The choroidal thickness and blood flow in the subfoveal area with idiopathic macular hole by spectral-domain optical coherence tomography_Chinese Journal of Ocular Fundus Diseases

Authors：

Lin Qiurong , Gao Min ,  Liu Haiyun

Shanghai General Hospital, Shanghai Jiaotong University, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China;

Corresponding author：

Liu Haiyun, Email: drliuhaiyun@126.com

Keywords：

Retinal perforations/diagnosis; Tomography, optical coherence; Diagnostic imaging

DOI：

10.3760/cma.j.issn.1005-1015.2017.04.016

Video：

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ObjectiveTo observe the subfoveal choroidal thickness (SFCT) and choriocapillary blood flow area (CBFA) in the patients with idiopathic macular hole (IMH).MethodsThis is a prospective clinical study. Thirty-two patients with unilateral IMH (4 in stage 2, 17 in stage 3, 11 in stage 4) and 32 age- and sex-matched normal controls were enrolled in this study. All eyes were divided into three groups, including group A (32 affected eyes), group B (32 fellow eyes) and group C (32 normal eyes of controls). There was no significant difference in age (t=0.865) and gender (χ²=0.000) in IMH patients versus normal control subjects (P＞0.05). There was no significant difference in refraction (F=0.957) and ocular axial length (F=0.562) between group A, B and C. The SFCT was detected by enhanced depth imaging of spectral-domain optical coherence tomography (OCT). The CBFA was detected by OCT angiography. The differences of SFCT and CBFA in three groups were analyzed by Kruskal-Wallis and non-parametric test.ResultsThe mean SFCT was (182.53±64.52) μm in group A, (199.21±73.07) μm in group B and (254.21±56.85) μm in group C respectively. The SFCT was thinner in group A and B than that in group C (Z=−4.362, −3.190; P＜0.05), but was the same in group A and B (Z=−1.171, P＞0.05). The mean CBFA was (5.09±0.31) mm² in group A, (5.41±0.20) mm² in group B and (5.39±0.15) mm² in group C respectively. The CBFA was reduced in group A than that in group B and C (Z=−4.467, −4.048; P＜0.05), but was same in group B and C (Z=0.420, P＞0.05).ConclusionSFCT and CBFA are both reduced in IMH eyes.

Citation： Lin Qiurong, Gao Min, Liu Haiyun. The choroidal thickness and blood flow in the subfoveal area with idiopathic macular hole by spectral-domain optical coherence tomography. Chinese Journal of Ocular Fundus Diseases, 2017, 33(4): 396-399. doi: 10.3760/cma.j.issn.1005-1015.2017.04.016 Copy

