水平[J]. 中华眼底病杂志, 2016, 32(3): 237-242. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.003.Zhang GM, Zeng J. Study pediatric fundus imaging techniques to improve the diagnosis of retinal diseases in children[J]. Chin J Ocul Fundus Dis, 2016, 32(3): 237-242. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.003.
21.	武雷, 李曼红, 张自峰, 等. 荧光素眼底血管造影在早产儿视网膜病变中的应用[J]. 国际眼科纵览, 2020, 44(5): 340-345. DOI: 10.3760/cma.j.issn.1673-5803.2020.05.008.Wu L, Li MH, Zhang ZF, et al. Application of fundus fluorescein angiography on retinopathy of prematurity[J]. Int Rev Ophthalmol, 2020, 44(5): 340-345. DOI: 10.3760/cma.j.issn.1673-5803.2020.05.008.
22.	Lepore D, Molle F, Pagliara MM, et al. Atlas of fluorescein angiographic findings in eyes undergoing laser for retinopathy of prematurity[J]. Ophthalmology, 2011, 118(1): 168-175. DOI: 10.1016/j.ophtha.2010.04.021.
23.	Purcaro V, Baldascino A, Papacci P, et al. Fluorescein angiography and retinal vascular development in premature infants[J]. J Matern Fetal Neonatal Med, 2012, 25(Suppl 3): S53-56. DOI: 10.3109/14767058.2012.712313.
24.	Nonobe N, Kaneko H, Ito Y, et al. Optical coherence tomography angiography of the foveal avascular zone in children with a history of treatment-requiring retinopathy of prematurity[J]. Retina, 2019, 39(1): 111-117. DOI: 10.1097/IAE.0000000000001937.
25.	Villegas VM, Capó H, Cavuoto K, et al. Foveal structure-function correlation in children with history of retinopathy of prematurity[J]. Am J Ophthalmol, 2014, 158(3): 508-512. DOI: 10.1016/j.ajo.2014.05.017.
26.	梁超群, 陈长征. 光相干断层扫描成像在早产儿视网膜病变中的应用[J]. 中华实验眼科杂志, 2019, 37(6): 493-496. DOI: 10.3760/cma.j.issn.2095-0160.2019.06.019.Liang CQ, Chen CZ. Progress of optical coherence tomography in retinopathy of prematurity[J]. Chin J Exp Ophthalmol, 2019, 37(6): 493-496. DOI: 10.3760/cma.j.issn.2095-0160.2019.06.019.
27.	Hamad AE, Moinuddin O, Blair MP, et al. Late-onset retinal findings and complications in untreated retinopathy of prematurity[J]. Ophthalmol Retina, 2020, 4(6): 602-612. DOI: 10.1016/j.oret.2019.12.015.
28.	Fulton AB, Hansen RM, Moskowitz A, et al. The neurovascular retina in retinopathy of prematurity[J]. Prog Retin Eye Res, 2009, 28(6): 452-482. DOI: 10.1016/j.preteyeres.2009.06.003.
29.	Ouyang LJ, Yin ZQ, Ke N, et al. Refractive status and optical components of premature babies with or without retinopathy of prematurity at 3-4 years old[J]. Int J Clin Exp Med, 2015, 8(7): 11854-11861.
30.	Hsieh CJ, Liu JW, Huang JS, et al. Refractive outcome of premature infants with or without retinopathy of prematurity at 2 years of age: a prospective controlled cohort study[J]. Kaohsiung J Med Sci, 2012, 28(4): 204-211. DOI: 10.1016/j.kjms.2011.10.010.

1. Hartnett ME, Penn JS. Mechanisms and management of retinopathy of prematurity[J]. N Engl J Med, 2012, 367(26): 2515-2526. DOI: 10.1056/NEJMra1208129.
2. Sen P, Wu WC, Chandra P, et al. Retinopathy of prematurity treatment: Asian perspectives[J]. Eye (Lond), 2020, 34(4): 632-642. DOI: 10.1038/s41433-019-0643-4.
3. Yan HX, Li MH, Wang L, et al. Twelve-year profile of screening results of retinopathy of prematurity at a tertiary care institute in Northwest China[J]. Int J Ophthalmol, 2022, 15(2): 312-319. DOI: 10.18240/ijo.2022.02.18.
4. Bashinsky AL. Retinopathy of prematurity[J]. N C Med J, 2017, 78(2): 124-128. DOI: 10.18043/ncm.78.2.124.
5. Koucheki R, Isaac M, N Tehrani N, et al. Natural history and outcomes of stage 3 retinopathy of prematurity persisting beyond 40 weeks of post-menstrual age: dilemma for treatment and follow up[J]. Clin Exp Ophthalmol, 2020, 48(7): 956-963. DOI: 10.1111/ceo.13827.
