The comparison of macular blood flow parameters in myopic choroidal neovascularization, high myopia and normal people_Chinese Journal of Ocular Fundus Diseases

Authors：

Shao Yirun , Mao Jianbo ,  Shen Lijun , Zhang Caiyun , Chen Yiqi , Xu Zhaokai , Zheng Zicheng , Lao Jimeng , Liu Bowen

Eye Hospital of Wenzhou Medical University at Hangzhou, Hangzhou 310020, China;

Corresponding author：

Shen Lijun, Email: slj@mail.eye.ac.cn

Keywords：

Myopia, degenerative; Choroidal neovascularization; Regional blood flow

DOI：

10.3760/cma.j.issn.1005-1015.2019.05.005

Video：

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Objective To compared the macular blood flow parameters among myopic choroidal neovascularization (mCNV), high myopia (HM) and normal subjects.Methods Retrospective study. Forty patients (40 eyes) diagnosed as mCNV (mCNV group) in the Eye Hospital of Wenzhou Medical University at Hangzhou from June 2016 to November 2018, age-matched, sex-matched and diopter-matched 40 HM patients (40 eyes, HM group), age-matched and sex-matched 40 healthy persons (40 eyes, normal group) were enrolled in this study. Retina superficial and deep vessel density, the area of foveal avascular zone (FAZ), a-circularity index (AI) and vessel density around the 300 μm width of the FAZ region (FD) on macular 3 mm×3 mm scan on OCTA of 3 groups were compared.Results There were significant differences in the average retina superficial, deep vessel density, the area of FAZ, AI and FD among 3 groups (F=24.82, 9.18, 3.58, 7.68, 14.15; P＜0.05). The average retina superficial and deep vessel density and FD in mCNV group were lower than those in HM group (P＜0.05). The average retina superficial and deep vessel density and FD in HM group were lower than those in control group (P＜0.05). The average area of FAZ in mCNV group was smaller than that in control group (P＜0.05). The average AI in mCNV group was less than that in the other 2 groups (P＜0.05).Conclusions The retina superficial, deep vessel density and FD decreased, the area and the form of FAZ remained unchanged in HM subjects comparing with normal subjects. While retina superficial, deep vessel density and FD decreased more, the area of FAZ reduced, the form of FAZ tend to be irregular in mCNV.

Citation： Shao Yirun, Mao Jianbo, Shen Lijun, Zhang Caiyun, Chen Yiqi, Xu Zhaokai, Zheng Zicheng, Lao Jimeng, Liu Bowen. The comparison of macular blood flow parameters in myopic choroidal neovascularization, high myopia and normal people. Chinese Journal of Ocular Fundus Diseases, 2019, 35(5): 446-450. doi: 10.3760/cma.j.issn.1005-1015.2019.05.005 Copy

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1. Wong TY, Ferreira A, Hughes R, et al. Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization: an evidence-based systematic review[J]. Am J Ophthalmol, 2014, 157(1): 9-25. DOI: 10.1016/j.ajo.2013.08.010.
2. Lan M, Chengguo Z, Xiongze Z, et al. Fluorescein leakage within recent subretinal hemorrhage in pathologic myopia: suggestive of CNV?[J/OL]. J Ophthalmol, 2018, 2018: 4707832[2018-08-13]. https://www.hindawi.com/journals/joph/2018/4707832/. DOI: 10.1155/2018/4707832.
3. 孙姣, 王艳玲, 王佳琳. 光相干断层扫描血管成像在近视中的应用研究进展[J]. 中华眼底病杂志, 2018, 34(1): 83-86. DOI: 10.3760/cma.j.issn.1005-1015.2018.01.025.Sun J, Wang YL, Wang JL. Advances of optical coherence tomography angiography in myopia[J]. Chin J Ocul Fundus Dis, 2018, 34(1): 83-86. DOI: 10.3760/cma.j.issn.1005-1015.2018.01.025.
4. Li M, Yang Y, Jiang H, et al. Retinal microvascular network and microcirculation assessments in high myopia[J]. Am J Ophthalmol, 2017, 174: 56-67. DOI: 10.1016/j.ajo.2016.10.018.
5. Qu D, Lin Y, Jiang H, et al. Retinal nerve fiber layer (RNFL) integrity and its relations to retinal microvasculature and microcirculation in myopic eyes[J/OL]. Eye Vis (Lond), 2018, 5: 25[2018-10-10]. https://eandv.biomedcentral.com/articles/10.1186/s40662-018-0120-3. DOI: 10.1186/s40662-018-0120-3.
6. Grossniklaus H. Clinicopathologic correlations of surgically excised type 1 and type 2 submacular choroidal neovascular membranes[J]. Am J Ophthalmol, 1998, 126(1): 59-69. DOI: 10.1016/S0002-9394(98)00145-7.
7. Taku W, Yasushi I, Yusuke O, et al. Aqueous concentrations of vascular endothelial growth factor in eyes with high myopia with and without choroidal neovascularization[J/OL]. J Ophthalmol, 2013, 2013: 257381[2013-03-06]. https://dx.doi.org/10.1155/2013/257381. DOI: 10.1155/2013/257381.
8. Mo J, Duan A, Chan S, et al. Vascular flow density in pathological myopia: an optical coherence tomography angiography study[J/OL]. BMJ Open, 2017, 7(2): 013571[2017-02-03]. http://bmjopen.bmj.com/cgi/pmidlookup?view=long&pmid=28159853. DOI: 10.1136/bmjopen-2016-013571.
9. Wang X, Kong X, Jiang C, et al. Is the peripapillary retinal perfusion related to myopia in healthy eyes? A prospective comparative study[J]. BMJ Open, 2016, 6(3): 010791[2016-03-11]. https://bmjopen.bmj.com/content/6/3/e010791.long. DOI: 10.1136/bmjopen-2015-010791.
10. Neelam K, Cheung CMG, Ohno-Matsui K, et al. Choroidal neovascularization in pathological myopia[J]. Prog Retin Eye Res, 2012, 31(5): 495-525. DOI: 10.1016/j.preteyeres.2012.04.001.
11. Tan Colin S, Lim Louis W, Chow Vernon S, et al. Optical coherence tomography angiography evaluation of the parafoveal vasculature and its relationship with ocular factors[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): 224-234. DOI: 10.1167/iovs.15-18869.
12. Samara WA, Say EA, Khoo CT, et al. Correlation of foveal avascular zone size with foveal morphology in normal eyes using optical coherence tomography angiography[J]. Retina, 2015, 35(11): 2188-2195. DOI: 10.1097/iae.0000000000000847.
13. 蔡萌, 田野, 王雅丽, 等. OCTA在玻璃体腔注射雷珠单抗治疗病理性近视脉络膜新生血管中的应用[J]. 国际眼科杂志, 2017, 17(10): 1945-1948. DOI: 10.3980/j.issn.1672-5123.2017.10.38.Cai M, Tian Y, Wang YL, et al. Role of optical coherence tomography angiography in myopic choroidal neovascularization after intravitreal injections of ranibizumab[J]. Int Eye Sci, 2017, 17(10): 1945-1948. DOI: 10.3980/j.issn.1672-5123.2017.10.38.

Chinese Journal of Ocular Fundus Diseases

The comparison of macular blood flow parameters in myopic choroidal neovascularization, high myopia and normal people

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