- 1. Guangxi University of Traditional Chinese Medicine, Graduate School, Nanning 530001, China;
- 2. The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530001, China;
Zhong Shuyang,
Email: 360068099@qq.com
Iron death is an alternative to normal cell death and is regulated by a variety of cellular metabolic pathways. Iron death has become a hot topic of research because it can cause damage to various organs and degenerative diseases in the body. Metabolism, signalling pathways, endoplasmic reticulum stress, and immune cells can all affect the occurrence of iron death, and the blood-retina destruction induced by iron death plays an important role in autoimmune uveitis. Exploring the components of the blood-retina regulatory mechanism of iron death in autoimmune uveitis can lead to the search for targeted drug targets, which can provide a new research idea for the subsequent study of the diagnosis and treatment of autoimmune uveitis.
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| 3. | 陈双兰, 刘青松, 胡双元, 等. 铁死亡及其在炎症性肠病中对肠上皮细胞作用机制的研究进展[J]. 中国药理学通报, 2023, 39(12): 2210-2215. DOI: 10.12360/CPB202205107.Chen SL, Liu QS, Hu SY, et al. Research progress of ferroptosis and its mechanism of action on intestinal epithelial cells in inflammatory bowel disease[J]. Chinese Pharmacological Bulletin, 2023, 39(12): 2210-2215. DOI: 10.12360/CPB202205107. |
| 4. | 王晓璇, 王彦, 张铭连, 等. 铁死亡在视网膜缺血再灌注损伤中的作用及中药治疗的研究进展[J]. 中国中医眼科杂志, 2023, 33(12): 1166-1170. DOI: 10.13444/j.cnki.zgzyykzz.2023.12.015.Wang XX, Wang Y, Zhang ML, et al. The role of ferroptosis in retinal ischemia-reperfusion injury and research progress in traditional Chinese medicine treatment[J]. Chinese Journal of Chinese Ophthalmology, 2023, 33(12): 1166-1170. DOI: 10.13444/j.cnki.zgzyykzz.2023.12.015. |
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| 6. | 徐丽程, 田霖丽, 刘鸣. 铁死亡的代谢关联机制及其在肿瘤免疫治疗中的作用研究进展[J]. 中国肿瘤临床, 2021, 48(1): 40-44. DOI: 10.3969/j.issn.1000-8179.2021.01.967.Xu LC, Tian LL, Liu M. Progress in the study of metabolism-associated mechanism of iron death and its role in tumour immunotherapy[J]. China Cancer Clin, 2021, 48(1): 40-44. DOI: 10.3969/j.issn.1000-8179.2021.01.967. |
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- 1. 杨明, 何笑英, 韩伟. 自身免疫性葡萄膜炎中免疫细胞的功能及变化的研究进展[J]. 细胞与分子免疫学杂志, 2023, 39(1): 81-87.Yang M, He XX, Han W. The function and changes of immune cells in autoimmune uveitis[J]. Chinese Journal of Cellular and Molecular Immunology, 2023, 39(1): 81-87.
- 2. 李江伟, 张艳雪, 彭静娴, 等. 彭清华分期辨治自身免疫性葡萄膜炎经验[J]. 中医杂志, 2023, 64(23): 2393-2396,2406. DOI: 10.13288/j.11-2166/r.2023.23.004.Li JW, Zhang YX, Peng JX, et al. Peng Qinghua's experience in the staged treatment of autoimmune uveitis[J]. Journal of Traditional Chinese Medicine, 2023, 64(23): 2393-2396,2406. DOI: 10.13288/j.11-2166/r.2023.23.004.
- 3. 陈双兰, 刘青松, 胡双元, 等. 铁死亡及其在炎症性肠病中对肠上皮细胞作用机制的研究进展[J]. 中国药理学通报, 2023, 39(12): 2210-2215. DOI: 10.12360/CPB202205107.Chen SL, Liu QS, Hu SY, et al. Research progress of ferroptosis and its mechanism of action on intestinal epithelial cells in inflammatory bowel disease[J]. Chinese Pharmacological Bulletin, 2023, 39(12): 2210-2215. DOI: 10.12360/CPB202205107.
- 4. 王晓璇, 王彦, 张铭连, 等. 铁死亡在视网膜缺血再灌注损伤中的作用及中药治疗的研究进展[J]. 中国中医眼科杂志, 2023, 33(12): 1166-1170. DOI: 10.13444/j.cnki.zgzyykzz.2023.12.015.Wang XX, Wang Y, Zhang ML, et al. The role of ferroptosis in retinal ischemia-reperfusion injury and research progress in traditional Chinese medicine treatment[J]. Chinese Journal of Chinese Ophthalmology, 2023, 33(12): 1166-1170. DOI: 10.13444/j.cnki.zgzyykzz.2023.12.015.
- 5. Stockwell BR, Friedmann Angeli JP, Bayir H, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease[J]. Cell, 2017, 171(2): 273-285. DOI: 10.1016/j.cell.2017.09.021.
