Recent research progress between the microvesicle and diabetic retinopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

Zhang Wei ,  Chen Song

Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University, Tianjin 300020, China;

Corresponding author：

Chen Song, Email: chensong9999@126.com

Keywords：

Diabetic retinopathy/etiology; Liposomes; Inflammation; Endothelium, vascular; Review

DOI：

10.3760/cma.j.issn.1005-1015.2017.03.028

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Microvesicles (MVs) is small membrane vesicles released from different cell types under different conditions. Studies have shown that MVs may mediate vascular inflammation, angiogenesis, and other pathological processes. MVs may play an important role in the pathogenesis of diabetic retinopathy (DR) by mediating endothelial cell injury, thrombosis and neovascularization. The plasma MV level may be an effective parameter to monitor the development of DR. This article will summarize the research progress of the relationship between MVs and DR in recent years.

Citation： Zhang Wei, Chen Song. Recent research progress between the microvesicle and diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2017, 33(3): 321-324. doi: 10.3760/cma.j.issn.1005-1015.2017.03.028 Copy

1.	Deatherage BL, Cookson BT. Membrane vesicle release in bacteria, eukaryotes, and archaea: a conserved yet underappreciated aspect of microbial life[J]. Infect Immun, 2012, 80(6): 1948-1957. DOI: 10.1128/IAI.06014-11.
2.	Liu ML, Williams KJ. Microvesicles: potential markers and mediators of endothelial dysfunction[J]. Curr Opin Endocrinol Diabetes Obes, 2012, 19(2): 121-127. DOI: 10.1097/MED.0b013e32835057e9.
3.	Chahed S, Leroyer AS, Benzerroug M, et al. Increased vitreous shedding of microparticles in proliferative diabetic retinopathy stimulates endothelial proliferation[J]. Diabetes, 2010, 59(3): 694-701. DOI: 10.2337/db08-1524.
4.	Gyorgy B, Modos K, Pallinger E, et al. Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters[J]. Blood, 2011, 117(4): 39-48. DOI: 10.1182/blood-2010-09-307595.
5.	Li M, Yu D, Williams KJ, et al. Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages[J]. Arterioscler Thromb Vasc Biol, 2010, 30 (9): 1818-1824. DOI: 10.1161/ATVBAHA.110.209577.
6.	França CN, Izar MC, Amaral JB, et al. Microparticles as potential biomarkers of cardiovascular disease[J]. Arq Bras Cardiol, 2015, 104(2): 169-174. DOI: 10.5935/abc.20140210.
7.	Liu ML, Scalia R, Mehta JL, et al. Cholesterol-induced membrane microvesicles as novel carriers of damage-associated molecular patterns: mechanisms of formation, action, and detoxification[J]. Arterioscler Thromb Vasc Biol, 2012, 32(9): 2113-2121. DOI: 10.1161/ATVBAHA.112.255471.
8.	Lacroix R, Judicone C, Poncelet P, et al. Impact of pre-analytical parameters on the measurement of circulating microparticles: towards standardization of protocol[J]. J Thromb Haemost, 2012, 10 (3): 437-446. DOI: 10.1111/j.1538-7836.2011.04610.x.
9.	Robert S, Lacroix R, Poncelet P, et al. High-sensitivity flow cytometry provides access to standardized measurement of small-size microparticles--brief report[J]. Arterioscler Thromb Vasc Biol, 2012, 32 (4): 1054-1058. DOI: 10.1161/ATVBAHA.111.244616.
