Relationship between diabetic retinopathy "metabolic memory" and oxidative stress_Chinese Journal of Ocular Fundus Diseases

Authors：

Gao Wei ,  Li Chunxia

Department of Ophthalmology, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China (Gao Wei, postgraduate, Bengbu Medical College);

Corresponding author：

Li Chunxia, Email: cxli_66@163.com

Keywords：

Diabetic retinopathy/physiopathology; Oxidative stress; Endoplasmic reticulum stress; Review

DOI：

10.3760/cma.j.issn.1005-1015.2017.03.030

Video：

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Abstract Full text Figures/Tables Video References Cited by

Metabolic memory means if the hyperglycemia can't be controlled at early stage of diabetes, chronic complications such as diabetic retinopathy (DR) will continue to develop even if the blood glucose level maintains normal level at later stage. Oxidative stress plays an important role in the "metabolic memory" of DR, which interacts with the nitrative stress, advanced glycation end products, genetic modification and endoplasmic reticulum stress in the pathogenesis of DR. Further elucidation of the relationship between oxidative stress and "metabolic memory" of DR can open the way for the discovery of novel therapeutic targets to prevent DR progression.

Citation： Gao Wei, Li Chunxia. Relationship between diabetic retinopathy "metabolic memory" and oxidative stress. Chinese Journal of Ocular Fundus Diseases, 2017, 33(3): 327-330. doi: 10.3760/cma.j.issn.1005-1015.2017.03.030 Copy