- 6. 徐丽程, 田霖丽, 刘鸣. 铁死亡的代谢关联机制及其在肿瘤免疫治疗中的作用研究进展[J]. 中国肿瘤临床, 2021, 48(1): 40-44. DOI: 10.3969/j.issn.1000-8179.2021.01.967.Xu LC, Tian LL, Liu M. Progress in the study of metabolism-associated mechanism of iron death and its role in tumour immunotherapy[J]. China Cancer Clin, 2021, 48(1): 40-44. DOI: 10.3969/j.issn.1000-8179.2021.01.967.
- 7. Böhm EW, Buonfiglio F, Voigt AM, et al. Oxidative stress in the eye and its role in the pathophysiology of ocular diseases[J/OL]. Redox Biol, 2023, 68: 102967[2023-11-18]. https://pubmed.ncbi.nlm.nih.gov/38006824/. DOI: 10.1016/j.redox.2023.102967.
- 8. Rademaker G, Boumahd Y, Peiffer R, et al. Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells[J]. Redox Biol, 2022, 53: 102324[2022-05-04]. https://pubmed.ncbi.nlm.nih.gov/35533575/. DOI: 10.1016/j.redox.2022.102324.
- 9. Huang J, Zhang J, Ma J, et al. Inhibiting ferroptosis: a novel approach for ulcerative colitis therapeutics[J/OL]. Oxid Med Cell Longev, 2022, 2022: 9678625[2022-03-26]. https://pubmed.ncbi.nlm.nih.gov/35378823/. DOI: 10.1155/2022/9678625 .
- 10. Stockwell BR. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications[J]. Cell, 2022, 185(14): 2401-2421. DOI: 10.1016/j.cell.2022.06.003.
- 11. Fan J, Jiang T, He D. Emerging insights into the role of ferroptosis in the pathogenesis of autoimmune diseases[J/OL]. Front Immunol, 2023, 14: 1120519[2023-03-30]. https://pubmed.ncbi.nlm.nih.gov/37063835/. DOI: 10.3389/fimmu.2023.1120519.
- 12. Battaglia AM, Chirillo R, Aversa I, et al. Ferroptosis and cancer: mitochondria meet the "Iron Maiden" cell death[J/OL]. Cells, 2020, 9(6): 1505[2022-06-20]. https://pubmed.ncbi.nlm.nih.gov/32575749/. DOI: 10.3390/cells9061505.
- 13. 李敏, 莫诗雯, 李伊, 等. 血-视网膜屏障损伤的机制及治疗对策[J]. 国际眼科杂志, 2020, 20(11): 1902-1906. DOI: 10.3980/j.issn.1672-5123.2020.11.13.Li M, Mo SW, Li Y, et al. Mechanisms and therapeutic countermeasures of blood-retinal barrier damage[J]. Int Eye Sci, 2020, 20(11): 1902-1906. DOI: 10.3980/j.issn.1672-5123.2020.11.13.
- 14. Yemanyi F, Bora K, Blomfield AK, et al. Wnt signaling in inner blood-retinal barrier maintenance[J/OL]. Int J Mol Sci, 2021, 22(21): 11877[2021-11-02]. https://pubmed.ncbi.nlm.nih.gov/34769308/. DOI: 10.3390/ijms222111877.
- 15. Chen YH, Eskandarpour M, Zhang X, et al. Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis[J]. J Neuroinflammation, 2021, 18(1): 49. DOI: 10.1186/s12974-021-02080-8.
- 16. Weigelt CM, Zippel N, Fuchs H, et al. Characterization and validation of in vitro and in vivo models to investigate TNF-α-induced inflammation in retinal diseases[J]. Transl Vis Sci Technol, 2022, 11(5): 18. DOI: 10.1167/tvst.11.5.18.
- 17. Fan W, Wang X, Zeng S, et al. Global lactylome reveals lactylation-dependent mechanisms underlying TH17 differentiation in experimental autoimmune uveitis[J/OL]. Sci Adv, 2023, 9(42): 4655[2023-10-20]. https://pubmed.ncbi.nlm.nih.gov/37851814/. DOI: 10.1126/sciadv.adh4655.
- 18. Galaris D, Barbouti A, Pantopoulos K. Iron homeostasis and oxidative stress: an intimate relationship[J/OL]. Biochim Biophys Acta Mol Cell Res, 2019, 1866(12): 118535[2019-08-22]. https://pubmed.ncbi.nlm.nih.gov/31446062/. DOI: 10.1016/j.bbamcr.2019.118535.
- 19. Yang S, Lian G. ROS and diseases: role in metabolism and energy supply[J]. Mol Cell Biochem, 2020, 467(1-2): 1-12. DOI: 10.1007/s11010-019-03667-9.
- 20. Tisi A, Feligioni M, Passacantando M, et al. The impact of oxidative stress on blood-retinal barrier physiology in age-related macular degeneration[J]. Cells, 2021, 10(1): 64. DOI: 10.3390/cells10010064.
- 21. Li D, Li Y. The interaction between ferroptosis and lipid metabolism in cancer[J]. Signal Transduct Target Ther, 2020, 5(1): 108. DOI: 10.1038/s41392-020-00216-5.
- 22. Iyer S, Lagrew MK, et al. The vitreous ecosystem in diabetic retinopathy: insight into the patho-mechanisms of disease[J/OL]. Int J Mol Sci, 2021, 22(13): 7142[2021-07-01]. https://pubmed.ncbi.nlm.nih.gov/34281192/. DOI: 10.3390/ijms22137142.
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