Comparative observation of indocyanine green angiography and optical coherence tomography angiography in polypoidal choroidal vasculopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

MaNan ,  ChenYouxin , GongDi , 李东辉

Department of Ophthalmology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100730, China;

Corresponding author：

ChenYouxin, Email: chenyouxinpumch@163.com

Keywords：

Choroid diseases/diagnosis; Indocyanine green/diagnostic use; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2015.05.003

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To observe the characteristics of indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA) in polypoidal choroidal vasculopathy (PCV). Methods 17 patients (17 eyes) with PCV referred to Peking Union Medical College Hospital from November 2014 to February 2015 were included in this cross-sectional study. There were 9 males (9 eyes) and 8 females (8 eyes), aged from 55 to 79 years, with the mean of (68.24±6.80) years. There were 10 right eyes and 7 left eyes. All patients were examined by fundus fluorescein angiography combined with ICGA, and OCTA was performed within 1 hour. Results ICGA showed 5 eyes with branching vascular network (BVN), 7 eyes with polyps, only 1 eye with both BVN and polyps. 4 eyes showed no positive findings, 3 of them with large hemorrhage. 5 eyes with BVN shared the similar location and range of the lesions in ICGA and OCTA. 7 eyes with polyps showed hot spot in OCTA, 5 of them shared the similar lesions with ICGA, the other 2 eyes showed slightly different in ICGA and OCTA. 1 eye showed both BVN and polyps, OCTA and ICGA were consistent for this. In the 3 eyes with large hemorrhage, 2 of them showed hot spot below pigment epithelial detachment, 1 eye show no positive findings in both ICGA and OCTA. Conclusions PCV patients with BVN shared similar findings in ICGA and OCTA, PCV patients with polyps showed highlight spot in OCTA. OCTA can visualize BNV and polyps of choroidal capillary, and it can showed the similar site and range of lesions in ICGA.

Citation： MaNan, ChenYouxin, GongDi. Comparative observation of indocyanine green angiography and optical coherence tomography angiography in polypoidal choroidal vasculopathy. Chinese Journal of Ocular Fundus Diseases, 2015, 31(5): 421-424. doi: 10.3760/cma.j.issn.1005-1015.2015.05.003 Copy

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1. Escano MF, Fujii S, Ishibashi K, et al. Indocyanine green videoangiography in macular variant of idiopathic polypoidal choroidal vasculopathy[J]. Jpn J Ophthalmol, 2000, 44(3):313-316.
2. Tokayer J, Jia Y, Dhalla AH, et al. Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography[J]. Biomed Opt Express, 2013, 4(10):1909-1924.
3. Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography[J].Opt Express, 2012, 20(4):4710-4725.
4. Japanese Study Group of Polypoidal Choroidal Vasculopathy. Criteria for diagnosis of polypoidal choroidal vasculopathy[J].Nippon GakkaiZasshi, 2005, 109(7):417-427.
5. 陈有信.吲哚青绿脉络膜血管造影Ⅰ.基本情况[J].中华眼底病杂志, 1994, 10(4):253-255.
6. Wei E, Jia Y, Tan O, et al. Parafoveal retinal vascular response to pattern visual stimulation assessed with OCT angiography. PLoS One, 2013, 8(12):81343.http://dx.plos.org/10.1371/journal.pone.0081343.
7. Jia Y, Bailey ST, Wilson DJ, et al. Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration[J]. Ophthalmology, 2014, 121(7):1435-1444.
8. Jia Y, Wei E, Wang X, et al. Optical coherence tomography angiography of optic disc perfusion in glaucoma[J]. Ophthalmology, 2014, 121(7):1322-1332.
9. Jia Y, Morrison JC, Tokayer J, et al. Quantitative OCT angiography of optic nerve head blood flow[J]. Biomed Opt Express, 2012, 3(12):3127-3137.

Chinese Journal of Ocular Fundus Diseases

Comparative observation of indocyanine green angiography and optical coherence tomography angiography in polypoidal choroidal vasculopathy

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