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2.	Mahmoud AM, Abd El-Twab SM, Abdel-Reheim ES. Consumption of polyphenol-rich morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism[J/OL]. Eur J Nutr, 2016, 2016: E1[2016-04-08]. . DOI: 10.1007/s00394-016-1214-0. [published online ahead of print].
3.	Engerman RL. Progression of incipient diabetic retinopathy during good glycemic control[J]. Diabetes, 1987, 36(7): 808-812.
4.	Kowluru RA, Chan PS. Metabolic memory in diabetes-from in vitro oddity to in vivo problem: role of apoptosis[J]. Brain Res Bull, 2010, 81(2-3): 297-302. DOI: 10.1016/j.brainresbull.2009.05.006.
5.	Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, Lachin JM, White NH, et al. Effect of intensive diabetes therapy on the progression of diabetic retinopathy in patients with type 1 diabetes: 18 years of follow-up in the DCCT/EDIC[J]. Diabetes, 2015, 64(2): 631-642. DOI: 10.2337/db14-0930.
6.	White NH, Sun W, Cleary PA, et al. Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial[J]. Arch Ophthalmol, 2008, 126(12): 1707-1715. DOI: 10.1001/archopht.126.12.1707.
7.	Ceriello A. The emerging challenge in diabetes: the " metabolic memory”[J]. Vascul Pharmacol, 2012, 57(5-6): 133-138. DOI: 10.1016/j.vph.2012.05.005.
8.	Giacco F, Brownlee M. Oxidative stress and diabetic complications[J]. Circ Res, 2010, 107(9): 1058-1070. DOI: 10.1161/CIRCRESAHA.110.223545.
9.	Li C, Miao X, Li F, et al. Oxidative stress-related mechanisms and antioxidant therapy in diabetic retinopathy[J/OL]. Oxid Med Cell Longev, 2017, 2017: 9702820[2017-02-06]. . DOI: 10.1155/2017/9702820.
10.	Zhong Q, Mishra M. Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy[J]. Invest Ophthalmol Vis Sci, 2013, 54(6): 3941-3948. DOI: 10.1167/iovs.13-11598.
11.	Voronova V, Zhudenkov K, Helmlinger G. Interpretation of metabolic memory phenomenon using a physiological systems model: what drives oxidative stress following glucose normalization?[J/OL]. PLoS One, 2017, 12(2): 0171781[2017-02-08]. . DOI: 10.1371/journal.pone.0171781.
12.	Sharma S, Saxena S, Srivastav K, et al. Nitric oxide and oxidative stress is associated with severity of diabetic retinopathy and retinal structural alterations[J]. Clin Exp Ophthalmol, 2015, 43(5): 429-436. DOI: 10.1111/ceo.12506.
13.	Serra AM, Waddell J, Manivannan A, et al. CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation[J]. Am J Pathol, 2012, 181(2): 719-727. DOI: 10.1016/j.ajpath.2012.04.009.
14.	Elsherbiny NM, Naime M, Ahmad S, et al. Potential roles of adenosine deaminase-2 in diabetic retinopathy[J]. Biochem Biophys Res Commun, 2013, 436(3): 355-361. DOI: 10.1016/j.bbrc.2013.05.023.
15.	Abdul Nasir NA, Agarwal R, Sheikh Abdul Kadir SH, et al. Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats[J/OL]. PLoS One, 2017, 12(3): 0174542[2017-03-28]. . DOI: 10.1371/journal.pone.0174542.
16.	Zuwała-Jagiełło J, Pazgan-Simon M, Simon K, et al. Elevated advanced oxidation protein products levels in patients with liver cirrhosis[J]. Acta Biochim Pol, 2009, 56(4): 679-685.
17.	Hirakawa Y, Tanaka T. Mechanisms of metabolic memory and renal hypoxia as a therapeutic target in diabetic kidney disease[J/OL]. J Diabetes Investig, 2017, 2017: E1[2017-01-17]. . DOI: 10.1111/jdi.12624. [published online ahead of print].
18.	Chilelli NC, Burlina S, Lapolla A. AGEs, rather than hyperglycemia, are responsible for microvascular complications in diabetes: a "glycoxidation-centric" point of view [J]. Nutr Metab Cardiovasc Diseases, 2013, 23(10): 913-919. DOI: 10.1016/j.numecd.2013.04.004.
19.	Tang J, Kern TS. Inflammation in diabetic retinopathy[J]. Prog Retin Eye Res, 2011, 30(5): 343-358. DOI: 10.1016/j.preteyeres.2011.05.002.
20.	Jiang T, Chang Q, Cai J, et al. Protective effects of melatonin on retinal inflammation and oxidative stress in experimental diabetic retinopathy[J/OL]. Oxid Med Cell Longev, 2016, 2016: 3528274[2016-04-06]. . DOI: 10.1155/2016/3528274.
21.	Chan PS, Kanwar M, Kowluru RA. Resistance of retinal inflammatory mediators to suppress after reinstitution of good glycemic control: novel mechanism for metabolic memory[J]. J Diabetes Complications, 2010, 24(1): 55-63. DOI: 10.1016/j.jdiacomp.2008.10.002.
22.	Mimura I, Tanaka T. New insights into molecular mechanisms of epigenetic regulation in kidney disease[J]. Clin Exp Pharmacol Physiol, 2016, 43(12): 1159-1167. DOI: 10.1111/1440-1681.12663.
23.	Reddy MA, Zhang E, Natarajan R. Epigenetic mechanisms in diabetic complications and metabolic memory[J]. Diabetologia, 2015, 58(3): 443-455. DOI: 10.1007/s00125-014-3462-y.
24.	Chen Z, Miao F, Paterson AD, et al. Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort[J]. Proc Natl Acad Sci USA, 2016, 113(21): 3002-3011. DOI: 10.1073/pnas.1603712113.
25.	Mishra M. The role of DNA methylation in the metabolic memory phenomenon associated with the continued progression of diabetic retinopathy[J]. Invest Ophthalmol Vis Sci, 2016, 57(13): 5748-5757. DOI: 10.1167/iovs.16-19759.
26.	Sánchez-Chávez G, Hernández-Ramírez E, Osorio-Paz I, et al. Potential role of endoplasmic reticulum stress in pathogenesis of diabetic retinopathy[J]. Neurochem Res, 2016, 41(5): 1098-1106. DOI: 10.1007/s11064-015-1798-4.
27.	Yu Z, Gong C, Lu B, et al. Dendrobium chrysotoxum Lindl alleviates diabetic retinopathy by preventing retinal inflammation and tight junction protein decrease[J/OL]. J Diabetes Res, 2015, 2015: 518317[2015-01-01]. . DOI: 10.1155/2015/518317.
28.	Zhong Y, Li J, Chen Y, et al. Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derive inflammatory cytokine production in diabetes[J]. Diabetes, 2012, 61(2): 492-504. DOI: 10.2337/db11-0315.
29.	Huang C, Wang JJ, Ma JH, et al. Activation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2[J]. J Biol Chem, 2015, 290(9): 5367-5380. DOI: 10.1074/jbc.M114.603738.
30.	Gomes MB. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases[J]. Diabetol Metab Syndr, 2014, 6(1): 80. DOI: 10.1186/1758-5996-6-80.
31.	Zhang L, Xia H, Han Q. Effects of antioxidant gene therapy on the development of diabetic retinopathy and the metabolic memory phenomenon[J]. Graefe’s Arch Clin Exp Ophthalmol, 2015, 253(2): 249-259. DOI: 10.1007/s00417-014-2827-8.

