Correlation of macular visual function and macular central retinal thickness in diabetic macular edema eyes_Chinese Journal of Ocular Fundus Diseases

Authors：

Wang Jianwei ,  Jie Chuanhong , Tao Yongjian , Wu Zhengzheng , Zhang Hong

Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China;

Corresponding author：

Jie Chuanhong, Email: jiechuanhong@163.com

Keywords：

Diabetic retinopathy/complications; Macular edema; Visual fields; Retina/ physiopathology; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2017.03.011

Video：

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Objective To investigate the correlation of microperimetric parameters, best-corrected visual acuity (BCVA) and central retinal thickness (CRT) in diabetic macular edema (DME) eyes. Methods It is a prospective, no controlled, open study. Twenty-four consecutive patients (40 eyes) with DME were included. There were 10 males (18 eyes),14 females (22 eyes); aged from 41 to 79 years, with the mean age of (56.84±8.96) years. All the patients were type 2 diabetes, the average duration of diabetes was 8 years. BCVA was evaluated using the international Snellen E vision test chart, and then recorded as logarithm of the minimum angle of resolution (logMAR). CRT was measured by Cirrus HD-OCT4000. MAIA microperimetric parameters were evaluated, including average threshold (AT) of retinal sensitivity, macular integrity index (MI), fixating points within a circle of 1° (P1) and 2° of radius (P2), bivariate contour ellipse area (BCEA) considering 63% and 95% of fixating points (A63,A95), and horizontal and vertical axes of that ellipse (H63,H95,V63,V95). Pearson correlation analysis was performed to evaluate the association between these variables. The independent factor influenced the type of fixation was analyzed by multiple linear regression analysis. Results Strong correlations of logMAR BCVA with CRT (r=0.58,P=0.000), V63 (r=0.44,P=0.004), V95 (r=0.41,P=0.008), MI (r=0.36,P=0.024), AT (r=−0.61,P=0.000), P1 (r=−0.41,P=0.009), P2 (r=−0.38,P=0.015) were found. AT was correlations with P1 (r=0.53,P=0.000), P2 (r=0.51,P=0.001), A63 (r=−0.39,P=0.012), A95 (r=−0.40,P=0.012), V63 (r=−0.53,P=0.000), V95 (r=−0.46,P=0.003), MI (r=−0.50,P=0.001). There was no correlation between AT and CRT (r=−0.21,P=0.190). Forty eyes were included in this study, 8 eyes (20%) had stable fixation,14 eyes (35%) had relatively unstable fixation,18 eyes (45%) had unstable fixation. Multiple linear regression analysis showed that fixation classification was independently affected by P1. Conclusions In DME eyes, logMAR BCVA was positively correlated with CRT, negatively correlated with AT, P1 and P2. There is no correlation between AT and CRT. The fixation classification was independently affected by P1.

Citation： Wang Jianwei, Jie Chuanhong, Tao Yongjian, Wu Zhengzheng, Zhang Hong. Correlation of macular visual function and macular central retinal thickness in diabetic macular edema eyes. Chinese Journal of Ocular Fundus Diseases, 2017, 33(3): 267-270. doi: 10.3760/cma.j.issn.1005-1015.2017.03.011 Copy

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2.	Kim DY, Yang HS, Kook YJ, et al. Association between microperimetric parameters and optical coherent tomographic findings in various macular diseases[J]. Korean J Ophthalmol, 2015, 29(2): 92-101. DOI: 10.3341/kjo.2015.29.2.92.
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4.	Fujii GY, De Juan E Jr, Humayun MS, et al. Characteristics of visual loss by scanning laser ophthalmoscope microperimetry in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration[J]. Am J Ophthalmol, 2003, 136(6): 1067-1078.
5.	Molina-Martín A, Piñero DP, Pérez-Cambrodí RJ.Fixation pattern analysis with microperimetry in nystagmus patients[J]. Can J Ophthalmol, 2015, 50(6): 413-421. DOI: 10.1016/j.jcjo.2015.07.012.
6.	Michalska A, Dorecka M, Jackiewicz K, et al. Evaluation of mean retinal sensitivity using MP-1 microperimeter in patients with diabetic macular edema before and after laser photocoagulation treatment[J]. Pol Arch Med Wewn, 2013, 123(3): 98-104.
7.	Kriechbaum K, Prager F, Geitzenauer W, et al. Association of retinal sensitivity and morphology during antiangiogenic treatment of retinal vein occlusion over one year[J]. Ophthalmology, 2009, 116(12): 2415-2421. DOI: 10.1016/j.ophtha.2009.05.001.
8.	Lupo S, Grenga PL, Vingolo EM. Fourier-domain optical coherence tomography and microperimetry findings in retinitis pigmentosa[J]. Am J Ophthalmol, 2011, 151(1): 106-111. DOI: 10.1016/j.ajo.2010.07.026.
9.	Hatef E, Colantuoni E, Wang J, et al. The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema[J]. Am J Ophthalmol, 2011, 152(3): 400-405. DOI: 10.1016/j.ajo.2011.02.024.
10.	Carpineto P, Ciancaglini M, Di Antonio L, et al. Fundus microperimetry patterns of fixation in type 2 diabetic patients with diffuse macular edema[J]. Retina, 2007, 27(1): 21-29.
11.	Okada K, Yamamoto S, Mizunoya S, et al. Correlation of retinal sensitivity measured with fundus-related microperimetry to visual acuity and retinal thickness in eyes with diabetic macular edema[J]. Eye (Lond), 2006, 20(7): 805-809.
12.	Kim YH, Yun C, Kim JT, et al. The correlation between retinal sensitivity assessed by microperimetry and contrast sensitivity in diabetic macular oedema[J]. Br J Ophthalmol, 2014, 98(12): 1618-1624. DOI: 10.1136/bjophthalmol-2013-304765.
13.	Raman R, Nittala MG, Gella L, et al. Retinal sensitivity over hard exudates in diabetic retinopathy[J]. J Ophthalmic Vis Res, 2015, 10(2): 160-164. DOI: 10.4103/2008-322X.163771.

