ZhangHong , LuoYingzi , SongKe , 张津京 , 杨佳 , 袁敏立 , 孟宁 , 范洋 , 庄曾渊
  • Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China;
ZhangHong, Email: zhanghong_zhbj@sina.com
Retinitis pigmentosa/complications; Choroid; Vision disorders/etiology; Tomography, optical coherence
10.3760/cma.j.issn.1005-1015.2015.05.006
Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables References Cited by

Objective To analyze the subfoveal choroidal thickness in retinitis pigmentosa (RP) patients and to evaluate the correlation between the subfoveal choroidal thickness (SCT) and visual function. Methods Totally 42 RP patients (84 eyes) and 49 age and diopter-matched normal controls (98 eyes) were enrolled in this study. All the patients were taken the enhanced depth imaging technique of optical coherence tomography (EDI-OCT) examination for the measurement of the SCT. The covariate analysis was used to analyze the interaction effect between age and group. Then the SCT was amended. The RP patients were examined by 30°visual field test (T32 or LVC program) and electroretinogram (ERG) test. 32 eyes examined by T32 program, 52 eyes examined by LVC program. The waveform of ERG, mean sensitivity (MS) and mean defect (MD) were recorded. The relationship of SCT, MS and MD were analyzed by Pearson correlation analysis. Results The SCT of RP patients and controls were (223.12±69.59), (288.29±52.36) μm. The covariate analysis of covariance with different age group interaction was not statistically significant (F=1.619, P=0.205), as amended SCT of RP patients and controls were (217.34±6.60), (293.20±6.00) μm, respectively. The SCT was decreased in RP patients (t=7.042, P < 0.001). Among 84 eyes, bright cone response weaken in 35 eyes, scotopic rod response weaken in 31 eyes. The difference of SCT in different ERG waveform was not significant (t=-0.976, -1.584; P=0.332, 0.117). The MS and MD of 32 eyes using T32 program were (9.05±6.42), (18.84±6.30) dB, the SCT was (209.83±71.48) μm; the MS and SCT of 52 eyes using LVC program were (7.14±5.03) dB and (228.32±66.32) μm. The SCT was related to MS (r=0.494, P=0.003) and MD (r=-0.448, P=0.009) in eyes using T32 program. There was no correlation between SCT and MD in eyes using LVC program (r=-0.232, P=0.095). Conclusions The SCT of RP patients is thinner than that of normal controls. The SCT of RP patients is related to MS and MD of T32 program, but not correlated to ERG waveform and MS of LVC program.

Citation： ZhangHong, LuoYingzi, SongKe. Correlation of choroidal thickness and visual function in retinitis pigmentosa patients. Chinese Journal of Ocular Fundus Diseases, 2015, 31(5): 435-438. doi: 10.3760/cma.j.issn.1005-1015.2015.05.006 Copy

  • Previous Article

    Ocular optical coherence tomography characteristics of pregnancy-induced hypertension syndrome and its correlation with ocular symptoms and degree of the systemic disease

  • Next Article

    Correlation study between retinal thickness and age, gender of normal children in the urban of Beijing