The difference of macular microvascular features in superficial and deep vascular plexi in patients with branch retinal vein occlusion_Chinese Journal of Ocular Fundus Diseases

Authors：

Wang Linni , Yu Rongguo , Yang Jin , Hu Liying , Gong Xue , Chen Lu , Li Zhiqing ,  Li Xiaorong

Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, Tianjin Medical University School of Optometry and Ophthalmology, Tianjin 300384, China;

Corresponding author：

Li Xiaorong, Email: lixiaorong@tmu.edu.cn

Keywords：

Retinal vein occlusion/diagnosis; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2018.01.004

Video：

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Objective To observe the difference of macular microvascular features in superficial and deep vascular plexi in patients with branch retinal vein occlusion (BRVO). Methods A total of 63 BRVO patients (63 eyes) were enrolled in this study. There were 28 males (28 eyes) and 35 females (35 eyes). The patients aged from 39 to 74 years, with the mean age of (59.76±8.48) years. All eyes were evaluated by optical coherence tomography angiography (OCTA). The macular angiography scan protocol covered a 3 mm×3 mm area. The focus of angiography analysis included superficial vascular plexus and deep vascular plexus. The following vascular morphological parameters were assessed in these two plexi: foveal avascular zone (FAZ) enlargement, capillary non-perfusion (CNP) occurrence, microvascular abnormalities (MA) appearance, and vascular congestion (VC) signs. The FAZ area was measured by the built-in software. The macular microvascular morphology changes in superficial and deep vascular plexi were compared through McNemar test. Results The superficial and deep plexi showed FAZ enlargement in 43 eyes (68.3%) and 50 eyes (79.4%), CNP in 51 eyes (81%) and 50 eyes (79.4%), MA in 62 eyes (98.4%) and 62 eyes (98.4%), VC in 23 eyes (36.5%) and 52 eyes (82.5%), respectively. FAZ area was (0.55±0.37) mm². There was no difference in CNP (P=1.000) and MA (P=1.000) between superficial and deep plexi. But, there was difference in FAZ enlargement (P=0.039) and VC signs (P＜0.001) between superficial and deep plexi. Conclusion Deep vascular plexus showed more FAZ enlargement and VC sign than superficial plexus in BRVO patients.

Citation： Wang Linni, Yu Rongguo, Yang Jin, Hu Liying, Gong Xue, Chen Lu, Li Zhiqing, Li Xiaorong. The difference of macular microvascular features in superficial and deep vascular plexi in patients with branch retinal vein occlusion. Chinese Journal of Ocular Fundus Diseases, 2018, 34(1): 13-16. doi: 10.3760/cma.j.issn.1005-1015.2018.01.004 Copy

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1. Spaide RF, Klancnik JM Jr, Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography[J]. JAMA Ophthalmol, 2015, 133(1): 45-50. DOI: 10.1001/jamaophthalmol.2014.3616.
2. Adhi M, Filho MA, Louzada RN, et al. Retinal capillary network and foveal avascular zone in eyes with vein occlusion and fellow eyes analyzed with optical coherence tomography angiography[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): 486-494. DOI: 10.1167/iovs.15-18907.
3. Shahlaee A, Hong BK, Ho AC. Optical coherence tomography angiography features of branch retinal vein occlusion[J]. Retin Cases Brief Rep, 2017, 11(1): 90-93. DOI: 10.1097/ICB.0000000000000297.
4. Novais EA, Waheed NK. Optical coherence tomography angiography of retinal vein occlusion[J]. Dev Ophthalmol, 2016, 56: 132-138. DOI: 10.1159/000442805.
5. Rispoli M, Savastano MC, Lumbroso B. Capillary network anomalies in branch retinal vein occlusion on optical coherence tomography angiography[J]. Retina, 2015, 35(11): 2332-2338. DOI: 10.1097/IAE.0000000000000845.
6. 卢宁, 张承芬. 视网膜静脉阻塞[M]//张承芬. 眼底病学. 2版.北京: 人民卫生出版社, 2010: 237-239.Lu N, Zhang CF. Retinal vein occlusion[M]//Zhang CF. Diseases of ocular fundus. 2nd ed. Beijing:People's Medical Publishing House, 2010: 237-239.
7. Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography[J]. Opt Express, 2012, 20(4): 4710-4725. DOI: 10.1364/OE.20.004710.
8. Ishibazawa A, Nagaoka T, Takahashi A, et al. Optical coherence tomography angiography in diabetic retinopathy: a prospective pilot study[J]. Am J Ophthalmol, 2015, 160(1): 35-44. DOI: 10.1016/j.ajo.2015.04.021.
9. Kuehlewein L, An L, Durbin MK, et al. Imaging areas of retinal nonperfusion in ischemic branch retinal vein occlusion with swept-source OCT microangiography[J]. Ophthalmic Surg Lasers Imaging Retina, 2015, 46(2): 249-252. DOI: 10.3928/23258160-20150213-19.
10. Tokayer J, Jia Y, Dhalla AH, et al. Blood flow velocity quantification using split spectrum amplitude-decorrelation angiography with optical coherence tomography[J]. Biomed Opt Express, 2013, 4(10): 1909-1924. DOI: 10.1364/BOE.4.001909.
11. Gorrand JM. Diffusion of the human retina and quality of the optics of the eye on the fovea and the peripheral retina [J]. Vision Res, 1979, 19(8): 907-912.
12. Samara WA, Say EA, Khoo CT, et al. Correlation of foveal avascular zone size with foveal morphology in normal eyes using optical coherence tomography angiography[J]. Retina, 2015, 35(11): 2188-2195. DOI: 10.1097/IAE.0000000000000847.

Chinese Journal of Ocular Fundus Diseases

The difference of macular microvascular features in superficial and deep vascular plexi in patients with branch retinal vein occlusion

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