The choroidal thickness in patients with nonarteritic anterior ischemic optic neuropathy_Chinese Journal of Ocular Fundus Diseases

Authors：

Wang Xuqian ,  Zhong Yong , Ma Jin , Wang Yuhan , Li Lue , Zhang Xia

Departments of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China;

Corresponding author：

Zhong Yong, Email: yzhong_eye@163.com

Keywords：

Optic neuropathy, ischemic; Choroid; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2017.05.005

Video：

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ObjectiveTo observe the changes in subfoveal choroidal thickness (SFCT) and peripapillary choroidal thickness (pCT) in nonarteritic anterior ischemic optic neuropathy (NAION).MethodsNineteen newly occurred NAION patients were included. The patients were divided into group A (20 affected eyes of 19 patients) and B (18 fellow eyes of 18 patients). Twenty eyes of 20 age, gender, intraocular pressure and axial length-matched healthy volunteers (group C) were enrolled in this study. The differences of age (t=1.58), gender ratios (χ²=0.107), intraocular pressure (t=0.092) and axial length (t=0.148) between 3 groups were not significant (P＞0.05). SFCT, pCT were measured at first visit, 1 month and 3 months after treatment using enhanced deep imaging technique of spectral domain optical coherence tomography. The correlation of best corrected visual acuity (BCVA) and the choroidal thickness was investigated.ResultsAt the first visit, the mean SFCT and pCT in group A were significant thicker than group C (t=2.957, 2.844; P=0.006, 0.009). There was no difference of SFCT and pCT between group B and C (t=2.019, 2.024; P=0.053, 0.057). There was no correlation between BCVA and SFCT, pCT (F=0.161, 0.033; P=0.695, 0.859). One month after treatment, SFCT in group A was still thicker than group C (t=2.803, P=0.009); while pCT was decreased in group A when compared to group C, but the difference was not significant (t=1.871, P=0.084). Three months after treatment, the differences of SFCT and pCT were not significant between group A and C (t=1.223, 1.105; P=0.236, 0.282).ConclusionsAt first visit, SFCT and pCT in NAION eyes showed a significant increase when compared to normal eyes. One month later, pCT in NAION eyes decreased to normal. Three months later, both SFCT and pCT decreased. These findings may suggest that a thickened choroid is a clinical characteristic at acute stage in NAION eyes.

Citation： Wang Xuqian, Zhong Yong, Ma Jin, Wang Yuhan, Li Lue, Zhang Xia. The choroidal thickness in patients with nonarteritic anterior ischemic optic neuropathy. Chinese Journal of Ocular Fundus Diseases, 2017, 33(5): 458-461. doi: 10.3760/cma.j.issn.1005-1015.2017.05.005 Copy

