The degree of choriocapillary ectasia and sub-foveal choroidal thickness in central serous chorioretinopathy with different activity and the correlation analysis among them_Chinese Journal of Ocular Fundus Diseases

Authors：

 YangZhi , WangHailin

Clinic Scientific Research Center, Department of Ophthalmology, The Forth People's Hospital of Shenyang, Shenyang 110031, China;

Corresponding author：

YangZhi, Email: sysywhl@aliyun.com

Keywords：

Central serous chorioretinopathy/diagnosis; Fluorescein angiography; Tomography, optical coherence; Diagnostic imaging

DOI：

10.3760/cma.j.issn.1005-1015.2016.03.008

Video：

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Objective To observe the degree of choriocapillary ectasia (CCE) and sub-foveal choroidal thickness (SFCT) in central serous chorioretinopathy (CSC) with different activity and discuss their relations. Methods Forty eyes of 40 CSC patients were recruited. The activity of CSC was determinate by fundus fluorescein angiography (FFA). There were 23 eyes with active CSC (active-CSC group), and 17 eyes with inactive CSC (inactive-CSC group). All eyes in both groups were examined with optical coherence tomography angiography(OCTA), and the CCE area of the choriocapillary layer was measured within a 3 mm×3 mm zone centered on the central fovea of macula. Ectasia was classified based on CCE area, more than 66% of examination area was high ectasia, and 33%-66% as medium ectasia, below 33% as low ectasia. SFCT was measured with frequency domain optical coherence tomography. The relationship between CCE degree, SFCT and CSC group was analyzed. Results Among the 23 eyes of active-CSC group, there were 5 eyes of low ectasia, 12 eyes of medium ectasia, 6 eyes of high ectasia. Among 17 eyes of inactive-CSC group, there were 11, 4, 2 eyes of low, medium and high ectasia respectively. Active-CSC group had more advanced degree of ectasia than that in inactive-CSC group(Z=-2.472, P=0.013).SFCT of active-CSC group and inactive-CSC group were (418.13±126.15), (429.76±105.80) μm respectively, the difference was not significant (t=-0.308, P=0.760). SFCT in eyes with low ectasia, medium ectasia, high ectasia were (419.13±105.60), (381.00±125.12), (515.13±67.68) μm respectively. The difference among the three group was statistical significant (F=4.106, P=0.025). SFCT in eyes of high ectasia was obviously thicker than low ectasia and medium ectasia, the difference was statistical significant (P=0.007, 0.048);the SFCT difference between low ectasia and medium ectasia did not appear statistical significance (P=0.326). There was no linear relation between SFCT and CCE degree (r=0.247, P=0.124). Conclusions Active-CSC eyes has more advanced CCE degree than inactive-CSC eyes, but SFCT is the same between the two groups. High ectasia eyes have thicker SFCT.

Citation： YangZhi, WangHailin. The degree of choriocapillary ectasia and sub-foveal choroidal thickness in central serous chorioretinopathy with different activity and the correlation analysis among them. Chinese Journal of Ocular Fundus Diseases, 2016, 32(3): 261-265. doi: 10.3760/cma.j.issn.1005-1015.2016.03.008 Copy

