Analysis of the contrast sensitivity of branch retinal vein occlusion without involving the macular region_Chinese Journal of Ocular Fundus Diseases

Authors：

 WangZhixue , CaoTingting , WangWenying , WangXue , LiuMingyuan

Ophthalmic Function Inspection Department, Cangzhou Central Hospital, Cangzhou 061001, China;

Corresponding author：

WangZhixue, Email: wangzhixue5@163.com

Keywords：

Retinal vein occlusion/physiopathology; Contrast sensitivity

DOI：

10.3760/cma.j.issn.1005-1015.2016.04.012

Video：

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Objective To observe the contrast sensitivity (CS) of patients with branch retinal vein occlusion (BRVO) without involving the macular region. Methods 92 BRVO patients (93 eyes) and 56 cases (112 eyes) without eye diseases (control group) were included in the study. According to different region, BRVO patients were divided into the nasal BRVO group (31 eyes) and temporal BRVO (62 eyes) group, and the average corrected visual acuity was 1.02±0.13 and 0.98±0.12 respectively. According to the type of ischemia, BRVO patients were divided into the nonischemic BRVO group (58 eyes) and ischemic BRVO group (35 eyes), the average corrected visual acuity was 1.01±0.14 and 0.99±0.12 respectively. The average corrected visual acuity of the control group was 1.03±0.11. There was no statistically significant difference of the average corrected visual acuity between nasal BRVO group, temporal BRVO group and control group (F=3.03, P=0.06), and between nonischemic BRVO group, ischemic BRVO group and control group (F=1.60,P=0.20). Contrast sensitivity (CS) was measured by OPTEC 6500 vision tester (Stereo Company, USA) under the standard lighting conditions and different spatial frequencies including low (1.5 and 3.0 c/d), medium (6.0 c/d) and high frequencies (12.0 and 18.0 c/d). Results The CS under each spatial frequency of the nasal BRVO group was the same as the control group (t=4.25, 9.48, 3.08, 5.86, 0.94; P>0.05), but the CS under each spatial frequency of the temporal BRVO group was different from the control group (t=8.59, 19.11, 10.38, 17.28, 6.01; P<0.05). The CS under high spatial frequency of the temporal and nasal BRVO group was statistically different (t=11.42, 6.95; P<0.05). The CS under each spatial frequency of the ischemic BRVO group was different from the control group (t=8.88, 10.56, 11.64, 19.06, 6.67; P<0.05).The CS under 6, 12 and 18 c/d spatial frequency of the nonischemic BRVO group was statistically different with the control group (t=10.14, 11.54, 2.82; P<0.05). The CS under 12 and 18 c/d spatial frequency of the nonischemic BRVO group was statistically different with the ischemic BRVO (t=7.52, 3.84; P<0.05). Conclusions The CS of the temporal BRVO and ischemic BRVO decreased more significantly under each spatial frequency. CS is a better indicator to evaluate the visual function than the visual acuity in BRVO without involving the macular region.

Citation： WangZhixue, CaoTingting, WangWenying, WangXue, LiuMingyuan. Analysis of the contrast sensitivity of branch retinal vein occlusion without involving the macular region. Chinese Journal of Ocular Fundus Diseases, 2016, 32(4): 395-398. doi: 10.3760/cma.j.issn.1005-1015.2016.04.012 Copy