1. Reddy MA, Zhang E. Epigenetic mechanisms in diabetic complications and metabolic memory[J]. Diabetologia, 2015, 58(3): 443-455. DOI: 10.1007/s00125-014-3462-y.
2. Mahmoud AM, Abd El-Twab SM, Abdel-Reheim ES. Consumption of polyphenol-rich morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism[J/OL]. Eur J Nutr, 2016, 2016: E1[2016-04-08]. . DOI: 10.1007/s00394-016-1214-0. [published online ahead of print].
3. Engerman RL. Progression of incipient diabetic retinopathy during good glycemic control[J]. Diabetes, 1987, 36(7): 808-812.
4. Kowluru RA, Chan PS. Metabolic memory in diabetes-from in vitro oddity to in vivo problem: role of apoptosis[J]. Brain Res Bull, 2010, 81(2-3): 297-302. DOI: 10.1016/j.brainresbull.2009.05.006.
5. Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, Lachin JM, White NH, et al. Effect of intensive diabetes therapy on the progression of diabetic retinopathy in patients with type 1 diabetes: 18 years of follow-up in the DCCT/EDIC[J]. Diabetes, 2015, 64(2): 631-642. DOI: 10.2337/db14-0930.
6. White NH, Sun W, Cleary PA, et al. Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial[J]. Arch Ophthalmol, 2008, 126(12): 1707-1715. DOI: 10.1001/archopht.126.12.1707.
7. Ceriello A. The emerging challenge in diabetes: the " metabolic memory”[J]. Vascul Pharmacol, 2012, 57(5-6): 133-138. DOI: 10.1016/j.vph.2012.05.005.
8. Giacco F, Brownlee M. Oxidative stress and diabetic complications[J]. Circ Res, 2010, 107(9): 1058-1070. DOI: 10.1161/CIRCRESAHA.110.223545.
9. Li C, Miao X, Li F, et al. Oxidative stress-related mechanisms and antioxidant therapy in diabetic retinopathy[J/OL]. Oxid Med Cell Longev, 2017, 2017: 9702820[2017-02-06]. . DOI: 10.1155/2017/9702820.
10. Zhong Q, Mishra M. Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy[J]. Invest Ophthalmol Vis Sci, 2013, 54(6): 3941-3948. DOI: 10.1167/iovs.13-11598.
11. Voronova V, Zhudenkov K, Helmlinger G. Interpretation of metabolic memory phenomenon using a physiological systems model: what drives oxidative stress following glucose normalization?[J/OL]. PLoS One, 2017, 12(2): 0171781[2017-02-08]. . DOI: 10.1371/journal.pone.0171781.
12. Sharma S, Saxena S, Srivastav K, et al. Nitric oxide and oxidative stress is associated with severity of diabetic retinopathy and retinal structural alterations[J]. Clin Exp Ophthalmol, 2015, 43(5): 429-436. DOI: 10.1111/ceo.12506.
13. Serra AM, Waddell J, Manivannan A, et al. CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation[J]. Am J Pathol, 2012, 181(2): 719-727. DOI: 10.1016/j.ajpath.2012.04.009.
14. Elsherbiny NM, Naime M, Ahmad S, et al. Potential roles of adenosine deaminase-2 in diabetic retinopathy[J]. Biochem Biophys Res Commun, 2013, 436(3): 355-361. DOI: 10.1016/j.bbrc.2013.05.023.
15. Abdul Nasir NA, Agarwal R, Sheikh Abdul Kadir SH, et al. Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats[J/OL]. PLoS One, 2017, 12(3): 0174542[2017-03-28]. . DOI: 10.1371/journal.pone.0174542.
16. Zuwała-Jagiełło J, Pazgan-Simon M, Simon K, et al. Elevated advanced oxidation protein products levels in patients with liver cirrhosis[J]. Acta Biochim Pol, 2009, 56(4): 679-685.