10.	Lee RD, Barcel DA, Williams JC, et al. Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity[J]. Thromb Res, 2012, 129 (1): 80-85. DOI: 10.1016/j.thromres.2011.06.004.
11.	Heinrich LF, Andersen DK, Cleasby ME, et al. Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells[J]. Br J Nutr, 2015, 113 (11): 1704-1711. DOI: 10.1017/S0007114515001117.
12.	Jorgensen MM, Baek R, Varming K. Potentials and capabilities of the extracellular vesicle (EV) array[J/OL]. J Extracell Vesicles, 2015, 4: 26048[2015-04-08]. . DOI: 10.3402/jev.v4.26048.
13.	Vicencio JM, Yellon DM, Sivaraman V, et al. Plasma exosomes protect the myocardium from ischemia-reperfusion injury[J]. J Am Coll Cardiol, 2015, 65 (15): 1525-1536. DOI: 10.1016/j.jacc.2015.02.026.
14.	Welton JL, Webber JP, Botos LA, et al. Ready-made chromatography columns for extracellular vesicle isolation from plasma[J/OL]. J Extracell Vesicles, 2015, 4: 27269. . DOI: 10.3402/jev.v4.27269.
15.	Kruger S, Abd Elmageed ZY, Hawke DH, et al. Molecular characterization of exosome-like vesicles from breast cancer cells[J]. BMC Cancer, 2014, 14: 44. DOI: 10.1186/1471-2407-14-44.
16.	Jansen F, Yang X, Franklin BS, et al. High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation[J]. Cardiovasc Res, 2013, 98(1): 94-106. DOI: 10.1093/cvr/cvt013.
17.	Ogata N, Nomura S, Shouzu A, et al. Elevation of monocyte-derived microparticles in patients with diabetic retinopathy[J]. Diabetes Res Clin Pract, 2006, 73(3): 241-248.
18.	Jung KH, Chu K, Lee ST, et al. Risk of macrovascular complications in type 2 diabetes mellitus: endothelial microparticle profiles[J]. Cerebrovasc Dis, 2011, 31(5): 485-493. DOI: 10.1159/000324383.
19.	Stępień E, Kabłak-Ziembicka A, Czyż J, et al. Microparticles, not only markers but also a therapeutic target in the early stage of diabetic retinopathy and vascular aging[J]. Expert Opin Ther Targets, 2012, 16(7): 677-688. DOI: 10.1517/14728222.2012.691471.
20.	Beltramo E, Lopatina T, Berrone E, et al. Extracellular vesicles derived from mesenchymal stem cells induce features of diabetic retinopathy in vitro[J]. Acta Diabetol, 2014, 51(6): 1055-1064. DOI: 10.1007/s00592-014-0672-1.
21.	Tsimerman G, Roguin A, Bachar A, et al. Involvement of microparticles in diabetic vascular complications[J]. Thromb Haemost, 2011, 106(2): 310-321. DOI: 10.1160/TH10-11-0712.
22.	Jansen F, Yang X, Hoelscher M, et al. Endothelial microparticle-mediated transfer of microRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles[J]. Circulation, 2013, 128(18): 2026-2038. DOI: 10.1161/CIRCULATIONAHA.113.001720.
23.	Jansen F, Yang X, Baumann K, et al. Endothelial microparticles reduce ICAM-1 expression in a microRNA-222-dependent mechanism[J]. J Cell Mol Med, 2015, 19(9): 2202-2214. DOI: 10.1111/jcmm.12607.
24.	Li J, Zhang Y, Liu Y, et al. Microvesicle-mediated transfer of miR-150 from monocytes to endothelial cells promotes angiogenesis[J]. J Biol Chem, 2013, 288(32): 23586-23596. DOI: 10.1074/jbc.M113.489302.