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2.	Kelkar AS, Bhanushali DR, Kelkar JA, et al. Spontaneous closure of a full-thickness stage 2 idiopathic macular hole without posterior vitreous detachment[J]. Case Rep Ophthalmol, 2013, 4(3): 188-191. DOI: 10.1159/000356125.
3.	Aras C, Ocakoglu O, Akova N. Foveolar choroidal blood flow in idiopathic macular hole[J]. Int Ophthalmol, 2004, 25(4): 225-231.
4.	Schaal KB, Pollithy S, Dithmar S. Is choroidal thickness of importance in idiopathic macular hole?[J]. Ophthalmologe, 2012, 109(4): 364-368. DOI: 10.1007/s00347-012-2529-8.
5.	Reibaldi M, Boscia F, Avitabile T, et al. Enhanced depth imaging optical coherence tomography of the choroid in idiopathic macular hole: a cross-sectional prospective study[J]. Am J Ophthalmol, 2011, 151(1): 112-117. DOI: 10.1016/j.ajo.2010.07.004.
6.	Gass JD. Reappraisal of biomicroscopic classification of stages of development of a macular hole[J]. Am J Ophthalmol, 1995, 119(6): 752-759.
7.	Branchini L, Regatieri CV, Flores-Moreno I, et al. Reproducibility of choroidal thickness measurements across three spectral domain optical coherence tomography systems[J]. Ophthalmology, 2012, 119(1): 119-123. DOI: 10.1016/j.ophtha.2011.07.002.
8.	Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes[J]. Am J Ophthalmol, 2009, 147(5): 811-815. DOI: 10.1016/j.ajo.2008.12.008.
9.	梁安怡, 曹丹, 张良. 脉络膜厚度与糖尿病视网膜病变相关性研究现状[J]. 中华眼底病杂志, 2017, 33(3): 315-318. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.Liang AY, Cao D, Zhang L. The correlation between choroidal thickness and diabetic retinopathy[J]. Chin J Ocul Fundus Dis, 2017, 33(3): 315-318. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.
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11.	Zeng J, Li J, Liu R, et al. Choroidal thickness in both eyes of patients with unilateral idiopathic macular hole[J]. Ophthalmology, 2012, 119(11): 2328-2333. DOI: 10.1016/j.ophtha.2012.06.008.
12.	陈迪, 李略, 杨治坤, 等. 频域光学相干断层扫描观察特发性黄斑裂孔患者脉络膜厚度[J]. 协和医学杂志, 2013, 4(2): 113-117. DOI: 10.3969/j.issn.1674-9081.2013.02.006.Chen D, Li L, Yang ZK, et al. Spectral-domain optical coherence tomography findings of choroidal thickness in eyes of patients with idiopathic macular holes[J]. Medical Journal of Peking Union Medical College Hospital, 2013, 4(2): 113-117. DOI: 10.3969/j.issn.1674-9081.2013.02.006.
13.	Karkhaneh R, Nikbakht M, Bazvand F, et al. Choroidal thickness in idiopathic macular hole[J]. J Curr Ophthalmol, 2016, 29(1): 45-49. DOI: 10.1016/j.joco.2016.08.005.
14.	Kim M, Kim SS, Kwon HJ, et al. Association between choroidal thickness and ocular perfusion pressure in young, healthy subjects: enhanced depth imaging optical coherence tomography study[J]. Invest Ophthalmol Vis Sci, 2012, 53(12): 7710-7717. DOI: 10.1167/iovs.12-10464.
15.	Kiel JW, van Heuven WA. Ocular perfusion pressure and choroidal blood flow in the rabbit[J]. Invest Ophthalmol Vis Sci, 1995, 36(3): 579-585.
16.	Lovasik JV, Kergoat H, Riva CE, et al. Choroidal blood flow during exercise-induced changes in the ocular perfusion pressure[J]. Invest Ophthalmol Vis Sci, 2003, 44(5): 2126-2132.
17.	王敏. 利用光相干断层扫描血管成像技术优势, 提升视网膜脉络膜血管疾病认知水平[J]. 中华眼底病杂志, 2016, 32(4): 349-352. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.003.Wang M. Evaluating retinal and choroidal vascular diseases with optical coherence tomography angiography[J]. Chin J Ocul Fundus Dis, 2016, 32(4): 349-352. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.003.

