Research progress on the safety of scleral collagen cross-linking in the prevention and control of pathological myopia_Chinese Journal of Ocular Fundus Diseases

Authors：

Wang Qingqiang ¹ , Du Xiaojun ¹ , Jia Xinguo ¹ , Mu Guoying ² , Liu Ruolan ³ ,  Chen Chunli ⁴

1. Department of Ophthalmology, Shandong Dongying Shengli Oilfield Central Hospital, Dongying 257000, China;
2. Department of Ophthalmology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, China;
3. Department of Ophthalmology, Shandong Dongying Boai Hospital, Dongying 257000, China;
4. Department of Ophthalmology, Beijing Tongren Hospital, Beijing 100010, China;

Corresponding author：

Chen Chunli, Email: chenchunli125@163.com

Keywords：

Scleral collagen crosslinking; Pathological myopia; Safety; Review

DOI：

10.3760/cma.j.cn511434-20230504-00199

Video：

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Abstract Full text Figures/Tables Video References Cited by

The incidence of myopia is increasing year by year and the trend of younger age is obvious. The situation of myopia prevention and control is very serious. The sclera is the target organ for the development of myopia. When myopia occurs and develops, the ultrastructure of the sclera tissue will undergo pathological changes, resulting in a decrease in its tensile strength, then progressive axial growth and posterior sclera expansion. Scleral collagen cross-linking can effectively increase the hardness and tensile strength of scleral tissue, which may have great potential in the prevention and control of myopia, especially pathological myopia. At present, the effectiveness of scleral collagen cross-linking technology in the prevention and treatment of pathological myopia researches are still in the stage of animal experiments, and there are a lot of controversies on the safety. The development of any new technology to ensure safety is the primary condition. A comprehensive understanding of the safety of scleral collagen crosslinking in the prevention and control of myopia can provide more basis and guidance for the further study of scleral collagen crosslinking.

Citation： Wang Qingqiang, Du Xiaojun, Jia Xinguo, Mu Guoying, Liu Ruolan, Chen Chunli. Research progress on the safety of scleral collagen cross-linking in the prevention and control of pathological myopia. Chinese Journal of Ocular Fundus Diseases, 2024, 40(1): 76-80. doi: 10.3760/cma.j.cn511434-20230504-00199 Copy