17. Hirakawa Y, Tanaka T. Mechanisms of metabolic memory and renal hypoxia as a therapeutic target in diabetic kidney disease[J/OL]. J Diabetes Investig, 2017, 2017: E1[2017-01-17]. . DOI: 10.1111/jdi.12624. [published online ahead of print].
18. Chilelli NC, Burlina S, Lapolla A. AGEs, rather than hyperglycemia, are responsible for microvascular complications in diabetes: a "glycoxidation-centric" point of view [J]. Nutr Metab Cardiovasc Diseases, 2013, 23(10): 913-919. DOI: 10.1016/j.numecd.2013.04.004.
19. Tang J, Kern TS. Inflammation in diabetic retinopathy[J]. Prog Retin Eye Res, 2011, 30(5): 343-358. DOI: 10.1016/j.preteyeres.2011.05.002.
20. Jiang T, Chang Q, Cai J, et al. Protective effects of melatonin on retinal inflammation and oxidative stress in experimental diabetic retinopathy[J/OL]. Oxid Med Cell Longev, 2016, 2016: 3528274[2016-04-06]. . DOI: 10.1155/2016/3528274.
21. Chan PS, Kanwar M, Kowluru RA. Resistance of retinal inflammatory mediators to suppress after reinstitution of good glycemic control: novel mechanism for metabolic memory[J]. J Diabetes Complications, 2010, 24(1): 55-63. DOI: 10.1016/j.jdiacomp.2008.10.002.
22. Mimura I, Tanaka T. New insights into molecular mechanisms of epigenetic regulation in kidney disease[J]. Clin Exp Pharmacol Physiol, 2016, 43(12): 1159-1167. DOI: 10.1111/1440-1681.12663.
23. Reddy MA, Zhang E, Natarajan R. Epigenetic mechanisms in diabetic complications and metabolic memory[J]. Diabetologia, 2015, 58(3): 443-455. DOI: 10.1007/s00125-014-3462-y.
24. Chen Z, Miao F, Paterson AD, et al. Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort[J]. Proc Natl Acad Sci USA, 2016, 113(21): 3002-3011. DOI: 10.1073/pnas.1603712113.
25. Mishra M. The role of DNA methylation in the metabolic memory phenomenon associated with the continued progression of diabetic retinopathy[J]. Invest Ophthalmol Vis Sci, 2016, 57(13): 5748-5757. DOI: 10.1167/iovs.16-19759.
26. Sánchez-Chávez G, Hernández-Ramírez E, Osorio-Paz I, et al. Potential role of endoplasmic reticulum stress in pathogenesis of diabetic retinopathy[J]. Neurochem Res, 2016, 41(5): 1098-1106. DOI: 10.1007/s11064-015-1798-4.
27. Yu Z, Gong C, Lu B, et al. Dendrobium chrysotoxum Lindl alleviates diabetic retinopathy by preventing retinal inflammation and tight junction protein decrease[J/OL]. J Diabetes Res, 2015, 2015: 518317[2015-01-01]. . DOI: 10.1155/2015/518317.
28. Zhong Y, Li J, Chen Y, et al. Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derive inflammatory cytokine production in diabetes[J]. Diabetes, 2012, 61(2): 492-504. DOI: 10.2337/db11-0315.
29. Huang C, Wang JJ, Ma JH, et al. Activation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2[J]. J Biol Chem, 2015, 290(9): 5367-5380. DOI: 10.1074/jbc.M114.603738.
30. Gomes MB. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases[J]. Diabetol Metab Syndr, 2014, 6(1): 80. DOI: 10.1186/1758-5996-6-80.
31. Zhang L, Xia H, Han Q. Effects of antioxidant gene therapy on the development of diabetic retinopathy and the metabolic memory phenomenon[J]. Graefe’s Arch Clin Exp Ophthalmol, 2015, 253(2): 249-259. DOI: 10.1007/s00417-014-2827-8.

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