1.	张菁, 蔡小军,陈晓敏,等.玻璃体腔注射康柏西普联合视网膜激光光凝治疗视网膜分支静脉阻塞继发黄斑水肿疗效观察[J].中华眼底病杂志, 2015, 31(1):22-26. DOI:10.3760/cma.j.issn.1005-1015.2015.01.007. Zhang J,Cai XJ,Chen XM,et al. A prospective randomized clinical trial on intravitreous injection of conbercept combined with laser photocoagulation for macular edema secondary to branch retinal vein occlusion[J].Chin J Ocul Fundus Dis,2015, 31(1):22-26.DOI:10.3760/cma.j.issn.1005-1015.2015.01.007.
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4.	田璐, 徐延山.视网膜颞上分支静脉阻塞光学相干断层扫描与多焦视网膜电图的观察[J].天津医科大学学报,2011,17(4):515-518.DOI:10.3969/j.issn.1006-8147.2011.04.025. Tian L,Xu YS.Optical coherence tomography and multifocai electroretinogram in superior temporal branch retinal vein occlusion[J].Journal of Tianjin Medical University,2011,17(4):515-518.DOI:10.3969/j.issn.1006-8147.2011.04.025.
5.	王文英, 冀向宁,王志学,等. 视觉对比敏感度和OCT在焊工体检中的应用[J].中华眼外伤职业眼病杂志,2015,37(8):596-600.DOI:10.3760/cma.j.issn.2095-1477.2015.08.009. Wang WY,Ji XN,Wang ZX,et al.The application of visual contrast sensitivity and OCT in physical examination of welder[J].Chin J Ocul Traum Occupat Eye Dis, 2015, 37(8):596-600.DOI:10.3760/cma.j.issn.2095-1477.2015.08.009.
6.	王文英, 冀向宁,韩风梅,等. 青年2型糖尿病早期视网膜神经纤维层厚度和视觉对比敏感度的动态变化[J].中华实验眼科杂志,2015,33(8):716-721.DOI:10.3760/cma.j.issn.2095-0160.2015.08.011. Wang WY,Ji XN,Han FM,et al.Dynamic changes of retinal nerve fiber layer thickness and visual contrast sensitivity in young population with type 2 diabetes mellitus[J].Chin J Exp Ophthalmol,2015,33(8):716-721.DOI:10.3760/cma.j.issn.2095-0160.2015.08.011.
7.	孙堂胜, 张卯年.无视网膜病变的糖尿病患者对比敏感度检测分析[J].中华眼科杂志, 2012,48(1):41-46.DOI:10.3760/cma.j.issn.0412-4081.2012.01.010. Sun TS,Zhang MN.Characters of contrast sensitivity in diabetic patients without diabetic retinopathy[J].Chin J Ophthalmol,2012,48(1):41-46.DOI:10.3760/cma.j.issn.0412-4081.2012.01.010.
8.	黎晓新. 热激光治疗中的反应分级和眼底标识的测量[M]//黎晓新,廖菊生.眼底病激光治疗指南.北京:人民卫生出版社,2009:12-13. Li XX. Thermal laser therapy measured response grading and identification of fundus[M]//Li XX,Liao JS. Fundus laser treatment guidelines.Beijing:The People's Medical Publishing House,2009:12-13.
9.	刘汉生. 黄斑区视网膜OCT检查与图像分析[M]//刘汉生.眼底病的频域OCT检查图谱.北京:科学技术文献出版社,2011:61-63. Liu HS.Macular OCT examination and image analysis[M]//Liu HS. Frequency domain OCT fundus examination atlas.Beijing:Science and Technology Literature Publishing House,2011:61-63.
10.	马景学. 视网膜静脉阻塞[M]//赵堪兴,杨培增.眼科学.8版.北京:人民卫生出版社,2014:213-215. Ma JX.Retinal vein occlusion[M]//Zhao KX,Yang PZ.Ophthalmology.8th ed.Beijing:People's Medical Publishing House,2014:213-215.
11.	徐静, 彭鹏,武思宇.飞行员准分子激光原位角膜磨镶术后对比敏感度的研究[J].国际眼科杂志,2015,15(4):675-677.DOI:10.3980/j.issn.1672-5123.2015.4.29. Xu J,Peng P,Wu SY. Study of the changes in contrast sensitivity of eyes after laser in situ keratomileuses surgery among pilots[J]. Int Eye Sci, 2015,15(4):675-677.DOI:10.3980/j.issn.1672-5123.2015.4.29.
12.	周晶, 皇甫晓瑾.飞秒激光联合LASlK术后明暗环境下对比敏感度的变化[J]. 国际眼科杂志,2015,15(1):125-127.DOI:10.3980/j.issn.1672-5123.2015.1.36. Zhou J,Huangpu XJ. Variation of contrast sensitivity after femtosecond laser in situ keratomileusis in changes environments[J]. Int Eye Sci, 2015,15(1):125-127.DOI:10.3980/j.issn.1672-5123.2015.1.36.
13.	张辉. Ⅱ型糖尿病患者的视觉对比敏感度检查意义[J].中国伤残医学,2010,18(3):82-83. DOI:10.3969/j.issn.1673-6567.2010.03.064. Zhang H. The check meaning of contrast sensitivity inⅡdiabetes[J].Chinese Journal of Trauma and Disability Medicine,2010,18(3):82-83. DOI:10.3969/j.issn.1673-6567.2010.03.064.
14.	张艳龙, 李丽华,高祥璐.对比敏感度的影响因素分析[J].眼视光学杂志,2009,11(3):221-226.DOI:10.3760/cma.j.issn.1674-845X.2009.03.016. Zhang YL,Li LH,Gao XL.Analysis of factors that influence contrast sensitivity[J]. Chinese Journal of Optometry & Ophthalmology,2009,11(3):221-226.DOI:10.3760/cma.j.issn.1674-845X.2009.03.016.
15.	黎晓新. 眼生理学[M]//刘家琦,李凤鸣.实用眼科学.2版.北京:人民卫生出版社,2003:47-48. Li XX. Eye Physiology[M]//Liu JQ,Li FM. Practical Ophthalmology.2nd ed.Beijing:People's Medical Publishing House,2003:47-48.
16.	何志明, 梁榆祯.2型糖尿病视网膜病变危险因素相关分析[J].中国慢性病预防与控制,2004,12(6):272-273.DOI:10.3969/j.issn.1004-6194.2004.06.014. He ZM,Liang YZ. Risk factors for type 2 diabetic retinopathy correlation analysis[J].Chin J Prev Contr Chron Non-commun Dis, 2004, 12(6):272-273.DOI:10.3969/j.issn.1004-6194.2004.06.014.