25.	Li CJ, Liu Y, Chen Y, et al. Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke[J]. Am J Pathol, 2013, 182(5): 1552-1562. DOI: 10.1016/j.ajpath.2013.01.035.
26.	Bergeron A, Pucci L, Bezzi P, et al. Analysis of synaptic-like microvesicle exocytosis of B-cells using a live imaging technique[J/OL]. PLoS One, 2014, 9(2): 87758[2014-02-04]. . DOI: 10.1371/journal.pone.0087758.
27.	Balabushevich NG, Pechenkin MA, Shibanova ED, et al. Multifunctional polyelectrolyte microparticles for oral insulin delivery[J]. Macromol Biosci, 2013, 13(10): 1379-1388. DOI: 10.1002/mabi.201300207.
28.	Zu L, Niu C, Li J, et al. Proteomic research of high-glucose-activated endothelial microparticles and related proteins to Alzheimer's disease[J]. Diab Vasc Dis Res, 2015, 12(6): 467-470. DOI: 10.1177/1479164115597865.
29.	Berezin AE, Kremzer AA, Berezina TA, et al. The pattern of circulating microparticles in patients with diabetes mellitus with asymptomatic atherosclerosis[J]. Acta Clin Belg, 2016, 71(1): 38-45. DOI: 10.1080/17843286.2015.1110894.
30.	Salem MA, Adly AA, Ismail EA, et al. Platelets microparticles as a link between micro- and macro-angiopathy in young patients with type 1 diabetes[J]. Platelets, 2015, 26(7): 682-688. DOI: 10.3109/09537104.2015.1018880.
31.	Schiro A, Wilkinson FL, Weston R, et al. Endothelial microparticles as conveyors of information in atherosclerotic disease[J]. Atherosclerosis, 2014, 234(2): 295-302. DOI: 10.1016/j.atherosclerosis.2014.03.019.
32.	Kent MW, Kelher MR, West FB, et al. The pro-inflammatory potential of microparticles in red blood cell units[J]. Transfus Med, 2014, 24(3): 176-181. DOI: 10.1111/tme.12123.
33.	Fu L, Hu XX, Lin ZB, et al. Circulating microparticles from patients with valvular heart disease and cardiac surgery inhibit endothelium-dependent vasodilation[J]. J Thorac Cardiovasc Surg, 2015, 150(3): 666-672. DOI: 10.1016/j.jtcvs.2015.05.069.
34.	Berezin A, Zulli A, Kerrigan S, et al. Predictive role of circulating endothelial-derived microparticles in cardiovascular diseases[J]. Clin Biochem, 2015, 48(9): 562-568. DOI: 10.1016/j.clinbiochem.2015.02.003.
35.	Świtońska M, Słomka A, Sinkiewicz W, et al. Tissue-factor-bearing microparticles (MPs-TF) in patients with acute ischaemic stroke: the influence of stroke treatment on MPs-TF generation[J]. Eur J Neurol, 2015, 22(2): 395-401. DOI: 10.1111/ene.12591.
36.	Lins LC, França CN, Fonseca FA, et al. Effects of ezetimibe on endothelial progenitor cells and microparticles in high-risk patients[J]. Cell Biochem Biophys, 2014, 70(1): 687-696. DOI: 10.1007/s12013-014-9973-9.
37.	Camargo LM, França CN, Izar MC, et al. Effects of simvastatin/ezetimibe on microparticles, endothelial progenitor cells and platelet aggregation in subjects with coronary heart disease under antiplatelet therapy[J]. Braz J Med Biol Res, 2014, 47(5): 432-437.
38.	Suades R, Padró T, Alonso R, et al. Circulating CD45+/CD3+ lymphocyte-derived microparticles map lipid-rich atherosclerotic plaques in familial hypercholesterolaemia patients[J]. Thromb Haemost, 2014, 111(1): 111-121. DOI: 10.1160/TH13-07-0612.

