Radiotherapy for refractory choroidal hemangioma_Chinese Journal of Ocular Fundus Diseases

Authors：

LiJi ,  WangShengzi , XuGezhi , 王文吉

Department of Radiotherapy, The EENT Hospital of Fudan University, Shanghai 200031 China;

Corresponding author：

WangShengzi, Email: shengziwang@fudan.edu.cn

Keywords：

Choroid neoplasms/therapy; Hemangioma/therapy; Radiotherapy

DOI：

10.3760/cma.j.issn.1005-1015.2014.05.010

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Objective To observe the effectiveness of radiotherapy for refractory choroidal hemangioma. Methods Eight patients (8 eyes) with choroidal hemangioma were enrolled in this retrospective study. All the patients had received laser or photodynamic therapy before without effectiveness. The patients included 7 males and 1 females. The age was ranged from 11 to 54 years old, with an average of (27.50±15.18) years. All the patients were affected unilaterally, including 3 right eyes and 5 left eyes. There were 5 eyes with circumscribed choroidal hemangioma, 3 eyes with diffused choroidal hemangioma. All eyes had extensively exudative retinal detachment. The vision was from light sensation to 0.01. The volume of the tumors was ranged from 1.96 to 5.35 cm³, with a mean of (3.37±1.06) cm³. All the patients were treated with X rays by conventional fractional radiotherapy. Four of 8 patients were applied 24Gy totally in 8 fractions, while the other 4 patients were applied 46Gy in 23 fractions. Follow-up period ranged from 7 to 95 months, with medium of 42 months. Results Retinas reattached in all the eyes while exudation being absorbed. No retinal detachment happened again. To the last follow-up, the vision was from light sensation to 0.6. Visual activity improved in 6 eyes while 2 eyes improved obviously. Visual acuity was stable in remaining 2 eyes. The volume of the tumors decreased to 1.24-2.16 cm³, with a mean of (1.68±0.30) cm³. The percentage of the tumor decreased by 14.6-72.7, with an average of (44.89±21.30)%. No radiotherapy-associated complication occurred. Conclusion Radiotherapy is an efficient and safe treatment for refractory choroidal hemangioma.

Citation： LiJi, WangShengzi, XuGezhi. Radiotherapy for refractory choroidal hemangioma. Chinese Journal of Ocular Fundus Diseases, 2014, 30(5): 470-472. doi: 10.3760/cma.j.issn.1005-1015.2014.05.010 Copy

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6.	Porrini G, Giovannini A, Amato G, et al. Photodynamic therapy of circumscribed choroidal hemangioma[J]. Ophthalmology, 2003, 110:674-680.
7.	Shields JA. Photodynamic therapy for choroidal hemangioma[J]. Graefe's Arch Clin Exp Ophthalmol, 2006, 244:1071-1072.
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10.	Higginson DS, Sahgal A, Lawrence MV, et al. External beam radiotherapy for head and neck cancers is associated with increased variability in retinal vascular oxygenation. PLos One, 2013,8:69657.[2013-08-06]http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0069657.

1. 彭晓燕,王光璐. 经瞳孔温热疗法治疗孤立性脉络膜血管瘤[J]. 中华眼底病杂志,2002,18:190-192.
2. Shields JA, Shields CL.A text and atlas[M]//Shields JA, Shields CL. Intraocular tumors. Philadelphia:WB Saunders, 1992:240-252.
3. 彭晓燕, 王光璐, 张风, 等. 孤立性脉络膜血管瘤的临床疗效观察[J]. 中国实用眼科杂志, 2003:906-907.
4. Jurklies B, Anastassiou G, Ortmans S, et al. Photodynamic therapy using verteporfin in circumscribed choroidal haemangioma[J]. Br J Ophthalmol, 2003, 87:84-89.
5. Verbraak FD, Schlingemann RO, Keunen JE, et al. Longstanding symptomatic choroidal hemangioma managed with limited PDT as initial or salvage therapy[J]. Graefe's Arch Clin Exp Ophthalmol, 2003, 241:891-898.
6. Porrini G, Giovannini A, Amato G, et al. Photodynamic therapy of circumscribed choroidal hemangioma[J]. Ophthalmology, 2003, 110:674-680.
7. Shields JA. Photodynamic therapy for choroidal hemangioma[J]. Graefe's Arch Clin Exp Ophthalmol, 2006, 244:1071-1072.
8. Bekkering GE, Rutjes AW, Vlassov VV, et al. The effectiveness and safety of proton radiation therapy for indications of the eye:a systematic review[J]. Strahlenther Onkol, 2009, 185:211-221.
9. Ritland JS, Eide N, Tausj∅ J. External beam irradiation therapy for choroidal haemangiomas:visual and anatomical results after a dose of 20 to 25 Gy[J]. Acta Ophthalmol Scand, 2001, 79:184-186.
10. Higginson DS, Sahgal A, Lawrence MV, et al. External beam radiotherapy for head and neck cancers is associated with increased variability in retinal vascular oxygenation. PLos One, 2013,8:69657.[2013-08-06]http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0069657.

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