6. 王亮, 张自峰, 李曼红, 等. 早产儿视网膜病变的自然退行[J]. 中华眼科杂志, 2021, 2(57): 150-155. DOI: 10.3760/cma.j.cn112142-20200331-00231.Wang L, Zhang ZF, Li MH, et al. Spontaneous regression of the retinopathy of prematurity[J]. Chin J Ophthalmol, 2021, 2(57): 150-155. DOI: 10.3760/cma.j.cn112142-20200331-00231.
7. Wang L, Li M, Zhu J, et al. Clinical features of spontaneous regression of retinopathy of prematurity in China: a 5-year retrospective case series[J/OL]. Front Med (Lausanne), 2021, 8: 731421[2021-08-31]. https://pubmed.ncbi.nlm.nih.gov/34532335/. DOI: 10.3389/fmed.2021.731421.
8. Chiang MF, Quinn GE, Fielder AR, et al. International classification of retinopathy of prematurity, third edition[J/OL]. Ophthalmology, 2021, 128(10): e51-e68[2021-07-08]. https://pubmed.ncbi.nlm.nih.gov/34247850/. DOI: 10.1016/j.ophtha.2021.05.031.
9. Repka MX, Palmer EA, Tung B. Involution of retinopathy of prematurity. Cryotherapy for Retinopathy of Prematurity Cooperative Group[J]. Arch Ophthalmol, 2000, 118(5): 645-649. DOI: 10.1001/archopht.118.5.645.
10. Wu WC, Lin RI, Shih CP, et al. Visual acuity, optical components, and macular abnormalities in patients with a history of retinopathy of prematurity[J]. Ophthalmology, 2012, 119(9): 1907-1916. DOI: 10.1016/j.ophtha.2012.02.040.
11. Mansukhani SA, Hutchinson AK, Neustein R, et al. Fluorescein angiography in retinopathy of prematurity: comparison of infants treated with bevacizumab to those with spontaneous regression[J]. Ophthalmol Retina, 2019, 3(5): 436-443. DOI: 10.1016/j.oret.2019.01.016.
12. 尹虹, 黎晓新. 与早产儿视网膜病变自然退行有关因素的分析[J]. 眼科研究, 2006, 24(6): 643-646. DOI: 10.3760/cma.j.issn.2095-0160.2006.06.021.Yin H, Li XX. Analysis of factors of spontaneous regression of prematurity retinopathy[J]. Chin Ophthalmol Res, 2006, 24(6): 643-646. DOI: 10.3760/cma.j.issn.2095-0160.2006.06.021.
13. Ni YQ, Huang X, Xue K, et al. Natural involution of acute retinopathy of prematurity not requiring treatment: factors associated with the time course of involution[J]. Invest Ophthalmol Vis Sci, 2014, 55(5): 3165-3170. DOI: 10.1167/iovs.13-13744.
14. Ju RH, Zhang JQ, Ke XY, et al. Spontaneous regression of retinopathy of prematurity: incidence and predictive factors[J]. Int J Ophthalmol, 2013, 6(4): 475-480. DOI: 10.3980/j.issn.2222-3959.2013.04.13.
15. 李慧林, 张国明, 张福燕, 等. 退行期早产儿视网膜病变广角荧光素眼底血管造影特征[J]. 中华眼底病杂志, 2016, 32(4): 430-431. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.020.Li HL, Zhang GM, Zhang FY, et al. Features of wide-angle fundus fluorescein angiography in the regression of retinopathy of prematurity[J]. Chin J Ocul Fundus Dis, 2016, 32(4): 430-431. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.020.
16. 吴桢泉, 赵金凤, 张福燕, 等. 早产儿视网膜病变自然消退患儿黄斑光学相干断层扫描血管成像(OCTA)变化[J]. 眼科新进展, 2019, 39(5): 449-452. DOI: 10.13389/j.cnki.rao.2019.0103.Wu ZQ, Zhao JF, Zhang FY, et al. Observation of macular changes in spontaneously regressed retinopathy of prematurity by optical coherence tomography angiography[J]. Rec Adv Ophthalmol, 2019, 39(5): 449-452. DOI: 10.13389/j.cnki.rao.2019.0103.