1. Deatherage BL, Cookson BT. Membrane vesicle release in bacteria, eukaryotes, and archaea: a conserved yet underappreciated aspect of microbial life[J]. Infect Immun, 2012, 80(6): 1948-1957. DOI: 10.1128/IAI.06014-11.
2. Liu ML, Williams KJ. Microvesicles: potential markers and mediators of endothelial dysfunction[J]. Curr Opin Endocrinol Diabetes Obes, 2012, 19(2): 121-127. DOI: 10.1097/MED.0b013e32835057e9.
3. Chahed S, Leroyer AS, Benzerroug M, et al. Increased vitreous shedding of microparticles in proliferative diabetic retinopathy stimulates endothelial proliferation[J]. Diabetes, 2010, 59(3): 694-701. DOI: 10.2337/db08-1524.
4. Gyorgy B, Modos K, Pallinger E, et al. Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters[J]. Blood, 2011, 117(4): 39-48. DOI: 10.1182/blood-2010-09-307595.
5. Li M, Yu D, Williams KJ, et al. Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages[J]. Arterioscler Thromb Vasc Biol, 2010, 30 (9): 1818-1824. DOI: 10.1161/ATVBAHA.110.209577.
6. França CN, Izar MC, Amaral JB, et al. Microparticles as potential biomarkers of cardiovascular disease[J]. Arq Bras Cardiol, 2015, 104(2): 169-174. DOI: 10.5935/abc.20140210.
7. Liu ML, Scalia R, Mehta JL, et al. Cholesterol-induced membrane microvesicles as novel carriers of damage-associated molecular patterns: mechanisms of formation, action, and detoxification[J]. Arterioscler Thromb Vasc Biol, 2012, 32(9): 2113-2121. DOI: 10.1161/ATVBAHA.112.255471.
8. Lacroix R, Judicone C, Poncelet P, et al. Impact of pre-analytical parameters on the measurement of circulating microparticles: towards standardization of protocol[J]. J Thromb Haemost, 2012, 10 (3): 437-446. DOI: 10.1111/j.1538-7836.2011.04610.x.
9. Robert S, Lacroix R, Poncelet P, et al. High-sensitivity flow cytometry provides access to standardized measurement of small-size microparticles--brief report[J]. Arterioscler Thromb Vasc Biol, 2012, 32 (4): 1054-1058. DOI: 10.1161/ATVBAHA.111.244616.
10. Lee RD, Barcel DA, Williams JC, et al. Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity[J]. Thromb Res, 2012, 129 (1): 80-85. DOI: 10.1016/j.thromres.2011.06.004.
11. Heinrich LF, Andersen DK, Cleasby ME, et al. Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells[J]. Br J Nutr, 2015, 113 (11): 1704-1711. DOI: 10.1017/S0007114515001117.
12. Jorgensen MM, Baek R, Varming K. Potentials and capabilities of the extracellular vesicle (EV) array[J/OL]. J Extracell Vesicles, 2015, 4: 26048[2015-04-08]. . DOI: 10.3402/jev.v4.26048.
13. Vicencio JM, Yellon DM, Sivaraman V, et al. Plasma exosomes protect the myocardium from ischemia-reperfusion injury[J]. J Am Coll Cardiol, 2015, 65 (15): 1525-1536. DOI: 10.1016/j.jacc.2015.02.026.
14. Welton JL, Webber JP, Botos LA, et al. Ready-made chromatography columns for extracellular vesicle isolation from plasma[J/OL]. J Extracell Vesicles, 2015, 4: 27269. . DOI: 10.3402/jev.v4.27269.
15. Kruger S, Abd Elmageed ZY, Hawke DH, et al. Molecular characterization of exosome-like vesicles from breast cancer cells[J]. BMC Cancer, 2014, 14: 44. DOI: 10.1186/1471-2407-14-44.
16. Jansen F, Yang X, Franklin BS, et al. High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation[J]. Cardiovasc Res, 2013, 98(1): 94-106. DOI: 10.1093/cvr/cvt013.
17. Ogata N, Nomura S, Shouzu A, et al. Elevation of monocyte-derived microparticles in patients with diabetic retinopathy[J]. Diabetes Res Clin Pract, 2006, 73(3): 241-248.
18. Jung KH, Chu K, Lee ST, et al. Risk of macrovascular complications in type 2 diabetes mellitus: endothelial microparticle profiles[J]. Cerebrovasc Dis, 2011, 31(5): 485-493. DOI: 10.1159/000324383.
19. Stępień E, Kabłak-Ziembicka A, Czyż J, et al. Microparticles, not only markers but also a therapeutic target in the early stage of diabetic retinopathy and vascular aging[J]. Expert Opin Ther Targets, 2012, 16(7): 677-688. DOI: 10.1517/14728222.2012.691471.
20. Beltramo E, Lopatina T, Berrone E, et al. Extracellular vesicles derived from mesenchymal stem cells induce features of diabetic retinopathy in vitro[J]. Acta Diabetol, 2014, 51(6): 1055-1064. DOI: 10.1007/s00592-014-0672-1.