1. Vujosevic S, Pilotto E, Bottega E, et al. Retinal fixation impairment in diabetic macular edema[J]. Retina, 2008, 28(10): 1443-1450. DOI: 10.1097/IAE.0b013e318183571e.
2. Kim DY, Yang HS, Kook YJ, et al. Association between microperimetric parameters and optical coherent tomographic findings in various macular diseases[J]. Korean J Ophthalmol, 2015, 29(2): 92-101. DOI: 10.3341/kjo.2015.29.2.92.
3. 中华医学会眼科学会眼底病学组. 我国糖尿病视网膜病变临床诊疗指南(2014年)[J]. 中华眼科杂志, 2014, 50(11): 851-865. DOI: 10.3760/cma.j.issn.0412-4081.2014.11.014.Ocular fundus diseases group of Chinese Ophthalmological Society. Guidelines for clinical diagnosis and treatment of diabetic retinopathy in China (2014) [J]. Chin J 0phthalmol, 2014, 50(11): 851-865. DOI: 10.3760/cma.j.issn.0412-4081.2014.11.014.
4. Fujii GY, De Juan E Jr, Humayun MS, et al. Characteristics of visual loss by scanning laser ophthalmoscope microperimetry in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration[J]. Am J Ophthalmol, 2003, 136(6): 1067-1078.
5. Molina-Martín A, Piñero DP, Pérez-Cambrodí RJ.Fixation pattern analysis with microperimetry in nystagmus patients[J]. Can J Ophthalmol, 2015, 50(6): 413-421. DOI: 10.1016/j.jcjo.2015.07.012.
6. Michalska A, Dorecka M, Jackiewicz K, et al. Evaluation of mean retinal sensitivity using MP-1 microperimeter in patients with diabetic macular edema before and after laser photocoagulation treatment[J]. Pol Arch Med Wewn, 2013, 123(3): 98-104.
7. Kriechbaum K, Prager F, Geitzenauer W, et al. Association of retinal sensitivity and morphology during antiangiogenic treatment of retinal vein occlusion over one year[J]. Ophthalmology, 2009, 116(12): 2415-2421. DOI: 10.1016/j.ophtha.2009.05.001.
8. Lupo S, Grenga PL, Vingolo EM. Fourier-domain optical coherence tomography and microperimetry findings in retinitis pigmentosa[J]. Am J Ophthalmol, 2011, 151(1): 106-111. DOI: 10.1016/j.ajo.2010.07.026.
9. Hatef E, Colantuoni E, Wang J, et al. The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema[J]. Am J Ophthalmol, 2011, 152(3): 400-405. DOI: 10.1016/j.ajo.2011.02.024.
10. Carpineto P, Ciancaglini M, Di Antonio L, et al. Fundus microperimetry patterns of fixation in type 2 diabetic patients with diffuse macular edema[J]. Retina, 2007, 27(1): 21-29.
11. Okada K, Yamamoto S, Mizunoya S, et al. Correlation of retinal sensitivity measured with fundus-related microperimetry to visual acuity and retinal thickness in eyes with diabetic macular edema[J]. Eye (Lond), 2006, 20(7): 805-809.
12. Kim YH, Yun C, Kim JT, et al. The correlation between retinal sensitivity assessed by microperimetry and contrast sensitivity in diabetic macular oedema[J]. Br J Ophthalmol, 2014, 98(12): 1618-1624. DOI: 10.1136/bjophthalmol-2013-304765.
13. Raman R, Nittala MG, Gella L, et al. Retinal sensitivity over hard exudates in diabetic retinopathy[J]. J Ophthalmic Vis Res, 2015, 10(2): 160-164. DOI: 10.4103/2008-322X.163771.

Chinese Journal of Ocular Fundus Diseases

Correlation of macular visual function and macular central retinal thickness in diabetic macular edema eyes

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