1.	Fard MA, Abdi P, Kasaei A, et al. Peripapillary choroidal thickness in nonarteritic anterior ischemic optic neuropathy[J/OL]. Invest Ophthalmol Vis Sci, 2015, 56(5): E15661[2015-05-26]. http://iovs.arvojournals.org/article.aspx?articleid=2319138. DOI: 10.1167/iovs.14-15661. [published online ahead of print].
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3.	García-Basterra I, Lahrach I, Morillo Sánchez MJ, et al. Analysis of peripapillary choroidal thickness in non-arteritic anterior ischaemic optic neuropathy[J]. Br J Ophthalmol, 2016, 100(7): 891-896. DOI: 10.1136/bjophthalmol-2015-307526.
4.	Gonul S, Gedik S, Koktekir BE, et al. Evaluation of choroidal thickness in non-arteritic anterior ischaemic optic neuropathy at the acute and chronic stages[J]. Neuroophthalmology, 2016, 40(4): 181-187. DOI: 10.1080/01658107.2016.1198918.
5.	Nagia L, Huisingh C, Johnstone J, et al. Peripapillary pachychoroid in nonarteritic anterior ischemic optic neuropathy[J]. Invest Ophthalmol Vis Sci, 2016, 57(11): 4679-4685. DOI: 10.1167/iovs.16-19315.
6.	刘玉平, 王应利, 周玉梅, 等.应用EDI-OCT+检测NAION患者脉络膜厚度的研究[J]. 国际眼科杂志, 2017, 17(2): 344-347. DOI: 10.3980/j.issn.1672-5123.2017.2.39.Liu YP, Wang YL, Zhou YM, et al. Choroidal thickness in nonarteritic anterior ischemic optic neuropathy measured by enhanced depth imaging OCT[J]. Int Eye Sci, 2017, 17(2): 344-347. DOI: 10.3980/j.issn.1672-5123.2017.2.39.
7.	中华医学会眼科学分会神经眼科学组.我国非动脉炎性前部缺血性视神经病变诊断和治疗专家共识(2015年)[J]. 中华眼科杂志, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.Neuro-ophthalmology group.Ophthalmology Branch of Chinese Medical Association.Diagnosis and treatment guideline of nonarteritic anterior ischemic optic neuropathy in china.[J]. Chin J Ophthalmol, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.
8.	Li L, Bian A, Zhou Q, et al. Peripapillary choroidal thickness in both eyes of glaucoma patients with unilateral visual field loss[J]. Am J Ophthalmol, 2013, 156(6): 1277-1284. DOI: 10.1016/j.ajo.2013.07.011.
9.	Regatieri CV, Branchini L, Carmody J, et al. Choroidal thickness in patients with diabetic retinopathy analyzed by spectral-domain optical coherence tomography[J]. Retina, 2012, 32(3): 563-568. DOI: 10.1097/IAE.0b013e31822f5678.
10.	Kang NH, Kim YT.Change in subfoveal choroidal thickness in central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy[J]. Eye (Lond), 2013, 27(3): 387-391. DOI: 10.1038/eye.2012.273.
11.	Unsal E, Eltutar K, Zirtiloğlu S, et al. Choroidal thickness in patients with diabetic retinopathy[J]. Clin Ophthalmol, 2014, 8: 637-642. DOI: 10.2147/OPTH.S59395.
12.	Yazgan S, Arpaci D, Celik HU, et al. Macular choroidal thickness may be the earliest determiner to detect the onset of diabetic retinopathy in patients with prediabetes: a prospective and comparative study[J]. Curr Eye Res, 2017, 42 (7): 1039-1047. DOI: 10.1080/02713683.2016.1264606.
13.	Kang HM, Choi JH, Koh HJ.Significant reduction of peripapillary choroidal thickness in patients with unilateral branch retinal vein occlusion [J/OL]. Retina, 2017, 2017: E1[2017-01-16]. https://insights.ovid.com/pubmed?pmid=28098732. DOI: 10.1097/IAE.0000000000001495. [published online ahead of print].
14.	Foroozan R.New treatments for nonarteritic anterior ischemic optic neuropathy[J]. Neurol Clin, 2017, 35(1): 1-15. DOI: 10.1016/j.ncl.2016.08.003.
15.	Takayama K, Kaneko H, Kachi S, et al. High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy [J]. Nagoya J Med Sci, 2017, 79(1): 103-108. DOI: 10.18999/nagjms.79.1.103.
16.	Brown JS, Flitcroft DI, Ying GS, et al. In vivo human choroidal thickness measurements: evidence for diurnal fluctuations[J]. Invest Ophthalmol Vis Sci, 2009, 50: 5-12. DOI: 10.1167/iovs.08-1779.
17.	Tan CS, Ouyang Y, Ruiz H, et al. Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2012, 53(1): 261-266. DOI: 10.1167/iovs.11-8782.

