Measurement of retinal thickness in different regions of macular in middle-aged and elderly myopic patients_Chinese Journal of Ocular Fundus Diseases

Authors：

BoQiyu , ZhangYan , YuGuangwei , 宫雪 , 邵彦 , 李筱荣 ,  王飞

Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, The College of Optometry and Ophthalmology, Tianjin Medical University. Tianjin 300384, China;

Corresponding author：

王飞, Email: wangfei1@gmail.com

Keywords：

Myopia/physiopathology; Retina; Macula lutea; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2014.06.004

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Objective To measure the macular retinal thickness of middle-aged and elderly myopic patients and examine the correlations between the macular retinal thickness and the axial length (AL), diopter, corrected visual acuity and gender. Methods Eight-five middle-aged and elderly myopic patients (96 eyes), including 43 females (52 eyes) and 42 males (44 eyes), with an average age of 63±6 years, were enrolled in this study. All subjects underwent a full ophthalmic examination including visual acuity, intraocular pressure, slit lamp, indirect ophthalmoscopy, OCT, refraction and diopter and A-scan ultrasound biometry. The patients were divided into three groups according to the AL and spherical equivalent degree (SED) that stands for diopter, including low and intermediate myopia group, high myopia group and super high myopia group. There were no significant differences in age (χ²=1.875), gender (χ²=0.667) and right/left eye distribution (χ²=0.375) among the 3 groups (P > 0.05), and significant differences were found in the AL (F=345.75), SED (F=239.05) and corrected visual acuity (F=3.679) among the 3 groups of patients (P < 0.05). SD-OCT was used to measure the total average macular thickness (TR), central subfield thickness, and the retina thickness in 4 quadrants of the inner and outer ring (IR/OR) of macular. Correlation between AL, SED, and corrected visual acuity with macular TR was analyzed by Pearson correlation analysis. Independent-Sample Test was used in TR comparison in different sex-group and macular retina area. Results The retinal thickness of all the macular regions, except those at inferior and superior inner ring of macular, was significantly different among the 3 groups (F=6.794, 10.155, 5.861, 6.692, 12.081, 10.729, 5.137; P < 0.05).The retinal thickness of IR, OR and TR was significantly different among the 3 groups(F=7.370, 17.939, 15.553; P < 0.05). Superior inner macular thickness had no correlations with both AL and SED (r=-0.103, -0.098; P > 0.05). Inferior inner macular thickness had no correlations with AL, but had negative correlations with SED (r=-0.203, P < 0.05). The central subfield thickness (t=-2.082), temporal inner macular thickness (t=-2.564), superior inner thickness (t=-2.958), average inner macular thickness (t=-2.777) and TR (t=-2.400) was lower in females compared to males, and significant differences were existed (P < 0.05). Conclusions In our study, middle-aged and elderly myopic patients featured generally thinner macular retinal thickness, and the central subfield thickness, temporary and nasal inner macular thickness and all the quadrants of outer macular thickness was decreased significantly. Females are characterized by thinner central subfield thickness, inner macular thickness and total average macular thickness compared to males.

Citation： BoQiyu, ZhangYan, YuGuangwei. Measurement of retinal thickness in different regions of macular in middle-aged and elderly myopic patients. Chinese Journal of Ocular Fundus Diseases, 2014, 30(6): 549-553. doi: 10.3760/cma.j.issn.1005-1015.2014.06.004 Copy

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2.	Grossniklaus HE, Green WR. Pathologic findings in pathologic myopia[J]. Retina, 1992, 12:127-133.
3.	张艳明, 张卫红.高度近视黄斑区视网膜厚度变化规律的分析[J].国际眼科杂志, 2013, 13:950-952.
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5.	黄志坚.谁是青年——关于青年年龄界定的研究报告[Z].中国青年研究, 2003(11):31-41.
6.	Song AP, Wu XY, Wang JR, et al. Measurement of retinal thickness in macular region of high myopic eyes using spectral domain OCT[J]. Int J Ophthalmol, 2014, 7:122-127.
7.	Ruiz-Moreno JM, Staicu C, Pinero DP, et al. Optical coherence tomography predictive factors for macular hole surgery outcome[J]. Br J Ophthalmol, 2008, 92:640-644.
8.	Kok PH, van den Berg TJ, van Dijk HW, et al. The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography[J]. Acta Ophthalmol, 2013, 91:418-424.
9.	Vijaya L, George R, Asokan R, et al. Prevalence and causes of low vision and blindness in an urban population:the Chennai Glaucoma Study[J]. Indian J Ophthalmol, 2014, 62:477-481.
10.	Danquah L, Kuper H, Eusebio C, et al. The long term impact of cataract surgery on quality of life, activities and poverty:results from a six year longitudinal study in bangladesh and the Philippines. PLoS One, 2014, 9:94140.[2014-04-18]http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0094140.
11.	Lam DS, Leung KS, Mohamed S, et al. Regional variations in the relationship between macular thickness measurements and myopia[J]. Invest Ophthalmol Vis Sci, 2007, 48:376-382.
12.	林巧雅, 李学喜, 黄雪丽.高度近视眼黄斑部视网膜神经上皮层厚度的分区测量研究[J].国际眼科杂志, 2010, 10:1165-1167.
13.	赵明慧, 贾丽丽, 胡萍, 等.青年近视患者黄斑厚度的相关因素分析[J].眼科新进展, 2013, 33:961-963.
14.	Wakitani Y, Sasoh M, Sugimoto M, et al. Macular thickness measurements in healthy subjects with different axial lengths using optical coherence tomography[J]. Retina, 2003, 23:177-182.
15.	Manassakorn A, Chaidaroon W, Ausayakhun S, et al. Normative database of retinal nerve fiber layer and macular retinal thickness in a Thai population[J]. Jpn J Ophthalmol, 2008, 52:450-456.
16.	Othman SF, Sharanjeet-Kaur, Manan FA, et al. Macular thickness as determined by optical coherence tomography in relation to degree of myopia, axial length and vitreous chamber depth in Malay subjects[J]. Clin Exp Optom, 2012, 95:484-491.
17.	Song WK, Lee SC, Lee ES, et al. Macular thickness variations with sex, age, and axial length in healthy subjects:a spectral domain-optical coherence tomography study[J]. Invest Ophthalmol Vis Sci, 2010, 51:3913-3918.
18.	Wagner-Schuman M, Dubis AM, Nordgren RN, et al. Race-and sex-related differences in retinal thickness and foveal pit morphology[J]. Invest Ophthalmol Vis Sci, 2011, 52:625-634.
19.	Wu PC, Chen YJ, Chen CH, et al. Assessment of macular retinal thickness and volume in normal eyes and highly myopic eyes with third-generation optical coherence tomography[J]. Eye (Lond), 2008, 22:551-555.
20.	The Eye Disease Case-Control Study Group.Risk factors for idiopathic macular holes[J]. Am J Ophthalmol, 1994, 118:754-761.
21.	Rudnicka AR, Jarrar Z, Wormald R, et al. Age and gender variations in age-related macular degeneration prevalence in populations of European ancestry:a meta-analysis[J]. Ophthalmology, 2012, 119:571-580.