1. 张菁, 蔡小军,陈晓敏,等.玻璃体腔注射康柏西普联合视网膜激光光凝治疗视网膜分支静脉阻塞继发黄斑水肿疗效观察[J].中华眼底病杂志, 2015, 31(1):22-26. DOI:10.3760/cma.j.issn.1005-1015.2015.01.007. Zhang J,Cai XJ,Chen XM,et al. A prospective randomized clinical trial on intravitreous injection of conbercept combined with laser photocoagulation for macular edema secondary to branch retinal vein occlusion[J].Chin J Ocul Fundus Dis,2015, 31(1):22-26.DOI:10.3760/cma.j.issn.1005-1015.2015.01.007.
2. 宋爽, 喻晓兵,戴虹.玻璃体腔注射雷珠单抗联合曲安奈德或激光光凝治疗视网膜分支静脉阻塞继发黄斑水肿疗效观察[J].中华眼底病杂志,2015,31(1):18-21. DOI:10.3760/cma.j.issn.1005-1015.2015.01.006. Song S,Yu XB,Dai H. The efficacy of intravitreal ranibizumab and or triamcinolone combined with laser photocoagulation for macular edema secondary to branch retinal vein occlusion[J]. Chin J Ocul Fundus Dis,2015,31(1):18-21. DOI:10.3760/cma.j.issn.1005-1015.2015.01.006.
3. 陶相宜, 董志军,石晶,等.视网膜分支静脉阻塞多焦视网膜电图特征及其与视野改变相关性分析[J].中国实用眼科杂志,2011,29(6):548-550.DOI:10.3760/cma.j.issn.1006-4443.2011.06.008. Tao XY,Dong ZJ,Shi J,et al.Characteristics of multifocal electroretinogram in branch retinal vein occlusion and analysis of its correlativity with perimetry[J].Chin J Pract Ophthalmol,2011,29(6):548-550.DOI:10.3760/cma.j.issn.1006-4443.2011.06.008.
4. 田璐, 徐延山.视网膜颞上分支静脉阻塞光学相干断层扫描与多焦视网膜电图的观察[J].天津医科大学学报,2011,17(4):515-518.DOI:10.3969/j.issn.1006-8147.2011.04.025. Tian L,Xu YS.Optical coherence tomography and multifocai electroretinogram in superior temporal branch retinal vein occlusion[J].Journal of Tianjin Medical University,2011,17(4):515-518.DOI:10.3969/j.issn.1006-8147.2011.04.025.
5. 王文英, 冀向宁,王志学,等. 视觉对比敏感度和OCT在焊工体检中的应用[J].中华眼外伤职业眼病杂志,2015,37(8):596-600.DOI:10.3760/cma.j.issn.2095-1477.2015.08.009. Wang WY,Ji XN,Wang ZX,et al.The application of visual contrast sensitivity and OCT in physical examination of welder[J].Chin J Ocul Traum Occupat Eye Dis, 2015, 37(8):596-600.DOI:10.3760/cma.j.issn.2095-1477.2015.08.009.
6. 王文英, 冀向宁,韩风梅,等. 青年2型糖尿病早期视网膜神经纤维层厚度和视觉对比敏感度的动态变化[J].中华实验眼科杂志,2015,33(8):716-721.DOI:10.3760/cma.j.issn.2095-0160.2015.08.011. Wang WY,Ji XN,Han FM,et al.Dynamic changes of retinal nerve fiber layer thickness and visual contrast sensitivity in young population with type 2 diabetes mellitus[J].Chin J Exp Ophthalmol,2015,33(8):716-721.DOI:10.3760/cma.j.issn.2095-0160.2015.08.011.
7. 孙堂胜, 张卯年.无视网膜病变的糖尿病患者对比敏感度检测分析[J].中华眼科杂志, 2012,48(1):41-46.DOI:10.3760/cma.j.issn.0412-4081.2012.01.010. Sun TS,Zhang MN.Characters of contrast sensitivity in diabetic patients without diabetic retinopathy[J].Chin J Ophthalmol,2012,48(1):41-46.DOI:10.3760/cma.j.issn.0412-4081.2012.01.010.