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1. Holden BA, Fricke TR, Wilson DA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050[J]. Ophthalmology, 2016, 123(5): 1036-1042. DOI: 10.1016/j.ophtha.2016.01.006.
2. Resnikoff S, Jonas JB, Friedman D, et al. Myopia-a 21st century public health issue[J/OL]. Invest Ophthalmol Vis Sci, 2019, 60(6): 1888[2019-02-28]. https://pubmed.ncbi.nlm.nih.gov/30817824/. DOI: 10.1167/iovs.18-25983.
3. 汪宇涵, 乔利亚. 后巩膜加固术治疗病理性近视眼的研究进展[J]. 中华眼科杂志, 2021, 57(12): 852-857. DOI: 10.3760/cma.j.cn112142-20210707-00324.Wang YH, Qiao LY. Analysis of the treatment effect of posterior scleral reinforcement on pathological myopia[J]. Chin J Ophthalmol, 2021, 57(12): 852-857. DOI: 10.3760/cma.j.cn112142-20210707-00324.
4. 徐玉珊, 宋彦铮, 张丰菊. 巩膜胶原交联术防控近视研究的新进展[J]. 中国科学(生命科学), 2022, 52(7): 1076-1088. DOI: 10.1360/SSV-2021-0078.Xu YS, Song YZ, Zhang FJ. Advances in preventing myopia by scleral collagen crosslinking[J]. Sci Sin Vitae, 2022, 52(7): 1076-1088. DOI: 10.1360/SSV-2021-0078.
5. Jiang B, Wu ZY, Zhu ZC, et al. Expression and role of speciﬁcity protein 1 in the sclera remodeling of experimental myopia in guinea pigs[J]. Int J Ophthalmol, 2017, 10(4): 550-554. DOI: 10.18240/ijo.2017.04.08.
6. Liu YX, Sun Y. MMP-2 participates in the sclera of guinea pig with form-deprivation myopia via IGF-1/STAT3 pathway[J]. Eur Rev Med Pharmacol Sci, 2018, 22(9): 2541-2548. DOI: 10.26355/eurrev_201805_14945.
7. She JM, Li B, Li T, et al. Modulation of the ERK1/2-MMP-2 pathway in the sclera of guinea pigs following induction of myopia by ﬂickering light[J]. Exp Ther Med, 2021, 21(4): 371. DOI: 10.3892/etm.2021.9802.
8. Liang Y, Song Y, Zhang F, et al. Effect of a single nucleotide polymorphism in theLAMA1 promoter region on transcriptional activity: implication for pathological myopia[J]. Curr Eye Res, 2016, 41(10): 1379-1386. DOI: 10.3109/02713683.2015.1118129.
9. Ohno-Matsui K, Jonas JB. Posterior staphyloma in pathologic myopia[J]. Prog Retin Eye Res, 2019, 70: 99-109. DOI: 10.1016/j.preteyeres.2018.12.001.
10. Wu D, Lim DK, Lim BXH, et al. Corneal cross-linking: the evolution of treatment for corneal diseases[J/OL]. Front Pharmacol, 2021, 12: 686630[2021-07-19]. https://pubmed.ncbi.nlm.nih.gov/34349648/. DOI: 10.3389/fphar.2021.686630.
11. 林晓, 周浩. 巩膜胶原交联术在近视中的研究进展[J]. 中国眼耳鼻喉科杂志, 2018, 18(40): 278-281. DOI: 10.14166/j.issn.1671-2420.2018.04.019.Lin X, Zhou H. Research advances of scleral collagen cross-linking techniques in prevention of myopia[J]. Chin J Ophthalmol and Otorhinolaryngol, 2018, 18(40): 278-281. DOI: 10.14166/j.issn.1671-2420.2018.04.019.
12. Wollensak G, Spoerl E. Collagen crosslinking of human and porcine sclera[J]. J Cataract Refract Sur, 2004, 30(3): 689-695. DOI: 10.1016/j.jcrs.2003.11.032.
13. Han D, He MN, Zhu Y, et al. Protective effects of riboflavin-UVA-mediated posterior sclera collagen cross-linking in a guinea pig model of form-deprived myopia[J]. Int J Ophthalmol, 2021, 14(3): 333-340. DOI: 10.18240/ijo.2021.03.01.
14. 蔡紫妍, 刘可, 段宣初. 巩膜交联在病理性近视和青光眼治疗中的应用进展[J]. 中华实验眼科杂志, 2021, 39(2): 1109-1114. DOI: 10.3760/cma.j.cn115989-20191107-00485.Cai ZY, Liu K, Duan XC, Progress of scleral cross-linking in the treatment of pathological myopia and glaucoma[J]. Chin J Exp Ophthalmol, 2021, 39(12): 1109-1114. DOI: 10.3760/cma.j.cn115989-20191107-00485.
15. Chen B, Li X, Sun Y, et al. Study of the effects of rabbit scleral fibroblasts on cellular biomechanical properties and MMP-2 expression using two modes of riboflavin/ultraviolet A wave collagen cross-linking[J/OL]. Exp Eye Res, 2021, 212: 108695[2021-07-03]. https://pubmed.ncbi.nlm.nih.gov/34228966/. DOI: 10.1016/j.exer.2021.108695.
16. Zhu SQ, Pan AP, Zheng LY, et al. Posterior scleral reinforcement using genipin-crosslinked sclera for macular hole retinal detachment in highly myopic eyes[J]. Br J Ophthalmol, 2018, 102(12): 1701-1704. DOI: 10.1136/bjophthalmol-2017-311340.
17. 明春秀, 刘丽梅, 张少斌. 影响核黄素-紫外线A巩膜胶原交联治疗病理性近视的主要因素[J]. 国际眼科纵览, 2019, 43(3): 180-183. DOI: 10.3760/cma.j.issn.1673-5803.2019.03.008.Ming CX, Liu LM, Zhang SB. Main factors affecting riboflavin-UVA scleral collagen cross-linking for pathological myopia[J]. Int Rev Ophthmol, 2019, 43(3): 180-183. DOI: 10.3760/cma.j.issn.1673-5803.2019.03.008.
18. Wollensak G, Iomdina E, Dittert DD, et al. Cross-linking of scleral collagen in the rabbit using riboflavin and UVA[J]. Acta Ophthalmol Scand, 2005, 83(4): 477-482. DOI: 10.1111/j.1600-0420.2005.00447.x.
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Chinese Journal of Ocular Fundus Diseases

Research progress on the safety of scleral collagen cross-linking in the prevention and control of pathological myopia

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