1. Gass JD. Idiopathic senile macular hole: its early stages and pathogenesis[J]. Arch Ophthalmol, 1988, 106(5): 629-639.
2. Kelkar AS, Bhanushali DR, Kelkar JA, et al. Spontaneous closure of a full-thickness stage 2 idiopathic macular hole without posterior vitreous detachment[J]. Case Rep Ophthalmol, 2013, 4(3): 188-191. DOI: 10.1159/000356125.
3. Aras C, Ocakoglu O, Akova N. Foveolar choroidal blood flow in idiopathic macular hole[J]. Int Ophthalmol, 2004, 25(4): 225-231.
4. Schaal KB, Pollithy S, Dithmar S. Is choroidal thickness of importance in idiopathic macular hole?[J]. Ophthalmologe, 2012, 109(4): 364-368. DOI: 10.1007/s00347-012-2529-8.
5. Reibaldi M, Boscia F, Avitabile T, et al. Enhanced depth imaging optical coherence tomography of the choroid in idiopathic macular hole: a cross-sectional prospective study[J]. Am J Ophthalmol, 2011, 151(1): 112-117. DOI: 10.1016/j.ajo.2010.07.004.
6. Gass JD. Reappraisal of biomicroscopic classification of stages of development of a macular hole[J]. Am J Ophthalmol, 1995, 119(6): 752-759.
7. Branchini L, Regatieri CV, Flores-Moreno I, et al. Reproducibility of choroidal thickness measurements across three spectral domain optical coherence tomography systems[J]. Ophthalmology, 2012, 119(1): 119-123. DOI: 10.1016/j.ophtha.2011.07.002.
8. Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes[J]. Am J Ophthalmol, 2009, 147(5): 811-815. DOI: 10.1016/j.ajo.2008.12.008.
9. 梁安怡, 曹丹, 张良. 脉络膜厚度与糖尿病视网膜病变相关性研究现状[J]. 中华眼底病杂志, 2017, 33(3): 315-318. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.Liang AY, Cao D, Zhang L. The correlation between choroidal thickness and diabetic retinopathy[J]. Chin J Ocul Fundus Dis, 2017, 33(3): 315-318. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.
10. Wei WB, Xu L, Jonas JB, et al. Subfoveal choroidal thickness: the Beijing Eye Study[J]. Ophthalmology, 2013, 120(1): 175-180. DOI: 10.1016/j.Ophtha.2012.07.048.
11. Zeng J, Li J, Liu R, et al. Choroidal thickness in both eyes of patients with unilateral idiopathic macular hole[J]. Ophthalmology, 2012, 119(11): 2328-2333. DOI: 10.1016/j.ophtha.2012.06.008.
12. 陈迪, 李略, 杨治坤, 等. 频域光学相干断层扫描观察特发性黄斑裂孔患者脉络膜厚度[J]. 协和医学杂志, 2013, 4(2): 113-117. DOI: 10.3969/j.issn.1674-9081.2013.02.006.Chen D, Li L, Yang ZK, et al. Spectral-domain optical coherence tomography findings of choroidal thickness in eyes of patients with idiopathic macular holes[J]. Medical Journal of Peking Union Medical College Hospital, 2013, 4(2): 113-117. DOI: 10.3969/j.issn.1674-9081.2013.02.006.
13. Karkhaneh R, Nikbakht M, Bazvand F, et al. Choroidal thickness in idiopathic macular hole[J]. J Curr Ophthalmol, 2016, 29(1): 45-49. DOI: 10.1016/j.joco.2016.08.005.
14. Kim M, Kim SS, Kwon HJ, et al. Association between choroidal thickness and ocular perfusion pressure in young, healthy subjects: enhanced depth imaging optical coherence tomography study[J]. Invest Ophthalmol Vis Sci, 2012, 53(12): 7710-7717. DOI: 10.1167/iovs.12-10464.
15. Kiel JW, van Heuven WA. Ocular perfusion pressure and choroidal blood flow in the rabbit[J]. Invest Ophthalmol Vis Sci, 1995, 36(3): 579-585.
16. Lovasik JV, Kergoat H, Riva CE, et al. Choroidal blood flow during exercise-induced changes in the ocular perfusion pressure[J]. Invest Ophthalmol Vis Sci, 2003, 44(5): 2126-2132.
17. 王敏. 利用光相干断层扫描血管成像技术优势, 提升视网膜脉络膜血管疾病认知水平[J]. 中华眼底病杂志, 2016, 32(4): 349-352. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.003.Wang M. Evaluating retinal and choroidal vascular diseases with optical coherence tomography angiography[J]. Chin J Ocul Fundus Dis, 2016, 32(4): 349-352. DOI: 10.3760/cma.j.issn.1005-1015.2016.04.003.

Chinese Journal of Ocular Fundus Diseases

The choroidal thickness and blood flow in the subfoveal area with idiopathic macular hole by spectral-domain optical coherence tomography

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