8. 黎晓新. 热激光治疗中的反应分级和眼底标识的测量[M]//黎晓新,廖菊生.眼底病激光治疗指南.北京:人民卫生出版社,2009:12-13. Li XX. Thermal laser therapy measured response grading and identification of fundus[M]//Li XX,Liao JS. Fundus laser treatment guidelines.Beijing:The People's Medical Publishing House,2009:12-13.
9. 刘汉生. 黄斑区视网膜OCT检查与图像分析[M]//刘汉生.眼底病的频域OCT检查图谱.北京:科学技术文献出版社,2011:61-63. Liu HS.Macular OCT examination and image analysis[M]//Liu HS. Frequency domain OCT fundus examination atlas.Beijing:Science and Technology Literature Publishing House,2011:61-63.
10. 马景学. 视网膜静脉阻塞[M]//赵堪兴,杨培增.眼科学.8版.北京:人民卫生出版社,2014:213-215. Ma JX.Retinal vein occlusion[M]//Zhao KX,Yang PZ.Ophthalmology.8th ed.Beijing:People's Medical Publishing House,2014:213-215.
11. 徐静, 彭鹏,武思宇.飞行员准分子激光原位角膜磨镶术后对比敏感度的研究[J].国际眼科杂志,2015,15(4):675-677.DOI:10.3980/j.issn.1672-5123.2015.4.29. Xu J,Peng P,Wu SY. Study of the changes in contrast sensitivity of eyes after laser in situ keratomileuses surgery among pilots[J]. Int Eye Sci, 2015,15(4):675-677.DOI:10.3980/j.issn.1672-5123.2015.4.29.
12. 周晶, 皇甫晓瑾.飞秒激光联合LASlK术后明暗环境下对比敏感度的变化[J]. 国际眼科杂志,2015,15(1):125-127.DOI:10.3980/j.issn.1672-5123.2015.1.36. Zhou J,Huangpu XJ. Variation of contrast sensitivity after femtosecond laser in situ keratomileusis in changes environments[J]. Int Eye Sci, 2015,15(1):125-127.DOI:10.3980/j.issn.1672-5123.2015.1.36.
13. 张辉. Ⅱ型糖尿病患者的视觉对比敏感度检查意义[J].中国伤残医学,2010,18(3):82-83. DOI:10.3969/j.issn.1673-6567.2010.03.064. Zhang H. The check meaning of contrast sensitivity inⅡdiabetes[J].Chinese Journal of Trauma and Disability Medicine,2010,18(3):82-83. DOI:10.3969/j.issn.1673-6567.2010.03.064.
14. 张艳龙, 李丽华,高祥璐.对比敏感度的影响因素分析[J].眼视光学杂志,2009,11(3):221-226.DOI:10.3760/cma.j.issn.1674-845X.2009.03.016. Zhang YL,Li LH,Gao XL.Analysis of factors that influence contrast sensitivity[J]. Chinese Journal of Optometry & Ophthalmology,2009,11(3):221-226.DOI:10.3760/cma.j.issn.1674-845X.2009.03.016.
15. 黎晓新. 眼生理学[M]//刘家琦,李凤鸣.实用眼科学.2版.北京:人民卫生出版社,2003:47-48. Li XX. Eye Physiology[M]//Liu JQ,Li FM. Practical Ophthalmology.2nd ed.Beijing:People's Medical Publishing House,2003:47-48.
16. 何志明, 梁榆祯.2型糖尿病视网膜病变危险因素相关分析[J].中国慢性病预防与控制,2004,12(6):272-273.DOI:10.3969/j.issn.1004-6194.2004.06.014. He ZM,Liang YZ. Risk factors for type 2 diabetic retinopathy correlation analysis[J].Chin J Prev Contr Chron Non-commun Dis, 2004, 12(6):272-273.DOI:10.3969/j.issn.1004-6194.2004.06.014.

Chinese Journal of Ocular Fundus Diseases

Analysis of the contrast sensitivity of branch retinal vein occlusion without involving the macular region

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