17. 袁海琴, 陈妙虹, 赵金凤, 等. 早产儿视网膜病变自然消退儿童的屈光研究[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 115-118. DOI: 10.6040/j.issn.1673-3770.0.2019.010.Yuan HQ, Chen MH, Zhao JF, et al. Refractive study of children with spontaneous regression of retinopathy of prematurity[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 115-118. DOI: 10.6040/j.issn.1673-3770.0.2019.010.
18. Fielder AR. The natural ocular outcome of premature birth and retinopathy: status at 1 year[J]. Arch Ophthalmol, 1995, 113(7): 850-851. DOI: 10.1001/archopht.1995.01100070020008.
19. Klufas MA, Patel SN, Ryan MC, et al. Influence of fluorescein angiography on the diagnosis and management of retinopathy of prematurity[J]. Ophthalmology, 2015, 122(8): 1601-1608. DOI: 10.1016/j.ophtha.2015.04.023.
20. 张国明, 曾键. 深入研究儿童适宜眼底影像检查技术, 努力提高小儿视网膜疾病诊断水平[J]. 中华眼底病杂志, 2016, 32(3): 237-242. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.003.Zhang GM, Zeng J. Study pediatric fundus imaging techniques to improve the diagnosis of retinal diseases in children[J]. Chin J Ocul Fundus Dis, 2016, 32(3): 237-242. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.003.
21. 武雷, 李曼红, 张自峰, 等. 荧光素眼底血管造影在早产儿视网膜病变中的应用[J]. 国际眼科纵览, 2020, 44(5): 340-345. DOI: 10.3760/cma.j.issn.1673-5803.2020.05.008.Wu L, Li MH, Zhang ZF, et al. Application of fundus fluorescein angiography on retinopathy of prematurity[J]. Int Rev Ophthalmol, 2020, 44(5): 340-345. DOI: 10.3760/cma.j.issn.1673-5803.2020.05.008.
22. Lepore D, Molle F, Pagliara MM, et al. Atlas of fluorescein angiographic findings in eyes undergoing laser for retinopathy of prematurity[J]. Ophthalmology, 2011, 118(1): 168-175. DOI: 10.1016/j.ophtha.2010.04.021.
23. Purcaro V, Baldascino A, Papacci P, et al. Fluorescein angiography and retinal vascular development in premature infants[J]. J Matern Fetal Neonatal Med, 2012, 25(Suppl 3): S53-56. DOI: 10.3109/14767058.2012.712313.
24. Nonobe N, Kaneko H, Ito Y, et al. Optical coherence tomography angiography of the foveal avascular zone in children with a history of treatment-requiring retinopathy of prematurity[J]. Retina, 2019, 39(1): 111-117. DOI: 10.1097/IAE.0000000000001937.
25. Villegas VM, Capó H, Cavuoto K, et al. Foveal structure-function correlation in children with history of retinopathy of prematurity[J]. Am J Ophthalmol, 2014, 158(3): 508-512. DOI: 10.1016/j.ajo.2014.05.017.
26. 梁超群, 陈长征. 光相干断层扫描成像在早产儿视网膜病变中的应用[J]. 中华实验眼科杂志, 2019, 37(6): 493-496. DOI: 10.3760/cma.j.issn.2095-0160.2019.06.019.Liang CQ, Chen CZ. Progress of optical coherence tomography in retinopathy of prematurity[J]. Chin J Exp Ophthalmol, 2019, 37(6): 493-496. DOI: 10.3760/cma.j.issn.2095-0160.2019.06.019.
27. Hamad AE, Moinuddin O, Blair MP, et al. Late-onset retinal findings and complications in untreated retinopathy of prematurity[J]. Ophthalmol Retina, 2020, 4(6): 602-612. DOI: 10.1016/j.oret.2019.12.015.
28. Fulton AB, Hansen RM, Moskowitz A, et al. The neurovascular retina in retinopathy of prematurity[J]. Prog Retin Eye Res, 2009, 28(6): 452-482. DOI: 10.1016/j.preteyeres.2009.06.003.
29. Ouyang LJ, Yin ZQ, Ke N, et al. Refractive status and optical components of premature babies with or without retinopathy of prematurity at 3-4 years old[J]. Int J Clin Exp Med, 2015, 8(7): 11854-11861.
30. Hsieh CJ, Liu JW, Huang JS, et al. Refractive outcome of premature infants with or without retinopathy of prematurity at 2 years of age: a prospective controlled cohort study[J]. Kaohsiung J Med Sci, 2012, 28(4): 204-211. DOI: 10.1016/j.kjms.2011.10.010.

Chinese Journal of Ocular Fundus Diseases

Pay attention to the study of spontaneous regression of retinopathy of prematurity

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