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5.	杨丽红, 田蓓, 魏文斌, 等.中心性浆液性脉络膜视网膜病变的脉络膜厚度改变[J].中华眼科杂志, 2012, 48(10):874-877. DOI:10.3760/cma.j.issn.0412-4081.2012.10.004.Yang LH, Tian B, Wei WB, et al. Changes of choroidal thickness in central serous chorioretinopathy[J]. Chin J Ocul Fundus Dis, 2012, 48(10):874-877. DOI:10.3760/cma.j.issn.0412-4081.2012.10.004.
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8.	潘英姿, 任泽钦, 李梅, 等.开角型青光眼与正常大陷凹眼中视乳头旁萎缩区的比较研究[J].中华眼科杂志, 2006, 42(12):1078-1083. DOI:10.3760/j:jssn:0412-4081.2006.12.006.Pan YZ, Ren ZQ, Li M, et. al. Peripapillary atrophies in primary open-angle glaucoma and glaucoma-like normal disks[J]. Chin J Ophthalmol, 2006, 42(12):1078-1083. DOI:10.3760/j:jssn:0412-4081.2006.12.006.
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1. 杨培增, 文峰.吲哚青绿血管造影[M]//李凤鸣.中华眼科学(上册). 2版.北京:人民卫生出版社, 2005:692-705.Yang PZ, Wen F. Indocyanine green angiography[M]//Li FM. Chinese Ophthalmology (Volume 1). 2nd ed. Beijing:People's Medical Publishing House, 2005:692-705.
2. Maruko I, Iida T, Sugano Y, et al.Subfoveal choroidal thickness in the fellow eyes of patients with central serous chorioretinopathy[J]. Retina, 2011, 31(8):1603-1608.DOI:10.1097/IAE.0b013e31820f4b39.
3. Kim YT, Kang SW, Bai KH. Choroidal thickness in both eyes of patients with unilaterally active central serous chorioretinopathy[J]. Eye (Lond), 2011, 25(12):1635-1640.DOI:10.1038/eye.2011.258.
4. Jia Y, Bailey ST, Hwang TS, et al. Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye[J]. Proc Natl Acad Sci USA, 2015, 112(18):2395-2402. DOI:10.1073/pnas.1500185112.
5. 杨丽红, 田蓓, 魏文斌, 等.中心性浆液性脉络膜视网膜病变的脉络膜厚度改变[J].中华眼科杂志, 2012, 48(10):874-877. DOI:10.3760/cma.j.issn.0412-4081.2012.10.004.Yang LH, Tian B, Wei WB, et al. Changes of choroidal thickness in central serous chorioretinopathy[J]. Chin J Ocul Fundus Dis, 2012, 48(10):874-877. DOI:10.3760/cma.j.issn.0412-4081.2012.10.004.
6. Imamura Y, Fujiwara T, Margolis R, et al. Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy[J].Retina, 2009, 29(10):1469-1473.DOI:10.1097/IAE.0b013e3181be0a83.
7. 卢宁, 王光璐, 张风, 等.多发性后极部色素上皮病变的吲哚青绿和荧光素眼底血管造影[J].中华眼底病杂志, 2000, 16(1):6-8.Lu N, Wang GL, Zhang F, et al. Indocyanine green and fluorescein angiographies of multifocal posterior pigment epitheliopathy[J]. Chin J Ocul Fundus Dis, 2000, 16(1):6-8.
8. 潘英姿, 任泽钦, 李梅, 等.开角型青光眼与正常大陷凹眼中视乳头旁萎缩区的比较研究[J].中华眼科杂志, 2006, 42(12):1078-1083. DOI:10.3760/j:jssn:0412-4081.2006.12.006.Pan YZ, Ren ZQ, Li M, et. al. Peripapillary atrophies in primary open-angle glaucoma and glaucoma-like normal disks[J]. Chin J Ophthalmol, 2006, 42(12):1078-1083. DOI:10.3760/j:jssn:0412-4081.2006.12.006.
9. Teussink MM, Breukink MB, van Grinsven MJ, et al.OCT angiography compared to fluorescein and indocyanine green angiography in chronic central serous chorioretinopathy[J]. Invest Ophthalmol Vis Sci, 2015, 56(9):5229-5237. DOI:10.1167/iovs.15-17140.
10. 陈有信, 张承芬, 韩宝玲.中心性浆液性脉络膜视网膜病变靛青绿血管造影[J].中华眼科杂志, 1997, 33(4):255-258.Chen YX, Zhang CF, Han BL. Indocyanine green angioguaphy in central serous chorioretinopathy[J]. Chin J Ophthalmol, 1997, 33(4):255-258.
11. 刘晓玲, 林冰, 瞿佳.中心性浆液性脉络膜视网膜病变的吲哚青绿和荧光素眼底血管造影[J].中华眼底病杂志, 2000, 16(1):14-16.Chen YX, Lin B, Qu J. Indocyanine green and fundus fluorescein angiography in central serous chorioretinopathy[J].Chin J Ocul Fundus Dis, 2000, 16(1):14-16.

Chinese Journal of Ocular Fundus Diseases

The degree of choriocapillary ectasia and sub-foveal choroidal thickness in central serous chorioretinopathy with different activity and the correlation analysis among them

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