1. Hayashi K, Ohno-Matsui K, Shimada N, et al. Long-term pattern of progression of myopic maculopathy:a natural history study[J]. Ophthalmology, 2010, 117:1595-1611.
2. Grossniklaus HE, Green WR. Pathologic findings in pathologic myopia[J]. Retina, 1992, 12:127-133.
3. 张艳明, 张卫红.高度近视黄斑区视网膜厚度变化规律的分析[J].国际眼科杂志, 2013, 13:950-952.
4. Tan CS, Chan YH, Wong TY, et al. Prevalence and risk factors for refractive errors and ocular biometry parameters in an elderly Asian population:the Singapore Longitudinal Aging Study (SLAS)[J]. Eye (Lond), 2011, 25:1294-1301.
5. 黄志坚.谁是青年——关于青年年龄界定的研究报告[Z].中国青年研究, 2003(11):31-41.
6. Song AP, Wu XY, Wang JR, et al. Measurement of retinal thickness in macular region of high myopic eyes using spectral domain OCT[J]. Int J Ophthalmol, 2014, 7:122-127.
7. Ruiz-Moreno JM, Staicu C, Pinero DP, et al. Optical coherence tomography predictive factors for macular hole surgery outcome[J]. Br J Ophthalmol, 2008, 92:640-644.
8. Kok PH, van den Berg TJ, van Dijk HW, et al. The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography[J]. Acta Ophthalmol, 2013, 91:418-424.
9. Vijaya L, George R, Asokan R, et al. Prevalence and causes of low vision and blindness in an urban population:the Chennai Glaucoma Study[J]. Indian J Ophthalmol, 2014, 62:477-481.
10. Danquah L, Kuper H, Eusebio C, et al. The long term impact of cataract surgery on quality of life, activities and poverty:results from a six year longitudinal study in bangladesh and the Philippines. PLoS One, 2014, 9:94140.[2014-04-18]http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0094140.
11. Lam DS, Leung KS, Mohamed S, et al. Regional variations in the relationship between macular thickness measurements and myopia[J]. Invest Ophthalmol Vis Sci, 2007, 48:376-382.
12. 林巧雅, 李学喜, 黄雪丽.高度近视眼黄斑部视网膜神经上皮层厚度的分区测量研究[J].国际眼科杂志, 2010, 10:1165-1167.
13. 赵明慧, 贾丽丽, 胡萍, 等.青年近视患者黄斑厚度的相关因素分析[J].眼科新进展, 2013, 33:961-963.
14. Wakitani Y, Sasoh M, Sugimoto M, et al. Macular thickness measurements in healthy subjects with different axial lengths using optical coherence tomography[J]. Retina, 2003, 23:177-182.
15. Manassakorn A, Chaidaroon W, Ausayakhun S, et al. Normative database of retinal nerve fiber layer and macular retinal thickness in a Thai population[J]. Jpn J Ophthalmol, 2008, 52:450-456.
16. Othman SF, Sharanjeet-Kaur, Manan FA, et al. Macular thickness as determined by optical coherence tomography in relation to degree of myopia, axial length and vitreous chamber depth in Malay subjects[J]. Clin Exp Optom, 2012, 95:484-491.
17. Song WK, Lee SC, Lee ES, et al. Macular thickness variations with sex, age, and axial length in healthy subjects:a spectral domain-optical coherence tomography study[J]. Invest Ophthalmol Vis Sci, 2010, 51:3913-3918.
18. Wagner-Schuman M, Dubis AM, Nordgren RN, et al. Race-and sex-related differences in retinal thickness and foveal pit morphology[J]. Invest Ophthalmol Vis Sci, 2011, 52:625-634.
19. Wu PC, Chen YJ, Chen CH, et al. Assessment of macular retinal thickness and volume in normal eyes and highly myopic eyes with third-generation optical coherence tomography[J]. Eye (Lond), 2008, 22:551-555.
20. The Eye Disease Case-Control Study Group.Risk factors for idiopathic macular holes[J]. Am J Ophthalmol, 1994, 118:754-761.
21. Rudnicka AR, Jarrar Z, Wormald R, et al. Age and gender variations in age-related macular degeneration prevalence in populations of European ancestry:a meta-analysis[J]. Ophthalmology, 2012, 119:571-580.

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Measurement of retinal thickness in different regions of macular in middle-aged and elderly myopic patients

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