Application value of RetCam Ⅲ in the diagnosis of retinoblastoma_Chinese Journal of Ocular Fundus Diseases

Authors：

XueKang ,  QianJiang , YueHan , 任慧 , 郭洁

Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China;

Corresponding author：

QianJiang, Email: qianjiang58@126.com

Keywords：

Retinoblastoma/diagnosis; Ophthalmoscopy; Ultrasonography

DOI：

10.3760/cma.j.issn.1005-1015.2015.04.010

Video：

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Objective To observe the application value of RetCam Ⅲ in the diagnosis of retinoblastoma (RB). Methods The clinical data of 125 eyes from 94 patients with RB were retrospectively analyzed. According to the International Intraocular Retinoblastoma Classification, the results of binocular indirect ophthalmoscope and RetCam Ⅲ was compared. The consistency between RetCam Ⅲ and binocular indirect ophthalmoscope was analyzed by Kappa test. The detectable rates of tumor between binocular indirect ophthalmoscope, RetCam Ⅲand B scan ultrasound were comparatively analyzed. Results By binocular indirect ophthalmoscope, there were 18 eyes (14.4%) in stage A, 15 eyes (12.0%) in stage B, 10 eyes (8.0%) in stage C, 28 eyes (22.4%) in stage D, and 54 eyes (43.2%) in stage E. Using RetCam Ⅲ, the classification was 18 eyes (14.4%) in stage A, 16 eyes (12.8%) in stage B, 11 eyes (8.8%) in stage C, 27 eyes (21.6%) in stage D, and 53 eyes (42.4%) in stage E. The RB classification of RetCam Ⅲ was quite consistent with binocular indirect ophthalmoscope (Weighted Kappa Coefficient=0.979 8, 95% confidence interval=0.960 1-0.999 5). A total of 150 tumors from stage A-D were observed by binocular indirect ophthalmoscope. In which, 147 tumors (98.0%) were found by RetCam Ⅲ, 122 tumors (81.3%) were found by B scan ultrasound. No serious complication was found in these patients. Conclusions RetCam Ⅲ can detect RB of different stage in clinic. It is quite consistent with binocular indirect ophthalmoscope.

Citation： XueKang, QianJiang, YueHan. Application value of RetCam Ⅲ in the diagnosis of retinoblastoma. Chinese Journal of Ocular Fundus Diseases, 2015, 31(4): 352-354. doi: 10.3760/cma.j.issn.1005-1015.2015.04.010 Copy

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1. 钱江.视网膜母细胞瘤治疗中应注意的若干问题[J]. 眼科,2009,18(6):367-369.
2. Shields CL, Lally SE, Leahey AM, et al. Targeted retinoblastoma management: when to use intravenous, intra-arterial, periocular, and intravitreal chemotherapy[J].Curr Opin Ophthalmol, 2014,25(5):374-385.
3. Kim JW, Ngai LK, Sadda S, et al. RetCam fluorescein angiography findings in eyes with advanced retinoblastoma[J]. Br J Ophthalmol, 2014,98(12):1666-1671.
4. Roth DB, Morales D, Feuer WJ, et al. Screening for retinopathy of prematurity employing the RetCam 120: sensitivity and specificity[J]. Arch Ophthalmol,2001,119(2):268-272.
5. 赵培泉,张琦,许宇. 提高小儿视网膜疾病的认知水平,推动我国小儿视网膜疾病研究的深入开展[J]. 中华眼底病杂志,2014,30(1):1-5.
6. Shields CL,孙红,张军军, 等.视网膜母细胞瘤的临床表现和诊断[J].中华眼底病杂志,2004,20(2):118-121.
7. Shields CL, Mashayekhi A, Au AK, et al. The international classification of retinoblastoma predicts chemoreduction success[J]. Ophthalmology, 2006, 113(12):2276-2280.
8. Sury MR, Harker H,Begent J, et al. The management of infants and children for painless imaging[J]. Clin Radiol,2005,60(7):731-741.
9. Lerman J, Jöhr M. Inhalational anesthesia vs.total intravenous anesthesia(TIVA)for pediatric anesthesia[J]. Paediatr Anaesth, 2009,19(5):521-534.

Chinese Journal of Ocular Fundus Diseases

Application value of RetCam Ⅲ in the diagnosis of retinoblastoma

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