21. Tsimerman G, Roguin A, Bachar A, et al. Involvement of microparticles in diabetic vascular complications[J]. Thromb Haemost, 2011, 106(2): 310-321. DOI: 10.1160/TH10-11-0712.
22. Jansen F, Yang X, Hoelscher M, et al. Endothelial microparticle-mediated transfer of microRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles[J]. Circulation, 2013, 128(18): 2026-2038. DOI: 10.1161/CIRCULATIONAHA.113.001720.
23. Jansen F, Yang X, Baumann K, et al. Endothelial microparticles reduce ICAM-1 expression in a microRNA-222-dependent mechanism[J]. J Cell Mol Med, 2015, 19(9): 2202-2214. DOI: 10.1111/jcmm.12607.
24. Li J, Zhang Y, Liu Y, et al. Microvesicle-mediated transfer of miR-150 from monocytes to endothelial cells promotes angiogenesis[J]. J Biol Chem, 2013, 288(32): 23586-23596. DOI: 10.1074/jbc.M113.489302.
25. Li CJ, Liu Y, Chen Y, et al. Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke[J]. Am J Pathol, 2013, 182(5): 1552-1562. DOI: 10.1016/j.ajpath.2013.01.035.
26. Bergeron A, Pucci L, Bezzi P, et al. Analysis of synaptic-like microvesicle exocytosis of B-cells using a live imaging technique[J/OL]. PLoS One, 2014, 9(2): 87758[2014-02-04]. . DOI: 10.1371/journal.pone.0087758.
27. Balabushevich NG, Pechenkin MA, Shibanova ED, et al. Multifunctional polyelectrolyte microparticles for oral insulin delivery[J]. Macromol Biosci, 2013, 13(10): 1379-1388. DOI: 10.1002/mabi.201300207.
28. Zu L, Niu C, Li J, et al. Proteomic research of high-glucose-activated endothelial microparticles and related proteins to Alzheimer's disease[J]. Diab Vasc Dis Res, 2015, 12(6): 467-470. DOI: 10.1177/1479164115597865.
29. Berezin AE, Kremzer AA, Berezina TA, et al. The pattern of circulating microparticles in patients with diabetes mellitus with asymptomatic atherosclerosis[J]. Acta Clin Belg, 2016, 71(1): 38-45. DOI: 10.1080/17843286.2015.1110894.
30. Salem MA, Adly AA, Ismail EA, et al. Platelets microparticles as a link between micro- and macro-angiopathy in young patients with type 1 diabetes[J]. Platelets, 2015, 26(7): 682-688. DOI: 10.3109/09537104.2015.1018880.
31. Schiro A, Wilkinson FL, Weston R, et al. Endothelial microparticles as conveyors of information in atherosclerotic disease[J]. Atherosclerosis, 2014, 234(2): 295-302. DOI: 10.1016/j.atherosclerosis.2014.03.019.
32. Kent MW, Kelher MR, West FB, et al. The pro-inflammatory potential of microparticles in red blood cell units[J]. Transfus Med, 2014, 24(3): 176-181. DOI: 10.1111/tme.12123.
33. Fu L, Hu XX, Lin ZB, et al. Circulating microparticles from patients with valvular heart disease and cardiac surgery inhibit endothelium-dependent vasodilation[J]. J Thorac Cardiovasc Surg, 2015, 150(3): 666-672. DOI: 10.1016/j.jtcvs.2015.05.069.
34. Berezin A, Zulli A, Kerrigan S, et al. Predictive role of circulating endothelial-derived microparticles in cardiovascular diseases[J]. Clin Biochem, 2015, 48(9): 562-568. DOI: 10.1016/j.clinbiochem.2015.02.003.
35. Świtońska M, Słomka A, Sinkiewicz W, et al. Tissue-factor-bearing microparticles (MPs-TF) in patients with acute ischaemic stroke: the influence of stroke treatment on MPs-TF generation[J]. Eur J Neurol, 2015, 22(2): 395-401. DOI: 10.1111/ene.12591.
36. Lins LC, França CN, Fonseca FA, et al. Effects of ezetimibe on endothelial progenitor cells and microparticles in high-risk patients[J]. Cell Biochem Biophys, 2014, 70(1): 687-696. DOI: 10.1007/s12013-014-9973-9.
37. Camargo LM, França CN, Izar MC, et al. Effects of simvastatin/ezetimibe on microparticles, endothelial progenitor cells and platelet aggregation in subjects with coronary heart disease under antiplatelet therapy[J]. Braz J Med Biol Res, 2014, 47(5): 432-437.
38. Suades R, Padró T, Alonso R, et al. Circulating CD45+/CD3+ lymphocyte-derived microparticles map lipid-rich atherosclerotic plaques in familial hypercholesterolaemia patients[J]. Thromb Haemost, 2014, 111(1): 111-121. DOI: 10.1160/TH13-07-0612.

Previous Article
Correlation between O-linked N-acetylglucosamine glycosylation modification and diabetic retinopathy
Next Article
Relationship between adiponectin and diabetic retinopathy

Chinese Journal of Ocular Fundus Diseases

Recent research progress between the microvesicle and diabetic retinopathy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content