1. Fard MA, Abdi P, Kasaei A, et al. Peripapillary choroidal thickness in nonarteritic anterior ischemic optic neuropathy[J/OL]. Invest Ophthalmol Vis Sci, 2015, 56(5): E15661[2015-05-26]. http://iovs.arvojournals.org/article.aspx?articleid=2319138. DOI: 10.1167/iovs.14-15661. [published online ahead of print].
2. García-Basterra I, González Gómez A, García-Ben A, et al. Macular choroidal thickness in non-arteritic ischemic optic neuropathy[J]. Arch Soc Esp Oftalmol, 2016, 91(5): 223-237. DOI: 10.1016/j.oftal.2015.12.019.
3. García-Basterra I, Lahrach I, Morillo Sánchez MJ, et al. Analysis of peripapillary choroidal thickness in non-arteritic anterior ischaemic optic neuropathy[J]. Br J Ophthalmol, 2016, 100(7): 891-896. DOI: 10.1136/bjophthalmol-2015-307526.
4. Gonul S, Gedik S, Koktekir BE, et al. Evaluation of choroidal thickness in non-arteritic anterior ischaemic optic neuropathy at the acute and chronic stages[J]. Neuroophthalmology, 2016, 40(4): 181-187. DOI: 10.1080/01658107.2016.1198918.
5. Nagia L, Huisingh C, Johnstone J, et al. Peripapillary pachychoroid in nonarteritic anterior ischemic optic neuropathy[J]. Invest Ophthalmol Vis Sci, 2016, 57(11): 4679-4685. DOI: 10.1167/iovs.16-19315.
6. 刘玉平, 王应利, 周玉梅, 等.应用EDI-OCT+检测NAION患者脉络膜厚度的研究[J]. 国际眼科杂志, 2017, 17(2): 344-347. DOI: 10.3980/j.issn.1672-5123.2017.2.39.Liu YP, Wang YL, Zhou YM, et al. Choroidal thickness in nonarteritic anterior ischemic optic neuropathy measured by enhanced depth imaging OCT[J]. Int Eye Sci, 2017, 17(2): 344-347. DOI: 10.3980/j.issn.1672-5123.2017.2.39.
7. 中华医学会眼科学分会神经眼科学组.我国非动脉炎性前部缺血性视神经病变诊断和治疗专家共识(2015年)[J]. 中华眼科杂志, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.Neuro-ophthalmology group.Ophthalmology Branch of Chinese Medical Association.Diagnosis and treatment guideline of nonarteritic anterior ischemic optic neuropathy in china.[J]. Chin J Ophthalmol, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.
8. Li L, Bian A, Zhou Q, et al. Peripapillary choroidal thickness in both eyes of glaucoma patients with unilateral visual field loss[J]. Am J Ophthalmol, 2013, 156(6): 1277-1284. DOI: 10.1016/j.ajo.2013.07.011.
9. Regatieri CV, Branchini L, Carmody J, et al. Choroidal thickness in patients with diabetic retinopathy analyzed by spectral-domain optical coherence tomography[J]. Retina, 2012, 32(3): 563-568. DOI: 10.1097/IAE.0b013e31822f5678.
10. Kang NH, Kim YT.Change in subfoveal choroidal thickness in central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy[J]. Eye (Lond), 2013, 27(3): 387-391. DOI: 10.1038/eye.2012.273.
11. Unsal E, Eltutar K, Zirtiloğlu S, et al. Choroidal thickness in patients with diabetic retinopathy[J]. Clin Ophthalmol, 2014, 8: 637-642. DOI: 10.2147/OPTH.S59395.
12. Yazgan S, Arpaci D, Celik HU, et al. Macular choroidal thickness may be the earliest determiner to detect the onset of diabetic retinopathy in patients with prediabetes: a prospective and comparative study[J]. Curr Eye Res, 2017, 42 (7): 1039-1047. DOI: 10.1080/02713683.2016.1264606.
13. Kang HM, Choi JH, Koh HJ.Significant reduction of peripapillary choroidal thickness in patients with unilateral branch retinal vein occlusion [J/OL]. Retina, 2017, 2017: E1[2017-01-16]. https://insights.ovid.com/pubmed?pmid=28098732. DOI: 10.1097/IAE.0000000000001495. [published online ahead of print].
14. Foroozan R.New treatments for nonarteritic anterior ischemic optic neuropathy[J]. Neurol Clin, 2017, 35(1): 1-15. DOI: 10.1016/j.ncl.2016.08.003.
15. Takayama K, Kaneko H, Kachi S, et al. High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy [J]. Nagoya J Med Sci, 2017, 79(1): 103-108. DOI: 10.18999/nagjms.79.1.103.
16. Brown JS, Flitcroft DI, Ying GS, et al. In vivo human choroidal thickness measurements: evidence for diurnal fluctuations[J]. Invest Ophthalmol Vis Sci, 2009, 50: 5-12. DOI: 10.1167/iovs.08-1779.
17. Tan CS, Ouyang Y, Ruiz H, et al. Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2012, 53(1): 261-266. DOI: 10.1167/iovs.11-8782.

Chinese Journal of Ocular Fundus Diseases

The choroidal thickness in patients with nonarteritic anterior ischemic optic neuropathy

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